(Beyond Pesticides, July 12, 2021) During Pollinator Week 2021 in June, U.S. Representatives Earl Blumenauer (D-OR) and Jim McGovern (D-MA) reintroduced the Saving America’s Pollinators Act (SAPA) to reverse ongoing declines in wild and managed pollinators. New data released in June for 2020-21 documents the second highest honey bee losses in 15 years. SAPA uses the latest scientific research and perspectives to ensure that pollinators are protected. The bill suspends the use of neonicotinoid (neonic) insecticides and other pesticides harmful to bees and other pollinators until an independent board of experts determines that they are safe to use, based on a strong scientific assessment. Ask your elected representative in Congress to support pollinators by cosponsoring Saving America’s Pollinators Act (SAPA). If they are already a cosponsor, use this occasion to thank them for their leadership on this critical issue. “Without our world’s pollinators, the world would be a very different place. These bees, butterflies, hummingbirds, and other creatures are essential elements of our food system. Losing them means we risk losing the very food we put on our table,” said Rep. Blumenauer. “We must use every tool at our disposal to provide pollinators with much-needed relief from bee-toxic pesticides and monitor […]

(Beyond Pesticides, July 2, 2021) The second highest bee loss in 15 years has reported by the Bee Informed Partnership (BIP) in its 2020–2021 National Colony Loss and Management Survey, released on June 30. For the “winter” period of October 1, 2020 through April 1, 2021, approximately 32% of managed bee colonies in the U.S. were lost. This represents an increase of 9.6% over the prior year’s winter loss and is roughly 4% higher than the previous 14-year average rate of loss. For all of the past year (April 1, 2020 to April 1, 2021) the colony loss was 45.5%. Beyond Pesticides has covered the related issues of Colony Collapse Disorder (CCD), the ongoing and devastating impacts of pesticides on bees and other pollinators, and the larger context of what some have called the “insect apocalypse.” These recent BIP data appear to indicate that “we,” writ large, are failing to remedy these problems. Three out of four food crops globally depend on pollinators, at least in part. Commercially kept bees account for a significant portion of pollination of some U.S. crops; almonds are the leading crop, followed by apples and melons. The commercial bee business is huge — a $691 million […]

(Beyond Pesticides, June 29, 2021) Maine Governor Janet Mills (D) last week vetoed legislation prohibiting the aerial use of glyphosate and other dangerous herbicides in forestry practices. LD125, An Act To Prohibit the Aerial Spraying of Glyphosate and Other Synthetic Herbicides for the Purpose of Silviculture, was supported by a wide range of health and conservation groups, and aimed to bring the state in line with best practices for public health and the environment. With Maine recently passing one of the strongest consumer bans on pollinator-toxic neonicotinoids, advocates are dismayed by the setback from the Governor’s office. In a statement to Maine Public Radio, Senate President Troy Jackson said that Governor Mills should stop referring to herself as an environmentalist. “The science across the country, across the world, says that this stuff kills people, kills wildlife,” Mr. Jackson says. “And all that it is, is a giveaway to the large landowners so they can maximize their profits off the lives of the people in Maine and the wildlife in Maine.” Senator Jackson’s words are stern yet factual. Glyphosate has been identified by the World Health Organization as a probable human carcinogen. Monsanto, now owned by Bayer, has been the subject […]

(Beyond Pesticides, June 24, 2021) This Pollinator Week 2021, U.S. Representatives Earl Blumenauer (D-OR) and Jim McGovern (D-MA) are reintroducing the Saving America’s Pollinators Act (SAPA) in an effort to reverse ongoing declines in wild and managed pollinators. SAPA uses the latest scientific research and perspectives to ensure that pollinators are protected. The bill suspends the use of neonicotinoids and other pesticides harmful to bees and other pollinators until an independent board of experts determine that they are safe to use, based on strong scientific assessment. “Without our world’s pollinators, the world would be a very different place. These bees, butterflies, hummingbirds, and other creatures are essential elements of our food system. Losing them means we risk losing the very food we put on our table,” said Rep. Blumenauer. “We must use every tool at our disposal to provide pollinators with much-needed relief from bee-toxic pesticides and monitor their populations to ensure their health and survival.”  Neonicotinoids are systemic pesticides; once applied to a seed or sprayed on a plant they make their way into the pollen, nectar and dew droplets that plants produce and pollinators feed upon. Exposure impairs pollinator navigation, foraging, and learning behavior, and also suppresses their […]

(Beyond Pesticides, June 21, 2021) Pollinator Week reminds us that change is critical to the survival of the planet and that we can take action, both in our households and communities and in the state and federal policy arena.  Here’s how YOU can take action… Create an organic habitat on your own property or a space in the community—such as the library grounds, medians, and rights-of-way. Given that plant starts in many garden centers across the country are grown from seeds coated with bee-toxic neonicotinoid pesticides, or drenched with them, Beyond Pesticides has compiled a comprehensive directory of companies and organizations that sell organic seeds and plants to the general public. Included in this directory are seeds for vegetables, flowers, and herbs, as well as living plants and seedlings. [We are always updating the directory, so send us names of companies that should be added and we will.] Go organic in the management of all your town’s public spaces—parks, playing fields, school grounds, and open space. Check out the information on talking with your neighbors, local organizations, and elected officials about advancing our model local policy. Then you can see what other communities are doing across the country. Also, see the cost […]

(Beyond Pesticides, June 18, 2021) As the U.S. Environmental Protection Agency (EPA) continues to drag its feet on protective regulation of neonicotinoid pesticides, states continue to step up to restrict their use. In April, the Maine legislature passed, and Governor Janet Mills has now signed, a new law that will prohibit use of neonicotinoid pesticides with the “active ingredient[s] dinotefuran, clothianidin, imidacloprid or thiamethoxam used for application in outdoor residential landscapes such as on lawn, turf or ornamental vegetation” [links by Beyond Pesticides]. Though short of an outright ban, this law is a solid step forward for Maine in reining in use of these compounds, which are neurotoxicants widely implicated in pollinator (and other insect, bird, and mammal) harms or declines. Until a federal ban happens, Beyond Pesticides offers guidance on avoiding use of neonicotinoid pesticides through its fact sheet, Managing Pests Safely Without Neonicotinoids, and its Bee Protective web pages. This new Maine law does, however, include exemptions for wood preservation, indoor pest control, use on pets, treatment of structure foundations, and controlling invasive insect pests, such as the Asian long-horned beetle, emerald ash borer, and hemlock wooly adelgid. The statute leaves other large loopholes that will permit continued use […]

(Beyond Pesticides, June 16, 2021) Uncultivated field margins contain almost twice as many beneficial insects as cropped areas around farm fields, according to research published this week in the Journal of Insect Science. The study finds that these predators and parasitoids overwinter in diverse vegetation, and can provide farmers an important jump start on spring pest problems. “A benefit of understanding overwintering is that those arthropods that emerge in the spring may be more inclined to feed on pests when pest populations are low,” said Scott Clem, PhD, coauthor of the study. “And so, they may be more likely to nip pest populations in the bud before the pest problem becomes a big deal.” The study focused on five organic farms, as conventional chemically sprayed fields are not conducive to a thriving overwintering insect population. The farms, all located in the Midwest, each had 10 emergence tents set up both in the middle of the field and around field edges. Emergence tents capture insects that have spent their winter in soil and prevent predatory insects from escaping scientific analysis. After the tents were set up in mid-March 2018, samples were taken in late March, mid-April, and at the end of […]

(Beyond Pesticides, June 11, 2021) On Sunday, June 13, Switzerland will hold a national vote on two landmark initiatives related to pesticide use (as well as several referenda). The vote on one initiative, dubbed by advocates “For a Switzerland Free of Synthetic Pesticides” (FSFSP), will determine whether or not the country will ban synthetic pesticides. If it does, it will become the first European nation to do so. The other initiative, which aims to eliminate direct subsidies of farmers who use synthetic pesticides or antibiotics for livestock, is focused on improving the quality of Switzerland’s drinking water and food supply. Beyond Pesticides covered the grassroots origin of the Swiss “no synthetic pesticides” initiative in 2018 and sees potential passage of both it and the water quality initiative as a watershed moment in the protection of health and the environment. These measures would go a long way to protecting and improving the health of humans and ecosystems, and the food supply, as well as protecting biodiversity in Switzerland. It could also — as advocates hope — encourage other European countries to follow suit. This vote has been scheduled, in part, as an outcome of a 2018 petition by the advocacy group, Future3, […]

(Beyond Pesticides, May 14, 2021) In a prime example of cart-before-the-horse, greenwashing, or perhaps “beewashing,” a British company has badly missed the mark in its latest attempt to market a product while “doing good” and generating goodwill with customers. As The Guardian reports, Marks & Spencer, the giant United Kingdom (UK) retailer, is releasing 30 million managed honey bees into rural British landscapes in what the company is promoting as an effort to support biodiversity and the beekeeping sector. However, according to experts and environmental advocates, unleashing that many honey bees may well actually harm both wild native bees and honey bees themselves. Critics of the move say this means that wild bees will likely face fiercer competition for already inadequate food sources. Beyond Pesticides adds that these honey bees have been dispatched to the same pesticide-contaminated habitats in which existing bee populations of all kinds face harmful exposures — exacerbating issues surrounding pollinator decline rather than solving them. Marks & Spencer’s Twitter marketing promotes the project in this way: “Did you know that bees contribute to a third of the food we eat? At M&S, we’re introducing more than 30 million bees to our Select Farms to help protect the […]

(Beyond Pesticides, May 11, 2021) Last week, multinational agrichemical company Bayer Cropscience lost its bid to overturn a 2018 ban on bee-toxic neonicotinoids throughout the European Union. The ruling from the European Court of Justice rejected all grounds on which the company filed its appeal, noting, “It must be held that the arguments put forward by Bayer CropScience cannot, in any event, succeed.” In denying the appeal, the court ruled Bayer responsible for paying its own legal fees, as well as the fees of environmental organizations that intervened to defend the ban. Environmental groups are applauding the ruling, as it reinforces several important aspects of the EU’s pesticide policy that favor greater public health and environmental protections. In an interview with EURACTIV, policy officer Martin Dermine at Pesticide Action Network Europe notes that the decision provides more leeway for pesticide regulators to consider new scientific evidence on pesticide hazards. “More than that,” he told EURACTIV, “the Court confirms the definition of the precautionary principle:  in case of doubts on the toxicity of a pesticide, the European Commission is entitled to ban it.” Pesticide regulators in Europe began restricting neonicotinoids in 2013, when a continent-wide moratorium was put in place based […]

(Beyond Pesticides, May 7, 2021) Soil health is one of the linchpins on which the food production that sustains human life — as well as biodiversity, pollinator health, and carbon sequestration — depend. A recent meta-review of nearly 400 studies finds that, in 71% of the cases reviewed, pesticides kill or otherwise harm soil invertebrates that contribute mightily to soil health. In their paper, “Pesticides and Soil Invertebrates: A Hazard Assessment,” published in Frontiers in Environmental Science in early May, the researchers write, “A wide variety of soil-dwelling invertebrates display sensitivity to pesticides of all types . . . [These results] support the need for pesticide regulatory agencies to account for the risks that pesticides pose to soil invertebrates and soil ecosystems.” Beyond Pesticides, which has long reported on impacts of pesticides on soil health, concurs with that conclusion, and adds that the real solutions to noxious pesticide impacts lie in the adoption of  regenerative organic approaches to all land management because they obviate any need for petroleum-based toxic chemical controls. The term “pesticide” can refer to myriad kinds of chemical treatments — including antimicrobials, disinfectants, rodenticides, and others — but in the agricultural and land management realms, primarily means insecticides, […]

(Beyond Pesticides, May 6, 2021) Nearly half of all breakdown products (transformation products) from four common-use environmental pesticides produce stronger endocrine (hormone) disrupting (ED) effects than the parent compound, according to new research published in Environment International. Over 300 environmental contaminants and their byproducts—from chemicals in plastics to cosmetic/personal care products—are commonly present in water bodies, food commodities, and human blood/urine samples. These toxicants can alter hormone metabolism, producing endocrine-disrupting effects that put the health of animals, humans, and the environment at risk. Many ecological and health risk assessments for pesticides focus on the effects of parent chemical compound products, overlooking the potential impacts of transformation products (TPs). Therefore, studies like these highlight the need to assess the implications of TPs to safeguard human, animal, and environmental health. The researchers note, “Since an increasing number of pesticide TPs have been detected in various environmental media, a more comprehensive understanding of the ecological risk of pesticide TPs is imperative for risk assessments more extensively and regulatory policy-making on pesticide restriction in the future.” Endocrine disruptors are xenobiotics (i.e., chemical substances like toxic pesticides foreign to an organism or ecosystem), including pesticides, bisphenols, phthalates, persistent organic pollutants (POPs), and heavy metals. Past research demonstrates exposure […]

(Beyond Pesticides, April 16, 2021) Recent research, published in Environmental Pollution in late 2020, examines levels and persistence of pesticide pollution in recreational lakes. The study finds: (1) concentrations of the neonicotinoid imidacloprid at levels exceeding ecotoxicity limits for aquatic invertebrates in a recreational lake that receives predominately urban runoff, and (2) that pesticide residues persist in the studied lakes throughout the growing season. Based on their findings, the scientists emphasized the importance of stricter regulation of insecticide compounds, and of better education about their impacts. Beyond Pesticides maintains that neonicotinoid pesticides should be banned for several reasons, not least of which is the extreme damage they cause to pollinators. The goal of the study was to evaluate potential ecosystem exposure to pesticide contamination in Midwestern recreational lakes, as well as the persistence of pesticide residues in those water bodies over the course of the growing season. Study authors hypothesized that watersheds with significant agricultural land uses would have higher concentrations of pesticides compared to largely urban and herbaceous watersheds. This research, out of the University of Nebraska–Lincoln and the University of Kentucky, looked to evaluate the occurrence of neonicotinoid and organothiophosphate insecticides, and some fungicides, in three lakes with differing […]

(Beyond Pesticides, April 13, 2021) A new study is making it increasingly clear that current laws are not protecting wild, ground nesting bees from the hazards of neonicotinoid insecticides. According to research conducted under a grant from the U.S. Department of Agriculture’s Sustainable Agriculture Research and Education (SARE) projects, Blue Orchard Mason Bees (Osima spp) are at particular risk from pesticide-contaminated soil they use to create their nest. Authors of the study note that with honey bees already in decline, pollination services provided wild managed bees like Mason bees are growing in importance. “Wild bees such as Osmia are becoming increasingly popular as managed pollinators in many systems, as there is growing concern that honeybees may not be able to continue to meet the increasing demands of agricultural pollination if these trends continue,” the study reads. The study looked at three overarching threats to mason bee populations, aiming to identify risks from pesticide contaminated soil used as a nest, effects on larvae exposed to contaminated soil, and whether female mason bees could determine the difference between contaminated and uncontaminated soil. “Imidacloprid is a neonicotinoid, which is a group of pesticides that are highly toxic to bees,” said Christine Fortuin, PhD, […]

(Beyond Pesticides, April 8, 2021) Pesticide use threatens aquatic and terrestrial invertebrates and plants more than ever, despite declining chemical use and implementation of genetically engineered (GE) crops in the U.S., according to a University Koblenz-Landau, Germany study. Since the publication of Rachel Carson’s Silent Spring (1962), many environmental agencies have banned the use of pesticides like organochlorines, organophosphates, and carbamates for their devastating toxic—sometimes lethal—effects, particularly on vertebrates, including humans. However, this ban created a pathway for a new generation of pesticides (e.g., neonicotinoids, pyrethroids) to take hold. Although these pesticides are more target-specific, requiring lower chemical concentrations for effectiveness, they have over double the toxic effects on invertebrates, like pollinators.  Invertebrates and plants are vital for ecosystem function, offering various services, from decomposition to supporting the food web. Furthermore, invertebrates and plants can act as indicator species (bioindicators) that scientists can observe for the presence and impact of environmental changes and stressors. Therefore, reductions in invertebrate and plant life have implications for ecosystem health that can put human well-being at risk. Study lead author Ralf Schulz, PH.D., notes, “[This study] challenge[s] the claims of decreasing environmental impact of chemical pesticides in both conventional and GM [genetically modified or genetically engineered (GE)] crops and […]

(Beyond Pesticides, March 29, 2021) New data on the hazards of neonicotinoid insecticides calls for urgent regulatory action. The same pesticides that are linked to the worldwide decline of insect pollinators also present significant risks to their avian counterparts, hummingbirds. Widely known for their nectar-fueled hovering flight powered by wings beating up to 80 times per second, hummingbirds display unique reactions to toxic pesticides. Research by scientists at the University of Toronto finds that hummingbirds exposed to systemic neonicotinoid insecticides for even a short period of time can disrupt the high-powered metabolism of this important and charismatic animal. Tell EPA and Congress to save the hummingbirds by suspending use of neonicotinoid insecticides and supporting the transition to organic practices. While hovering, a hummingbird consumes calories faster than any other bird or mammal. That’s why the finding that exposure to the neonicotinoid insecticide imidacloprid slows metabolism up to 25% is so disturbing. Systemic pesticides like imidacloprid and other neonics are transported throughout the plant, including nectar. Findings on the danger neonicotinoids pose to hummingbirds decades after the chemicals were first permitted to be used in the environment, and by independent scientists, not regulatory agencies, is indicative of a regulatory approach that fails […]

(Beyond Pesticides, March 10, 2021) Deer populations throughout the state of Minnesota are contaminated with neonicotinoid insecticides, according to preliminary results published earlier this month by the Minnesota Department of Natural Resources (MDNR). Although neonicotinoids are mostly known for contributing to the decline of pollinator populations, like most pesticides brought to market with approval of an inadequate U.S. regulatory review process, there are considerable uncertainties on its impacts after it is released into the environment. As scientists continue to discover novel harms from the use of these systemic insecticides, advocates say it becomes increasingly important to eliminate their use, and take preventive, precautionary measures to ensure similar patterns do not emerge in the future. MDNR launched its testing project on the state’s deer population in Fall 2019, after a study published by researchers at South Dakota State University found harmful impacts on white-tail deer. The neonicotinoid imidacloprid was found to reduce the body weight and metabolism of white tailed deer and increase the rate of birth defects and mortality in fawns. The state asked deer hunters to send them the spleens they harvested from wild deer. “We wanted to know if wild deer in natural settings are being exposed to neonics and […]

(Beyond Pesticides, March 3, 2021) Earlier this week, pesticide regulators in the commonwealth of Massachusetts voted to restrict outdoor consumer uses of neonicotinoid insecticides. The move is the result of sustained advocacy from broad coalition of individuals and organizations focused on protecting pollinators and ecosystem health. While advocates are pleased that the Pesticide Board Subcommittee made Massachusetts the first state in the country to restrict neonicotinoids through a regulatory process, they note this is only the first step in eliminating these hazardous insecticides. “This marks an incremental victory which took us 6 years to land, and it only happened because of immense, ongoing grassroots action and legislative allies who are willing to hold state regulators accountable,” said Martin Dagoberto, Policy Director of the Northeast Organic Farming Association, Mass. Chapter in a press release. “We still have a monumental endeavor ahead if we are to reduce toxins and rein in the toxic influence of the chemical lobby,” Mr. Dagoberto added. Advocates had been pushing the legislature to pass An Act to protect Massachusetts Pollinators, sponsored by pollinator champion Representative Carolyn Dykema, since 2014. Following several failures by state lawmakers to bring the bill over the finish line, efforts in 2019 resulted […]

(Beyond Pesticides, March 2, 2021) Populations of solitary ground nesting bees decline after exposure to neonicotinoid insecticides, according to a study published in Scientific Reports late last month. In addition to ground-nesting bees, neonicotinoids have been shown to harm butterflies, hummingbirds, songbirds, aquatic species and mammals, including humans. As independent science continues to look beyond the effects of these systemic chemicals on honey and bumblebees, advocates maintain that it has become increasingly clear that the high hazards presented by neonicotinoids necessitate their complete elimination. “Farmers need to protect their crops from pests, but they also absolutely need to protect pollinators from the unintended effects of pesticides,” said study coauthor Susan Willis Chan, PhD. “The data on this particular [neonicotinoid] product are so clear that there’s really no question about what has to happen. We have to find something else.” Researchers focused their effort investigating how various systemic pesticides effect the hoary squash bee (Eucera pruinosa), a ground nesting bee found throughout North America that feeds entirely on pollen from cucurbits (including squash, cucumber, pumpkin, gourds, etc). The hoary squash bee provides essential pollinator services for these crops throughout the U.S. and Canada. Neonicotinoids and other systemic insecticides are often applied […]

(Beyond Pesticides, February 23, 2021) The same pesticides implicated in the worldwide decline of insect pollinators also present significant risks to their avian counterparts, hummingbirds. Well known for their nectar-fueled hovering flight powered by wings beating over 50 times per second, hummingbirds display unique reactions to toxic pesticides. Research by scientists at the University of Toronto finds that hummingbirds exposed to systemic neonicotinoid insecticides for even a short period of time can disrupt the high-powered metabolism of this important and charismatic animal. Scientists began their experiment by trapping 23 wild ruby-throated hummingbirds and housing them in an animal care facility. One group of birds acted as a control and received no pesticide exposure, while the rest were assigned either low, middle, or high exposure (1 part per million [ppm], 2ppm, and 2.5ppm, respectively) to the neonicotinoid imidacloprid. Scientists determined these amounts based upon probable nectar contamination in the real world. The pesticide was incorporated into the sugar solution provided to the birds over the course of three days. Within two hours of exposure to the pesticides, hummingbird metabolism dropped significantly. While the control group increased energy expenditure between 1% to 7%, the low exposed group displayed a 6% average decline, […]

(Beyond Pesticides, February 19, 2021) Governments and policy makers are feeling a lot of pressure to mount effective responses to the climate crisis and to extraordinary levels of pollution in our environment. Tackling any one problem without precautionary attention to potential consequences of a solution — before it is enacted — is the opposite of the holistic understandings and strategies needed to solve environmental crises. Piecemeal approaches often generate unintended consequences. To wit: Vermont Public Radio (VPR) reports on revelations from a retired state scientist, Nat Shambaugh, who finds that farmers’ efforts to reduce agricultural runoff from fields into waterbodies, by planting cover crops, has resulted in significant increases in the use of herbicides to kill off those crops. So as one kind of pollution is reduced, another has become intensified. In Vermont and elsewhere, there has been much attention paid to nutrient pollution of waterbodies and waterways from agricultural runoff, largely because phosphorous and nitrates from fertilizers lead to contaminated drinking water, as well as to blooms of algae (some of which have their own toxic byproducts) and hypoxic dead zones in water bodies. The most notorious of these dead zones in North America are at the mouth of […]

(Beyond Pesticides, February 9, 2021) Multinational agrichemical corporation Bayer/Monsanto released a proposal last week to provide up to $200,000 per claimant in compensation to future victims of its Roundup weed killer, according to Reuters. The proposed settlement, agreed to with lawyers representing victims, continues Bayer/Monsanto’s attempts to limit the spiraling cost Roundup lawsuits, which have awarded individual victims millions of dollars in damages. The company appears to consider the proposal a good investment, as it has announced no plans to stop sale and production of its carcinogenic weed killer. However, under the current proposal, plaintiffs would not be forced to go through a compensation fund, and could seek additional punitive damages through a separate suit. As the attorney for Roundup victims, Elizabeth Casbraser, of Lieff Cabraser Heimann & Bernstein, told the Wall Street Journal, “It’s really about options, and it’s really about choice. I think it’s a great option that offers predictability and transparency for people who don’t want to wait, who want to be compensated.” To stop the surge of cancer victims – comprising roughly 125,000 lawsuits – from further damaging the company financially, Bayer/Monsanto last year proposed a $10.9 billion settlement with current litigants. Unresolved future claims were […]

(Beyond Pesticides, February 2, 2021) The U.S. Environmental Protection Agency (EPA) will evaluate the effect of the neonicotinoid insecticide imidacloprid on endangered species, after an agreement was reached between the agency and the Natural Resources Defense Council (NRDC). Imidacloprid is one of the most commonly used insecticides in the world today and, like other neonicotinoids in its chemical class, has been linked to a range of adverse impacts on wildlife and their habitat. While the agreement to the assess effects on endangered species is important, advocates note that EPA should already have conducted this review, and further, that imidacloprid and other neonicotinoids should already be banned. NRDC’s successful lawsuit follows a separate legal challenge by the Center for Food Safety, Beyond Pesticides, beekeepers, and other environmental organizations which was settled in 2019. The judge in that case, focused on the neonicotinoids clothianidin and thiamethoxam, did not order EPA to consult with the U.S. Fish and Wildlife Service (FWS) and National Marine Fisheries Service (NMFS) (which is required when registering a pesticide in order to mitigate risks to endangered species). Instead, she directed the parties, including the plaintiffs, defendant EPA, and intervenor Bayer CropScience (the manufacturer of neonicotinoids), to move forward […]