(Beyond Pesticides, January 4, 2022) A study published in Environmental Science and Technology finds neonicotinoids (neonics) and their breakdown products (metabolites), like other chemical pesticide compounds, can readily transfer from mother to fetus. The National Health and Nutrition Examination Survey (NHANES) finds U.S. pregnant women experience frequent exposure to environmental pollutants that pose serious health risks to both mother and newborn. Many known pollutants (i.e., heavy metals, polychlorinated biphenyl, and pesticides) are chemicals that can move from the mother to the developing fetus at higher exposure rates. Hence, prenatal exposure to these chemicals may increase the prevalence of birth-related health consequences like natal abnormalities and learning/developmental disabilities. Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. Moreover, a mother’s pesticide exposure can have a stronger association with health disorders than childhood exposure, and a newborn can still encounter pesticides. Therefore, it is essential to understand how pesticides impact the health and well-being of individuals during critical developmental periods. Beyond Pesticides has covered a variety of pregnancy risks from pesticides and other toxic chemicals, including these in just the last three years: pesticides and children’s sleep disorders; prenatal exposures to a multitude of chemicals; insecticides and childhood leukemia; insecticides and Attention Deficit/Hyperactivity Disorder. The study […]

(Beyond Pesticides, January 3, 2023) The California Department of Pesticide Regulation (DPR) announced new rules that remove existing limits on the use of 1,3-dichloropropene (1,3-D or Telone), allowing Californians to breathe much more 1,3-D than state toxicologists in the Office of Environmental Health Hazard Assessment (OEHHA) say is safe and highlighting the dangers to which farmworkers are routinely exposed. It is outrageous that the state of California and the U.S. Environmental Protection Agency (EPA) would allow farmworkers—whose labor was judged “essential” during the pandemic—to be routinely exposed to highly toxic pesticides, which could be replaced by organic practices. While the state of California describes its action as increasing protection, advocates point to continued use, unacceptable harm, and the availability of alternative organic agricultural production methods that eliminate the use of 1,3-D. Since over a third of the country’s vegetables and three-quarters of the country’s fruits and nuts are grown in California, most people who buy their food in a grocery store have a stake in how food is grown in the state and the impact that it has on those who live and work there. Tell the state of California, U.S. EPA, an the U.S. Congress to cancel the registration […]

(Beyond Pesticide, December 20, 2022) A meta-analysis published in Chemosphere finds prenatal pesticide exposure, or pesticide exposure during pregnancy has a positive association with autism spectrum disorder (ASD) and attention deficit/hyperactive disorder (ADHD). Particularly, exposure to chemical classes organophosphate (OP) and pyrethroid (PYR) insecticides, in addition to the mother’s age during pregnancy (≥30 years old), increased the risk factor of ASD. ADHD risk increases among offspring whose mothers encounter organochlorine pesticides (OCPs) during gestation. The etiology or cause of ASD and ADHD involves the interaction of multiple components, including lifestyle and genetics. However, emerging evidence indicates that environmental contaminants like pesticides (e.g., occupational exposures, air pollution, solvents, dietary residues, etc.) play a role in disease etiology. Pesticide contamination is widespread in all ecosystems, and chemical compounds can accumulate in human tissues resulting in chronic health effects.  ADHD is estimated to affect 8-12% of school-age children worldwide. While it is a complex disease, and genetics may play a role, no specific genes have been identified, and there is increasing evidence that environmental factors like pesticide exposure facilitate the development of the condition. Additionally, U.S. Centers for Disease Control and Prevention (CDC) estimates that 1 in 54 children have been diagnosed with an autism spectrum […]

(Beyond Pesticides, December 16, 2022) A report released last week — Merchants of Poison: How Monsanto Sold the World on a Toxic Pesticide — exposes not only Bayer/Monsanto malfeasance in its “promotion” of its glyphosate-based herbicide products, including the notorious Roundup®, but also, the broader landscape of corporate efforts to white- or green-wash products that companies know are harmful to people and the environment. The report was issued by U.S. Right to Know (USRTK, a nonprofit investigative research group focused on promoting transparency for public health), Friends of the Earth (FOE), and Real Food Media. It carries the pithy subtitle, “A case study in disinformation, corrupted science, and manufactured doubt about glyphosate,” a description cited by the Friends of the Earth press release as “at the core of the pesticide industry’s public relations playbook.” Beyond Pesticides welcomes this report, which comports with much of our previous coverage of the pesticide industry’s egregious misbehavior, and of glyphosate, the world’s most widely used herbicide. FOE calls the report the “first comprehensive review” of the Bayer/Monsanto “defense strategy” employed in attempts to deny science, manufacture doubt, and discredit critics who have researched, reported on, and/or advocated against the company’s flagship glyphosate products because […]

(Beyond Pesticides, December 13, 2022) Pesticides have a long history associated with hormone (endocrine)-disrupting properties that induce various molecular changes, prompting disease development. Adding to the science, a review published in Environmental Exposure, Biomonitoring and Exposure Assessment highlights how specific estrogen-mimicking pesticides increase the risk of disease, particularly hormone-related cancers among women (i.e., breast, ovarian, endometrial cancer) and men (i.e., testicular, prostate cancer). Like pesticides, endocrine disruptors are xenobiotic (i.e., chemical substances foreign to an organism or ecosystem). Many reports demonstrate that exposure to endocrine-disrupting chemicals can adversely affect human, animal—and thus environmental—health by altering the natural bodily hormones responsible for conventional reproductive, physical, and mental development. Endocrine disruption can lead to several health problems, including hormone-related cancer development (i.e., thyroid, breast, ovarian, prostate, testicular), reproductive dysfunction, and diabetes/obesity that can span generations. Therefore, studies related to pesticides and endocrine disruption help scientists understand the underlying mechanisms that indirectly or directly cause cancer, among other health issues. Pesticides are one of the most potent xeno-estrogenic compounds, as estrogenic strength and environmental half-life exceed those of other xeno-estrogenic compounds. Focusing on organochlorine pesticides (OCs), the study evaluates the chemical effects on the physiological (anatomic) system to increase cancer risk. Using human studies, researchers assessed how estrogen-medicated cancer develops in women and men. […]

(Beyond Pesticides, December 12, 2022) It is time for the U.S. Department of Agriculture (USDA) to follow through on its duty to assess individual “inert” ingredients used in organic production. In creating the original regulations for the National Organic Program (NOP), USDA—based on the recommendation of the National Organic Standards Board (NOSB)—decided to postpone the evaluation of so-called “inert” ingredients until active materials had been reviewed for the National List of Allowed and Prohibited Substances. In this context, “inert” is a misleading legal term since the ingredient may be chemically or biologically active, but not included for purposes of attacking a target organism. The first regulation and all subsequent revisions have allowed the use of “inert” ingredients on EPA’s former Lists 4A (“minimal risk inert ingredients”) and 4B (“other ingredients for which EPA has sufficient information to reasonably conclude that the current use pattern in pesticide products will not adversely affect public health or the environment”). A limited number on List 3 (“inerts of unknown toxicity”) were allowed in pheromone products. [This action requires a submission at Regulations.gov. You can copy and paste from the suggested comment below. Comments are due December 31, 2022.] Tell USDA that the National Organic Program […]

(Beyond Pesticides, December 6, 2022) Persistent organic pollutants (POPs)—including banned pesticides—present a health risk to humpback whales (Megaptera novaeangliae), according to a study published in Environmental Pollution. Regarding female humpback whales, levels of POPs in blubber are higher in juveniles and subadults than in adults, primarily from the transference of contaminants from the mother to her calf.  Organochlorine compounds (OCs), such as organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), are well-known persistent organic pollutants. The international Stockholm Convention treaty (signed by 152 countries, but not the U.S.) banned these primary pollutants of concern (UNEP, 2009) in 2001 (taking effect in 2004) because of their persistence, toxicity, and adverse effects on environmental and biological health. These pollutants have a global distribution, with evaporation and precipitation facilitating long-range atmospheric transport, deposition, and bioaccumulation of hazardous chemicals in the environment. However, these chemicals can remain in the environment for decades and interact with various current-use pesticides, including organophosphates, neonicotinoids, and pyrethroids. Although various studies demonstrate the volatile, toxic nature of POPs, much less research evaluates the impact POPs have on maternal offloading or transfer of contaminates to offspring and respective health consequences. The globe is currently going through the Holocene Extinction, Earth’s 6th mass extinction, with one […]

(Beyond Pesticides, December 1, 2022) The U.S. Environmental Protection Agency (EPA) must put measures in place to protect endangered species from the hazardous insecticide cyantraniliprole before September 2023. The requirements stems from a recent federal appeals court ruling that found EPA in violation of its statutory obligations under the Endangered Species Act (ESA). The agency originally lost its legal case on this chemical in 2017, but has since done nothing to fulfill the initial court order, necessitating further litigation by conservation groups. “It’s outrageous that the EPA is thumbing its nose at a federal court order even as cyantraniliprole wreaks havoc on our most endangered wildlife,” said Jonathan Evans, environmental health legal director at the Center for Biological Diversity. “The EPA has acknowledged that this pesticide is incredibly toxic to bees and other invertebrates, but the agency is so accustomed to putting the profits of the pesticide industry ahead of its duty to protect human health and our environment that for years it simply ignored a direct court order.” Cyantraniliprole is a systemic insecticide registered for use in 2014. It presents similar risks to pollinators and wildlife as other widely used systemics, such as the neonicotinoid class of chemicals. Its […]

(Beyond Pesticides, November 25, 2022) A study published in Chemosphere adds to the growing body of research demonstrating the endocrine (hormone) disrupting effects of glyphosate play in breast cancer development. Exposure to the herbicide glyphosate and other glyphosate-based herbicides (GBHs) at high concentrations mimics the estrogen-like cellular effects of 17β-estradiol (E2), altering binding activity to estrogen receptor α (ERα) sites, thus causing fundamental changes in breast cancer cell proliferation (abundance).  Glyphosate is the most commonly used active ingredient worldwide, appearing in many herbicide formulas, not just Bayer’s (formerly Monsanto) Roundup®. The use of this chemical has been increasing since the inception of crops genetically modified to tolerate glyphosate over two decades ago. The toxic herbicide readily contaminates the ecosystem with residues pervasive in food and water commodities. In addition to this study, literature proves time and time again that glyphosate has an association with cancer development, as well as human, biotic, and ecosystem harm. Therefore, advocates point to the need for national policies to reassess hazards associated with disease development and diagnosis upon exposure to chemical pollutants. The researchers note, “The results obtained in this study are of toxicological relevance since they indicate that glyphosate could be a potential endocrine disruptor in the mammalian system. Additionally, […]

(Beyond Pesticides, November 23, 2022) A new study throws into question the value of the pest management concept of setting action levels around pest infestations. In the course of watermelon production over a span of two years, pollination, not pest levels, was the key determining factor for yield. “These data advocate for a reprioritization of management, to conserve and protect wild bee pollination, which could be more critical than avoiding pest damage for ensuring high yields,” the study, published in Proceedings of the Royal Society B, indicates. Action levels are considered an important aspect of an integrated pest management (IPM) approach in agriculture, whereby a pest infestation reaches levels considered economically unacceptable, leading to a decision to engage in pest control. The concept of IPM however has been influenced by the chemical industry over the decades since its original definition and recent data indicates that it has failed to stop toxic pesticide use. The original intent of IPM was the adoption of preventive practices and utilization of nonchemical tools, placing pesticide use as a last resort when pest control is warranted. However, farms that self-identify as IPM operations use pesticides, sometimes as the first line of defense, while attempting to […]

(Beyond Pesticides, November 22, 2022) Fungus that survive a fungicide application may be able to multiply and thrive, putting plant yields at risk. This finding comes from research recently published by scientists at University of Illinois, focusing on the impact of fungicide use on soybean yields and the disease Septoria brown spot, caused by the fungus Septoria glycines. The research underlines the danger of preventive chemical applications in an attempt to protect yield and shows how precarious pesticide use can be when subject to the complexity seen in field conditions. Scientists began with the intent of analyzing the soybean’s phyllosphere mycobiome, the fungal microbial make-up of the outside of the plant, including all its surfaces above-ground. A field trial was established near Urbana, Illinois, and soybeans plants were separated into four different plots according to their treatment. One group was inoculated with Septoria glycines, another inoculated and sprayed with a fungicide, a third not inoculated yet sprayed with a fungicide, and a final control group neither inoculated nor treated with a fungicide. A range of different analyses were conducted to view changes in the disease development and mycobiome composition over time. Soybean plants that had been inoculated with Septoria showed […]

(Beyond Pesticides, November 21, 2022) Once again, the Environmental Protection Agency (EPA) has registered a new pesticide without performing a thorough review of its impacts on biodiversity as well as threatened and endangered species. Inpyrfluxam was registered in 2020 and only after being sued by the Center for Biological Diversity for failure to comply with the Endangered Species Act (ESA) did EPA commit to completing draft effects determinations by Fall 2022. Once again, EPA’s draft biological evaluation is incomplete and inadequate. EPA is accepting comments on its draft biological evaluation at Regulations.gov.  Tell EPA and Congress that Pesticide Registrations Require Complete Science. The Review of Inpyrfluxam is Incomplete and Inadequate.  The agency’s draft effects assessment is flawed and incomplete. We share the details because it shows that EPA is out of step with the science and its regulatory responsibility when it comes a thorough review for ecosystem effects of pesticides.   The agency used fish early life stage (ELS) tests to estimate chronic fish toxicity. This is inappropriate. The fish ELS is a sub-chronic test of sensitive life stages. Although it is often used as a surrogate or predictor of chronic toxicity, it does not adequately address potential adverse effects on reproduction or transfer of the test chemical to eggs/offspring […]

(Beyond Pesticides, November 17, 2022) A report published in Toxicology and Applied Pharmacology finds organophosphate (OP) insecticides and the coronavirus (SARS-CoV-2/Covid-19) illicit similar damage to the heart and co-occurring exposure to both can escalate cardiac (heart) injury. Previous research suggests OPs may increase the ability of SARS-CoV-2 to cause COVID-19, especially among vulnerable individuals with underlying medical conditions. OPs have a wide range of biological uses—from insecticides to flame retardants—that make these chemicals ubiquitous, significantly contributing to ecosystem contamination. These compounds have a global distribution, with evaporation and precipitation facilitating long-range atmospheric transport, deposition, and bioaccumulation of hazardous chemicals in the environment. OPs are highly toxic, originating from the same compounds as World War II nerve agents, and residues are consistently present in human and animal blood, urine, tissues, and milk. Moreover, OPs are one of the leading causes of poisoning globally. Therefore, it is vital to understand how OP exposure will impact human health in conjunction with other immunologically compromising diseases like COVID-19. Cardiovascular diseases are among the leading causes of death globally. Additionally, heart conditions are one leading cause of disability in the U.S., as research demonstrates environmental pollutant exposure can increase the risk of developing cardiovascular disease, including stroke, heart attack, heart failure, atrial fibrillation, and cardiac […]

(Beyond Pesticides, November 15, 2022) Spraying a flowering plant with synthetic fertilizers makes it less attractive to bumblebees, according to research published this month in PNAS Nexus.  “A big issue is thus—agrochemical application can distort floral cues and modify behaviour in pollinators like bees,” said study author Ellard Hunting, PhD, of the University of Bristol, UK. The findings underscore the limited understanding that proponents of chemical agriculture have for the complex processes that food production relies upon and reinforce calls for a broad scale transition to regenerative, organic farming practices. Scientists began with the knowledge that spray applications of various agrichemicals affect the visitation patterns of bumblebees and other pollinators through a range of different processes. Past research finds that notorious bee-killing neonicotinoid insecticides not only kill bees outright, but also result in a range of complex damage, including their ability to impede bees’ olfactory senses and adversely affect their vision and flying ability. Other chemicals like glyphosate weaken bees’ ability to distinguish between colors.   A growing area of research is investigating the ways in which pollinators use static electric fields surrounding flowers to find food sources. A 2013 study found that bumblebees use floral electrical fields to discriminate […]

(Beyond Pesticides, November 14, 2022) Glyphosate weed killers induce antibiotic resistance in deadly hospital-acquired bacteria, according to a new study published late last month in the journal Scientific Reports. This is the latest finding connecting commonly used herbicides to the rise of antibiotic resistant bacteria. To put this finding in context, antibiotic resistance is rising to dangerously high levels in all parts of the world, according to the World Health Organization. In the May 1, 2022, issue of the Bulletin of the World Health Organization, Samira Choudhury, PhD, et al. writes, “Often referred to as the silent pandemic, antimicrobial resistance claims the lives of over 700,000 people annually.” The authors continue, “A study suggests that if no actions are taken, antimicrobial resistance will cause 10 million deaths per year by 2050 and an economic impact of over 100 trillion United States dollars.” Tell EPA and Congress that antibiotic pesticides in agriculture, lawns, and landscapes must be eliminated. Use of antibiotics in animal agriculture has long been recognized as a contributor to widespread antibiotic resistance. More recently, recognition of the contribution of antibiotics in plant agriculture has led to pressure to eliminate agricultural uses of antibiotics used in medicine. However, two facts […]

(Beyond Pesticides, November 11, 2022) A paper published in Trends in Ecology & Evolution in late October sounds an unnerving alarm about the globally ubiquitous use of herbicides and the ecological destruction being caused. It asserts that widespread environmental contamination with these herbicide compounds is influencing soil, plant, and animal microbiomes in ways that are not only not well understood, but also, can have significant impacts on the functioning of organisms and their ecosystems — with evolutionary implications. Impacts of herbicides on microbiota in soils include, for example, those on nutrient cycling, and altered organism and plant performance, which can affect pollination and animal consumption of plants. This research reinforces what Beyond Pesticides wrote in covering a 2021 study: “The popular herbicide glyphosate negatively affects microbial communities, indirectly influencing plant, animal, and human health. Exposure to sublethal concentrations of glyphosate shifts microbial community composition, destroying beneficial microorganisms while preserving pathogenic organisms.” Herbicides are a category of pesticide used to control weeds in agriculture and commercial forests, on managed landscapes, byways, gardens, and lawns, and directly on surface waters to control aquatic weeds. They are designed to kill “target” plant species considered undesirable in any of those circumstances. Herbicide use has exploded […]

(Beyond Pesticides, November 9, 2022) A team of Dutch researchers has developed an artificial predator dubbed the RobotFalcon that can quickly and successfully scare bird flocks away from fields, providing a new practical, ethical tool to deter bird strikes near airports. Although it sounds like a conspiracy theory, in the skies above Workum, The Netherlands, for a period of time, some of the birds were not real. Current data indicate there are over 17,000 wildlife strikes to aircraft each year in the U.S., costing an estimated $500 million in economic losses, yet these problems are ongoing despite the U.S. Department of Agriculture’s Wildlife Services program killing hundreds of thousands of birds in and around airports each year through a range of lethal means, including the use of guns and pesticides. As a result, new management approaches that focus on effective, nonlethal alternatives to the use of toxic chemicals are urgently needed. Scientists began their research with the understanding that most bird deterrent methods “suffer from some degree of habituation: after repeated exposure, birds respond less.”  While habitation can be reduced through natural threats, the authors note that approaches like falconry are lethal and can be prohibitively expensive and difficult to […]

(Beyond Pesticides, November 8, 2022) Glyphosate weed killers induce antibiotic resistance in deadly hospital-acquired bacteria, according to a new study published late last month in the journal Scientific Reports. This is the latest finding connecting commonly used herbicides to the rise of antibiotic resistant bacteria, with prior research showing glyphosate, 2,4-D, and dicamba able to create resistance in Salmonella and E. coli. While federal regulatory agencies continue ignore the role of pesticides in the development of antibiotic resistance, it is critical for states and localities to take action to protect their most vulnerable both from toxic exposure to these herbicides and the multitude of indirect effects caused by their use. This is all happening as antibiotic resistance is rising to dangerously high levels in all parts of the world, according to the World Health Organization. In the May 1, 2022 issues of the Bulletin of the World Health Organization, Samira Choudhury, PhD, et al. writes, “Often referred to as the silent pandemic, antimicrobial resistance claims the lives of over 700,000 people annually.” The authors continue, “A study suggests that if no actions are taken, antimicrobial resistance will cause 10 million deaths per year by 2050 and an economic impact of […]

(Beyond Pesticides, November 7, 2022) The Maine Congressional delegation — Senators Collins (R) and Angus King (I), and Representatives Chellie Pingree (D) and Jared Golden (D), along with New Hampshire Senator Jeanne Shaheen (D) — have  introduced a bipartisan bill — the Relief for Farmers Hit with PFAS Act — to help farmers who have been adversely affected by the scourge of PFAS (perfluoroalkyl and polyfluoroalkyl substances) chemicals. The bills are the identical S. 5070 and H.R. 9186, both titled “Relief for Farmers Hit with PFAS Act.” Tell your U.S. Senators and Representative to cosponsor the Relief for Farmers Hit with PFAS Act. If they are already cosponsors, thank them. Tell EPA to stop the spread of legacy chemicals. PFAS chemicals, also known as “forever chemicals,” are legacy contaminants or those whose historical use, including many decades ago in some instances, has led to their toxic persistence in the environment and in organisms. PFAS chemicals are not the only legacy contaminants. Others include wood preservatives, DDT, dioxins, and the termiticide chlordane. Unfortunately, some of these continue to be added to the environment, sometimes inadvertently, but also intentionally, particularly through pesticide use. As indicated by the title of these bills, farmers […]

(Beyond Pesticides, November 3, 2022) In a fight against global warming, environmental groups Center for Biological Diversity (CBD) and Californians for Pesticide Reform (CPR) filed a formal legal petition in October 2022 urging the California Air Resources Board (CARB) to phase out the use of sulfuryl fluoride insecticides. Sulfuryl fluoride is a fluoride compound with various adverse health effects, including cancer, endocrine disruption, neurotoxicity (reduced IQ), and reproductive damage. CARB added sulfuryl fluoride to its list of “short-lived climate pollutants,” being the only state to do so since 1990. However, California does not include sulfuryl fluoride in the list of GHG emissions to reduce by 2020 as researchers were unaware the chemical was a greenhouse gas (GHG) until 2008. These termite and food use insecticides are 4,800 times more potent GHG than carbon dioxide at trapping carbon in the atmosphere. Furthermore, sulfuryl fluoride has high global warming potential and can remain in the atmosphere for more than 36 years. The case of sulfuryl fluoride presents an all too familiar pattern of widespread chemical use without proper knowledge of health and environmental effects before implementation and a failure to take regulatory action on known hazards after allowed in commerce. Therefore, CBD’s […]

(Beyond Pesticides, October 31, 2022) Just as the Environmental Protection Agency (EPA) issued a request for information on improving indoor air quality, it approved 32 varieties of a new “air sanitizer” to kill bacteria and viruses in the air. These products contain 14% dipropylene glycol and 86% secret (“other”) ingredients, including fragrances. Tell EPA that clean air, NOT “sanitized” air, protects against disease. Through its approval of such sanitizers, EPA promotes the false reasoning that a chemical that kills a pathogen necessarily protects health. Although disinfectants and sanitizers kill viruses, bacteria, and other microbes, they can also negatively affect the immune system, thus reducing resistance to disease. People who have a preexisting condition or are of advanced age, who may have a weakened immune or respiratory system, are more vulnerable to the effects of the virus. Children are at elevated risk from exposure. When managing viral and bacterial infections, chemicals that exacerbate the risk to vulnerable individuals are of serious concern. EPA opened a 60-day public comment period “to solicit information and recommendations from a broad array of individuals and organizations with knowledge and expertise relating to the built environment and health, indoor air quality, epidemiology, disease transmission, social sciences […]

(Beyond Pesticides, October 28, 2022) The Maine Congressional delegation — Senators Collins (R) and Angus King (I), and Representatives Chellie Pingree (D) and Jared Golden (D) — along with New Hampshire Senator Jeanne Shaheen (D), have introduced a bipartisan and bicameral bill — the Relief for Farmers Hit with PFAS Act — to help farmers who have been impacted by the scourge of PFAS (perfluoroalkyl and polyfluoroalkyl substances) chemicals. (The Senate version of the bill is available; the House version should be soon.) PFAS contamination has, as Beyond Pesticides documented in two Daily News Blog articles (here and here), become a huge, life-altering problem for agricultural producers in Maine and many other states. An early 2022 Safer States analysis of state-level legislation on PFAS demonstrated the extent of the problem via the response: more than 32 states have begun to act on the issue. Beyond Pesticides has covered the presence of PFAS in pesticides and pesticide containers, and in so-called “biosludge” or “biosolids”— realities that only reinforce the call for a rapid transition off of chemical-dependent agriculture and to regenerative organic agricultural practices that do not carry the enormous health and environmental risks of pesticide products and contaminated fertilizers. There […]

(Beyond Pesticides, October 27, 2022) A study published in Environment International adds to the growing body of research evaluating the association between neonicotinoid insecticides (neonics/NIs) and breast cancer. Past studies suggest neonics act as endocrine disruptors, affecting the development and regulation of estrogen hormones that promote breast cancer. However, this study is one of the few to evaluate the toxicological and molecular mechanisms involved in initiating breast cancer events. According to the Centers for Disease Control and Prevention (CDC), breast cancer is a disease that causes breast cells to grow out of control, with the type of breast cancer depending on the cells themselves. Most common forms of breast cancer have receptors on the cell surface that can increase cancer growth when activated by estrogen, progesterone, or too much of the protein called HER2. One in ten women will receive a breast cancer diagnosis, and genetics can only account for five to ten percent of cases. When a cancer cell lacks receptors for these molecules, G protein-coupled estrogen receptors (GPERs) are an essential biological target of estrogen and plays a role in hormone-dependent cancer development. GPERs regulate estrogen through non-genetic cellular pathways, forgoing attachment to standard molecular receptors, leading to triple-negative breast cancer (TNBC). Although past […]