(Beyond Pesticides, May 9, 2013) A review of the scientific literature of the toxic effects of glyphosate, one of the most popular weed killers in the U.S. and the active ingredient in Roundup, links the herbicide  to a wide range of diseases and suggests  that more research is needed. The review, conducted by a scientist at Massachusetts Institute of Technology (MIT), looks at the mechanisms through which the adverse effects may be happening and points to  the chemical’s inhibition of cytochrome P450 (CYP) enzymes, which plays the crucial role of detoxifying xenobiotics. Thus, glyphosate can enhance the negative effects of other environmental toxicants on the body. Authors argue that this has been a critically overlooked component in research on glyphosates’ toxicity to mammals. We “have hit upon something very important that needs to be taken seriously and further investigated,” Stephanie Seneff, PhD, lead author and research scientist at MIT, told Reuters. Not surprisingly, Monsanto, the developer of Roundup, the leading product containing glyphosate, has attempted to discredit the study, claiming that its product has a long track record of being safe – read Another Bogus “Study.” However, Beyond Pesticides has assembled  extensive documentation on the human health and environmental risks […]

(Beyond Pesticides, April 26, 2013) Female agricultural workers experience the same hardships as their male counterparts, but have additional responsibilities and danger at home and in the field, according to a report released by the Association of Farmworker Opportunity Programs (AFOP). While women make up only 22 percent of agricultural labor in the U.S., AFOP makes a strong argument that women face disproportionate burdens, while at the same time earning less for their labor: On average they earn  just over $11,000 per year compared to male agricultural workers who earn $16,000. Through hundreds of interviews and focus groups of female farmworkers in California and Florida, AFOP revealed some of the most dangerous  conditions associated with farm work, among the worst being pesticide exposure. Carmela, a farmworker from Florida, indicated in the AFOP report that, “More than anything else, we have problems with pesticides. Sometimes they put us to work right after they’ve sprayed the pesticides. And this is bad for us because when we go in the field and start working with the plants, it gets in our eyes. It makes your head hurt too.” According to the EPA’s “Pesticide Industry Sales and Usage: 2000 and 2001 Market Estimates,” female […]

(Beyond Pesticides, April 24, 2013) Using the aquatic species Daphnia, commonly referred to as “water fleas,” scientists at North Carolina State University (NC State) determined that exposure to the pesticide pyriproxyfen impacted multiple generations, ultimately resulting in more male offspring, and causing reproductive problems in female offspring. Lead author Gerald LeBlanc, PhD, notes, “This work supports the hypothesis that exposure to some environmental chemicals during sensitive periods of development can cause significant health problems for those organisms later in life —and affect their offspring and, possibly, their offspring’s offspring.” The study, published in the journal PLoS One, provides the scientific community with new information on how organisms respond to the environmental signals resulting from pesticide exposure. Environmental cues normally determine whether the Daphina offspring will be male or female, according to the researchers. This study is part of an investigation to understand the mechanisms involved with these environmental cues. The NC State team had previously identified the hormone methyl farnesoate (Mf) as an important factor in determining the sex of the organisms at the embryotic stage. The scientists exposed Daphnia to varying levels of the pesticide pyriproxyfen, an insecticide that mimics the Mf hormone. The exposure resulted in Daphnia producing […]

(Beyond Pesticides, December 10, 2012) Long-term low-level exposure to organophosphate pesticides produces lasting damage to neurological and cognitive functions, according to researchers at University College London (UCL). This research pulls data from 14 studies over the past 20 years, including more than 1,600 participants, in order to provide a quantitative analysis of the current literature on these dangerous chemicals. Lead author of the study, Sarah Mackenzie Ross, Ph.D., notes, “This is the first time anyone has analyzed the literature concerning the neurotoxicity of organophosphate pesticides, using the statistical technique of meta-analysis.” UCL’s systematic review, published in the journal Critical Reviews in Toxicology, comes to an unsettling conclusion about the hazards of constant low-level occupational exposure to organophosphates. The study notes, “The majority of well designed studies found a significant association between low-level exposure to [organophosphates] and impaired neurobehavioral function which is consistent, small to moderate in magnitude and concerned primarily with cognitive functions such as psychomotor speed, executive function, visuospatial ability, working and visual memory.” In other words, low-level exposure had significant detrimental effect on working memory and information processing. The researchers are hopeful that the results of their analysis will be used to inform governments performing reviews on the […]

(Beyond Pesticides, August 10, 2012) A new study is the first to find a difference between how boys and girls respond to prenatal exposure to the insecticide chlorpyrifos. Researchers at the Columbia Center for Children’s Environmental Health (CCCEH) at the Mailman School of Public Health found that, at age 7, boys had greater difficulty with working memory, a key component of IQ, than girls with similar exposures. On the plus side, having nurturing parents improved working memory, especially in boys, although it did not lessen the negative cognitive effects of exposure to the chemical. Results are published online in the journal Neurotoxicology and Teratology. In 2011, research led by Virginia Rauh, ScD, Co-Deputy Director of CCCEH, established a connection between prenatal exposure to chlorpyrifos and deficits in working memory and IQ at age 7. Earlier this year, a follow-up study showed evidence in MRI scans that even low to moderate levels of exposure during pregnancy may lead to long-term, potentially irreversible changes in the brain. The latest study, led by Megan Horton, PhD, explored the impact of sex differences and the home environment on these health outcomes. Dr. Horton and colleagues looked at a subset of 335 mother-child pairs enrolled […]

(Beyond Pesticides, August 1, 2012) New research is adding to the evidence that some pesticides and industrial chemicals may increase women’s risk of uterine and ovarian diseases, such as endometriosis. The research supports the decades old theory that hormone-mimicking chemicals impact human reproductive systems. Scientists have long suspected a link between estrogen-mimicking pollutants and gynecological diseases. According to Environmental Health News, research investigating a link between hormone-disrupting chemicals in the environment and gynecological diseases has had mixed results. But a new study, “Persistent Lipophilic Environmental Chemicals and Endometriosis: The ENDO Study,” from researchers at the National Institutes of Health and others, found that two groups of women in the Salt Lake City and San Francisco areas — one group with pelvic pain and the other with no symptoms — were more likely to be diagnosed with endometriosis if they had high blood levels of the estrogen-like pesticide hexachlorocyclohexane (HCH) than women with low levels. HCH, a persistent organic pollutant (POP), and a byproduct of the production of the insecticide lindane (head lice treatments), has been banned as a crop pesticide in the United States but it persists in the environment and remains in some food supplies. Endometriosis is a female […]

(Beyond Pesticides, July 5, 2012) After a 2006 cancellation of uses due to unreasonable risks to farmworker health and the environment, and a 6-year phase out scheduled to conclude this September, the U.S. Environmental Protection Agency (EPA) is conducting a risk-benefit analysis to make a determination whether to keep in place or amend the cancellation order for the organophosphate azinphos-methyl (AZM), citing new information on the economic costs of using alternatives. In 2001, EPA found that insecticides azinphos-methyl (AZM) posed unacceptable risks to farmworkers and announced that 28 crop uses were being canceled, seven crop uses were to be phased-out over four years, and eight crop uses were to be allowed to continue under a “time-limited” registration for another four years. Farmworker advocates challenged that decision in federal court citing that EPA failed to take into account the costs of poisoning workers, exposing children, and polluting rivers and streams. A settlement agreement effectively stayed the legal challenge pending EPA’s reconsideration of the “time limited” uses of AZM. In November 2006, EPA decided that AZM poses unreasonable adverse effects and issued a final decision to cancel AZM, but allowed continued use on some fruit crops (apples, cherries, pears) for six more […]

(Beyond Pesticides, June 15, 2012) Researchers at the Duke University School of Medicine have developed a laboratory screening system for detecting neurotoxic chemicals and successfully tested it on more than 1,400 potential toxicants. The study confirms the high toxic activity of the chemical piperonyl butoxide (PBO), a chemical “synergist” used to increase the potency of more than 700 insecticides, including synthetic pyrethroids widely used in mosquito and community spray programs and for home use. The study, entitled “The Insecticide Synergist Piperonyl Butoxide Inhibits Hedgehog Signaling: Assessing Chemical Risks,” was published in the May 2012 edition of the journal Toxicological Sciences. The testing shows that PBO disrupts a biological signaling system that is “critical in neurological development,” the researchers reported in the abstract of their paper. The study finds that the disruption of this critical pathway “may be the molecular basis for profound developmental defects in children exposed in utero to PBO.” Piperonyl butoxide is not itself classified as a pesticide, but companies combine it with insecticides to increase their potency. PBO came into widespread use when the U.S. Environmental Protection Agency (EPA) phased out chlorpyrifos and other organophosphate pesticides nearly a decade ago after determining that they posed a risk […]

(Beyond Pesticides, May 2, 1012) New research published online at the Proceedings of the National Academy of Sciences reports that babies exposed in the womb to a commonly used insecticide have brain abnormalities after birth. The insecticide, chlorpyrifos (used in agriculture, mosquito control, and golf course management) , is well documented as inducing neurodevelopmental abnormalities in infants exposed in their mother’s womb, including ADHD, cognitive deficits, and serious learning, behavioral or emotional disorders. Entitled, “Brain anomalies in children exposed prenatally to a common organophosphate pesticide,” the study investigated associations between chlorpyrifos exposure and brain morphology using magnetic resonance imaging in 40 New York City children. It found significant associations of prenatal exposure, at standard use levels, with structural changes in the developing human brain, including enlargement of superior temporal, posterior middle temporal, and enlarged superior frontal gyrus, gyrus rectus, cuneus, and precuneus along the mesial wall of the right hemisphere. These areas of the brain impacted are related to attention, language, reward systems, emotions and control may be affected by the chemical. Twenty high-exposure children (upper third of chlorpyrifos concentrations in umbilical cord blood) were compared with 20 low-exposure children. The children, ages 6-11 years, considered to have a high […]

(Beyond Pesticides, April 9, 2012) A new study finds that exposure of pregnant women to organophosphate (OP) pesticides —a widely used class of pesticides in North American agriculture— may affect both length of pregnancy and birth weight. Environmental Health Perspectives published the paper, “Associations of Prenatal Exposure to Organophosphate Pesticide Metabolites,” last Thursday, April 5, 2012. The study, by a Simon Fraser University researcher, finds that the population of 306 women in Cincinnati, Ohio, is representative of the type of exposures most North American women and their children experience. Although the use of OPs in Canada and the U.S. has declined in recent years, exposures remain widespread, and these findings add to growing evidence about the harmful effects of low-level exposures to environmental toxicants. The researchers collected urine from each of the women in Cincinnati twice during their pregnancies for organophosphate metabolites as well as other factors that could influence the fetus’ health, including exposure to second hand smoke, race, and poverty. Women with higher levels of organophosphates were found to have pregnancies that were three to four days shorter and babies that were about â…“ pound lighter on average than women with lower levels of pesticides. “For an individual […]

(Beyond Pesticides, December 9, 2011) A recent study published in the journal NeuroToxicology has found a positive link between exposure to the pesticide propoxur and poor motor development in infants. At the age of two, children exposed to propoxur in the womb experience poor development of motor skills, according to a test of mental development. The study joins numerous others that consistently show birth defects and developmental problems when fetuses and infants are exposed to pesticides. The study, undertaken by researchers at Wayne State University in Michigan, the University of the Philippines, and Davao Regional Hospital in the Philippines, is entitled “Fetal exposure to propoxur and abnormal child neurodevelopment at 2 years of age.” It examines levels of exposure to multiple pesticides in pregnant women living in areas of high pesticide use in the Philippines. Pesticide exposure was monitored by measuring the pesticide content of hair and blood for both mothers and children. The researchers then compare these exposure levels to adverse outcomes regarding the health of the infants once they were born. To accomplish this, the team used a method called path analysis modeling in order to determine what effects the pesticides might have on fetal development. The striking […]

(Beyond Pesticides, November 29, 2011) New research shows that women who drink water containing the widely used herbicide atrazine may be more likely to have irregular menstrual cycles and low estrogen levels, even at concentrations far below federal drinking water standards considered safe by the U.S. Environmental Protection Agency (EPA). Researchers compared women living in Illinois farm towns where atrazine is used regularly to women living in Vermont where the herbicide is used sparingly, and found that the women in Illinois were almost five times more likely to report irregular menstrual cycles, including more than six weeks between periods. Consumption of over two cups of unfiltered Illinois water daily was associated with increased risk of irregular periods. The study, entitled “Menstrual cycle characteristics and reproductive hormone levels in women exposed to atrazine in drinking water,” was published in the journal Environmental Research earlier this month, and is based on municipal tap water tested between July and September of 2005. In the study, participants maintained menstrual cycle diaries, answered a questionnaire, and provided daily urine samples for analyses of luteinizing hormone and estradiol and progesterone metabolites. To measure exposure, analysts looked at the state of residence, concentrations of atrazine and chlorotriazine […]

(Beyond Pesticides, July 25, 2011) Exposure to certain pesticides and polycyclic aromatic hydrocarbons (PAHs) in the womb has been linked to neural tube defects, which lead to conditions such as spina bifida, according to researchers at Peking University in China. The study finds elevated levels of the organochlorine pesticides DDT, alpha-hexachlorocyclohexane (a lindane contaminant) and endosulfan, as well as PAHs in the placentas of women who had babies or aborted fetuses with such birth defects. The study, “Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects,” was published July 8, 2011 in the online edition of the Proceedings of the National Academy of Sciences. While most organochlorine pesticides are banned or restricted, they still continue to cause problems decades after their widespread use has ended. This study reinforces the need for a more precautionary approach to regulating pesticides and industrial chemicals. Once released into the environment, many chemicals can affect health for generations, either through persistence or genetic means. PAHs are a group of over 100 different chemicals that are formed during the incomplete burning of coal, oil and gas, garbage, or other organic substances like tobacco or charbroiled meat. PAHs are usually […]

(Beyond Pesticides, June 20, 2011) In a study published this week in the journal Pediatrics, researchers report findings that link mothers’ exposure to organochlorine pesticides during pregnancy with infants’ sizes at birth. The trend shows that the more mothers are exposed to the pesticides during pregnancy, the higher the chances are for reduced birth weight and length of their newborns. Comprising a total of 494 women and infants in Valencia, Spain from the years 2003-2006, the study evaluates umbilical cord blood for residues of four pesticides or pesticide degradates: DDT, DDE, hexachlorobenzene (HCB), and beta-hexachlorocyclohexane. The results show that a 10-fold increase in pesticide concentrations in the blood corresponds to a reduction in birth weight of 2-4 ounces. Additional results are correlated to specific pesticides. Higher concentrations of DDT results in a reduction in head circumference of 0.26cm, which the researchers call a “significant decrease.” Additionally, a decrease of 0.39cm in birth length is correlated with each 10-fold increase in concentration of HCB. The researchers note several concerns related to the findings, aside from the results themselves. Since people are exposed to a wide variety of chemicals in general throughout their everyday lives, higher pesticide exposure could betray higher exposure […]

(Beyond Pesticides, June 13, 2011) A new report released early last week shows that industry regulators have known for a long time that glyphosate, the active ingredient in the world’s best selling herbicide, RoundUp, causes birth defects. The report, “RoundUp and Birth Defects: Is the public being kept in the dark?” published by Earth Open Source, says that regulators misled the public about the safety of glyphosate for over 20 years. According to the report, the German government has known since 1998 and the EU Commission’s expert scientific review panel has known since 1999 that glyphosate causes malformations. As recently as last year, however, the German Federal Office for Consumer Protection and Food Safety told the Commission that there was no evidence of glyphosate causing birth defects. Meanwhile, these actions by industry and regualtors that have kept the public in the dark, the authors point out, has seriously endangered public health. Considering that Monsanto, as well as other producers of genetically engineered (GE) seeds are now pushing for glyphosate-tolerant crop approval in Europe, this is particularly disconcerting. If the Commission grants the approval as the U.S. Department of Agriculture (USDA) had done for GE alfalfa and sugar beets in the […]

(Beyond Pesticides, May 10, 2011) In three new studies published in the May issue of the journal Health Affairs (Vol. 30, No. 5), Mount Sinai School of Medicine researchers reveal the staggering economic impact of toxic chemicals and air pollutants in the environment, and propose new legislation to mandate testing of new chemicals and also those already on the market. The studies, “Environmental Disease in Kids Cost $76.6 Billion in 2008,” “Children’s Vulnerability to Toxic Chemicals,” and “Pollutants and Respiratory Illness in Infants,” are available on the Health Affairs website. Leonardo Trasande, MD, Associate Professor of Preventive Medicine and Pediatrics at Mount Sinai School of Medicine, analyzed the costs of conditions — including lead poisoning, childhood cancer, asthma, autism, and attention deficit hyperactivity disorder (ADHD) — associated with exposure to toxic chemicals. Dr. Trasande and his team calculated the annual cost for direct medical care and the indirect costs, such as parents’ lost work days, and lost economic productivity caring for their children, of these diseases in children. The researchers found the annual cost in the United States to be an estimated $76.6 billion, representing 3.5 percent of all U.S. health care costs in 2008. The breakdown includes: lead poisoning […]

(Beyond Pesticides, March 29, 2011) According to a French study published March 2, 2011 in the online edition of Environmental Health Perspectives, prenatal exposure to the herbicide atrazine is linked to small head circumference and fetal growth restriction. The authors say the study “raises particular concerns for countries where atrazine is still in use.” Atrazine is a widespread contaminant in drinking water and is linked to various birth defects, endocrine disruption and cancer, even at concentrations below EPA standards. Although it has been excluded from re-registration in the European Union because it is found above allowable thresholds in groundwater, it is still one of the most widely used herbicides in the U.S. and around world. The study, “Urinary Biomarkers of Prenatal Atrazine Exposure and Adverse Birth Outcomes in the PELAGIE Birth Cohort,” used a case-cohort design nested in a prospective birth cohort conducted in the Brittany region from 2002 through 2006. It collected maternal urine samples to examine pesticide exposure biomarkers before the 19th week of gestation. Quantifiable levels of atrazine were found in urine samples from 5.5% of 579 pregnant women, and various metabolites were identified in 20-40% of samples. The presence versus absence of quantifiable levels of atrazine […]

(Beyond Pesticides, March 28 2011) Researchers found that exposure to organochlorine pesticides significantly alters semen quality in young men from southeast Spain. The study found 18 pesticides in the blood of the study participants, including some banned in Spain, such as DDT, and others legal in in the country, such as the fungicide vinclozolin. The analysis was conducted by Clemente Aguilar from the Medical Research Laboratory of the University Hospital San Cecilio, Granada, Spain, and coordinated by Marieta Fernández, Marina Lacasaña and Nicolás Olea (University of Granada), basing on a sample of 280 volunteer students aged 18-23 years from the University of Almería, Spain. All the study participants had at least one pesticide in considerable concentrations. The average number of pesticides detected in the blood tests was 11. Southeast Spain is a region where two out of ten young men have poor sperm density. Even though exposure to some organochlorines proved to increase total spermatic number and total sperm motility levels, other pesticides were highly associated with a reduction in sperm levels. This might be due to the fact that some of these pesticides are considered to be estrogenic endocrine disruptors. Endocrine disruptors are substances that interfere with natural hormones […]

(Beyond Pesticides, December 6, 2010) A new study finds that exposure to dioxin in the womb can affect female reproduction for generations, reducing fertility and increasing the chance for premature delivery. Scientists from the Women’s Reproductive Health Research Center at Vanderbilt University School of Medicine examined the effects of a specific variety of dioxin on female mice and found that subsequent generations of the mice exposed to dioxin are at risk. The study, entitled “Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations,” was published in the journal Reproductive Toxicology. Dioxin refers to a family of chemicals linked to cancer, endocrine disruption, weakened immune systems and reproductive problems. They are persistent organic pollutants that bioaccumulate in humans and other animals, especially in fatty tissue, meaning that concentrations of dioxin in the body generally increase with age. So, even in very low doses, dioxins can cause health problems. Scientists in this study specifically looked at the variety of dioxin that is considered the most toxic, known as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD is a well-known contaminant of the herbicide 2,4-D, which was originally a part of the deadly chemical weapon Agent Orange. As such, TCDD is still found […]

(Beyond Pesticides, November 16, 2010) A French study published November 15, 2010 in the journal Environmental Health finds that pregnant women living in a municipality where peas or potatoes are grown have an increased risk of giving birth to an infant with a small head circumference. Head circumference also tends to be lower where wheat is grown, but not to statistically significant degree. The study finds no association between head circumference and proximity to other crops. The study’s authors suggest that pesticides, specifically organophosphates (OPs), are a possible cause. OPs were applied to most of the area devoted to pea and potato crops, but used less frequently in areas growing corn and wheat. The study, “Impact on fetal growth of prenatal exposure to pesticides due to agricultural activities: a prospective cohort study in Brittany, France,” utilized a prospective birth cohort of 3421 pregnant women in a French agricultural region (Brittany, 2002-2006) through gynecologists, ultrasonographers, and maternity hospitals during routine prenatal care visits before 19 weeks of gestation. The national agricultural census in 2000 provided the percentages of the municipality area devoted to cultivation of corn, wheat, colza, peas, potatoes, and fresh vegetables. The link between exposure to pesticides and birth […]

(Beyond Pesticides, June 2, 2010) After decades-long litigation over the use of the toxic pesticide dibromochloropropane, or DBCP, in the 1970’s which has been linked to sterility and has since been banned, Dole Food Co. is proposing new settlements for farm workers claiming they were injured by exposure to the pesticide. A request has been filed by lawyers for Dole in the Los Angeles Superior Court asking that nearly 1,500 Honduran farm workers who are suing Dole be allowed to drop out of those suits and settle their claims out of court under an existing program arranged by the company and Honduran government officials. This could potentially end years of legal action inexpensively for Dole while providing compensation to workers quickly, however some people view this plan as a way for the company to back out of its responsibilities to former plantation workers. The pesticide DBCP was used by workers from Nicaragua, Costa Rica, Guatemala, Honduras, and Panama to kill worm infestations in the trees’ roots. In the U.S., DBCP was used as a soil fumigant and nematocide on over 40 different crops until 1977. According to the U.S. Environmental Protection Agency (EPA), DBCP causes male reproductive problems, including low […]

(Beyond Pesticides, February 10, 2009) Living near farms that use the weed killer atrazine increases the risk of a rare birth defect, according to a study presented February 5, 2010 at the annual meeting of the Society for Maternal-Fetal Medicine in Chicago. Gastroschisis, a rare birth defect in which an infant’s intestines stick out of the body through a defect on one side of the umbilical cord, affects 1 in 5000 babies born in the U.S. each year. Babies with this condition have problems with movement and absorption in the gut, because the unprotected intestine is exposed to irritating amniotic fluid. Surgery is required to repair this defect. The rate of gastroschisis has risen 2- to 4-fold over the last three decades, especially in areas where agriculture is the primary industry, according to Sarah Waller, PhD, of the University of Washington, Seattle, and colleagues. Dr. Waller’s team studied the potential link between atrazine and the birth defect because, as they note in their conference abstract, “During the last 10 years, the highest percentage per population of gastroschisis was in Yakima County, in the eastern part of the state, where agriculture is the primary industry.” Overall, Washington state has about double […]

(Beyond Pesticides, December 15, 2009) Exposure to the endocrine-disrupting herbicide atrazine triggers the release of stress hormones in rats, according to a new study published in the December 2009 issue of the journal Toxicological Sciences. The researchers believe this may explain how the popular weed killer produces some its harmful reproductive effects. The study, “Characterization of the Hypothalamic-Pituitary-Adrenal Axis Response to Atrazine and Metabolites in the Female Rat,” was conducted by the Environmental Protection Agency’s (EPA) National Health and Environmental Effects Research Laboratory. According to a December 4 analysis by Environmental Health Sciences, a foundation-funded journalism organization, the researchers discovered that female rats fed atrazine at the time of ovulation released a flow of stress hormones that are known to interfere with hormones essential for reproduction. The findings reveal one way atrazine may impact female reproduction. Elevated stress hormones can disrupt the hormone signals that spur ovulation. Such a stress response to atrazine could partially explain why previous studies find that the herbicide inhibits reproduction. The stress reaction is similar to that seen when the animals are restrained against their will. One of the most widely used agricultural pesticides in the U.S., atrazine can currently legally be applied before and […]