(Beyond Pesticides, May 31, 2007) Adding to the weight of the evidence tying pesticide use to Parkinson’s disease, a study by University of Aberdeen researchers has found that pesticide exposure increases the likelihood of developing the disease. The researchers also found that the risk factor for developing Parkinson’s increases with high levels of pesticide exposure. The European Commission funded study indicates that both pesticides and traumatic head injury play a causative role in Parkinson’s disease. The researchers found that exposure to low levels of pesticides increases the likelihood of being affected by the disease by 1.09 times compared to those with no reported exposure. Those exposed to high levels of pesticides were 1.39 times more likely to develop the disease. The study is one of the largest conducted to date of genetic, environmental and occupational risk factors for Parkinson’s disease and other degenerative parkinsonian syndromes. The researchers identified 959 cases of parkinsonism, 767 of which are diagnosed with Parkinson’s, and 1,989 control cases in Scotland, Italy, Sweden, Romania and Malta. Data on exposure was self-reported by the subjects. The results further compound previous studies suggesting a link between pesticides and Parkinson’s. Several recent findings have also revealed mechanisms that help […]

(Beyond Pesticides, May 22, 2007) In a study published in the latest issue of Environmental Toxicology and Chemistry, scientists found that seafood products from southern China contain high concentrations of DDT and hexachlorocylohexane (HCH). While banned in China since 1983, humans are being exposed to organochlorine pesticides (OCP) at rates high enough to pose health threats. The study responded to high rates of DDT and HCH found in sediment, water and biota in the Pearl River delta and neighboring coast, where land is being rapidly industrialized, urbanized, and transferred from agriculture to commercial development. Researchers tested 212 seafood products, including shrimp, crabs, and mollusks, from 11 coastal cities for 21 OCPs, including DDT, HCH, heptachlor, dieldrin, and endosulfan. The highest concentrations of DDT were found in four species of shellfish, although concentrations varied widely depending on sampling location. The study reported, “These results suggest that bioaccumulation of DDTs in seafood products was highly species-specific, probably due to different feeding habits and habitats.” By taking a large sample of one indicator species, it also concluded “the coastal region of southern China is probably one of the most DDT-polluted areas in the world.” Researchers also found HCH to be more widely prevalent […]

(Beyond Pesticides, May 15, 2007) According to a study commissioned by Susan G. Komen for the Cure and the Silent Spring Institute, 216 chemicals, many found in urban air and everyday consumer products, cause breast cancer in animal tests. The study, “Environmental Factors in Breast Cancer,” the most comprehensive review to date of scientific research on environmental factors that may increase breast cancer risk, was published in the online version of the American Cancer Society’s journal Cancer on May 14, 2007. The state-of-the-science review collected and assessed existing scientific reports on potential links between specific environmental factors and breast cancer. The researchers synthesized national and international data sources and identified 216 chemicals that cause breast tumors in animals, including ten pesticides. They used the information to create a searchable online database featuring detailed information on the carcinogens. The database, accessible at www.komen.org/environment, is available free of charge. The database includes references to 900 studies, 460 of which are human breast cancer studies that were critically evaluated by the research team. The studies measure breast cancer risk related to body size, physical activity, environmental pollutants, and prospective studies of diet. For each study, bibliographic information, key methods and findings, and a […]

(Beyond Pesticides, May 10, 2007) The risk of non-Hodgkin’s lymphoma is significantly increased with substantial exposure to pesticides, regardless of asthma or atopy history, according to findings from a study published in the May issue of the International Journal of Cancer. This study further strengthens the link between exposure to pesticides and cancer and specifically to lymphoma. “Occupational exposure to pesticides and a personal history of atopy have been widely examined as risk factors for non-Hodgkin’s lymphoma (NHL), a neoplasm arising from cells of the immune system,” writes Claire M. Vajdic, Ph.D., of the University of New South Wales, Australia, and colleagues. “These studies have typically found that exposure to pesticides increases risk of NHL, while asthma, or atopy more generally, has been inconsistently protective.” In an Australian population-based, case-control study, the researchers examined the interaction between occupational pesticide exposure and atopy on the risk of NHL. Included in the study were 694 incident cases and 694 randomly selected controls that were matched to cases by age, sex, and state of residence. Participants completed telephone-administered job-specific questionnaires. Experts used the information collected to determine occupational pesticide exposure. History of atopy (including asthma, hay fever, eczema, and food allergy) was self-reported. […]

(Beyond Pesticides, May 8, 2007) A new study, presented yesterday at the Pediatric Academic Societies’ annual meeting, has found a strong correlation between the month of conception and both likelihood of premature birth and future academic achievement. Researchers found that students conceived in June through August, when statewide pesticide applications are at their highest, clearly scored the lowest on the Indiana Statewide Testing for Educational Progress (ISTEP) examinations. Dr. Paul Winchester, M.D., of the Indiana University School of Medicine, studied over 1.5 million third- through tenth-grade students in Indiana. Dr. Winchester explained the correlation saying, “The fetal brain begins developing soon after conception. The pesticides we use to control pests in fields and our homes and the nitrates we use to fertilize crops and even our lawns are at their highest level in the summer.” The study also monitored levels of pesticide and fertilizer use during the year. He continued, “Exposure to pesticides and nitrates can alter the hormonal milieu of the pregnant mother and the developing fetal brain. While our findings to do not represent absolute proof that pesticides and nitrates contribute to lower ISTEP scores, they strongly support such a hypothesis.” In conjunction with the ISTEP study, the […]

(Beyond Pesticides, April 24, 2007) Three recent studies were presented earlier this month at the Parkinson’s Disease Environmental Research meeting in California strengthening the theory that pesticides increase risk of the disease. The studies clarify how pesticide exposure can lead to the development of Parkinson’s. Two pesticides named in the studies are paraquat and dieldrin, both of which have been linked to Parkinson’s in the past. The three new studies, however, combine information from human and animal studies to show how exposure can lead to onset of the disease. As William Langston, M.D., founder of the Parkinson’s Institute, told Reuters, “All of these pieces really look like they are coming together now.” The first study examined a cohort of 80,000 licensed private pesticide applicators and spouses. Researchers found farm workers exposed to paraquat had twice the expected risk of Parkinson’s. The second and third studies address a protein called alpha-synuclein. The second study shows the protein builds up in rodents exposed to paraquat. The third study connects this protein to Parkinson’s by finding that the protein kills the dopamine-producing brain cells affected by the disease. One common difficulty in tracking pesticide-induced diseases is the amount of time that passes between […]

(Beyond Pesticides, April 12, 2007) A new study has found the proportion of boys born over the past three decades has unexpectedly dropped in both the United States and Japan. In all, more than a quarter of a million boys are missing, compared to what would have been expected had the sex ratio existing in 1970 remained unchanged. The study’s authors hypothesize that the skewed sex ratio may be linked to prenatal exposure to endocrine-disrupting chemicals such as pesticides. Although the researchers do not know why boys are taking a hit, they suspect contributing causes could include widespread exposure to hormone-mimicking pollutants by women during pregnancy and by men before they conceive children. “We hypothesize that the decline in sex ratio in industrial countries may be due, in part, to prenatal exposure to metalloestrogens and other endocrine disrupting chemicals,” the authors note in the study, published this week in Environmental Health Perspectives, a peer reviewed journal of the U.S. National Institute of Environmental Health Sciences. These endocrine-disrupting chemicals include some pesticides, dioxin and methylmercury, a pollutant from coal-fired power plants and many industrial sources that is commonly found in seafood. The study also flagged a host of other possible factors, […]

(Beyond Pesticides, April 10, 2007) Scientists have reported several environmental estrogens can affect the immune system, promoting allergic diseases such as asthma. Researchers have observed this response using pesticides and other environmental contaminants. Focusing on six environmental estrogens (xenoestrogens), researchers were able to reveal how these contaminants affect the immune system. Using doses representative of present human exposures, these estrogen-mimics were tested on human and mouse cells. The observed effect of exposure was both an increase in speed and intensity of immune reactions. Three of the environmental estrogens tested were organochlorine pesticides or metabolites: endosulfan, dieldrin and DDE (DDT metabolite). The other contaminants included nonylphenol, a by-product of plastics manufacturing, and two PCBs. The study reveals that the accelerated and increased level of degranulation of mast cells is the mechanism that causes more severe allergic reactions than would otherwise take place. According to Environmental Health News, mast cells play a vital role in allergic reactions because they are primed by past experience with allergens to release inflammatory agents into the body, which causes an allergic reaction. If the mast cell has been primed to react to a specific allergen, it will degranulate, releasing molecules such as histamine. The more intense […]

(Beyond Pesticides, March 29, 2007) While it seems to allergy-sufferers that symptoms get worse year after year, most figure it’s all in our heads. However, research by Lewis Ziska, Ph.D., a plant physiologist with the USDA Agricultural Research Service’s Crop Systems and Global Change Lab and speaker at the upcoming National Pesticide Forum, shows that common pollen allergens – including the troublesome ragweed pollen – may be getting worse as a result of global climate change. The conventional response to unwanted plants is increased pesticide use, which raises concerns among environmental and public health advocates. According to Dr. Ziska’s research, elevated levels of carbon dioxide (CO2), the top greenhouse gas, and warmer temperatures appear to increase ragweed pollen production. Dr. Ziska’s research uses sealed growth chamber systems to simulate current levels of CO2 (370 parts per million by volume, ppmv) and that projected for the mid-21st century (600 ppmv). The ragweed increased pollen productivity by 131 and 3200% respectively, compared to ragweed grown at pre-industrial CO2 levels (280 ppmv). A recent two-year real-world observational study of ragweed also found that urbanization-induced increases in CO2 and temperature were associated with increased ragweed growth, pollen production and pollen allergenicity, suggesting a probable […]

(Beyond Pesticides, March 26, 2007) A new study finds exposure of pregnant women to agricultural pesticides during the first trimester may increase the risk of gestational diabetes. The over twofold increase in risk is associated with some of the most commonly used agricultural pesticides. The study, published in the March issue of Diabetes Care, used a study group comprised of wives of licensed pesticide applicators. Self-reported pesticide-related activities during the first trimester of the most recent pregnancy were analyzed for 11,273 women. Of this group, 506 women reported having gestational diabetes. Agricultural pesticide exposure during pregnancy, such as mixing or applying pesticides or repairing pesticide application equipment, resulted in an odds ratio of 2.2 [95% CI 1.5-3.3] for reporting gestational diabetes — in other words, the women were 2.2 times more likely to develop the disease. No association was found between residential pesticide exposure during pregnancy and gestational diabetes, but it should be noted that the study group is not necessarily representative of urban/suburban populations. The increased risk of developing gestational diabetes was associated with the frequent use of 2,4,5-T, 2,4,5-TP, atrazine, butylate, diazinon, phorate and carbofuran. The data for this study was collected through the Agricultural Health Study (AHS), […]

(Beyond Pesticides, March 23, 2007) Using advanced risk assessment techniques, researchers have shown pesticide usage in the Salinas Valley, California, exposes pregnant women to pesticides through air, water, and soil. The study tracks how agricultural pesticides can travel from the field into the body. A team of scientists investigating whether there is a correlation between the high levels of pesticides in pregnant women in the Salinas Valley and the high pesticide usage in the surrounding farmland has discovered important pathways of exposure that greatly inform traditional risk assessment. At first, applying a simple statistical model suggested no direct correlation, but upon applying advanced modeling techniques that combine multiple fate and exposure models with biomonitoring data they found that the study population of 600 Latina women have a significantly higher intake of organophosphorus (OP) pesticides from exposure to the surrounding air, water, and soil, but not food. The study, part of a larger study on women and children’s environmental health called the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) project, is conducted by Thomas McKone, Ph.D., and his colleagues at Lawrence Berkeley National Laboratory and the University of California, Berkeley. Results are published in Environmental Science […]

(Beyond Pesticides, March 12, 2007) Environmental Protection Agency (EPA) Administrator Stephen Johnson appeared before the Environmental and Hazardous Materials and Energy and Air Quality Subcommittees of the House Energy and Commerce Committee on March 8, 2007 to discuss the EPA’s Budget for the first time in his six-year tenure as Administrator. Representative Hilda Solis (D-CA) pressed the Administrator for answers related to EPA’s Performance Track Program, the closure of EPA libraries, changes made to the Toxic Release Inventory, closure of Region 10’s Office of Environmental Justice, failure to implement the Executive Order 12898 on Environmental Justice (EJ), and the overall budget for environmental justice. According to Rep. Solis, three Monsanto facilities are members of the Performance Track Program, despite the fact that their parent company paid one million dollars in fines to the Department of Justice last year after being criminally indicted in 2005. Eligibility of the program requires that a company not be convicted of any environmental fines within the past five years. When asked why the three Monsanto facilities were members, Mr. Johnson deferred to staff from EPA to comment, at which time Rep. Solis was told they must review the documents and respond at a later date. […]

(Beyond Pesticides, March 9, 2007) New research shows that frogs are more sensitive to hormone-disturbing environmental pollutants than was previously thought. Male tadpoles that swim in water with environmentally relevant levels of such substances become females, according to the study that will be published in the scientific journal Environmental Toxicology and Chemistry (ET&C) in May (See University Press Release). The results may shed light on at least one reason that up to a third of frog species around the world are threatened with extinction, suggests the study. In a laboratory experiment by researchers in Sweden, two species of frogs, the European common frog (Rana temporaria) and the African clawed frog (Xenopus tropicalis), were exposed to levels of oestrogen (estrogen or chemicals mimicking the effect of estrogen) similar to those detected in natural bodies of water in Europe, the United States and Canada.The results were startling: whereas the percentage of females in two control groups was under 50 percent – not unusual among frogs – the sex ratio in the groups of tadpoles who matured in water dosed with different levels of oestrogen were significantly skewed. Even tadpoles exposed to the weakest concentration of the hormone were, in one of the […]

(Beyond Pesticides, February 28, 2007) Residents in the Canadian town of Pickering, Ontario, pleaded with their local government to ban the use of pesticides on public and private lands for cosmetic use with the exception of emergencies, infestations and agricultural uses. Meanwhile, well-known medical, public-health and environmental organizations have been lobbying Ontario officials to institute a provincewide ban on the aesthetic use of pesticides. According to Durham Region News, Ward 1 City Councillor Jennifer O’Connell said she knew the mere mention that pesticides can cause a low sperm count would get Pickering City Council’s attention. At the February 19th meeting, the council unanimously passed the motion to have staff first investigate pesticide ban bylaws in other municipalities and then draft a Pickering bylaw. The draft will be brought back before the summer recess for council’s consideration. The interest to introduce a bylaw to ban pesticides comes from Councillor O’Connell and Ward 3 Councillor David Pickles. Councillor O’Connell provided a presentation at the meeting on the chronic effects of pesticide use. Also supporting the ban, Gideon Forman, executive director of the Canadian Association of Physicians for the Environment said, “There is a great body of science to support that it has […]

(Beyond Pesticides, February 22, 2007) On February 16, 2007, Representatives Hilda Solice (D-CA), Alcee Hastings (D-FL) and Mark Udall (D-CO) and Senators Dick Durbin (D-IL) and John Kerry (D-MA) introduced the Environmental Justice Act of 2007 to the 110th Congress. The legislation was introduced to protect communities of color and low-income communities from the on-going disproportionate burden of the negative human health and environmental impacts of pollution that they are exposed to. The act was introduced as a way to fully implement the 1994 Executive Order 12898, Federal Actions to Address Environmental Justice in Minority Populations and Low-Income Populations, an act to ensure that all federal agencies and their programs and rules are protecting our nation’s most vulnerable communities. The bill will require the Environmental Protection Agency (EPA) to fully implement recommendations included in three recent government reports and it will create reporting requirements, including an update on the inclusion of environmental justice in EPA’s emergency command response structure. The reports noted the failure of EPA to ensure that its policies, rules and regulations protect environmental justice communities. In 2004, the EPA’s Office of Inspector General (OIG) found that the agency has not fully implemented the Executive Order nor has […]

(Beyond Pesticides, Feb 21, 2007) Exposure to environmental chemicals found in everyday plastics and pesticides while in the womb may make a person more prone to obesity later in life, new research indicates. Frederick vom Saal, Ph.D, professor of biological sciences at University of Missouri-Columbia’s College of Arts and Science, has found that when fetuses are exposed to endocrine-disrupting chemicals, the way their genes function may be altered to make them more prone to obesity and disease. Dr. vom Saal presented his research last week at the annual meeting of the American Association for the Advancement of Science (AAAS) in San Francisco. “Perinatal Programming of Obesity: Interaction of Nutrition and Environmental Exposures” is the title of Dr. vom Saal’s AAAS presentation. “Certain environmental substances called endocrine-disrupting chemicals can change the functioning of a fetus’s genes, altering a baby’s metabolic system and predisposing him or her to obesity,” said Dr. vom Saal. “This individual could eat the same thing and exercise the same amount as someone with a normal metabolic system, but he or she would become obese, while the other person remained thin,” he said. Obesity puts people at risk for other problems, including cancer, diabetes, cardiovascular disease and hypertension. […]

(Beyond Pesticides, February 13, 2007) As Valentine’s Day approaches, dozens of roses and bouquets are being stocked at stores nationwide. The intentions may be sweet but many of the flowers are not — most of them have been treated with toxic chemicals. Pesticides are used on most conventionally grown flowers. A good portion of this use takes place in the waterlogged savannah surrounding the capital of Colombia, which has the world’s second-largest cut-flower industry after the Netherlands, producing 62 percent of all flowers sold in the United States. With 110,000 employees — many of them single mothers — and annual exports of US$1 billion, the industry provides an important alternative to growing coca, source crop of the Andean nation’s better known illegal export: cocaine. But these economic gains come at a cost to workers’ health and Colombia’s environment. Colombia’s flower exporters association has attempted to respond by launching the Florverde program, but with limited success; its members have reduced pesticide use by 38 percent since 1998, to an average of 97 kilograms (213 pounds) of active ingredient per hectare (2.4 acres) per year. However, 36 percent of the chemicals used by Florverde farms in 2005 were still listed as “extremely” […]

(Beyond Pesticides, February 8, 2007) Investigators at St. Jude Children’s Research Hospital have shed new light on the suspected role of pesticides in the development of Parkinson’s disease (PD). The study, “GST expression mediates dopaminergic neuron sensitivity in experimental parkinsonism” appearing in the Proceedings of the National Academy of Sciences (January 31, 2007), illustrates the mechanism of nerve cell damage by pesticide exposure. The enzyme that prevents damage to the substantia nigra, the part of the brain where nerve cell damage associated with PD occurs, is called GST pi (“pie”). This enzyme stands like a sentry at the crossroads of several biochemical pathways, any one of which can lead to PD. GST pi protects the nerve cell from death caused by either environmental toxics, such as pesticides, or a self-destruction process called apoptosis (cell suicide), triggered by certain stressful conditions in the cell. If GST pi levels are reduced or this enzyme is overwhelmed by toxics, these nerves are at increased risk of death, according to studies in mouse models. GST pi is one of a family of similar enzymes that eliminate free radicals generated by pesticides and other chemicals. Two members of this family are present in the brain, […]

(Beyond Pesticides, February 6, 2007) Conservation groups have challenged a government plan that would allow six more years use of a deadly pesticide it admits needs to be banned. The groups, represented by Earthjustice, have reopened a lawsuit in federal district court aiming at speeding up the removal of azinphos-methyl, commonly called AZM or guthion. The legal actions also takes aim at getting rid of two other deadly pesticides, phosmet and chlorpyrifos. All three pesticides were developed from World War I-era nerve toxins. AZM is used primarily to kill insects on orchard crops such as apples, cherries, pears, peaches, and nectarines. The highest uses occur in Washington, Oregon, California, Michigan, Georgia, New York, New Jersey, and Pennsylvania. Chlorpyrifos is used widely on corn and orchard crops. Use of phosmet on orchard crops and blueberries poses particularly serious risks to workers. In November 2006, EPA decided that AZM poses unreasonable adverse effects and must be banned but allowed its continued use on fruit crops for six more years — until 2012 — and on nut crops for three more years — until 2009. “With safer alternatives already in widespread use, EPA has betrayed the trust of the men, women, and children […]

(Beyond Pesticides, January 30, 2007) Breast cancer groups across the country have a new issue to add to the repertoire of risk factors: Pesticide use. A study published online in the American Journal of Epidemiology has found a strong link between residential pesticide use and breast cancer risk in women. Responding to the study, Susan Teitelbaum, Ph.D., assistant professor in the department of community medicine at the Mount Sinai School of Medicine in New York, says the options are simple”” “Stop using pesticides.” The study, published December 13, is the first to examine the relation between breast cancer and pesticides through self-reported residential pesticide use. Using women from New York, the study looks not at one or two incidents of pesticide contact, but at the impact of lifelong pesticide use in the home, lawn and garden. Using a sample of 1,508 women who were diagnosed with breast cancer between 1996 and 1997, the study compares these women to 1,556 control subjects who were randomly selected. The results show that those women whose blood samples had higher levels of organochlorines are at an increased risk of breast cancer. Organochlorines are a broad class of chemicals, including DDT, dieldrin, and chlordane, and […]

(Beyond Pesticides, January 19, 2007) A recent study conducted in Manitoba, Canada, has found that residents in communities in which agricultural pesticides have been applied heavily are at a higher risk for eye disorders and for giving birth to children with abnormalities or birth defects. Significantly, these results are not confined to those who work with pesticides directly””such as farmers””but are relevant among entire populations. “Often studies are done on a particular people like, let’s say, the group of farmers who have direct contact with pesticides,” says Patricia Martens, Ph.D., director of the Manitoba Center for Health Policy. “This study was looking at the entire population.” Jennifer Magoon, a graduate student from the University of Manitoba, looked at Manitoba’s database of public health records, comparing records from areas of intensive agricultural pesticide use with areas that use little. She studied 323,368 health records from the years 2001 to 2004, which included pharmaceutical files, physician claims, and hospital separations. What she has found are “statistically significant” links between higher pesticide use and health problems. She has found that, compared with areas of average pesticide use, the chance for abnormalities in babies born in high-use areas rose four percentage points for males […]