(Beyond Pesticides, November 1, 2024) In a study published earlier this year in Soil Science Society of America Journal, researchers at Kansas State University document direct evidence that organic amendments (e.g., manure and compost) in a no-till agricultural system “facilitat[e] microbial diversity” that cycles plant-available nutrients. The study was published just as farmers are looking for less expensive practices that support the economic vitality of their farms amid surging prices for petrochemical pesticides and fertilizers and as agricultural support programs are threatened by unresolved issues in Farm Bill talks on Capitol Hill. [See the recent Action of the Week calling on Congress to take action.] Simultaneously, awareness is growing among environmental and public health advocates about the importance of soil health to ecosystem stability in combatting climate change-induced natural disasters and stopping plummeting biodiversity. Demands for new systems rooted in organic principles and land management practices continue to become more widely recognized by farmers, environmentalists, and the broad public. The study adds to earlier findings and contributes to the body of scientific literature on soil health and its importance to ecosystem and human health. Methodology and Results The study was led by researchers at Kansas State University specializing in agronomy […]

(Beyond Pesticides, August 15, 2024) Adding to research that has linked insecticide disruption of the gut microbial community to the progression of Parkinson’s Disease (PD) in the brain is a recently published study that further examines the gut-brain mechanism at work. A review by neuroscientist Nabanita Ghosh, PhD in Chemical Research in Toxicology—coauthored by Krishnendu Sinha, PhD, molecular toxicologist and applied pharmacologist, and molecular toxicologist Parames C. Sil, PhD—focuses on how pesticide-induced microbial community alterations specifically drive the initiation of PD and the precise mechanism. The study also explores microbiota changes at different stages of PD progression, offering recent findings.     The researchers derive their data from the examination of PD patients, evaluating the “interaction between pesticides and gut bacteria in PD patients, summarizing how pesticides cause imbalances in gut bacteria, the resulting changes, and their overall effects on the PD prognosis.”   The review “looks at how pesticides and gut bacteria separately influence PD development and progression, highlighting the harmful effects of pesticides and changes in gut bacteria.” The team concludes that pesticide exposure is connected to PD onset through “disturbances in gut function and alterations in intestinal microbiota.” However, the “exact role of microbial factors in this connection remains […]

(Beyond Pesticides, August 9, 2024)​​ A study in the journal Biology and Fertility of Soils has confirmed once again that organic agriculture contributes significantly to soil health, improving ecological functions that are harmed by conventional, chemical-intensive farming practices. Organic soil amendments (fertilizers) that feed soil organisms increase beneficial protistan predators and support sustainable predator-prey relationships within the soil microbiome. [‘Protist’ is a catch-all term that describes ancient lineages of eukaryotes—organisms with a nucleus—that are neither a true plant, animal, or fungus.] The study shows that organic farming creates a healthy ecosystem able to support a balance of life forms in the soil. Moreover, the study finds that the use of chemical fertilizers for agricultural management disrupt the stable biological relationship between protistan predators and their bacterial prey in soils, adding to the argument for transitioning away from conventional systems that lean on toxic inputs.   Healthy soil contains millions of living species that form the microbiome. Most of the biodiversity in soil consists of bacteria and fungi, and their number and type are regulated partially by predatory protists and nematodes that feed on bacteria. Akin to the impact of predators keeping a herd of prey healthy by hunting the sick, […]

(Beyond Pesticides, May 15, 2024) A study published recently in the journal Environmental Research finds a significant correlation between exposure to certain pesticides and an elevated risk of inflammatory bowel disease (IBD), a chronic autoimmune condition of the gastrointestinal tract. The study, adding to the body of science on this subject, evaluates self-reported data from licensed pesticide applicators and their spouses exposed to pesticides for over 20 years. In addition, while some of the chemicals found to be most closely associated with incidents of IBD have been banned from use, they are “forever” chemicals that persist in the environment for generations. These findings demonstrate once again the failings of the current regulatory process to identify hazards before they are put into the environment. The study found evidence that exposure to several organochlorine insecticides (dieldrin, DDT, and toxaphene), as well as organophosphate insecticides (parathion, terbufos, and phorate) and herbicides (2,4,5-T, 2,4,5-TP, and metolachlor), is associated with elevated IBD risk. IBD is a generic term for diseases that result in chronic inflammation of the gastrointestinal tract, such as Crohn’s disease and ulcerative colitis. It is estimated that 6.8 million patients globally suffered from IBD in 2017. IBD may result from an imbalance […]

(Beyond Pesticides, April 26, 2024) Researchers build on existing research when assessing the relationship between long-term exposure to organophosphorus pesticides—widely used in food production and homes and gardens—and the human gut microbiome. In a new study published in Environmental Health, an interdisciplinary research team from University of California, Los Angeles determined, “that exposure to [organophosphorus pesticides] is associated with changes in the abundance of several bacterial groups and differential functional capacity in metabolic pathways supported by the human gut microbiome.” The study draws upon data from a “Parkinson’s, Environment and Gene study (PEG)” in which 190 participants were asked to submit fecal samples and answer interview questions. “[The study] was initially designed to investigate the etiology of Parkinson’s disease (PD) and participants were recruited in two study waves [‘over the full 10-year exposure window’]: 2001–2007 and 2012–2017. At baseline, [Parkinson’s disease] patients were diagnosed within the past 5 years and randomly selected community controls were also recruited,” the research team shares in their Methodology section. “Since 2017, we invited previous study participants who could be contacted to enroll in a pilot study of the gut microbiome. In addition, we invited a household or community member of [Parkinson’s] patients to participate.” […]

(Beyond Pesticides, December 19, 2023) Last week, farmworker organizations and Beyond Pesticides, represented by the Center for Food Safety, filed a petition with the U.S. Environmental Protection Agency (EPA) urging that the weed killer glyphosate be removed from the market. The petition cites 200 studies, which represent a fraction of the independent scientific literature on the hazards of glyphosate and formulation ingredients of glyphosate products. This action follows previous litigation in 2022 in which a federal court of appeals struck down EPA’s human health assessment, finding that the agency wrongfully dismissed glyphosate’s cancer risk. The farmworker groups petitioning include Farmworker Association of Florida, Organización en California de Lideres Campesinas, Alianza Nacional de Campesinas, and the Rural Coalition.   Meanwhile, verdicts against glyphosate’s manufacturer, Bayer, continue to pile up with a December jury verdict in Pennsylvania awarding $3.5 million and a November jury in Missouri ordering $1.56 billion to be paid to four plaintiffs. All link their cancer to use of the Roundup. Bayer has lost almost all of the cases filed against it for compensation and punitive damages associated with plaintiffs’ charge that its product (previously manufactured by Monsanto) caused them harm.  The petition summarizes its purpose and justification as […]

(Beyond Pesticides, November 15, 2023) A study previously published in the Federation of American Societies for Experimental Biology (FASEB) is drawing renewed attention to the gut microbiome in the scientific community. The study, involving a team including Demetrio Sierra-Mercado, PhD, of the University of Puerto Rico School of Medicine, initially established a link between glyphosate exposure and increased anxiety and fear-related behavior in rats. Glyphosate, a widely-used herbicide, has been detected in trace amounts in fruits, vegetables, grains, and other food and beverages, according to the U.S. Environmental Protection Agency (EPA). Originally deemed safe for humans due to the way it interacts with the shikimic acid pathway—a metabolic route that is absent in humans—glyphosate’s indirect effects on human health are now under scrutiny as the research linking it to anxiety-like behavior grows.  Dr. Sierra-Mercado’s team is expanding on his previous research to take a closer look at the compound’s potential disruption of the gut microbiome, which plays a pivotal role in regulating both physical and mental health. His upcoming study, anticipated in August 2024, aims to delve into the intricate relationship between glyphosate exposure and the gut-brain axis, with a focus on how this may influence neurological and emotional health […]

(Beyond Pesticides, June 14, 2023) The exoskeleton of the black soldier fly (BSF; Hermetica illucens) has the potential to be an effective organic fertilizer. A study in the journal Agriculture, Ecosystems & Environment highlights the positive impacts on plant size, flower count, seed production, appeal to pollinators, and resilience to herbivory that the fly’s molted exoskeleton (or exuviae) can have when used as a soil supplement. The use of insect exuviae as an organic alternative to harmful synthetic fertilizers is an important step toward an environment free from chemical contaminants, and BSF are uniquely equipped to contribute to a regenerative organic agricultural system. The study set out to determine the impacts of BSF exuviae on plant growth, resilience to herbivory, and pollination. The scientists divided black mustard plants into four different treatment groups: 1) grown in soil amended with BSF powdered exuviae; 2) control group planted in chemically-treated (conventional) soil; 3) grown in amended soil and subjected to increased herbivory from caterpillars (Pieris brassicae) and aphids (Brevicoryne brassicae); and 4) planted in conventional soil and subjected to increased pest exposure. Scientists measured plant growth, flowering status, seed production, herbivore abundance, and pollinator activity. After three weeks, the supplemented soil grew […]

(Beyond Pesticides, June 27, 2023) Pesticides interfere with biological processes. This is their purpose. Unfortunately, they nearly always have unintended consequences, many of which have been ignored by their manufacturers. A new review article by Irish and Dutch researchers in the ISME Journal adds to the emerging scientific literature examining how pesticides affect the relationship between the human gut and the human brain (the “gut-brain axis”). Often called the “second brain” because it houses nerve cells and produces neurotransmitters, the gut-brain axis may be the most important locus where microbes and pesticides meet. The human gut plays host to a variety of microorganisms, ranging from bacteria and archaea to fungi, viruses and yeasts.[1] In a healthy person these microbes remain in balance and often cooperate both with each other and with human cells. The gut and the brain are deeply integrated through the vagus nerve and the neuroendocrine system. The vagus nerve is a treelike bundle of fibers extending from the lower part of the brain to nearly every body organ, but particularly the heart, lungs and digestive tract. The neuroendocrine system comprises specialized cells inhabiting nearly all the organs of the body that respond to signals from the brain […]

(Beyond Pesticides, March 21, 2023) Placing honey bee hives in agricultural areas creates stress that leads to microbial imbalances, according to research published in Scientific Reports by Croatian scientists this month. The research highlights the fragility and absurdity of chemical-driven agricultural systems dependent upon both pollinators and products that harm or kill off these sensitive species. While regulators in the United States continue to prop up unsustainable practices, more and more consumers are seeking out and engaging with the key alternative to this system by supporting organic farms and foodstuffs at their farmers market and grocery store. Scientists began by creating 33 colonies from three apiaries within an agricultural region in Croatia, utilizing four brood frames, two honey frames, and mated queens. Of these 33 newly created hives, 22 were relocated to a separate agricultural region, and 11 were placed roughly six miles away from a nature preserve and considered a semi-natural area. A separate group of 10 hives that had been established on a small island (Unije, Croatia) in the Adriatic Sea were included in the study in order to represent a completely natural location. After roughly two weeks of colony formation, scientists collected samples to represent the multiple […]

(Beyond Pesticides, March 2, 2023) Populations experiencing higher levels of environmental pollutant exposure, specifically pesticides, also experience a higher rate of irritable bowel syndrome (IBS), according to a study published in Environmental Toxicology and Pharmacology. IBS is a gastrointestinal disorder that causes abdominal pain or discomfort and changes in bowel behaviors. IBS affects 25 to 45 million individuals in the U.S., mostly female (two-thirds). Additionally, a quarter to half of all gastrointestinal-related visits are for IBS symptoms. Despite the unknown etiology of IBS, ample evidence demonstrates environmental contaminants, like pesticides, negatively affect the gut microbiota, causing a microorganism imbalance and resulting in inflammation associated with IBS. The gut, also known as the “second brain,” shares similar structural and chemical parallels to the brain. The microbiota in the gut plays a crucial role in lifelong digestion, immune and central nervous system regulation, as well as other bodily functions. Although studies show how chemical exposures affect overall human health, a growing body of peer-reviewed scientific literature is now questioning how these toxic chemicals influence gut health and the subsequent occurrence of diseases. The study notes, “These findings may help to understand the relationship between pesticide exposure and IBS; however, more epidemiological and experimental research is needed to understand […]

(Beyond Pesticides, January 26, 2023) A study published in Food Safety and Toxicology finds that the widely used fungicide azoxystrobin (AZO), used in food production and turf management, can disrupt the function of the intestinal (colonic) barrier responsible for the absorption of nutrients and defense against harmful substances. This and other similar data are important because the U.S. Environmental Protection Agency (EPA), with its required pesticide testing protocol, says that the chemical has “low acute and chronic toxicity to humans, birds, mammals, and bees,” and speaks to the need for the agency to modernize its registration requirements. [The agency does note that AZO is “is highly toxic to freshwater fish, freshwater invertebrates, and estuarine/marine fish, and very highly toxic to estuarine/marine invertebrates.] AZO is a broad-spectrum chemical used in wheat, barley, oats, rye, soya, cotton, rice, strawberry, peas, beans, onions, and a long list of other vegetables, as well as on lawns and golf courses, on a range of fungal diseases. The intestinal (colonic) barrier prevents the internal environment from damage caused by exogenous toxins to ensure internal homeostasis, impeding incidences of systemic inflammatory response syndrome (SIRS), sepsis, and multiple organ dysfunction syndrome (MODS). The intestines host a group of microorganisms that form […]

(Beyond Pesticides, November 22, 2022) Fungus that survive a fungicide application may be able to multiply and thrive, putting plant yields at risk. This finding comes from research recently published by scientists at University of Illinois, focusing on the impact of fungicide use on soybean yields and the disease Septoria brown spot, caused by the fungus Septoria glycines. The research underlines the danger of preventive chemical applications in an attempt to protect yield and shows how precarious pesticide use can be when subject to the complexity seen in field conditions. Scientists began with the intent of analyzing the soybean’s phyllosphere mycobiome, the fungal microbial make-up of the outside of the plant, including all its surfaces above-ground. A field trial was established near Urbana, Illinois, and soybeans plants were separated into four different plots according to their treatment. One group was inoculated with Septoria glycines, another inoculated and sprayed with a fungicide, a third not inoculated yet sprayed with a fungicide, and a final control group neither inoculated nor treated with a fungicide. A range of different analyses were conducted to view changes in the disease development and mycobiome composition over time. Soybean plants that had been inoculated with Septoria showed […]

(Beyond Pesticides, November 1, 2022) Honey bees exposed to a combination of multiple pesticides suffer a reduced lifespan and experience adverse changes to their gut microbiome, increasing susceptibility to pathogens and disease. This finding comes from a study published recently in Science of the Total Environment, which examines the interactions between the insecticides flupyradifurone and sulfoxaflor and the fungicide azoxystrobin on honey bee health. Both insecticides studied are considered substitutes for notorious bee-killing neonicotinoid insecticides, which move through the vascular system of the plant and contaminates its pollen, nectar, and guttation droplets. As declines in pollinator and insect life continue throughout the world, it is critical not only to understand and restrict widely used chemicals like neonicotinoids, but also the regrettable and deleterious substitutions the agrichemical industry has developed to replace them. As the present study reveals, pesticide risk assessments do not inadequately capture the range of harm that can result when pesticides are combined, necessitating a shift toward safer, alternative, and regenerative organic farming systems that do not use these dangerous chemicals. To better understand the impacts of combined pesticide exposure on honey bees, researchers employed three colonies located in Germany’s Martin Luther University that were inspected and free […]

(Beyond Pesticides, August 25, 2022) A study published in World Journal of Pediatrics finds an association between antibiotic and neonicotinoid (neonic) exposure and onset of pediatric (childhood) type 1 diabetes (T1D) through effects on the gut microbiome. Individuals with type 1 diabetes are at higher risk of other autoimmune disorders, including thyroid and celiac disease. Ample evidence demonstrates environmental contaminants like pesticides and antibiotics negatively affect human mouth and gut microbes. Through the gut biome, pesticide exposure can enhance or exacerbate the adverse effects of additional environmental toxicants on the body. Moreover, studies find low levels of pesticide exposure during pregnancy or childhood cause adverse health effects from metabolic/immune disorders to mental and physical disabilities. Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. Although studies show how chemical exposures affect overall human health, more research is now questioning how these toxic chemicals influence gut health and subsequent occurrence of diseases. In children, gut microbiome disruption, or gut dysbiosis, has significant associations with type 1 diabetes development, and disruption of gut microbiota plays a role in type 2 diabetes development. Over 11 percent (>37 million) of individuals in the U.S. have diabetes, and cases are growing by millions annually. With increasing rates of type 1 and […]

(Beyond Pesticides, May 26, 2022) A study published in The International Journal of Biochemistry & Cell Biology finds environmental exposure to neurotoxic pesticides increases Parkinson’s Disease (PD) risk through gastrointestinal (GI) disruption. Research finds exposure to chemical toxicants, like pesticides, can cause neurotoxic effects or exacerbate preexisting chemical damage to the nervous system. Although the mechanism by which pesticides induce disease development remains unclear, this study suggests environmental pesticide exposure disrupts GI cells responsible for supporting the autonomic nervous system. Enteric glial cells (EGCs) are GI cells that play a critical role in the functional changes that accompany GI dysfunction, as this dysfunction is one of the earliest symptoms indicating the onset of PD. Parkinson’s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses each year. The disease affects 50% more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and sleep disturbances. Identifying early biomarkers of PD, such as pesticide-mediated toxicity on GI cells, is crucially important as symptoms intensify overtime, with no current cure for this fatal disease. While only […]

(Beyond Pesticides, May 12, 2022) A report published in Environmental Health finds that exposure to environmentally relevant concentrations of pesticides can alter gut microbial communities, as demonstrated through fecal samples. Over 300 environmental contaminants and their byproducts, including pesticides, are chemicals commonly present in human blood and urine samples. Ample evidence demonstrates that environmental contaminants, including pesticides, negatively affect the human mouth and gut microbes. However, fecal samples provide an accurate representation of the microbial community existing in the gut. These toxicants can alter hormone metabolism, which adversely affects health outcomes. Adverse health effects of environmental contaminants include reproductive and developmental defects, diabetes, cardiovascular disease, liver disease, obesity, thyroid disorders, and improper immune operation. Although studies show how chemical exposures affect human health, more research is now questioning how these toxic chemicals influence gut health. Therefore, studies like these highlight the importance of evaluating how chemical contaminants deregulate normal bodily function through microbiome changes. The report notes, “Our results highlight the need for future dietary intervention studies to understand effects of pesticide exposure on the gut microbiome and possible health consequences.” Researchers examined dietary exposure to 186 common pesticide residues in the fecal excrement to determine impacts on the microbiome among 65 twins in the United Kingdom. […]

(Beyond Pesticides, May 5, 2022) A report published in Biological Conservation finds environmental pollutants, including pesticides, pharmaceuticals, plastics, and particulate matter, adversely affect tropical terrestrial wildlife. Specifically, these contaminants can interact with one another, altering the chemical landscape of the ecosystem, and causing changes in the endocrine and microbiome systems of mammals. Since the publication of Rachel Carson’s Silent Spring (1962), global attention to the danger of pesticides has increased, with environmental agencies banning the use of legacy pesticides like organochlorines for their devastating toxic—sometimes lethal—effects. However, these chemicals can remain in the environment for decades and interact with various current-use pesticides, including organophosphates, neonicotinoids, and pyrethroids. Although many studies demonstrate that environmental pollution plays a significant role in premature deaths among humans, there is a lack of research on how environmental pollution directly affects tropical species mortality. Considering human and wildlife habitats tend to overlap, and chemical pollutants can drift from chemically treated areas, wildlife populations are more likely to experience similar health effects. With the number of chemicals in the ecosystem growing, studies like these highlight the need for pesticide policies that protect human health in addition to the integrity of the chemical landscapes accommodating wildlife. The researchers note, “Using […]

(Beyond Pesticides, February 16, 2022) Pesticide exposure disturbs the gut microbiome of social bees, leading to a range of alterations that could affect fitness in the wild, finds a major literature review recently published by researchers at the University of Ottawa, Canada. With research on bee gut microbiomes is still in its infancy, the review provides a centralized overview of data collected to date, and highlights areas for further research to fill in remaining knowledge gaps. “Social bees have gut microbiotas that contribute to their health, just like we (humans) do,” said Michelle Hotchkiss, a PhD candidate in the Faculty of Science at the University of Ottawa. “Further research on the interactions between pesticides, bee gut microbiotas, and bee hosts will help us better understand how pesticides affect bee health and performance.” To conduct their review, scientists collected research relating to bee gut over the last 50 years. “The earliest studies we found were published in the 1970s and the most recent ones in 2020,” said Dr. Hotchkiss. “We summarized what methods were used to collect data, including which bee hosts and pesticides were examined. To summarize how the abundances of core microbes changed after pesticide exposure, we looked at […]

(Beyond Pesticides, January 25, 2022) Research at the University of North Carolina at Chapel Hill identifies how triclosan (TCS), an antimicrobial agent used in many household products, impacts the microbial communities in the gut, causing inflammation. According to the study published in Nature Communications, triclosan worsens the effects of ulcerative colitis, an inflammatory bowel disease (IBD), through the retention of harmful bacteria. Ample evidence demonstrates environmental contaminants, including pesticides like triclosan, negatively affect microbes in the human mouth and gut. Although studies show how triclosan exposure affects human health, more research is now questioning how exposure to these toxic chemical influences gut health. Therefore, studies like these highlight the importance of evaluating how chemical contaminant deregulates normal bodily function through microbiome changes. Furthermore, the study has significant implications for considerations that should be, but are not currently, a part of pesticide review and registration by the U.S. Environmental Protection Agency (EPA). The researchers note, “Together, our results define a mechanism by which intestinal microbes contribute to the metabolic activation and gut toxicity of TCS, and highlight the importance of considering the contributions of the gut microbiota in evaluating the toxic potential of environmental chemicals.” Instances of intestinal bowel disease (IBD)—involving the chronic inflammation […]

(Beyond Pesticides, October 28, 2021) A study published in Frontiers in Environmental Science finds the popular herbicide glyphosate negatively affects microbial communities, indirectly influencing plant, animal, and human health. Exposure to sublethal concentrations of glyphosate shifts microbial community composition, destroying beneficial microorganisms while preserving pathogenic organisms. Glyphosate is the most commonly used active ingredient worldwide, appearing in many herbicide formulas, including Bayer’s (formerly Monsanto) Roundup®. The use of this chemical has been increasing since the inception of crops genetically modified to tolerate glyphosate over two decades ago. The toxic herbicide readily contaminates the ecosystem with residues pervasive in both food and water commodities. In addition to this study, the scientific literature commonly associates glyphosate with human, biotic, and ecosystem harm, as a doubling of toxic effects on invertebrates, like pollinators, has been recorded since 2004. The authors caution, “[O]utbreaks of several animal and plant diseases have been related to glyphosate accumulation in the environment. Long-term glyphosate effects have been underreported, and new standards will be needed for residues in plant and animal products and the environment.” With an increasing number of reports on the relationship between glyphosate and human health, including potential effects on the human gut microbiome, advocates are calling on global leaders to eliminate chemical […]

(Beyond Pesticides, September 29, 2021) Bats foraging in chemical-intensive banana plantations have much less gut diversity than bats foraging in organic banana fields and natural forestland, finds research published this month in the journal Frontiers in Ecology and Evolution. Although there is increasing recognition that a diet of conventional, chemically grown food leads to adverse disruptions of the gut microbiome (also known as dysbiosis), little research has been conducted on the effect of production practices on the gut of wild foraging species. According to the present study there are significant differences that regulators must begin to account for in pesticide risk assessments, and consumers should consider when making choices at the supermarket. Researchers focused their investigation on Pallas’s long-tongued bat (Glossophaga soricina), a nectar feeding bat native to Central and South America. The bat is highly adapted to human environments, sustaining populations in both conventional and organic banana plantations, as well as surrounding forest land. For the study, researchers trapped nearly 200 bats across the country of Costa Rica over a 22-month time span. After trapping, physiological characteristics, like size and body weight, were measured, and bat guano was analyzed for its microbial population. All sampled bats were released back […]

(Beyond Pesticides, April 30, 2021) A bioinformatics tool developed by researchers from the University of Turku in Finland indicates that “54% of species in the core human gut microbiome are sensitive to glyphosate.” This tool may help predict which microbes in the human gut could be negatively affected by exposure to the ubiquitous herbicide. Because damage to the gut biome is linked to a variety of diseases, this information could prove critical in recognition of the role(s) glyphosate may play in the development of human diseases. Published in the Journal of Hazardous Materials, the researchers’ paper states, “The widespread use of glyphosate may have a strong effect on gut microbiomes as well as on human health.” Beyond Pesticides has long reported on the relationship between glyphosate and human health, including potential effects on the human gut microbiome. Used in multiple herbicide formulations, glyphosate has become widely known as the active ingredient in Bayer/Monsanto’s Roundup®, the most-used herbicide worldwide. The pervasiveness of glyphosate-based herbicide (GBH) use in agriculture, and of Roundup in particular, is due largely to their pairing with genetically engineered (GE) seeds for soy, canola, and corn crops. In many regions, these GE seeds — engineered to resist the glyphosate […]