(Beyond Pesticides, April 8, 2021) Pesticide use threatens aquatic and terrestrial invertebrates and plants more than ever, despite declining chemical use and implementation of genetically engineered (GE) crops in the U.S., according to a University Koblenz-Landau, Germany study. Since the publication of Rachel Carson’s Silent Spring (1962), many environmental agencies have banned the use of pesticides like organochlorines, organophosphates, and carbamates for their devastating toxic—sometimes lethal—effects, particularly on vertebrates, including humans. However, this ban created a pathway for a new generation of pesticides (e.g., neonicotinoids, pyrethroids) to take hold. Although these pesticides are more target-specific, requiring lower chemical concentrations for effectiveness, they have over double the toxic effects on invertebrates, like pollinators.  Invertebrates and plants are vital for ecosystem function, offering various services, from decomposition to supporting the food web. Furthermore, invertebrates and plants can act as indicator species (bioindicators) that scientists can observe for the presence and impact of environmental changes and stressors. Therefore, reductions in invertebrate and plant life have implications for ecosystem health that can put human well-being at risk. Study lead author Ralf Schulz, PH.D., notes, “[This study] challenge[s] the claims of decreasing environmental impact of chemical pesticides in both conventional and GM [genetically modified or genetically engineered (GE)] crops and […]

(Beyond Pesticides, March 18, 2021) A new study published in Environmental Toxicology and Pharmacology finds chronic (long-term) organophosphate (OP) pesticide exposure increases adverse health and cancer risk for U.S. women relative to men. Organophosphorus pesticides have a wide range of biological uses—from insecticides to flame retardants—that make these chemicals ubiquitous, significantly contributing to ecosystem contamination. Furthermore, while organophosphates have less bioaccumulation potential, residues are consistently present in human and animal blood, urine, tissues, and milk. Although research demonstrates that OPs are highly toxic, there remains an inadequate understanding of how OP exposure impacts the nonagricultural population in the U.S., especially women. Therefore, it is essential to investigate the sex-specific health effects chemical contaminants can produce to mitigate exposure among vulnerable populations. Study researchers note, “Given the higher burden of OP exposure and their significantly higher overall health risk, including cancer, reducing OP exposure in U.S. women needs to be prioritized.” To examine the relationship between OP exposure and health risks, researchers investigated the presence of commonly detected OP metabolite concentrations in urine using participants from the U.S. National Health and Nutrition Examination Survey (NHANES). Urine samples measure OP metabolite as an indicator of OP exposure like previous agriculture-related population surveys. Study participants report health issues […]

(Beyond Pesticides. January 25, 2021) First registered in 1970 and voluntarily cancelled in 2010, aldicarb (Temik™) was being manufactured in Bhopal, India in 1984 when a leak of a precursor—methyl isocyanate (MIC)—spread over the city, ultimately killing more than 25,000 people and leaving more than 120,000 people who still suffer from severe health problems as a result of their exposure. In 1989, Union Carbide Corporation—the manufacturer of aldicarb at the time—paid $470 million (equivalent to $860 million in 2019) to settle litigation stemming from the disaster. Aldicarb has been allowed by the outgoing Trump EPA for use on oranges. >>Tell EPA to Reverse Approval of Highly Toxic Insecticide Aldicarb! No pesticide epitomizes the “cradle-to-grave” dangers of pesticides better than aldicarb. The disaster in Bhopal was followed by others, including a leak in Institute, WV in 1985 that injured at least 135 people and a 2008 explosion in Institute, WV that killed two and injured at least eight. In use, it has been implicated in poisoning of workers and their children, poisoning deer and other game consuming contaminated seeds, and notably, poisoning food grown in soil treated with the chemical. The effects don’t stop there—aldicarb is also notorious for contaminating groundwater. […]

(Beyond Pesticides, January 22, 2021) After the past four devastating years, hopes and expectations of the Biden/Harris administration abound among the environmental and public health communities. The ears and eyes of many advocates, as well as those in the agricultural community, are attuned (among myriad candidates) to the fate of the pesticide aldicarb. Although Environmental Protection Agency (EPA) registration of this terribly toxic insecticide was cancelled in 2010, various limited-use reapprovals since then have meant that the compound has found its way to increasing levels of use. On January 12, as another parting shot of midnight rulemaking, Trump’s EPA approved expanded uses (see below). The $64,000 question is whether the new administration will use its authority under the Congressional Review Act — which enables Congress to pass a joint resolution (then signed by the President) to overturn a new federal agency rule and prevent its reissuance in the future — to get this pesticide retired for good. Beyond Pesticides urges President Biden’s EPA to do so. Notably, the Trump administration used the Congressional Review Act to destroy myriad environmental rules when it came into power. This permitting of expanded aldicarb uses fits the pattern. Environmental Health News notes that, as of early […]

(Beyond Pesticides, December 23, 2020) The litany of parting shots by the waning Trump administration got longer on December 4, when the Environmental Protection Agency (EPA) announced a proposed interim decision on the very toxic pesticide chlorpyrifos, functionally continuing its registration for many agricultural uses. The interim decision purports to put in place new limitations on use of this pesticide, but they are wholly inadequate to the threat this compound represents — to young children, most concerningly, as well as to farmworkers, critical species and ecosystems, and the public. Chlorpyrifos should not be re-registered for use — i.e., its sale and use should be banned altogether, as Beyond Pesticides has asserted for years. Chlorpyrifos is an organophosphate pesticide used on scores of food crops, for mosquito (and other pest) control, and for some turf management (golf courses, especially). It has been demonstrated to be highly neurotoxic, especially to young children, leading to impaired cognitive function, developmental delays, lower IQs, attention deficit disorder, and a variety of other pervasive developmental and learning disorders. The essence of the compound’s toxicity to developing brains lies in its function as a cholinesterase inhibitor; chlorpyrifos binds to the receptor sites for acetylcholinesterase (AChE), an enzyme […]

(Beyond Pesticides, December 17, 2020) The U.S. Environmental Protection Agency (EPA) is contemplating the reapproval of toxic, widely banned insecticide aldicarb for use on citrus fruits in Texas and Florida. A vast amount of scientific evidence reports a dramatic decline in insect population (i.e., the insect apocalypse), like pollinators and other beneficial biotas, from environmental pollution sources like pesticides. Therefore, it is important to assess regulatory decisions that can potentially jeopardize the protection of these species and, consequently, human health. Nathan Donley, PhD, a senior scientist at the Center for Biological Diversity (CBD), states, “The fact that U.S. regulators would even consider expanding use of this dangerous, widely banned pesticide is a stunning indictment of our broken regulatory system. This application vividly reaffirms why the pesticide industry considers us the dumping ground for the world’s worst pollutants. We’ll be watching closely to see whether the Biden administration steps up and puts public health before pesticide company profits.” Aldicarb is a highly toxic, systemic carbamate insecticide, with initial production beginning in 1965. The chemical is a fast-acting cholinesterase inhibitor that permanently binds to the active site of an essential enzyme for normal nerve impulse transmission, acetylcholinesterase (AChE), deactivating the enzyme. In […]

(Beyond Pesticides, November 25, 2020) New research from the Centre for Environment and Occupational Health Research at the University of Cape Town (UCT), South Africa, finds a link between pesticide exposure and adverse neurological symptoms among children and adolescents living in agricultural areas. Considering the etiology (cause) of many brain and neurological disorders are unknown, research like this is significant for understanding how pesticide exposure promotes disease development, especially among vulnerable populations. Researcher notes, “Children who indicate activities related to pesticide exposure may be at higher risk for developing headaches and lower cognitive performance in the domains of attention, memory and processing speed. […]Given [the] history and socio-economic divide to the farm laborers, […]future interventions should aim to reduce the health risks of these vulnerable populations, including their children.” The study demonstrates that there is a relationship between pesticide exposure from various farm-related and leisure activities and headaches and neurocognitive functioning (i.e., autism, attention deficit hyperactivity disorder (ADHD), lower intelligence (IQ), and harmful social behavior and behavioral regulation) in children and adolescents. To assess which farm-related/leisure activities concerning pesticide exposure cause cognitive symptoms, researchers administered a questionnaire addressing child pesticide handling, direct consumption of field crops, interaction with field adjacent water sources, […]

(Beyond Pesticides, October 23, 2020) In central California, what promises to be a landmark series of lawsuits against Corteva (formerly DowAgroSciences), maker of the pesticide chlorpyrifos, is under way, spearheaded by the case Alba Luz Calderon de Cerda and Rafael Cerda Martinez v. Corteva Inc., et al. This first suit, brought by the parents of Rafael Cerda Calderon, Jr. on his behalf, charges that his lifelong disabilities were caused by chronic exposures to chlorpyrifos. The parents are suing for general damages, compensatory damages (due to Rafael, Jr.’s loss of earning capacity), medical care costs, and “punitive damages for the willful, reckless, and recklessly indifferent conduct of the Defendants” in intentionally hiding the dangers of their chlorpyrifos products from customers and the public. As with so many dangerous pesticides, absent effective federal regulation, states, cities, and other entities are taking action to protect people from this compound, and as in this case, individuals are seeking redress for harms suffered. Beyond Pesticides has long advocated for a ban on the use of chlorpyrifos because of the grave risks it poses. The case was filed in mid-September in California Superior Court, Kings County, and names not only Corteva, but also, the cities of Huron and Avenal, Woolf […]

(Beyond Pesticides, October 19, 2020) The COVID-19 epidemic has made clear to the general public what we at Beyond Pesticides have been stressing since our inception—some populations have disproportionate risk of severe outcomes, exposures to toxic chemicals can affect susceptibility to disease, comorbidity increases risk, and bad government can kill you. As Trump declares that “unborn children have never had a stronger defender in the White House,” we are reminded of Erik Jansson, who ran the National Network to Prevent Birth Defects and helped to convene the founding meeting of Beyond Pesticides, and took on then-Administrator of EPA Anne Gorsuch, calling her a “baby killer” because of policies that allowed exposures to toxic chemicals—exposures that endangered children and fetuses. Those were harsh words in the 1980s even when the Reagan administration’s environmental and toxics policies were tied to elevated harm to people, and children in particular. In today’s world, scientists and medical doctors are regularly linking elevated death rates from coronavirus to the federal government’s inadequate coronavirus policy and its attack on science. And, they are pointing to those in charge. Policies and decisions under the Trump administration that threaten the health of children and the unborn include: COVID-19 misinformation. […]

(Beyond Pesticides, October 15, 2020) A review of scientific literature on the correlation between respiratory diseases and pesticides exposure—published in the journal Annals of Agricultural and Environmental Medicine (AAEM), “Influence of pesticides on respiratory pathology—a literature review”—finds that exposure to pesticides increases incidents of respiratory pathologies (i.e., asthma, lung cancer, and chronic obstructive pulmonary disease [COPD]—or chronic bronchitis). The review by researchers at the Iuliu Hatieganu’ University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania, looks at how pesticide exposure adversely propagates and reinforces respiratory diseases in humans. This review highlights the significance of evaluating how pesticide exposure impacts respiratory function, especially since contact with pesticides can happen at any point in the production, transportation preparation, or application treatment process. Researchers in the study note, “Knowing and recognizing these respiratory health problems of farmers and their families, and also of [pesticide] manipulators/retailers, are essential for early diagnosis, appropriate treatment, and preventive measures.” This study results are critically important at a time when exposure to respiratory toxicants increases vulnerability to Covid-19, which attacks the respiratory system, among other organic systems. The respiratory system is essential to human survival, regulating gas exchange (oxygen-carbon dioxide) in the body to balance acid and base tissue cells for normal […]

(Beyond Pesticides, October 2, 2020) The U.S. Environmental Protection Agency’s (EPA) September 22 announcement asserts that, “despite several years of study, the science addressing neurodevelopmental effects [of the insecticide chlorpyrifos] remains unresolved,” as reported in The New York Times. This conclusion contradicts both ample scientific evidence and the agency’s own findings. Beyond Pesticides has repeatedly advocated for a ban on the use of chlorpyrifos because of the grave risks it poses. This organophosphate pesticide is used on approximately 60 different crops, including almonds, cotton, citrus fruits, grapes, corn, broccoli, sugar beets, peaches, and nectarines. It is also commonly employed for mosquito-borne disease control, and on some kinds of managed turf, including golf courses. Exposure to the pesticide has been identified repeatedly as problematic. Most residential uses were taken off the market in 2000, after the manufacturer, DowDupont (now Corteva) was faced with EPA action. Chlorpyrifos is a cholinesterase inhibitor that binds irreversibly to the receptor sites of acetylcholinesterase (AChE), an enzyme that is critical to normal nerve impulse transmission. In so doing, chlorpyrifos inactivates the enzyme, damages the central and peripheral nervous systems, and disrupts neurological activity. The compound is associated with harmful reproductive, renal, hepatic, and endocrine disrupting effects, and most […]

(Beyond Pesticides, September 4, 2020) When pesticide drift is investigated, it is most often drift from agricultural fields that is examined. A new study shows that off-target drift of pesticides from greenhouses is also a reality. This research deduced such drift of organophosphate and carbamate pesticides from crop applications done in Ecuadoran floriculture greenhouses by evaluating the acetylcholinesterase enzyme (AChE) activity, necessary to the transmission of nerve impulses, in children residing nearby. The team finds that children living in homes near greenhouses in which these insecticides (widely recognized as cholinesterase inhibitors) are used exhibit reduced activity of this enzyme and abnormal functioning of the nervous system. Beyond Pesticides has monitored the pesticide drift issue intensively, and has long advocated for far better protections for farmworkers. This new information connects those issues, and expands the “drift” concerns to include risks to people working in greenhouses, and to those, especially children, who happen to live near greenhouse-type structures in which these toxic chemicals are used. The study evaluates data during three separate periods (2008, April 2016, and July–October 2016) on 623 children, aged 4–17, living in floricultural communities in Ecuador. The research is part of the study of the Secondary Exposure to Pesticides […]

(Beyond Pesticides, August 26, 2020) Neonicotinoid insecticides damage the health of shrimp and oysters, according to two (1, 2) new studies published by Australian researchers. Although this class of chemicals is best known for its hazardous impacts on pollinator populations, it is becoming increasingly clear that the entire food chain is at risk from continued neonicotinoid use. This study builds on an already established body of literature showing these systemic chemicals poison waterways. Researchers began by collecting samples of shrimp and oysters from growers along the coast, and acclimating the species to laboratory conditions. Both collections were separated into different test groups. Oysters where exposed in their tanks to various concentrations of the neonicotinoid imidacloprid. Shrimp were exposed to imidacloprid through two methods: in their feed, and in their tanks. Each separate test group was further separated into high and low exposures. A control group that did not receive any pesticide exposure was also established in each experiment. For the oyster populations, scientists found a range of negative effects. Imidacloprid inhibits the proper functioning of the enzyme acetylcholinesterase, a well-known impact of many pesticides that results in damage to the nervous system. Detoxification mechanisms are activated, and changes are observed […]

(Beyond Pesticides, August 30, 2019) The indictment of organophosphate pesticides gained more traction with the publication, in the Proceedings of the National Academy of Sciences, of a new research study out of the University of California, Berkeley. The research, among the first to use advanced brain imaging to assess cortical activation, shows altered brain activity, during tasks that call on executive function, in teenagers from California’s Salinas Valley (the site of significant organophosphate use) whose mothers were exposed prenatally. The UC Berkeley study underscores the slow-motion calamity of the Trump administration Environmental Protection Agency’s (EPA’s) failure to ban the use of this class of pesticides, and of chlorpyrifos in particular, which compounds carry extreme risks for children. The effects of this prenatal exposure continue to unfold during children’s critical developmental periods. Researchers used fNIRS (functional near-infrared spectroscopy) imaging to monitor blood flow in the brains of the teens, 15–17, born and raised in the Salinas Valley. They used data from the California Pesticide Use Reporting program (which documents locations and times of pesticide spraying) to estimate the subjects’ mothers’ proximity to organophosphate (OP) applications during pregnancy. The subject adolescents — estimated to have relatively high levels of prenatal exposure to organophosphates — […]

(Beyond Pesticides, July 9, 2019) Teens and adolescents living in agricultural areas and exposed to organophosphate insecticides are at higher risk of depression, according to the findings of a new study in the International Journal of Hygiene and Environmental Health. As rates of depression and suicide rise for teenagers in the US and throughout the world, public health researchers are working to find out why by investigating potential triggers. Toxic pesticide use represents a risk that can be addressed head on, protecting children and their families from a range of diseases that threaten public health. Jose R. Suarez-Lopez, MD, PhD, at the University of California San Diego School of Medicine, has been studying children living in the Ecuadorian Andes since 2008. His team assessed 529 individuals aged between 11 and 17 for their blood levels of acetylcholinesterase (AChE), an enzyme necessary for the proper functioning of nerves in the body. Exposure to organophosphate insecticides like chlorpyrifos and malathion have been shown to lower levels of AChE in the body. An assessment was also given to the children to fill out, in order to determine the severity of depressive symptoms or anxiety. Results showed that children with lower levels of AChE […]

(Beyond Pesticides, June 26, 2019)  “We were drooling excessively. My eyes would not stop watering,” Kaylynn Knull said to Denver ABC7, after she and her boyfriend filed suit against a Dominican Republic resort they claimed poisoned them with toxic pesticides. This year, the same resort, the Grand Bajia Principe, has had three Americans die on its premises. This is not the first time an island resort has been implicated in improper, potentially illegal pesticide use. In 2015, a family of four was poisoned by Terminix after the highly toxic fumigant methyl bromide was applied in a nearby room seeped in while they slept. Ms. Knull told ABC7 that the couple’s symptoms began after rejecting a time share offer at the resort. “As soon as we came back to the room, we noticed it smelled like somebody had dumped paint everywhere. I was having the worst intestinal cramping I have ever experienced. It felt like a chainsaw going through my gut.” The couple booked the first flight off the island, and went to a doctor, who diagnosed them with “Likely Organophosphate poisoning.” Organophosphates are acutely toxic insecticides that bind to and block the transmission of the acetylcholinesterase, an enzyme important to […]

(Beyond Pesticides, November 9, 2018) A Tunisian study (published in January 2018) on the effects in pre-pubertal mice of exposure to malathion — an organophosphate pesticide first registered for use in the U.S. in 1956 — demonstrates significant distortion of liver and kidney biochemistry and function in the animals. Deleterious effects include compromise of feeding ability, metabolism performance, neurologic deficits, reduction of overall body weight, and simultaneous increases in the weights of livers and kidneys, with structural anomalies and lesions in those organs. Organophosphates (OPs) have raised alarm bells for years. Some, such as chlorpyrifos and diazinon, have had their registrations cancelled for household uses because of the extreme health risks to children, but agricultural, golf course, and “public health” (mosquito control) uses remain commercially available and in use. Recently, Beyond Pesticides reported on research whose investigators support — and called publicly for — a worldwide ban on the compounds because of the serious health and environmental risks they pose, particularly for children. Beyond Pesticides has written extensively on OP pesticides, including malathion and chlorpyrifos. Both are used widely in agriculture. Chlorpyrifos has been the subject of quite a ping-pong match in recent years: a scheduled ban by the Environmental Protection […]

(Beyond Pesticides, November 2, 2018) A group of leading toxics experts, who published a paper in the journal PLOS Medicine on their research on organophosphate exposure during pregnancy and impacts on child development, are calling for a ban on organophosphate pesticides. The study evaluates current science on the risks of this class of compounds, produced by Corteva Agriscience (formerly Dow AgroSciences); its conclusions warn of the multitude of dangers of organophosphates for children, and makes recommendations for addressing these risks. The experts conclude that: (1) widespread use of organophosphate (OP) pesticides to control insects has resulted in ubiquitous human exposures; (2) acute exposures to OPs is responsible for poisonings and deaths, particularly in developing countries; and (3) evidence demonstrates that prenatal exposures, even at low levels, put children at risk for cognitive and behavioral deficits, and for neurodevelopmental disorders. Among the authors’ recommendations are these: Governments and subsidiary agencies, including the Environmental Protection Agency (EPA), should phase out chlorpyrifos and other organophosphate pesticides; ban non-agricultural uses of OP pesticides (including in household products); monitor watersheds and drinking water sources of human exposure; promote the use of integrated pest management (IPM) through incentives and training; and establish pesticide use and illness reporting […]

(Beyond Pesticides, September 15, 2017) Illegal cannabis grow operations are polluting California waterways with banned pesticides, according to reports from Reuters. Despite recent legalization of recreational marijuana in the state, California still accounts for over 90% of illegal grow operations within the U.S. The extent of contamination puts wildlife and drinking water at risk, necessitating increased monitoring and enforcement to stop ongoing ecological damage. Unreleased reports obtained by Reuters indicate the presence of pesticides, such as diazanon and carbofuran, which have been linked to a range of adverse human health outcomes. Both chemicals inhibit acetylcholinesterase (AChE), an enzyme important for the transmission of nerve impulses. When AChE is inhibited, acetylcholine accumulates leading to overstimulation of neurotransmitters, resulting in muscle weakness, confusion, and paralysis, among other symptoms. Both chemicals have also been shown to be highly toxic to birds. According to EPA reports from the 1980s, carbofuran applications contributed to the death of between one and two million birds each year. Diazinon has likewise been linked to hundreds of bird kill incidents, with reports in the 1980s involving over 23 bird species in 18 states. Reuters reports that law enforcement officers have been hospitalized from only touching plants or equipment contaminated […]

(Beyond Pesticides, January 25, 2017) A study conducted at the University of Buffalo recently revealed a connection between two common insecticides and an increased risk for certain metabolic diseases, including diabetes. Researchers found that by binding to and disrupting melatonin receptors that control numerous physiological functions, chemicals such as insecticides can affect melatonin levels, creating a higher risk for metabolic diseases to develop. The study, Carbamate Insecticides Target Human Melatonin Receptors, was published in Chemical Research in Toxicology and was funded by a grant from the National Institute of Environmental Health Sciences, which is part of the National Institutes of Health. The implicated chemicals in this research, carbaryl and carbofuran, are notoriously dangerous carbamate insecticides. Carbamates share structural characteristics and an ability to inhibit acetylcholinesterase (AChE), an enzyme important for the transmission of nerve impulses. When AChE is inhibited, acetylcholine accumulates leading to overstimulation of neurotransmitters, resulting in muscle weakness, confusion, and paralysis, among other symptoms. Carbaryl is said by EPA to be “one of the most widely applied insecticides in the U.S.,” since use began in 1959, with 10-15 million pounds used annually. It is a broad-spectrum insecticide used on a variety of crops, in forestry and on ornamentals, in […]

(Beyond Pesticides, February 26, 2013) The world’s most commonly used synthetic insect repellent is not  as effective as it once was, according to scientists at the London School of Hygiene and Tropical Medicine. While researchers found DEET to be an effective repellent after an initial application, subsequent rounds of testing mere hours later showed mosquitoes to be unaffected by its presence. The study, published in the journal PLOS One, underlines the need to develop safe, natural, effective alternative preventions to this hazardous chemical. To perform their experiment, researchers took the mosquito species Aedes aegypti, a carrier for dengue and yellow fever, and exposed it to a human arm covered in DEET. A few hours later they repeated the experiment, but this time the mosquitoes largely ignored the presence of the chemical. To find out what caused this to occur, researchers placed electrodes on the antennas of the insects. “We were able to record the response of the receptors on the antenna to DEET, and what we found was the mosquitoes were no longer as sensitive to the chemical, so they weren’t picking it up as well,”   co-author James Logan, PhD told the BBC.  “There is something about being exposed […]

(Beyond Pesticides, April 13, 2012) A study has found that the children of flower plantation workers in Ecuador are neurologically affected by the pesticide residues that their parents unwittingly carry home on their clothes, tools, and skin. The study documents significantly reduced activity for the essential enzyme acetycholinesterase (AChE) in children whose parents work on flower plantations compared to others whose parents do not. The two main classes of pesticides that the researchers identify as used in the region’s flower production, organophosphates and carbamates, are known to suppress the enzyme’s activity. AChE activity is crucial to healthy neurological functioning in humans and its suppression during childhood can hinder nervous system and cognitive development causing immediate and long-term impairment. In the study, Lower acetylcholinesterase activity among children living with flower plantation workers (Environ Res. 2012 Apr;114:53-9. Epub 2012 Mar 10), children whose parents work on a flower plantation are more than three times more likely to be in the group of lowest AChE activity. Additionally, the children who live the longest with a flower plantation worker are four times more likely to have lower enzyme activity than children who never live with a plantation worker. The researchers obtained their results by […]

(Beyond Pesticides, January, 21, 2009) A new study concludes that exposures during pregnancy and childhood to insecticides that target the nervous system, such as organophosphates (OPs) and carbamates, are associated with childhood brain tumors. The researchers hypothesize that this susceptibility might be increased in children with genetic variations that affect the metabolism of these chemicals. The study, “Childhood Brain Tumors, Residential Insecticide Exposure, and Pesticide Metabolism Genes,” examines whether childhood brain tumors (CBT) are associated with the functional genetic variations. The study provides evidence that exposure to insecticides, paired with specific metabolism gene variants, may increase the risk of CBT. DNA was extracted from archival screening samples for 201 cases ≤ 10 years of age and born in California or Washington State between 1978 and 1990. Insecticide exposures during pregnancy and childhood were classified based on interviews with participants’ mothers. The children’s mothers reported whether they or anyone else had chemically treated the child’s home for insects including termites, fleas, ants, cockroaches, silverfish, or “other” pests. The results are consistent with the possibility that children with a reduced ability to metabolize organophosphate and carbamate insecticides might be at increased risk of CBT when sufficiently exposed. The researchers observed multiplicative interactions […]