(Beyond Pesticides, June 20, 2011) In a study published this week in the journal Pediatrics, researchers report findings that link mothers’ exposure to organochlorine pesticides during pregnancy with infants’ sizes at birth. The trend shows that the more mothers are exposed to the pesticides during pregnancy, the higher the chances are for reduced birth weight and length of their newborns. Comprising a total of 494 women and infants in Valencia, Spain from the years 2003-2006, the study evaluates umbilical cord blood for residues of four pesticides or pesticide degradates: DDT, DDE, hexachlorobenzene (HCB), and beta-hexachlorocyclohexane. The results show that a 10-fold increase in pesticide concentrations in the blood corresponds to a reduction in birth weight of 2-4 ounces. Additional results are correlated to specific pesticides. Higher concentrations of DDT results in a reduction in head circumference of 0.26cm, which the researchers call a “significant decrease.” Additionally, a decrease of 0.39cm in birth length is correlated with each 10-fold increase in concentration of HCB. The researchers note several concerns related to the findings, aside from the results themselves. Since people are exposed to a wide variety of chemicals in general throughout their everyday lives, higher pesticide exposure could betray higher exposure […]

(Beyond Pesticides, June 13, 2011) A new report released early last week shows that industry regulators have known for a long time that glyphosate, the active ingredient in the world’s best selling herbicide, RoundUp, causes birth defects. The report, “RoundUp and Birth Defects: Is the public being kept in the dark?” published by Earth Open Source, says that regulators misled the public about the safety of glyphosate for over 20 years. According to the report, the German government has known since 1998 and the EU Commission’s expert scientific review panel has known since 1999 that glyphosate causes malformations. As recently as last year, however, the German Federal Office for Consumer Protection and Food Safety told the Commission that there was no evidence of glyphosate causing birth defects. Meanwhile, these actions by industry and regualtors that have kept the public in the dark, the authors point out, has seriously endangered public health. Considering that Monsanto, as well as other producers of genetically engineered (GE) seeds are now pushing for glyphosate-tolerant crop approval in Europe, this is particularly disconcerting. If the Commission grants the approval as the U.S. Department of Agriculture (USDA) had done for GE alfalfa and sugar beets in the […]

(Beyond Pesticides, May 10, 2011) In three new studies published in the May issue of the journal Health Affairs (Vol. 30, No. 5), Mount Sinai School of Medicine researchers reveal the staggering economic impact of toxic chemicals and air pollutants in the environment, and propose new legislation to mandate testing of new chemicals and also those already on the market. The studies, “Environmental Disease in Kids Cost $76.6 Billion in 2008,” “Children’s Vulnerability to Toxic Chemicals,” and “Pollutants and Respiratory Illness in Infants,” are available on the Health Affairs website. Leonardo Trasande, MD, Associate Professor of Preventive Medicine and Pediatrics at Mount Sinai School of Medicine, analyzed the costs of conditions — including lead poisoning, childhood cancer, asthma, autism, and attention deficit hyperactivity disorder (ADHD) — associated with exposure to toxic chemicals. Dr. Trasande and his team calculated the annual cost for direct medical care and the indirect costs, such as parents’ lost work days, and lost economic productivity caring for their children, of these diseases in children. The researchers found the annual cost in the United States to be an estimated $76.6 billion, representing 3.5 percent of all U.S. health care costs in 2008. The breakdown includes: lead poisoning […]

(Beyond Pesticides, March 29, 2011) According to a French study published March 2, 2011 in the online edition of Environmental Health Perspectives, prenatal exposure to the herbicide atrazine is linked to small head circumference and fetal growth restriction. The authors say the study “raises particular concerns for countries where atrazine is still in use.” Atrazine is a widespread contaminant in drinking water and is linked to various birth defects, endocrine disruption and cancer, even at concentrations below EPA standards. Although it has been excluded from re-registration in the European Union because it is found above allowable thresholds in groundwater, it is still one of the most widely used herbicides in the U.S. and around world. The study, “Urinary Biomarkers of Prenatal Atrazine Exposure and Adverse Birth Outcomes in the PELAGIE Birth Cohort,” used a case-cohort design nested in a prospective birth cohort conducted in the Brittany region from 2002 through 2006. It collected maternal urine samples to examine pesticide exposure biomarkers before the 19th week of gestation. Quantifiable levels of atrazine were found in urine samples from 5.5% of 579 pregnant women, and various metabolites were identified in 20-40% of samples. The presence versus absence of quantifiable levels of atrazine […]

(Beyond Pesticides, March 28 2011) Researchers found that exposure to organochlorine pesticides significantly alters semen quality in young men from southeast Spain. The study found 18 pesticides in the blood of the study participants, including some banned in Spain, such as DDT, and others legal in in the country, such as the fungicide vinclozolin. The analysis was conducted by Clemente Aguilar from the Medical Research Laboratory of the University Hospital San Cecilio, Granada, Spain, and coordinated by Marieta Fernández, Marina Lacasaña and Nicolás Olea (University of Granada), basing on a sample of 280 volunteer students aged 18-23 years from the University of Almería, Spain. All the study participants had at least one pesticide in considerable concentrations. The average number of pesticides detected in the blood tests was 11. Southeast Spain is a region where two out of ten young men have poor sperm density. Even though exposure to some organochlorines proved to increase total spermatic number and total sperm motility levels, other pesticides were highly associated with a reduction in sperm levels. This might be due to the fact that some of these pesticides are considered to be estrogenic endocrine disruptors. Endocrine disruptors are substances that interfere with natural hormones […]

(Beyond Pesticides, December 6, 2010) A new study finds that exposure to dioxin in the womb can affect female reproduction for generations, reducing fertility and increasing the chance for premature delivery. Scientists from the Women’s Reproductive Health Research Center at Vanderbilt University School of Medicine examined the effects of a specific variety of dioxin on female mice and found that subsequent generations of the mice exposed to dioxin are at risk. The study, entitled “Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations,” was published in the journal Reproductive Toxicology. Dioxin refers to a family of chemicals linked to cancer, endocrine disruption, weakened immune systems and reproductive problems. They are persistent organic pollutants that bioaccumulate in humans and other animals, especially in fatty tissue, meaning that concentrations of dioxin in the body generally increase with age. So, even in very low doses, dioxins can cause health problems. Scientists in this study specifically looked at the variety of dioxin that is considered the most toxic, known as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD is a well-known contaminant of the herbicide 2,4-D, which was originally a part of the deadly chemical weapon Agent Orange. As such, TCDD is still found […]

(Beyond Pesticides, November 16, 2010) A French study published November 15, 2010 in the journal Environmental Health finds that pregnant women living in a municipality where peas or potatoes are grown have an increased risk of giving birth to an infant with a small head circumference. Head circumference also tends to be lower where wheat is grown, but not to statistically significant degree. The study finds no association between head circumference and proximity to other crops. The study’s authors suggest that pesticides, specifically organophosphates (OPs), are a possible cause. OPs were applied to most of the area devoted to pea and potato crops, but used less frequently in areas growing corn and wheat. The study, “Impact on fetal growth of prenatal exposure to pesticides due to agricultural activities: a prospective cohort study in Brittany, France,” utilized a prospective birth cohort of 3421 pregnant women in a French agricultural region (Brittany, 2002-2006) through gynecologists, ultrasonographers, and maternity hospitals during routine prenatal care visits before 19 weeks of gestation. The national agricultural census in 2000 provided the percentages of the municipality area devoted to cultivation of corn, wheat, colza, peas, potatoes, and fresh vegetables. The link between exposure to pesticides and birth […]

(Beyond Pesticides, June 2, 2010) After decades-long litigation over the use of the toxic pesticide dibromochloropropane, or DBCP, in the 1970’s which has been linked to sterility and has since been banned, Dole Food Co. is proposing new settlements for farm workers claiming they were injured by exposure to the pesticide. A request has been filed by lawyers for Dole in the Los Angeles Superior Court asking that nearly 1,500 Honduran farm workers who are suing Dole be allowed to drop out of those suits and settle their claims out of court under an existing program arranged by the company and Honduran government officials. This could potentially end years of legal action inexpensively for Dole while providing compensation to workers quickly, however some people view this plan as a way for the company to back out of its responsibilities to former plantation workers. The pesticide DBCP was used by workers from Nicaragua, Costa Rica, Guatemala, Honduras, and Panama to kill worm infestations in the trees’ roots. In the U.S., DBCP was used as a soil fumigant and nematocide on over 40 different crops until 1977. According to the U.S. Environmental Protection Agency (EPA), DBCP causes male reproductive problems, including low […]

(Beyond Pesticides, February 10, 2009) Living near farms that use the weed killer atrazine increases the risk of a rare birth defect, according to a study presented February 5, 2010 at the annual meeting of the Society for Maternal-Fetal Medicine in Chicago. Gastroschisis, a rare birth defect in which an infant’s intestines stick out of the body through a defect on one side of the umbilical cord, affects 1 in 5000 babies born in the U.S. each year. Babies with this condition have problems with movement and absorption in the gut, because the unprotected intestine is exposed to irritating amniotic fluid. Surgery is required to repair this defect. The rate of gastroschisis has risen 2- to 4-fold over the last three decades, especially in areas where agriculture is the primary industry, according to Sarah Waller, PhD, of the University of Washington, Seattle, and colleagues. Dr. Waller’s team studied the potential link between atrazine and the birth defect because, as they note in their conference abstract, “During the last 10 years, the highest percentage per population of gastroschisis was in Yakima County, in the eastern part of the state, where agriculture is the primary industry.” Overall, Washington state has about double […]

(Beyond Pesticides, December 15, 2009) Exposure to the endocrine-disrupting herbicide atrazine triggers the release of stress hormones in rats, according to a new study published in the December 2009 issue of the journal Toxicological Sciences. The researchers believe this may explain how the popular weed killer produces some its harmful reproductive effects. The study, “Characterization of the Hypothalamic-Pituitary-Adrenal Axis Response to Atrazine and Metabolites in the Female Rat,” was conducted by the Environmental Protection Agency’s (EPA) National Health and Environmental Effects Research Laboratory. According to a December 4 analysis by Environmental Health Sciences, a foundation-funded journalism organization, the researchers discovered that female rats fed atrazine at the time of ovulation released a flow of stress hormones that are known to interfere with hormones essential for reproduction. The findings reveal one way atrazine may impact female reproduction. Elevated stress hormones can disrupt the hormone signals that spur ovulation. Such a stress response to atrazine could partially explain why previous studies find that the herbicide inhibits reproduction. The stress reaction is similar to that seen when the animals are restrained against their will. One of the most widely used agricultural pesticides in the U.S., atrazine can currently legally be applied before and […]

(Beyond Pesticides, December 3, 2009) Pregnant women should reconsider applying insect repellent after a study finds a link to an increasingly common birth defect. European researchers have found an association between mothers who used insect repellent in the earliest phase of pregnancy and an increased rate of “hypospadias” in the penises of their male children. Hypospadias is the condition where the opening of the penis is in the wrong place – usually back from the tip and on the underside – and often requires corrective surgery. The condition is thought to affect around one to two baby boys in every 500. According to a report published online November 30 in Occupational and Environmental Medicine and entitled “Use of biocides and insect repellents and risk of hypospadias,” infants born to mothers who used insect repellent during the first trimester of pregnancy are more likely to have hypospadias (OR 1.81, 95% CI 1.06 to 3.11) after adjusting for other factors. The research includes 471 babies with hypospadias and 490 acting as a comparison group. Their mothers were asked a series of questions, including whether they had been exposed to insect repellents and biocide chemicals, such as pesticides or weedkillers. They were asked […]

(Beyond Pesticides, November 17, 2009) According to a new study by researchers at the University of Wisconsin-Madison, exposure to low levels of the organophosphate insecticide chorpyrifos during pregnancy can impair learning, change brain function and alter thyroid levels of offspring into adulthood for tested mice, especially females. The study, “Long-term sex selective hormonal and behavior alterations in mice exposed to low doses of chlorpyrifos in utero,” was led by Beyond Pesticides board member and professor of zoology and environmental toxicology, Warren Porter, PhD. Read the full analysis of the study on the Rodale Institute website. On June 8, 2000, the Environmental Protection Agency (EPA) and Dow AgroSciences, reached an agreement to stop the sale of most home, lawn and garden uses for chlorpyrifos because of its health risks to children. However, its use continues in agriculture. According to advocates, this new study provides further evidence for the need to ban chlorpyrifos and fully protect farmworkers, their families, and rural communities from the toxic hazards of this outdated, unnecessary pesticide. According to the Rodale Institute, which provided part of the funding for the study, “The new animal study accentuates the risk of ultra-low levels of the common pesticide chlorpyrifos to cause […]

(Beyond Pesticides, October 27, 2009) U.S. District Judge Paul Huck (Miami) has said a multimillion dollar judgment against U.S. food giant Dole and the Dow Chemical Company cannot be enforced because, “[T]he judgment was rendered under a system which does not provide impartial tribunal or procedures compatible with the requirements of due process of law, and the rendering court did not have jurisdiction over Defendants.” A trial court in Chinandega, Nicaragua, had awarded the money in 2005 to 150 Nicaraguan citizens who believe they were injured by exposure to the pesticide dibromochloropropoane, or DBCP, when they worked on Dole banana plantations between 1970 and 1982. This actiion was taken despite findings in the U.S. that DBCP causes sterility and regulatory action to remove it from the market. The trial court awarded Plaintiffs approximately $97 million under “Special Law 364,” enacted by the Nicaraguan legislature in 2000 specifically to handle DBCP claims. The average award was approximately $647,000 per plaintiff. According to the Nicaraguan trial court, these sums were awarded to compensate plaintiffs for DBCP-induced infertility and its accompanying adverse psychological effects. In similar cases in the past, the companies have refused to pay. Dow Chemical has called such judgments “unenforceable” […]

(Beyond Pesticides, July 28, 2009) A new study by researchers at the National Food Institute, Technical University of Denmark shows that exposure to a mixture of pesticides and other chemicals has a synergistic effect on the development of male sex organs. Synergy occurs when the effect of multiple chemicals is greater than the sum of the individual effects. The study, “Synergistic Disruption of External Male Sex Organ Development by a Mixture of Four Antiandrogens,” was published July 15, 2009 in the online edition of Environmental Health Perspectives. The researchers designed their study to determine the consequences of simultaneous exposure to multiple “antiandrogens.” An antiandrogen, or androgen antagonist, is any of a group of hormone receptor antagonist compounds that are capable of preventing or inhibiting the biologic effects of androgens, male sex hormones, on normally responsive tissues in the body. Disrupting the action of androgens during gestation, certain chemicals present in food, consumer products and the environment can induce irreversible malformations of sex organs among male offspring. The team investigated the effects of mixtures of a widely used plasticizer, di(2-ethylhexyl) phthalate (DEHP), used in medical devices such as IV bags and tubing, beauty products, PVC toys, vinyl shower curtains, car seats, […]

(Beyond Pesticides, May 22, 2009) A balanced, organic diet – both before and during pregnancy – can significantly reduce a child’s likelihood of being overweight, obese or developing diabetes. That, according to a literature review of over 150 scientific studies assembled by The Organic Center (TOC), an organic industry research institute focused on the science of organic food and farming. The TOC review”That First Step: Organic Food and a Healthier Future” documents that exposure to pesticides during pregnancy increases the risk of premature birth, low-birth weight, neurological problems and diabetes. Outlining six ways in which a balanced organic diet can contribute to healthy development, the report also examines how enzymes found in organic foods can slow and even reverse aspects of the aging process. With the time between initial conception to the early years of development being the most critical in establishing lifelong health, a well-balanced diet rich in organic fruits and vegetables helps establish healthy food-taste preferences, promotes healthy patterns of cell division and largely eliminates exposures to approximately 180 pesticides known to increase the risk of developmental abnormalities. Furthermore, this combination of reducing pesticide exposure and consuming nutrient-dense organic foods can help people manage weight and prevent diabetes. […]

(Beyond Pesticides, April 1, 2009) A study published in the April 2009 issue of the medical journal Acta Paediatrica reports that the highest rates of birth defects for U.S. babies arise when conception occurs during the spring and summer months, when pesticide use increases and high concentrations of pesticides are found in surface waters. The study entitled, “Agrichemicals in surface water and birth defects in the United States” is the first study to link increased seasonal concentration of pesticides in surface water with the peak in birth defects in infants conceived in the same months. Researchers analyzed all 30.1 million births in the U.S. between 1996 and 2002. A strong association between higher rates of birth defects among women whose last menstrual period was in April, May, June or July and elevated levels of nitrates, atrazine and other pesticides in surface water during those same months was found. The correlation between the month of last menstrual period and higher rates of birth defects is statistically significant for half of the 22 categories of birth defects reported in the Centers for Disease Control database from 1996 to 2002, including spina bifida, cleft lip, clubfoot and Down’s syndrome. “Elevated concentrations of pesticides […]

(Beyond Pesticides, January 23, 2009) A study by researchers at the UC Davis M.I.N.D. Institute has found that the seven- to eight-fold increase in the number children born in California with autism since 1990, a trend which shows no sign of abating, cannot be explained by either changes in how the condition is diagnosed or counted, and that environmental factors must be looked at more closely. Published in the January 2009 issue of the journal Epidemiology, the study is entitled “The Rise in Autism and the Role of Age at Diagnosis.” Results from the study suggest that research should shift from genetics to the host of chemicals and infectious microbes in the environment that are likely at the root of changes in the neurodevelopment of California’s children, including pesticides and household chemicals. “It’s time to start looking for the environmental culprits responsible for the remarkable increase in the rate of autism in California,” said UC Davis M.I.N.D. Institute researcher Irva Hertz-Picciotto, PhD, a professor of environmental and occupational health and epidemiology and an internationally respected autism researcher. Dr. Hertz-Picciotto said that many researchers, state officials and advocacy organizations have viewed the rise in autism’s incidence in California with skepticism. The […]

(Beyond Pesticides, January 14, 2009) Two-headed bass found in the Noosa River are at the center of a controversy surrounding pesticide drift from neighboring farms in Queensland, Australia. The pesticides, endosulfan and carbendazim, have been implicated in the contamination of the river, which has yielded thousands of chronically deformed fish. Experts believe that the mutated fish, which survive only 48 hours after hatching, are the victims of pesticide drift from neighboring macadamia nut farms that routinely use endosulfan and the fungicide, carbendazim. Aquatic health expert and vice-president of the Australian College of Veterinarian Scientists’ Aquatic Animal Health Chapter, Matt Landos, PhD, has been investigating the phenomenon and concludes that there were no other probable causes to explain the fish and larval mortality. Dr. Landos documented evidence and completed a report which was sent to the state’s Department of Primary Industries and Fisheries last year. “The timing between the mist spraying and the affected larvae fits hand in glove,” Dr. Landos said. His report also found that chickens, sheep and horses raised at nearby fish hatcheries are also recording abnormally high levels of fetal deaths and birth defects. Gwen Gilson, who runs a Boreen Point fish hatchery, says she has observed […]

(Beyond Pesticides, December 5, 2009) On November 10, 2008, the Austrian government released a report of long term research showing genetically engineered (GE) corn fed to mice significantly reduced their fertility over three to four breeding cycles within one generation. Similar effects were found in mice fed GE corn and bred over four generations. The study, “Biological effects of transgenic maize NK603xMON810 fed in long term reproduction studies in mice,” was sponsored by the Austrian Ministry of Health, Families, and Youth, and led by Dr. Jürgen Zentek, Professor of Veterinary Medicine at the University of Vienna. Three series of experiments were done. The first was a multigeneration feeding trial in which the mice were fed and bred for four successive generations, beginning with the parents that were fed the diets from birth. The second was a multi-cycle breeding trial lasting 20 weeks in which breeding pairs of mice were fed beginning one week prior to co-habitation until the end of experiment, and allowed to go through four breeding cycles in the same generation. The third was a life-term trial involving feeding the mice without breeding from conception (via the pregnant mothers) to their eventual death. The researchers report that it […]

(Beyond Pesticides, September 26, 2008) On September 24, the U.S. Ninth Circuit Court of Appeals dismissed Ivory Coast farmworkers’ claims that they were victims of genocide when pesticide exposure made them sterile. The nearly 700 plaintiffs were exposed to the soil fumigant and nematocide 1,2-Dibromo-3-Chloropropane, or DBCP, while working on Dole Food Company farms in Africa. The original First Amended Complaint was filed on April 6, 2007, and despite the latest setback, the Africans’ attorney, Raphael Metzger, said he would pursue a rehearing. Until 1977, DBCP was widely used in U.S. agriculture, when it was banned for all uses except pineapples. In contrast, DBCP was widely used for fruit production in developing countries in to the 1990s in spite of its U.S. regulatory status. “The manufacturers continued making money on [DBCP] by shipping it to Third World countries where farmworkers were given it to use,” Mr. Metzger said. The suit, Abagninin v. Amvac Chemical Co, was filed under the Alien Torts Statute and contended “that such conduct supports claims under the ATS for genocide and crimes against humanity because the conduct was undertaken with knowledge of DBCP’s effects and pursuant to a State or organizational policy.” The court rejected Abagninin’s […]

(Beyond Pesticides, September 11, 2008) The North Carolina Pesticide Board has begun hearing evidence in a case from 2004 over suspected pesticide violations that were investigated after three female Ag-Mart farmworkers gave birth to babies with severe birth defects. In 2006, the family of Carlos Herrera Candelario, who was born without arms or legs, sued Ag-Mart over illegal pesticide exposure resulting in the boy’s birth defects. The case was settled out of court, with Ag-Mart agreeing to pay the medical expenses of the boy for life and provide him with a permanent income, but insisting that the settlement was not an admission of guilt. The current hearing will look at whether Ag-Mart’s farm manager, Jeff Oxley, is indeed guilty of over 200 violations, including forcing workers into the field too soon after dangerous pesticides were applied. The hearing is significant because the company insists that adequate practices are and have been in place to ensure workers are not exposed to pesticides, even though the testimony of Ag-Mart employees runs counter to this claim. This hearing could do a great deal to elucidate the truth about farmworker pesticide exposure, an important issue for the thousands of workers who plant and harvest […]

(Beyond Pesticides, May 27, 2008) A population-based study looking at how genes and environmental factors interact shows that pet shampoos containing insecticides may trigger autism spectrum disorders (ASD), reports New Scientist. The study findings, presented at the International Meeting for Autism Research, show that mothers of children with an ASD are twice as likely to have used an insecticidal pet shampoo during the prenatal and/or postnatal period when compared to mothers of healthy children. The strongest association was during the second trimester of pregnancy. According to the researchers, pet shampoos often contain pyrethrins and previous animal research has found that pyrethrins are designed to target the central nervous system in insects, rodents and other species and can cause death of neurons and compromise the blood-brain barrier in early life.Examining participants in the Childhood Autism Risks from Genetics and the Environment (CHARGE) study, researchers from the University of California, Davis looked at 333 children with ASD and 198 healthy children between the ages of two and five, and their families. In-depth questionnaires and blood and urine samples were collected. Isaac Pessah, Ph.D., a researcher involved in the study and professor in the Department of Molecular Biosciences, College of Veterinary Medicine at […]

(Beyond Pesticides, May 6, 2008) Pregnant veterinarians who have occupational exposures to pesticides, anesthetic gases or radiation may have twice the risk of miscarriage, according to a new study published in the May 2008 issue of the journal Occupational and Environmental Medicine. The study, “Maternal occupational exposures and risk of spontaneous abortion in veterinary practice,” looked at the experiences of 1197 female veterinarians working in clinical practice, who graduated from Australian veterinary schools between 1960 and 2000, responding to a questionnaire-based survey. There was a twofold increase in the risk of miscarriage in women veterinarians who use pesticides at work. The researchers found that there was also a twofold increase for those exposed to anaesthetic gases for more than an hour a week without using equipment to remove the gas from the air, and an 80 percent greater risk of miscarriage in those who performed more than five x-ray examinations per week compared with those who performed five or less. Veterinarians are often unable to leave the room whilst performing an x-ray because they have to hold the animal being x-rayed in order to restrain it. Adeleh Shirangi, Ph.D., author of the research from the Department of Epidemiology and Public […]