(Beyond Pesticides, February 5, 2014) According to a new study published in Environmental Health Perspectives, chemical contaminants in waterways that mimic estrogen -endocrine disruptors- target developing heart valves in fish and impair the growth of fish hearts. The study illustrates that these hormone-mimicking compounds, which include some pesticides, pharmaceuticals, and other household chemicals often found in sewage effluent and runoff that flows into waterways, are being linked to mounting science that show serious human and environmental adverse effects. Researchers from the Fish Health Branch of the U.S. Geological Survey (USGS) and the Carnegie Institution for Science exposed zebrafish embryos to water from 19 sites in the Susquehanna, Delaware, Allegheny and Shenandoah watersheds. Water from 16 of the sites triggered proteins in the fish that were estrogen receptors, indicating that the rivers contained endocrine disrupting chemicals. These receptors are attached to DNA, which turn genes on and off. While such activity is common in the liver, this is the first experiment to show estrogenic activity in heart valves. “This tells us that endocrine-disrupting chemicals could lead to improper heart development. We were quite surprised, since this is something that others hadn’t observed before,” said study co-author Luke Iwanowicz, PhD, and research […]

(Beyond Pesticides, November 7, 2013) A study released this week established a strong connection between endometriosis and exposure to two dangerous pesticides: lindane and mirex. While the results are not surprising given past connections between these pesticides and their endocrine-disrupting effects, this new study, Organochlorine Pesticides and Risk of Endometriosis: Findings from a Population-Based Case-Control Study, is one of the first to examine the association between organochlorine pesticides (OCPs) and endometriosis, one of the most common gynecological diseases, in women in the general population. The study’s authors, Kristen Upson, Ph.D. et al,  explained to Environmental Health Perspectives, “Our study suggests that exposure from extensive past use of environmentally persistent OCPs in the United States, or present use in other countries may impact the health of the current generation of reproductive-age women with regard to a hormonally-mediated disease.” In conducting the study, researchers selected a group of women with surgically-confirmed cases of endometriosis from the greater Pacific Northwest area. This group of women was then divided into four groups, based on the level of pesticide in each woman’s blood. Women in the second-highest exposure group for beta-hexacyclochlorohexane (beta-HCH), a byproduct of lindane, had a 70 percent greater risk of endometriosis than […]

(Beyond Pesticides, September 11, 2013) In a report released Monday, the Government Accountability Office (GAO) finds that the U.S. Environmental Protection Agency (EPA)’s use and oversight of conditional registrations is lacking and unreliable. Conditional registration allows pesticides onto the consumer market without all the required data to assess the chemical’s safety. This has created many serious human and environmental health problems, including bee decline, tree death and potential increases in human health risks. GAO recommends that EPA better track conditional registrations, however, Beyond Pesticides and other concerned groups urge the agency to cancel registrations until all relevant data is submitted and reviewed. According to the findings of the GAO’s report, EPA’s system for tracking pesticides with conditional registration is unreliable and thus, the total number of conditional registrations granted is unclear.   This lack of a reliable system for managing conditional registrations constitutes an ”˜internal control weakness’ because the agency lacks an effective mechanism for program oversight and decision making, according to federal internal control standards cited by GAO. The report states, “The extent to which EPA ensures that companies submit additional required data and EPA reviews these data is unknown. Specifically, EPA does not have a reliable system, such […]

(Beyond Pesticides, July 12, 2013) New research concludes that exposure to a combination of both arsenic and estrogen, at levels U.S. Environmental Protection Agency (EPA) considers “safe” for humans, can cause cancer at elevated levels in prostate cells. Texas Tech University researchers revealed that humans exposed to a combination of both toxicants were almost twice as likely to develop cancerous cells in their prostate. The study is published in the peer-reviewed journal The Prostate. While it is established that both arsenic and estrogen can cause cancer, the research raises concerns about the dangers of chemicals in combination, and the efficacy of regulations that are established by testing one chemical at a time. Kamaleshwar Singh, PhD., is an assistant professor at the Institute of Environmental and Human Health at Texas Tech. “The majority of cancers are caused by environmental influences,” Dr. Singh remarked to Texas Tech Today, “Only about 5 to 10 percent of cancers are due to genetic predisposition. Science has looked at these chemicals, such as arsenic, and tested them in a lab to find the amounts that may cause cancer. But that’s just a single chemical in a single test. In the real world, we are getting exposed […]

(Beyond Pesticides, June 28, 2013) The U.S. Environmental Protection Agency (EPA) released a draft “State of the Science” report last week acknowledging that low dose responses “do occur in biological systems” while defending its current risk assessment procedures as adequate for evaluating low dose effects. This report comes after EPA’s long running failure to fully implement a 1996 Congressionally mandated program to evaluate endocrine disruptors, and heavy criticism last year from prominent scientists who said EPA’s testing procedures are outdated. In 1999 the Natural Resources Defense Council (NRDC) filed a lawsuit against the EPA for failing to meet a statutory deadline for implementation of the Endocrine Disruptor Screening Program (EDSP) required under the 1996 Food Quality Protection Act, forcing the EPA to make a settlement agreement. As a result of  NRDC et al. v. EPA (No. C-99-03701 CAL) filed in the Northern District of California, EPA agreed to start requiring screening and testing of certain chemicals varying by date, using a tiered system. EPA’s two-tiered screening and testing system, requires that EPA will identify which chemicals are able to interact with the endocrine system in Tier 1. Tier 2 screening process was designed to go one step further, requiring EPA […]

(Beyond Pesticides, June 19, 2013) The Director of the National Institute of Environmental Health Sciences (NIEHS), Linda Birnbaum, PhD, is being criticized by some Republicans for authoring an article that describes linkages between endocrine disrupting chemicals and the onset of disease, as well as the need to understand and monitor the effects of these chemicals. Instead of encouraging efforts for greater understanding of these chemicals, the members of Congress instead blasted the article as a potential breach of National Institutes of Health (NIH) policy. NIEHS, a program of NIH, seeks to reduce the burden of human illness and disability by understanding how the environment influences the development and progression of human disease. The short article entitled, “When environmental chemicals act like uncontrolled medicine,” published online on May 7, 2013, in Trends in Endocrinology and Metabolism, lays out the case that environmental chemicals can produce unwanted endocrine effects, leading to an increase in certain diseases.  It states, “In the same way as physicians endeavor to understand and monitor the effect of medicines on endocrine pathways, we ought to achieve the same understanding and control of the effects on environmental chemicals.” Dr. Birnbaum also notes, “The proliferation of inadequately tested chemicals in […]

(Beyond Pesticides, March 1, 2013) In a literature review published in Toxicology last week, researchers found that environmental and occupational pesticide exposure was strongly associated with declines in sperm count. Researchers Sheena Martenies, BS, and Melissa Perry, ScD., MHS., determined that of the 17 studies evaluated, 15 of them reported significant associations between pesticides and semen quality. The researchers counted semen quality according to concentration of sperm over an area, their motility and ability to move, as well as their shapes. Researchers targeted studies on DDT, HCH, and abamectin, grouping pyrethroids and organophosphates by class. What they found was striking: almost all the studies reported a decrease in sperm concentration; decreased motility was also reported though less frequently; while morphological changes were not strongly associated in studies””only two indicated any changes to sperm shape. These findings build on a growing body of evidence that pesticide exposure at environmental or occupational levels diminished sperm health. In addition to the U.S. findings,  studies conducted on French, New Zealander, Indian, Tunisian, and Israeli men have all found decline in sperm count. Some studies record a drop by approximately 50% between 1940 and 1990, no small amount. These results might not be surprising as […]

(Beyond Pesticides, February 20, 2013) A new report by the United Nations Environment Programme (UNEP) and the World Health Organization (WHO) has identified endocrine disrupting chemicals as having significant health implications for the global population. According to the report, these chemicals have the capacity to interfere with tissue and organ development and function, and therefore they may alter susceptibility to different types of diseases throughout life, and represents a global threat that needs to be resolved. The report cites insufficient reporting and information on chemicals in products, materials and goods and calls for more research and collaboration. The State of the Science of Endocrine Disrupting Chemicals,   a joint study by UNEP and WHO, finds that endocrine disrupting chemicals (EDCs) are important environmental risk factors for endocrine diseases. Exposures during critical phases of development play an important role in the onset of many diseases, affecting future generations. Trends indicate an increasing burden of certain endocrine diseases across the globe, and it is clear from human studies that populations are exposed to perhaps hundreds of environmental chemicals at any one time. This UN study, which is the most comprehensive report on EDCs to date, highlights some association between exposure to EDCs […]

(Beyond Pesticides, October 2, 2012) The herbicide atrazine may be linked to an amplified risk of choanal atresia, a congenital abnormality of the nasal cavity, according to researchers at Baylor College of Medicine and other Texas institutions. Choanal atresia is recognized when tissue formed during fetal development blocks an infant’s nasal cavity. Though it is a rare condition, it is considered quite serious because it can affect an infant’s ability to breathe. The study, scheduled for publication in The Journal of Pediatrics, focused on atrazine because, although there are very few risk factors for choanal atresia, endocrine disrupting chemicals are suspected to be associated with the condition. “Endocrine disrupters aren’t fully understood, but it is believed they interfere with or mimic certain hormones, thereby blocking their proper function and potentially leading to adverse outcomes,” said Dr. Phillip Lupo, lead author of the study. Looking at mothers from Texas counties with the highest levels of estimated atrazine application, researchers discovered that they are 80 percent more likely to have children with choanal atresia or stenosis (a less severe form of the condition) than compared to mothers who live in counties with the lowest levels. The herbicide atrazine and over 50 other […]

(Beyond Pesticides, March 16, 2012) A report published online this week in the journal Endocrine Reviews documents extensive scientific research showing that endocrine disrupting chemicals, or endocrine disruptors, can be toxic to humans even in minutely small doses. The report, three years in the making, was published Wednesday by a team of 12 scientists who study hormone-altering chemicals. Authors include the University of Missouri’s Frederick vom Saal, PhD., who has linked low doses of bisphenol A (BPA) to a variety of effects, Theo Colborn, PhD., who is credited with first spreading the word about hormone-disrupting chemicals in the late 1980s, and University of California at Berkeley’s Tyrone Hayes, PhD., who has documented the effects of the pesticide atrazine on frogs. Drs. Colborn, Hayes, and vom Saal are all former speakers at the National Pesticide Forum. One of the reporrt’s authors is Pete Myers, PhD, the founder of Environmental Health News and chief scientist of Environmental Health Sciences. Dozens of substances that can mimic or block estrogen, testosterone and other hormones are found in the environment, the food supply and consumer products, including plastics, pesticides and cosmetics. One of the biggest, longest-lasting controversies about these chemicals is whether the tiny doses […]

(Beyond Pesticides, November 8, 2011) The Environmental Protection Agency (EPA) published a petition to ban the endocrine (hormone) disrupting herbicide atrazine on September 14, 2011, opening a 60-day comment period for the public to weigh-in on the issue that ends Friday. Tell EPA that because atrazine poses unacceptable risks to humans and wildlife, the agency should remove this hazardous pesticide from the market immediately. Submit comments directly to EPA’s atrazine petition docket by November 14, 2011 or sign your organization or business onto Beyond Pesticides’ comments by Friday, November 11. According to its Federal Register notice, EPA received a petition from the non-profit organization Save the Frogs that includes over 10,000 signatures and select statements from the public, as well as two brief summaries of published literature, one by Jason Rohr, PhD (University of South Florida), and one by Tyrone Hayes, PhD (University of California, Berkeley), that is co-authored by 39 other scientists. In conjunction with the petition, EPA received nearly 50,000 emails from supporters of the Center for Biological Diversity and the Natural Resources Defense Council requesting that EPA “immediately take steps to phase out atrazine use in the United States,” stating that atrazine poses an unreasonable risk to […]

(Beyond Pesticides, July 22, 2011) Parallel bills have been introduced in the U.S. Senate and U.S. House of Representatives designed to increase federal research on endocrine disrupting chemicals and ensure public safety by restricting or eliminating chemicals found to present unacceptable risks to public health. S 1361, introduced by Senator John Kerry (D-MA), and HR 2521, introduced by Rep. Jim Moran (D-VA), are both titled the Endocrine-Disrupting Chemicals Exposure Elimination Act. The bills would establish a scientific panel at the National Institute of Environmental Health Sciences (NIEHS) to evaluate up to ten chemicals per year that potentially affect the endocrine system and would create a trigger to ban those found most harmful to public health. The bills would create a more updated scientific evaluation process than any that currently exists in the federal government for reviewing potential endocrine disruptors and would have a strong regulatory mandate to ban or restrict chemicals that are found to present serious health risks. The specific process outlined directs the National Toxicology Program at NIEHS to evaluate each chemical according to (i) the amount of evidence that it is an endocrine disruptor, (ii) the “level of concern” that it may disrupt hormones, and (iii) the […]

(Beyond Pesticides, July 22, 2011) Parallel bills have been introduced in the U.S. Senate and U.S. House of Representatives designed to increase federal research on endocrine disrupting chemicals and ensure public safety by restricting or eliminating chemicals found to present unacceptable risks to public health. S. 1361, introduced by Senator John Kerry (D-MA), and H.R. 2521, introduced by Rep. Jim Moran (D-VA), are both titled the Endocrine-Disrupting Chemicals Exposure Elimination Act. The bills would establish a scientific panel at the National Institute of Environmental Health Sciences (NIEHS) to evaluate up to ten chemicals per year that potentially affect the endocrine system and would create a trigger to ban those found most harmful to public health. The bills would create a more updated scientific evaluation process than any that currently exists in the federal government for reviewing potential endocrine disruptors and would have a strong regulatory mandate to ban or restrict chemicals that are found to present serious health risks. The specific process outlined directs the National Toxicology Program at NIEHS to evaluate each chemical according to (i) the amount of evidence that it is an endocrine disruptor, (ii) the “level of concern” that it may disrupt hormones, and (iii) the […]

(Beyond Pesticides, June 20, 2011) In a study published this week in the journal Pediatrics, researchers report findings that link mothers’ exposure to organochlorine pesticides during pregnancy with infants’ sizes at birth. The trend shows that the more mothers are exposed to the pesticides during pregnancy, the higher the chances are for reduced birth weight and length of their newborns. Comprising a total of 494 women and infants in Valencia, Spain from the years 2003-2006, the study evaluates umbilical cord blood for residues of four pesticides or pesticide degradates: DDT, DDE, hexachlorobenzene (HCB), and beta-hexachlorocyclohexane. The results show that a 10-fold increase in pesticide concentrations in the blood corresponds to a reduction in birth weight of 2-4 ounces. Additional results are correlated to specific pesticides. Higher concentrations of DDT results in a reduction in head circumference of 0.26cm, which the researchers call a “significant decrease.” Additionally, a decrease of 0.39cm in birth length is correlated with each 10-fold increase in concentration of HCB. The researchers note several concerns related to the findings, aside from the results themselves. Since people are exposed to a wide variety of chemicals in general throughout their everyday lives, higher pesticide exposure could betray higher exposure […]

(Beyond Pesticides, May 9, 2011) The Endocrine Disruptor Exchange Inc. (TEDX), founded by Theo Colborn, PhD, has released a list of chemicals with the potential to affect the endocrine system. According to TEDX, every chemical on the TEDX List has one or more verified citations to published, accessible, primary scientific research demonstrating effects on the endocrine system. Endocrine disruptors are chemicals that impact traditional endocrine glands, their hormones and receptors such as estrogens, anti-androgens, and thyroid hormones. To date there are approximately 800 endocrine disruptors on the TEDX List. Download the TEDX List (Excel) Many everyday chemicals that people are exposed to can wreak havoc on the body’s endocrine system. Pesticides such as triclosan, atrazine, permethrin and many others have been associated with effects on the body’s hormone system. Visit the Pesticide Induced Disease Database for more on the chemicals linked to endocrine disruption. Endocrine effects include direct effects on traditional endocrine glands, their hormones and receptors such as estrogens, anti-androgens, and thyroid hormones, as well as signaling cascades that affect many of the body’s systems, including reproductive function and fetal development, the nervous system and behavior, the immune and metabolic systems, the liver, bones and many other organs, glands […]

(Beyond Pesticides, April 28, 2011) In recognition of the 3rd annual Save the Frogs Day, a “Save the Frogs/Ban Atrazine Rally” will be held tomorrow, Friday, April 29th in Washington, DC. The rally will take place at the steps of the U.S. Environmental Protection Agency (1200 Pennsylvania Ave, NW), and is intended to raise awareness of the rapid disappearance of frog species worldwide, and bring attention to the harmful effects of the endocrine disrupting herbicide atrazine. Amphibian populations worldwide have been declining at unprecedented rates, and nearly one-third of the world’s amphibian species are threatened with extinction. Up to 200 species have completely disappeared in recent years. Amphibians are faced with an onslaught of environmental problems, including climate change, infectious diseases, habitat loss, invasive species, and over-harvesting for the pet and food trades. Numerous studies have definitively linked pesticide use with significant effects on amphibians. Pesticides can cause abnormalities, diseases, injury and death in these frogs and other amphibians. Because amphibians breathe through their permeable skin, they are especially vulnerable to chemical contamination. Frog eggs float exposed on the water surface, where pesticides tend to concentrate, and hatched larvae live solely in aquatic environments for five to seven months before […]

(Beyond Pesticides, March 10, 2011) The American Public Health Association (APHA) recently adopted 17 new policies at its 138th Annual Meeting in Denver, addressing a broad range of public health concerns, including a new policy calling for greater government action to protect the public from endocrine-disrupting chemicals (EDCs). The policy statement follows official positions released earlier in 2010 by both the American Medical Association (AMA) and the Endocrine Society in that more needs to be done to protect the public from endocrine-disrupting chemicals, or those that interfere with hormone action. Specifically, APHA urges: ”¢ Support for the Endocrine Society and the American Medical Association in proclaiming that more needs to be done to protect the public from potential health risks of exposure to EDCs. ”¢ That given the magnitude and urgency of the public health threat and the recognition that collectively EDCs likely will have common or overlapping effects on the endocrine system, steps should therefore be taken by federal agencies with regulatory oversight for various individual EDCs to coordinate and find synergies among themselves to coordinate and find synergy among federal agencies with regulatory oversight over various individual EDCs. ”¢ Health professionals and scientists with expertise in various aspects […]

(Beyond Pesticides, February 16, 2011) Many agricultural pesticides —including some previously untested and commonly found in food— disrupt male hormones, according to new tests conducted by British scientists. Meanwhile, U.S. researchers at the National Institutes of Health have found that people who used two specific varieties of pesticide were 2.5 times as likely to develop Parkinson’s disease. Pesticides Impact Male Hormones Evidence suggests that there is widespread decline in male reproductive health and anti-androgenic pollutants, also known as endocrine disruptors, may play a significant role. Thirty out of 37 pesticides tested by the researchers at the University of London altered male hormones, including 16 that had no known hormonal activity until now. There was some previous evidence for the other 14. Most are fungicides applied to fruit and vegetable crops, including strawberries and lettuce. The study, “Widely Used Pesticides with Previously Unknown Endocrine Activity Revealed as in Vitro Anti-Androgens,” is published in Environmental Health Perspectives. The British researchers screened the chemicals using in vitro assays, which use human cells to check whether the pesticides activate or inhibit hormone receptors in cells that turn genes on and off. Scientists, however, are uncertain what actually happens in the human body at the […]

(Beyond Pesticides, December 8, 2010) A new study finds that oral contraceptives are not the main culprit in estrogenic pollution of U.S. rivers and drinking water. Instead, the contribution of contraceptives is quite small compared to other human, industrial and agricultural sources, including pesticides. Recent observed feminization of aquatic animals has raised concerns about estrogenic compounds in water supplies and the potential for these chemicals to reach drinking water. Public perception frequently attributes this feminization to oral contraceptives (OCs) in wastewater and raises concerns that exposure to OCs in drinking water may contribute to the recent rise in human reproductive problems. Studies have suggested that long-term exposure to low levels of estrogens in water may adversely affect human health. This new information eases concerns that contraceptives are a major factor contributing to feminized fish and frogs. This study, “Are Oral Contraceptives a Significant Contributor to the Estrogenicity of Drinking Water?” reviews the literature regarding various sources of estrogens, in surface, source and drinking water, to determine whether OCs were the source of estrogen in surface waters, with an emphasis on the active molecule that comes from OCs. The authors find that industrial and agricultural sources not only discharge estrogens, but […]

(Beyond Pesticides, November 18, 2010) Yesterday, the U.S. Environmental Protection Agency (EPA) announced that it has identified a list of 134 chemicals that will be screened for their potential to disrupt the endocrine system, along with a draft of the policies and procedures that the agency will follow for testing. Endocrine disruptors are chemicals that that interfere with the hormones produced or secreted by the human or animal endocrine system, which regulates development, metabolism, growth, and reproduction. These man-made chemicals are used in everyday materials but appearing in increasing levels throughout the environment. For years, scientists have noted strange anomalies in fish and wildlife in locations where endocrine disrupting chemicals (EDCs) are found. A recent study found that an astounding 100 percent of small mouth bass in certain sites of the Potomac River basin have exhibited both male and female organs, a characteristic linked to EDCs. According to a 2009 study by the U.S. Geologic Survey, the occurrence of “intersex” fish is now found to be nationwide. EPA is currently proceeding with endocrine disruptor screening on three fronts: 1) Developing and validating Tier 2 tests; 2) Selecting chemicals for screening and testing; and 3) Implementing the policies and procedures the […]

(Beyond Pesticides, September 14, 2010) A new study confirms that indoor uses of consumer products, including pesticides, are the primary sources of indoor exposure to endocrine disruptors —chemicals that disrupt hormones and cause adverse developmental, disease, and reproductive problems— and shows that indoor levels are higher than those outdoors. Researchers from Silent Spring Institute, Columbia University, and the University of California-Berkeley measured airborne concentrations of endocrine disruptors in two California communities: Bolinas, a rural, affluent coastal town, and Richmond, a working-class city ringed by oil refineries. The study is published online in the September 1, 2010 issue of Environmental Science & Technology. The researchers analyzed 104 chemicals in 50 homes, including both chemicals that penetrate indoors from outdoor industrial and transportation sources and those from indoor use of consumer products and building materials. Similar levels of contamination were found inside homes in both communities, but outdoor levels were higher in Richmond. Among the chemicals found were pesticides, phthalates, parabens, PBDE flame retardants, and PCBs. A total of 38 pesticides are evaluated, including banned organochlorines (e.g., DDT, PCP), and current use products such as carbamates (e.g., propoxur), organophosphates (e.g., chlorpyrifos), and pyrethroids (cypermethrin). Thirteen pesticides were detected outdoors and sixteen pesticides […]

(Beyond Pesticides, August 31, 2010) As the Environmental Protection Agency (EPA) continues its review of the popular herbicide atrazine, a new study shows that male rats prenatally exposed to low doses of the gender-bending chemical are more likely to develop prostate inflammation and to go through puberty later than non-exposed animals. The research adds to a growing body of literature on atrazine, an herbicide used in agriculture, especially in corn and sugar cane production, and on golf courses and residential lawns. Atrazine and its byproducts are known to be relatively persistent in the environment, potentially finding their way into water supplies. It has been linked to a myriad of health problems in humans including disruption of hormone activity, birth defects, and cancer. The research, “Effects of prenatal exposure to a low dose atrazine metabolite mixture on pubertal timing and prostate development of male Long-Evans rats,” which is available online and will be featured on the cover of Reproductive Toxicology (Vol. 30, # 4), found that the incidence of prostate inflammation went from 48 percent in the control group to 81 percent in the male offspring who were exposed to a mixture of atrazine and its breakdown products prenatally. The severity […]

(Beyond Pesticides, January 14, 2010) Stating that current water-quality criteria does not reflect the latest scientific knowledge, The Center for Biological Diversity petitioned the U.S. Environmental Protection Agency (EPA) to establish new water-quality criteria for numerous endocrine-disrupting chemicals (EDC) under the Clean Water Act. If adopted, it will be a big step in regulating and eliminating persistent and widespread chemicals that damage reproductive functions in wildlife and humans. The Center for Biological Diversity formally requested that the EPA publish water quality criteria and information taking into account overwhelming science about the effects of EDC pollution on January 11. It says that under the Clean Water Act, EPA has a duty to periodically update water quality criteria to reflect the latest scientific knowledge. The petition presents scientific information on endocrine disrupting chemical pollution found in our waters and requests that the EPA promptly update water quality criteria reflecting this scientific information. Last month, legislation was introduced into Congress to explore linkages between hormone disrupting chemicals in the environment and everyday products and the dramatic increase of autism, hyperactivity, diabetes, obesity, breast cancer, prostate cancer and other hormone related disorders. After the identification of endocrine disruptors, the bill, The Endocrine Disruption Prevention […]