(Beyond Pesticides, July 1, 2020) As the U.S. is subject to searing criticism for inadequately regulated hazardous pesticides domestically, administration officials are standing in the way as other countries’ work toward modest reforms. According to a report published in Reuters, the U.S. is standing alongside the corrupt Bolsonaro administration in Brazil to oppose Thailand’s efforts to protect its citizens from highly toxic pesticides used in food production. Both countries launched separate complaints to the World Trade Organization after Thailand announced it would ban imports of the brain-damaging insecticide chlorpyrifos and weedkiller paraquat, which has been strongly linked to Parkinson’s disease. On June 1, Thailand added paraquat and chlorpyrifos to its list of most hazardous substances. This listing initiated a follow-on regulation that banned the import of these substances on food, set to take effect in mid-July. Thailand has been feeling the brunt of U.S. diplomatic pressure since it first proposed restrictions on toxic chemicals late last year. By December, the U.S. was able to get Bangkok to remove glyphosate from its proposal, and delay the listing of paraquat and chlorpyrifos until June. But as the current situation shows, the U.S. had no plans to stop pressuring the Bangkok government after […]

(Beyond Pesticides, March 3, 2020) Pregnant mothers living in areas where carcinogenic pesticides have been used are at increased risk of their child developing an acute form of leukemia, according to research published last month in the International Journal of Hygiene and Environmental Health by researchers at the University of California, Los Angeles. The findings are based on a review of pesticide use data in rural, agricultural areas of California, where many minority, low-income and farmworking communities live. Under current laws, the U.S. Environmental Protection Agency (EPA) permits the use of cancer-causing pesticides with an expectation that a certain number of cancers (anywhere from 1 in 1,000 to 1 in 1,000,000, based on the pesticide in question) should be considered ‘acceptable risk.’ While past studies have shown similar connections between pesticide exposure in the womb and the development of childhood cancer, this is one of the first to utilize geographic information systems (GIS) data, rather than parental interviews on past exposures. Researchers used California public records of cancer incidence from 1998-2011, alongside statewide pesticide use reports (California is the only state to make this information publicly accessible and searchable). A list of 65 pesticides were investigated for their specific connection […]

(Beyond Pesticides, October 17, 2019) The U.S. Environmental Protection Agency (EPA) is downplaying the connection between exposure to the herbicide paraquat and the development of Parkinson’s disease, per registration review documents released by the agency this week. Although unsurprising given the current administration’s track record of defending some of the most heinous chemicals still on the market, the review nonetheless marks a low point for scientific integrity within EPA’s Office of Pesticide Programs, according to advocates. Health and environmental advocates have already discounted EPA’s industry-biased review, and are instead pushing hard for Congressional action – namely HR 3817, the Protect Against Paraquat Act, introduced by Congresswoman Nydia Velazquez (D-NY). Under federal law, pesticides are required to undergo reevaluation every 15 years. Paraquat is a potent restricted use herbicide, not available to be applied by residential users, but permitted for use on multiple agriculture crops. Over the last decade, independent peer-reviewed scientific studies have repeatedly found strong associations between paraquat to the development of Parkinson’s disease. Many of these studies have been covered in Beyond Pesticides’ Daily News or are recorded in the Pesticide-Induced Diseases Database. In response to this growing body of literature, EPA conducted an epidemiological evaluation of published […]

(Beyond Pesticides, August 1, 2019) Last month, the Brazilian Ministry of Agriculture approved the registration of 51 additional hazardous pesticides and brought the total to 262 newly approved pesticides this year. Moreover, Brazil’s health surveillance agency, Anvisa, approved new rules that establish risk of death as the singular criteria for determining toxicity of pesticides. Human Rights Watch, a nonprofit that conducts local investigations, reports that the government has simultaneously been unresponsive to incidents of pesticide poisoning. Brazil’s president, Jair Bolsonoro, is known for his far-right politics, and has been accused of corruption, scandals, and disregard for the environment. This rapid registration of novel pesticides is unprecedented in Brazil. Many of the products are generic versions of existing formulas, with government officials seeking to lower the price of pesticides. Products include insecticides with the active ingredient sulfoxaflor, a bee-toxic pesticide that has also recently gained traction in the U.S. despite pushback from beekeepers and environmentalists. While an American license for a pesticide, for example, lasts 15 years, Brazilian registration of pesticides never expires. Generic products lower the price barrier to amplified use of these interminable, toxic pesticides. In 1989, Brazil established one of the toughest pesticide laws in the world that […]

(Beyond Pesticides, July 23, 2019) Last week, U.S. Representative Nydia M. Velazquez introduced legislation to cancel all uses of the pesticide paraquat, which is acutely toxic and strongly linked to Parkinson’s disease. The move is supported by the Unified Parkinson’s Advocacy Council – a group led by The Michael J. Fox Foundation for Parkinson’s Research – as well as other health and environmental groups such as Beyond Pesticides. Paraquat, which is a dangerous, fast-acting nonselective herbicide that kills by burning living tissues, is also unnecessary. Organic agriculture provides an alternative that does not depend on toxic chemicals like paraquat. Tell your U.S. Representative to support H.R. 3817 to cancel the use of paraquat. According to the EPA, “one small sip [of paraquat] can be fatal, and there is no antidote.” Advocates are pushing for its elimination from the American agriculture system for many reasons, including acute toxicity and organ failure by inhalation, oral intake and dermal absorption; chronic toxicity affecting the eyes, lungs, liver, kidneys and endocrine system; and a higher incidence of various cancers after exposure. The EPA characterizes paraquat as “extremely biologically active and toxic to plants and animals.” The agency has previously determined that exposure to this herbicide […]

(Beyond Pesticides, February 20, 2019) Women exposed to DDT during ‘early windows of susceptibility’ in their childhood are at increased risk of developing breast cancer, according to new research published in the Journal of the National Cancer Institute. Nearly 75 years after the chemical was first used in the U.S., and 50 years after its ban, DDT is continuing to adversely affect the health of Americans. The data brings needed attention to the dangers of early-life pesticide exposure, and underlines the need to take a precautionary approach to the introduction of biocides in our environment so that future generations do not suffer from the same mistakes of the past. “What we have learned is that timing really matters. We know that if harmful exposures occur at times when breast tissue is rapidly changing, such as during puberty, they impact breast development in ways that can later result in cancer,” said lead author Barbara A. Cohn, PhD, of the Public Health Institute’s (PHI) Child Health and Development Studies. “The research published today suggests that DDT affects breast cancer as an endocrine disruptor, that the period of time between first exposure and cancer risk seems to be around 40 years–and that other […]

(Beyond Pesticides, December 20, 2018) Using low doses of the herbicide paraquat and common proteins found in food called lectins, researchers were able to recreate the symptoms of Parkinson’s disease in rats. Results of this study, published in the journal Parkinson’s disease, provide scientists with fresh insights into the development of the disease, and a new model to test potential remedies. Paraquat, a neurotoxic herbicide with a well-established body of literature linking it to Parkinson’s disease, is currently undergoing a registration review by the U.S. Environmental Protection Agency, and groups like the Michael J Fox Foundation are calling for its ban. Researchers based their study on the Braak Staging hypothesis of Parkinson’s, which posits that the disease is brought on by foreign agents entering the body through the gut or nose and making their way to the brain. Rats were exposed to low doses of paraquat combined with lectin every day for a week. After two weeks, the animals’ motor function was tested and compared to an unexposed control group. Rats exposed to lectin and paraquat exhibited Parkinson-like symptoms. Primary author R. Alberto Travagli, PhD, notes, “After observing that these animals did indeed show symptoms of Parkinsonism, we wanted to […]

(Beyond Pesticides, May 21, 2018)  490,000 Pounds of Toxic Pesticides Sprayed on National Wildlife Refuges in 2016 The nation’s 562 national wildlife refuges play a critical role in protecting fish, plants, and other wildlife. They include forests, wetlands, and waterways vital to thousands of species of plants and animals, including 280 that are protected under the Endangered Species Act. However, private chemical-intensive commercial farming of crops like corn, soybeans, and sorghum has become common on refuge lands, with the increasing use of highly toxic pesticides that threaten the long-term health of sensitive habitats and the creatures who depend on them. The Center for Biological Diversity (CBD) estimates that 490,000 pounds of pesticides were applied to commodity crops like corn, soybeans, and sorghum grown in national wildlife refuges in 2016, the most recent year for which data are available. Tell FWS to take toxic pesticides out of wildlife refuges. The nearly half million pounds of pesticides used on wildlife refuges in 2016 include 2,4-D, dicamba, and paraquat, all of which are toxic to fish, amphibians, crustaceans, and other animals. Also included are 116,200 pounds of glyphosate, the herbicide that has caused widespread decreases in milkweed plants, helping to trigger the 80 percent […]

(Beyond Pesticides, February 12, 2018)  The most recent findings on the development of Parkinson’s disease after exposure to the highly toxic paraquat add to the well-established body of scientific literature linking the herbicide to Parkinson’s — which should lead to finally eliminating the use of the herbicide in the U.S. The chemical was banned in the European Union in 2007, and many health groups, including Beyond Pesticides and The Michael J. Fox Foundation for Parkinson’s Research, are calling on the U.S. Environmental Protection Agency (EPA) to stop the use of paraquat by denying its upcoming reregistration. In addition to its connection with Parkinson’s disease, paraquat is known to be highly acutely toxic. By generating free radicals, it essentially burns its way through the body, targeting the lungs —causing lung fibrosis— and other organs. Most acutely toxic exposures result in death, sometimes delayed by as much as three weeks. Although paraquat is a restricted use pesticide (RUP), EPA is proposing to eliminate the minimum age for applying RUPs, which would permit teenagers to use it. Tell EPA and Congress to ban paraquat! This link will send the following message to EPA and your Congressional delegation: I urge EPA to join other countries […]

(Beyond Pesticides, February 1, 2018) Scientists at the European Institute for the Biology of Aging are finding new information about how Parkinson’s disease manifests itself after exposure to the herbicide paraquat, in hopes of finding ways to prevent the progression of the disease. Despite a well-established body of scientific literature linking the paraquat to Parkinson’s, and a ban on the use of the chemical in the European Union that dates back to 2007, its use is still permitted in the U.S. Many health groups, including Beyond Pesticides and organizations like the Michael J Fox Foundation are calling on the U.S. Environmental Protection Agency stop the use of paraquat by denying its upcoming reregistration. Published in the journal Cell Reports, this new research on Parkinson’s investigates the impact of “senescent” cells in the body. Senescent cells are those which, despite being able to divide, stop doing so in response to stress. This is an anti-cancer mechanism, as stress would otherwise cause the cells to multiply unchecked and create malignancies. Researchers suspected that despite the benefit of stopping cancer, senescent cells may be causing other problems in the body. Rather than dying, these cells can cause inflammation in the area around where […]

(Beyond Pesticides, November 10, 2014) According to a new Government Accountability (GAO) report, the U.S. Food and Drug Administration (FDA) does not test food for several commonly used pesticides with established tolerance levels —including glyphosate, one of the most commonly used pesticides in the U.S. This and other disturbing findings documented in GAO’s report,  Food Safety: FDA and USDA Should Strengthen Pesticide Residue Monitoring Programs and Further Disclose Monitoring Limitations,  issued last Thursday, sounds an alarm that GAO began sounding  in the 1980’s in several reports that identify shocking limitations of  FDA’s approach to monitoring for pesticide residue violations in food. GAO sharply criticizes FDA for not using statistically valid methods consistent with Office of Management and Budget (OMB) standards to collect information on the incidence and level of pesticide residues. In fact, GAO states that it “was unable to find publicly available estimates of the overall toxicity or risk associated with the use of agricultural pesticides in the United States.” According to GAO, FDA is testing less than one-tenth of one  percent of all imported fruits and vegetables and less than 1 percent of domestic fruits and vegetables.  The report is also critical of U.S. Department of Agriculture’s (USDA) […]

(Beyond Pesticides, May 7, 2014) A new report from the California Department of Public Health finds 36 percent of public schools in the state have pesticides of public health concern applied within a quarter mile of the school. Persistent and toxic pesticides like chlorpyrifos, methyl bromide, and malathion are among the pesticides found to be applied near schools. The report also finds that Latino children are also more likely to attend schools near areas with the highest use of pesticides of concern. The report, “Agricultural Pesticide Use near Public Schools In California,” released this month, looked at 2,511 schools in the 15 California counties with the highest overall use of farm pesticides in California for 2010, and finds that counties in the southern part of the Central Valley had the most schools near farms where pesticides were applied. Fresno County had the highest number of schools —131 — with pesticides applied nearby. Five percent of schools are within a quarter mile of where the highest volumes of pesticides are used: 2,635—28,979 pounds of active ingredient. Latino children are 46 percent more likely than white children to attend schools where pesticides of concern were applied nearby. The report’s findings are being […]

(Beyond Pesticides, January 13, 2013) As medical and recreational production of marijuana in the U.S. increases, new and complicated questions have risen over how to limit consumers’ exposure to pesticides through marijuana consumption. Many growers are facing limited institutional knowledge and economic forces that could lead to the unnecessary use of pesticides. States are also still wrestling with the adequate  regulation of production and testing practices. Exposure to pesticides from marijuana consumption may also be more harmful than exposure through food consumption when consumed through inhalation. As marijuana consumption becomes more widely legalized, many are calling for  stronger safety standards for marijuana production. Alan Schreiber, Ph.D., President of the Agriculture Development Group, believes that the legalization of recreational marijuana use in Colorado and Washington will lead to immense demand for pest prevention research. Currently, growers of marijuana lack institutional assistance from federal agencies or state agricultural extension services, which have limited understanding of marijuana production. There is a concern that the lack of  field research and increased demand may lead to heavy pesticide use. In Washington, the state will allow the equivalent of 46 acres to be grown for recreational use, a factor that Dr.. Schreiber says will drive most […]

(Beyond Pesticides, May 30, 2013) New research published in the journal Neurology further supports the causative link between pesticide exposure and Parkinson’s disease. Emanuel Cereda, M.D., Ph.D., of the IRCCS university Hospital San Matteo Foundation in Pavia, Italy, and coauthor Gianni Pezzoli, M.D., analyzed 104 studies published between 1975 and 2011 to determine the link between pesticides and solvents to Parkinson’s disease. The researchers analyzed exposure using information on proximity to large farms likely to use pesticides, likelihood of well water consumption, and occupations that cause greater exposure to pesticides and solvents used to kill weeds, insects, fungus, and rodents. Overall, researchers found exposure to pesticides increased the risk of developing the disease by 33%  to 80%.   Some pesticides were considered to be of higher risk than others, with weed killers like paraquat and fungicides maneb and mancozeb causing twice the risk for development of Parkinson’s disease. While risk increased the longer people were exposed to pesticides, researchers indicate there is still a need for further research on the chemical threshold for harm to the brain. The study builds on recent research that has linked Parkinson’s disease to pesticide exposure. In a 2011 article published in the journal Molecular […]

(Beyond Pesticides, November 14, 2012) For years, scientists have shown that pesticide exposures are linked to the onset of Parkinson’s disease. Now a new study by researchers at University of California, Los Angeles, (UCLA) finds that exposure to pesticides and suffering a head injury are associated with a three-fold increase in one’s chances of developing Parkinson’s disease. Parkinson’s disease is the second most common neurodegenerative disease, and occurs when nerve cells in the substantia nigra region of the brain are damaged or destroyed and can no longer produce dopamine, a nerve-signaling molecule that helps control muscle movement. People with Parkinson’s disease have a variety of symptoms, including loss of muscle control, trembling and lack of coordination. Over time, symptoms intensify. At least one million Americans have Parkinson’s and about 50,000 new cases are diagnosed each year. The study, “Traumatic brain injury, paraquat exposure, and their relationship to Parkinson disease,” published in the journal Neurology surveyed more than 1,000 adults ages 35 and older who lived in central California. Some 357 of the participants were diagnosed with Parkinson’s disease. Participants with the disease were nearly twice as likely as those without the disease to report having had a head injury in […]

(Beyond Pesticides, June 28, 2011) Recent studies have linked Parkinson’s disease to pesticide exposure. In a new article published in the journal Molecular Neurodegeneration, researchers at the University of Missouri School of Medicine take some of the first steps toward understanding this link and unraveling the molecular dysfunction that occurs when proteins are exposed to environmental toxins. The study, “Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation,” helps further explain recent NIH findings that demonstrate the link between Parkinson’s disease and two particular pesticides — rotenone and paraquat. “Fewer than 5 percent of Parkinson’s cases are attributed to genetics, but more than 95 percent of cases have unknown causes,” said Zezong Gu, MD, PhD, assistant professor of pathology and anatomical sciences. “This study provides the evidence that oxidative stress, possibly due to sustained exposure to environmental toxins, may serve as a primary cause of Parkinson’s. This helps us begin to unveil why many people, such as farmers exposed to pesticides, have an increased incidence of the disease.” Scientists previously understood that Parkinson’s is associated with oxidative stress, which is when electronically unstable atoms or molecules damage cells. The MU study yields […]

(Beyond Pesticides, May 31, 2011) A study has found that people whose workplaces were close to fields sprayed with chemicals — not just those who live nearby — are at higher risk of developing Parkinson’s disease (PD). The pesticide chemicals in question include two fungicides -maneb (in the ethylene bisdithiocarbamate (EDBC) family and ziram (in the dimethylthiocarbamate family)- and the herbicide paraquat that appear to raise the risk of developing the movement disorder. In a study published in the European Journal of Epidemiology, entitled, “Parkinson’s disease risk from ambient exposure to pesticides,” a team of researchers led by UCLA neurologist Beate Ritz, PhD found that exposures to the trio of pesticides are actually higher in workplaces located near sprayed fields than they were in residences. And the combination of exposure to all three pesticides, which act in different ways to harm brain cells involved in Parkinson’s disease, appears to be cumulative, the team led by Dr. Ritz concludes. The study found that the combined exposure to pesticides ziram, maneb and paraquat near any workplace increased the risk of Parkinson’s disease threefold, while combined exposure to ziram and paraquat alone was associated with an 80% increase in risk. The researchers estimate […]

(Beyond Pesticides, February 17, 2011) According to a recent investigative report, a company known for conducting scientific research for the pesticide industry has, in an attempt to refute research linking pesticides to Parkinson’s disease, paid a U.S. government agency, the National Institute for Occupational Safety and Health (NIOSH), to prove that certain pesticides are safe. According to the report, the company, Exponent Inc., is a member of CropLife America, a trade group that represents pesticide manufacturers, and also has worked regularly for Syngenta, which makes paraquat, one of the chemicals it is looking prove as safe. Specifically, the company is looking to refute the research which shows that even small amounts of agricultural chemicals, maneb and paraquat, when combined, can raise the risk of Parkinson’s disease. According to the report, managing scientist of Exponent, Laura McIntosh, PhD, said in an interview that the company donated the money and sought participation at NIOSH to enhance the credibility of its study of maneb and paraquat; they wanted to make their research “bulletproof.” NIOSH is a division of the Centers for Disease Control and Prevention (CDC). Generally, government agencies are supposed to be unbiased, and federal ethics rules prohibit employees from accepting money […]

(Beyond Pesticides, February 16, 2011) Many agricultural pesticides —including some previously untested and commonly found in food— disrupt male hormones, according to new tests conducted by British scientists. Meanwhile, U.S. researchers at the National Institutes of Health have found that people who used two specific varieties of pesticide were 2.5 times as likely to develop Parkinson’s disease. Pesticides Impact Male Hormones Evidence suggests that there is widespread decline in male reproductive health and anti-androgenic pollutants, also known as endocrine disruptors, may play a significant role. Thirty out of 37 pesticides tested by the researchers at the University of London altered male hormones, including 16 that had no known hormonal activity until now. There was some previous evidence for the other 14. Most are fungicides applied to fruit and vegetable crops, including strawberries and lettuce. The study, “Widely Used Pesticides with Previously Unknown Endocrine Activity Revealed as in Vitro Anti-Androgens,” is published in Environmental Health Perspectives. The British researchers screened the chemicals using in vitro assays, which use human cells to check whether the pesticides activate or inhibit hormone receptors in cells that turn genes on and off. Scientists, however, are uncertain what actually happens in the human body at the […]

(Beyond Pesticides, November 18, 2009) A report released yesterday and authored by Charles Benbrook, PhD, chief scientist at The Organic Center (TOC), finds that the rapid adoption by U.S. farmers of genetically modified corn, soybeans and cotton has promoted increased use of pesticides, an epidemic of herbicide-resistant weeds, and more chemical residues in foods. The report, “Impacts of Genetically Engineered Crops on Pesticide Use in the United States: The First Thirteen Years,” explores the impact of the adoption of genetically modified (GM) corn, soybean, and cotton on pesticide use in the United States, drawing principally on data from the U.S. Department of Agriculture (USDA). The most striking finding, is that GM crops have been responsible for an increase of 383 million pounds of herbicide use in the U.S. over the first 13 years of commercial use of GE crops (1996-2008). The report identifies, and discusses in detail, the primary cause of the increase–the emergence of herbicide-resistant weeds. The steep rise in the pounds of herbicides applied with respect to most GM crop acres is not news to farmers. Weed control is now widely acknowledged as a serious management problem within GM cropping systems. The rise in herbicide use comes as […]

(Beyond Pesticides, September 16, 2009) A new study published in the September issue of Archives of Neurology reports that the risk of Parkinsonism doubled with increased occupational exposure to pesticides, including eight agents associated with experimental Parkinsonism. These data add to the growing number of studies that lend credence to a causative role of certain pesticides in neurological disorders. The study, “Occupation and Risk of Parkinsonism: A Multicenter Case-Control Study,” set out to investigate occupations, specific job tasks, or exposures and risk of parkinsonism in collaboration with eight movement disorders centers in North America including, the Parkinson’s Institute, CA, Department of Neurology, Baylor College of Medicine and Department of Neurology, Beth Israel Medical Center, New York. The investigation focused on five occupations previously suggested as posing an increased risk of Parkinsonism: agriculture, education, healthcare, welding, and mining. This examination of toxicant exposures included solvents and pesticides putatively associated with Parkinsonism. 519 people with Parkinson’s disease and 511 similar people who did not have Parkinson’s were studied. Overall, the study finds that those whose jobs involve using pesticides are 80 percent more likely to develop the condition. The data reveals that any exposure to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) almost triples […]

(Beyond Pesticides, August 7, 2009) A recent study published in the journal Environmental Health Perspectives has added to evidence that certain pesticides significantly increase one’s risk of developing Parkinson’s disease (PD). Researchers found that rural residents who drank private well water within 500 meters of fields sprayed with certain pesticides had an increased – up to 90 percent – risk of developing PD, and those with Parkinson’s “were more likely to have consumed private well water, and had consumed it on average 4.3 years longer.” The study evaluated more than 700 people, including carefully chosen controls, in Fresno, Kent, and Tulare counties. 17 percent reported drinking private well water between 1974 and 1999. Researchers focused on wells’ proximity to agricultural fields sprayed with pesticides, since private wells are not regulated, and many are shallow enough to be contaminated by pesticides seeping into groundwater. Researchers looked at 26 pesticides and six in particular, “selected for their potential to pollute groundwater or because they are of interest for PD, and to which at least 10% of our population were exposed.” Those are: diazinon, chlorpyrifos, propargite, paraquat, dimethoate, and methomyl. Propargite exposure was most closely correlated with incidence of PD, with a 90 […]

(Beyond Pesticides, March 16, 2009) Exposure to a mixture of the fungicide maneb and the herbicide paraquat significantly increases the risk of developing Parkinson’s disease, according to a new University of California, Berkeley study, “Parkinson’s Disease and Residential Exposure to Maneb and Paraquat from Agricultural Applications in the Central Valley of California.” Published in the American Journal of Epidemiology, the study findings show that exposure to both pesticides within 500 meters of an individual’s home increases the risk of developing Parkinson’s by 75 percent. For individuals 60 years of age or younger at the time of diagnosis, there is a more than four-fold increase in risk of the disease when exposed to a combination of maneb and paraquat and a more than doubling of risk when exposed to either maneb or paraquat alone. The Berkeley researchers used geographic information systems that analyzed data from California Pesticide Use Reports and land-use maps to calculate historical residential exposure to agricultural exposure to the two pesticides. From 1998 to 2007, the researchers enrolled 368 incident Parkinson’s disease cases and 341 population controls from California’s Central Valley and developed potential exposure estimates incurred between 1974 and 1999. Also published this month by some of […]