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Daily News Blog

Archive for the 'Disease/Health Effects' Category


11
Aug

Acute Kidney Failure Higher Among Farmers: High-Middle-Low Income Countries Suffer Disparities

(Beyond Pesticides, August 11, 2022) A study in the International Journal of Environmental Research and Public Health finds that Brazilian agricultural workers are more likely to die from acute kidney failure (AKF) than other acute illnesses. Among the agricultural workers, the prevalence of AKF is higher for individuals at younger ages, who are female, and located in regions south of chemical use, particularly rural areas. However, the AKF mortality rate in urban areas is also increasing, but not as fast as in rural areas. Over six million people in the U.S. have kidney disease (i.e., nephritis [kidney inflammation], nephrotic syndrome (improper protein filtration), and nephrosis). Although many studies find an association between exposure to environmental contaminants like pesticides and chronic kidney disease (CKD), the association between pesticides and acute kidney failure remains unclear. CKD is a risk factor for AKF, and other environmental factors can increase the risk of AKF mortality. Therefore, studies like this highlight the need for comprehensive information regarding co-occurring exposure patterns and disease prevalence that can have global implications. The study notes, “Our findings reinforce the need for more robust epidemiological studies that account for co-exposures and conditions of agricultural work in the relationship between pesticide exposure and kidney […]

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09
Aug

“Inert” Pesticide Ingredients and Failure to Regulate Raise Dangers for All U.S. Residents

(Beyond Pesticides, August 9, 2022) The most widely used pesticide chemicals in the United States are not listed on product labels, yet pose widespread environmental and public health hazards, according to commentary published this month in Environmental Health Perspectives by two veteran researchers. At issue are adjuvants and so-called “inert” (or “other”) ingredients, chemicals that are added to formulated pesticide products, but do not undergo the same safety reviews as the active ingredient in pesticide products. This donut hole of regulation has permitted, as the commentary shows, millions of pounds of chemicals to be applied in California and throughout the country without proper scientific evaluation of their human health or ecological impact. Researchers first draw a distinction between adjuvant products and inert ingredients in pesticide products. Adjuvants are materials specifically designed to improve the performance of a pesticide spray and are sold separately from formulated pesticide products. Adjuvants are “tank mixed” with a pesticide prior its application. Inert ingredients are any ingredient within a formulated pesticide product that is not designed to prevent, destroy, or repel a pest. Adjuvants and inert ingredients can be the same material – the difference lies in when they are added to a formulated pesticide […]

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04
Aug

Glyphosate Weed Killer Crosses Blood-Brain Barrier, Linked to Alzheimer’s and Other Neurodegenerative Diseases

(Beyond Pesticides, August 4, 2022) An Arizona State University (ASU) study shows that the popular herbicide glyphosate can infiltrate the brain through the blood (blood-brain barrier), increasing neurological disease risk. The blood-brain barrier filters various molecules entering the brain from the circulatory system. However, the permeation of glyphosate molecules elevates the expression of TNFÎą and the accumulation of soluble beta-amyloid (Aβ) proteins in the brain and has associations with immune, inflammatory, and neurodegenerative diseases like Alzheimer’s disease (AD). More than 6 million people in the U.S. are living with Alzheimer’s, and cases are expected to double by 2050. Although Alzheimer’s research has focused heavily on finding genetic causes of the disease, fewer than half of cases are genetic. Thus, researchers are now evaluating how environmental contaminants may increase disease risk. Over 300 environmental contaminants and their byproducts, including pesticides, are chemicals commonly present in human blood and urine samples and can increase neurotoxicity risk when crossing the brain barrier. Therefore, studies like this highlight the importance of understanding how chemical accumulation in the body can impact long-term health and disease prognosis. The study notes, “Brain glyphosate correlates with increased TNFÎą levels, suggesting that exposure to this herbicide may trigger neuroinflammation in the brain, which may […]

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03
Aug

Scientific Literature Review Again Connects Pesticides and Male Fertility Problems

(Beyond Pesticides, August 3, 2022) A systematic review of scientific studies on pesticides and fertility finds exposure associated with lower semen quality, DNA fragmentation, and chromosomal abnormalities. Published in the journal Andrology, the review is yet another warning from a long string of researchers sounding the alarm over the connection between global fertility and toxic chemical exposure. With data from the U.S. Centers for Disease Control and Prevention (CDC)  indicating roughly 1 in 5 couples are unable to conceive after a year of trying, and trends continuing to slope downwards, it is critical that contributing factors be identified so that protective changes can be made.   After screening over 1,300 studies, researchers narrowed their review down to 64 papers assessing semen parameters and DNA integrity after pesticide exposure. Each study is analyzed for its design, the pesticide investigated,  the population studied, controls, and reproductive effects determined. Pesticides are evaluated for their impacts to sperm quality and DNA integrity based on their chemical class. Organochlorine insecticides, which are all banned but still persistent in soil, air, water, and food in the United States, include a range of impacts to sperm quality. Higher levels of DDT or its breakdown metabolite DDE are […]

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26
Jul

Inspector General Finds Secret EPA Meetings with Industry and Use of Untested Science to Lower Cancer Risk for Dangerous Fumigant

(Beyond Pesticides, July 26, 2022) Secret meetings with industry, the elevation of unqualified individuals to decision-making roles, using an untested scientific approach, failing to conduct a simple literature review, and an overall absence of public transparency. This is how the U.S. Environmental Protection Agency’s (EPA) conducted its cancer review for the potent fumigant pesticide 1,3-Dichloropropane (1,3-D; brand name: Telone), according to a report from EPA’s Office of Inspector General (OIG). EPA’s actions allowed a product once considered to pose a 1 in 10,000 risk of cancer to Americans to increase exposure by 9,000% (from 7.7 Îźg/m3 to 690 Îźg/m3). “These departures from established standards during the cancer assessment for 1,3-D undermine the EPA’s credibility, as well as public confidence in and the transparency of the Agency’s scientific approaches, in its efforts to prevent unreasonable impacts on human health,” the OIG report states. Yet, even with the agency’s failings laid out in clear view, EPA’s lackluster response to OIG’s corrective actions in this case add insult to its injurious actions against public health. OIG initiated a review of EPA’s cancer assessment for 1,3-D after the submission of multiple complaints. 1,3-D is a highly toxic fumigant used on a variety of crops, […]

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21
Jul

Pesticide Exposure Driving Liver Disease through Hormone Disrupting Mechanisms

(Beyond Pesticides, July 21, 2022) Research published in Scientific Reports finds an association between the increasing emergence of nonalcoholic fatty liver disease (NAFLD) and exposure to endocrine (hormone) disrupting chemicals, like organochlorine pesticides (OCPs). It is well-known that traces of legacy (past-use) pesticides, like organochlorines, remain in the environment for decades—possibly centuries, post-final application, as OCPs have greater chemical stability and gradual attenuation. However, these chemicals have profound adverse impacts on human health, especially on the endocrine system. Obesity, insulin resistance, type 2 diabetes, and elevated liver enzyme resulting from endocrine disruption contribute to NAFLD and can lead to liver cirrhosis. Although some, but not all, manufacturing and use of specific OCPs have declined in the U.S., OCPs remain a global issue, as much of the developing world still reports usage. Considering the lack of studies on OCP-induced endocrine disruption and NAFLD, research like this highlights the need to understand the underlying mechanisms that contribute to growing endocrine disease incidents.   The study determined that there is an association between OCP exposure and NAFLD using the fatty liver index (FLI), a predictor of lipid (fat) accumulation in the liver. The researcher collected blood serum to measure the concentration of OCPs, specifically evaluating detectable […]

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19
Jul

Banned Pesticides Still Present in the Environment Linked to Hearing Loss

(Beyond Pesticides, July 19, 2022) Banned pesticides still persistent in the environment pose an increased risk of hearing impairment for U.S. adults, according to research published this month in Scientific Reports. Although regular use of DDT and hexachlorobenzene (HCB) no longer occurs in the United States, exposure to these persistent chemicals can still occur through a range of sources, including air, water, sediment, soil and food. As new science continues to find harmful health effects of older pesticides, advocates say new laws are needed to ensure long term hazards don’t arise from the more than 1,200 active ingredients currently registered by the US Environmental Protection Agency (EPA) with little to no independent scientific oversight. Hearing loss affects nearly 40 million (~15%) American adults over age 18. While it is clear that common causes like aging and noise exposure can result in hearing loss, there has been increasing attention to the role environmental contaminants may be playing in hearing disorders. To explore any potential connection, researchers analyzed data from the long-running U.S. National Health and Nutrition Examination Survey (NHANES). Blood serum levels of the organochlorine insecticides HCB, p, p’-DDE (a breakdown product of DDT), trans-nonachlor, and dieldrin were compared against audiometry […]

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18
Jul

Take Action: Male Fertility Harmed by Pesticides and EPA Dysfunction

(Beyond Pesticides, July 18, 2022) The failure of the U.S. Environmental Protection Agency (EPA) to meet its statutory responsibility to protect people and wildlife from the dire consequences of exposure to endocrine disrupting chemicals must end. A study published in Toxicology and Applied Pharmacology adds urgency to the need to eliminate endocrine-disrupting pesticides. The authors find that prepubescent exposure to endocrine-disrupting chemicals (EDCs), including pesticides, impairs male reproduction through the interruption of testicular homeostasis and development of reproductive Leydig cells, and can have multigenerational effects. This adds to the long list of scientific articles showing EPA neglect of the devastating effects of widely used pesticides. Tell EPA that pesticide use cannot continue without findings of no endocrine disruption. Tell Congress to ensure that EPA does its job. More than 50 pesticide active ingredients have been identified as endocrine disruptors that mimic the action of a naturally-produced hormone, such as estrogen or testosterone, thereby setting off similar chemical reactions in the body; block hormone receptors in cells, thereby preventing the action of normal hormones; or affect the synthesis, transport, metabolism and excretion of hormones, thus altering the concentrations of natural hormones. Endocrine disruptors have been linked to attention deficit hyperactivity disorder (ADHD), […]

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14
Jul

Endocrine-Disrupting Chemicals Impair Juvenile Male Fertility Development and Threatens Future Reproductive Health

(Beyond Pesticides, July 14, 2022) A study published in Toxicology and Applied Pharmacology finds prepubescent exposure to endocrine-disrupting chemicals (EDCs), including pesticides, impairs male reproduction through the interruption of testicular homeostasis and development of reproductive Leydig cells. Endocrine disruptors are xenobiotic (i.e., chemical substances like toxic pesticides foreign to an organism or ecosystem). Many reports demonstrate that exposure to endocrine-disrupting chemicals can adversely affect human, animal—and thus environmental—health by altering the natural hormones in the body responsible for conventional reproductive, physical, and mental development. Scientists and health officials already associate pesticide exposure with a decrease in male fertility, including reduced sperm count, quality, and abnormal sperm development. The presence of pesticides in the body has implications for human health, especially during vulnerable life stages, such as childhood, puberty, pregnancy, and old age. Therefore, it is essential to understand how exposure to toxic chemicals in the environment affects future reproductive success and health. The researchers note, “Recent studies revealed that exposures to EDCs during so-called critical windows of susceptibility (prenatal, prepubertal, pubertal, and aging periods) could disrupt healthy patterns of testes development and homeostasis, which can be demonstrated as an impaired testicular function later in life. However, much more work is needed to understand better the cellular […]

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30
Jun

Common Fungicide Again Linked to Parkinson’s Disease with Molecular Disruption

(Beyond Pesticides, June 30, 2022) A study by Zhongnan University and Shandong University in China finds that the broad-spectrum fungicide maneb increases Parkinson’s disease (PD) risk and development through alterations in protein and metabolite pathways, resulting in neurotoxicity. Several studies find exposure to chemical toxicants, like pesticides, have neurotoxic effects or exacerbate preexisting chemical damage to the nervous system. Although the mechanism by which pesticides induce disease development remains unclear, this study suggests neurological damage from oxidative stress, cell dysfunction, and synapses impairment, among others, increases the incidence of PD subsequent to pesticide exposure. Parkinson’s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses annually. The disease affects 50 percent more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and sleep disturbances. Over time, symptoms intensify, but there is no current cure for this fatal disease. While only 10 to 15 percent of PD cases are genetic, PD is quickly becoming the world’s fastest-growing brain disease. Therefore, research like this highlights the need to examine molecular mechanisms involved in altering chemical […]

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28
Jun

Pesticides Linked to Adult and Childhood Cancer in Western U.S., with Incidence Varying by County

(Beyond Pesticides, June 28, 2022) There is a strong connection between pesticide use and cancer rates in the Western United States, finds research recently published by scientists at University of Idaho and Northern Arizona University. Two studies (here and here) published in the peer-reviewed journal GeoHealth used geospatial data and publicly available pesticide databases to uncover the relationship between chemical heavy agricultural practices and cancer in both adults and children. As the rate of chronic diseases like cancer continue to increase in the United States, and more and more studies find these diseases to be pesticide-induced, it is imperative for the public to put increased pressure on regulators and lawmakers to enact meaningful measures that eliminate pesticide use and the hazards these chemicals pose. Of the two studies conducted by the research team, the first study modeled the connection between pesticide use and cancer incidence for adults and children in 11 western states (Arizona, California, Colorado, Idaho, Montana, Nevada, New Mexico, Oregon, Utah, Washington, and Wyoming), while the second study focuses on childhood cancer rates in Idaho’s 44 counties. Both studies utilized databases established by public entities, including U.S. Geological Survey (USGS) Pesticide National Synthesis Project database, EPA Pesticide Industry […]

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22
Jun

Supreme Court Permits Large Jury Verdicts on Roundup, Appeals Court Finds EPA Registration Unlawful

(Beyond Pesticides, June 22, 2022) Bad news is piling up for Bayer (Monsanto) and its carcinogenic flagship weed killer, glyphosate (Roundup). Last week, the Court of Appeals for the Ninth Circuit handed down a ruling that held the U.S. Environmental Protection Agency’s (EPA) 2020 approval of its notorious weed killer glyphosate unlawful. Then, yesterday, the U.S. Supreme Court declined to consider (deny certiorari) Bayer’s “Hail Mary” petition attempt to save the company from being held accountable to those diagnosed with cancer after using Roundup (glyphosate) herbicides. In both cases, the courts are acting as a check on a company, while EPA regulators charged with stopping this behavior continue to rubber stamp the agrichemical industry’s dangerous decisions. This is not the first time that the Supreme Court has upheld the rights of victims of the pesticide industry. In 2004, Bates v. Dow Agrosciences (U.S. Supreme Court, No. 03-388), the court found: “The long history of tort litigation against manufacturers of poisonous substances adds force to the basic presump­tion against pre-emption. If Congress had intended to deprive injured parties of a long available form of compen­sation, it surely would have expressed that intent more clearly. See Silkwood v. Kerr-McGee Corp., 464 U. […]

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16
Jun

Farmed Salmon Just as Toxic to Human Health as Junk Food

(Beyond Pesticides, June 16, 2022) Farmed salmon serves as an inferior food source, accumulating more toxic chemicals in fatty tissue with fewer healthy nutrient properties based on a study from the University of Bergen, Norway and Alternative Medicine Review. However, the issue of toxic chemical contamination in fish dates back decades with investigations demonstrating high levels of persistent organic pollutants (POPs), including polybrominated diphenyl ethers (PBDEs) flame retardants restricted or banned in the U.S. and U.K., polychlorinated biphenyl (PCBs), dioxin (a by-product of pesticide manufacturing), and ethoxyquin (a pesticide preservative in fish feed). The aquaculture industry (e.g., farmed seafood/fish) repeatedly faces sustainability issues, failing to adhere to environmental regulations and threatening marine health. Extensive use of pesticides in local marine ecosystems has induced coastal habitat loss and increased genetic and health risks to wild marine populations. Moreover, insecticides used to kill salmon parasites (e.g., fish lice) has led to widespread disease persistence and pest resistance. Marine species biodiversity is rapidly declining due to overfishing, global warming, pathogens, and pollution. Thus, further biodiversity loss can change aquatic and terrestrial ecosystem functions and reduce ecosystem services. Food analysis results find the consumption of farmed salmon fillets contributes to higher rates of metabolic disorders, including diabetes and obesity. These farmed salmon also contain levels […]

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14
Jun

U.S. Attorneys Bust Pesticide Smuggling Operation, but Online Purchasing Continues

(Beyond Pesticides, June 14, 2022) The ringleader of a pesticide smuggling operation conducted across the United States border with Mexico has been sentenced to eight months in prison by a U.S. District Court Judge. According to a press release by the U.S. Attorney’s Office for the Southern District of California, Sofia Mancera Morales used individuals recruited over social media Bovitraz and Taktic, pesticide products banned in the US that pose hazards to pollinators and cancer risks to humans. “In exchange for ill-begotten profits, this cavalier smuggling operation was more than willing to risk the public’s health and the honeybee industry, which is critical to pollinating our food supply,” said U.S. Attorney Randy Grossman. While the Department of Justice deserves praise for this enforcement action, health and environmental advocates say that more must be done to stop illegal pesticide sales. A quick search for the two pesticide products in question brings up webpages, including well-known sites like Etsy.com, where the same illegal pesticides cited in this case are currently being sold to U.S. consumers. Over Facebook, Ms. Morales offered to pay individuals between $40-150 per package of pesticide products they delivered across the border. Those recruited were instructed to open a […]

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02
Jun

California Court Bans State-Run Pesticide Spraying for Failure to Consider Adverse Impacts

(Beyond Pesticides, June 2, 2022) A California judge ordered state-run pesticide spraying to cease on public, agricultural, wild lands, and private properties. The judge states that government officials fail to consider and minimize the potential health and environmental risk associated with pesticide use. Moreover, officials failed to notify the public on the risks of pesticide spraying. The suit was brought by the Environmental Working Group (EWG), the City of Berkeley and ten other public health, conservation and food safety organizations, including Beyond Pesticides. Board member of the California Environmental Health Initiative Nan Wishner states, “The court made the right decision to throw out CDFA’s plan to cement into place for the indefinite future the agency’s ‘spray now, ask questions later approach to pest management, which would have perpetuated the existing situation, in which Californians learn their yards or neighborhoods are to be sprayed only when the treatments are about to happen and have little or no recourse to stop the use of pesticides.”  On May 19, 2022, the Superior Court of California – County of Sacramento ruled to remove an environmental impact report allowing California’s Department of Food and Agriculture (CDFA) to spray pesticides at any time and any place. Removal […]

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30
May

This Memorial Day Show Your Support for Veterans Harmed by Toxic Chemical Exposure

(Beyond Pesticides, May 30, 2022) This Memorial Day, ask the U.S. government to show respect for veterans by recognizing Gulf War Illness (GWI) and honoring our commitment to those who have served the country. New research is providing strong causal evidence that Gulf War Illness (GWI) is the result of exposure to sarin gas, an organophosphate nerve agent, when Iraqi chemical weapons storage and production facilities were bombed during the Gulf War. The findings, published earlier this month in Environmental Health Perspectives, have important implications for the hundreds of thousands of American service members suffering from a constellation of chronic symptoms without a true understanding of how they became sick. “Quite simply, our findings prove that Gulf War illness was caused by sarin, which was released when we bombed Iraqi chemical weapons storage and production facilities,” said Robert Haley, MD, lead author of the study and epidemiologist at University of Texas Southwestern. “There are still more than 100,000 Gulf War veterans who are not getting help for this illness and our hope is that these findings will accelerate the search for better treatment.” Tell the Secretary of Veterans Affairs and the U.S. Senate to provide disability benefits to those veterans […]

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26
May

Neurotoxic Pesticides Disrupt Gut Function Linked to Parkinson’s Disease Development

(Beyond Pesticides, May 26, 2022) A study published in The International Journal of Biochemistry & Cell Biology finds environmental exposure to neurotoxic pesticides increases Parkinson’s Disease (PD) risk through gastrointestinal (GI) disruption. Research finds exposure to chemical toxicants, like pesticides, can cause neurotoxic effects or exacerbate preexisting chemical damage to the nervous system. Although the mechanism by which pesticides induce disease development remains unclear, this study suggests environmental pesticide exposure disrupts GI cells responsible for supporting the autonomic nervous system. Enteric glial cells (EGCs) are GI cells that play a critical role in the functional changes that accompany GI dysfunction, as this dysfunction is one of the earliest symptoms indicating the onset of PD. Parkinson’s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses each year. The disease affects 50% more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and sleep disturbances. Identifying early biomarkers of PD, such as pesticide-mediated toxicity on GI cells, is crucially important as symptoms intensify overtime, with no current cure for this fatal disease. While only […]

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25
May

Agrichemical Industry Demands Biden Administration Rescind Support for Cancer Victims Before Supreme Court

(Beyond Pesticides, May 25, 2022) Earlier this month, the U.S. Department of Justice urged the Supreme Court to deny a request by Bayer to review a verdict that found the corporation liable for damages from the use of its Roundup (glyphosate) herbicides. Now, Bayer is using proxy organizations to place pressure on the Biden Administration and Justice Department to rescind its decision. Alongside a range of chemical industry umbrella groups, many of which—like Croplife America—Bayer is a member of, a letter was sent to President Biden expressing “grave concern” about the opinion filed by Solicitor General Elizabeth Prelogar. Among a range of baseless claims, the agrichemical industry is deflecting lower court findings on the hazards and cancer risk of their products with the claim that their toxic chemicals are needed to feed the world, as crops shipments from Ukraine have been halted during the ongoing war. “The agrichemical industry has long tried to sell the idea that their toxic pesticides are needed to feed the world, as if to suggest that their motives are altruistic when, in fact, they have shown a callous disregard for life and a sustainable future,” said Jay Feldman, executive director of Beyond Pesticides. ” We […]

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24
May

Breakthrough Study Shows Organophosphate Nerve Gas Caused Gulf War Illness

(Beyond Pesticides, May 24, 2022) New research is providing strong causal evidence that Gulf War Illness (GWI) is the result of exposure to sarin gas, an organophosphate nerve agent used by Saddam Hussein as a chemical weapon during the Gulf War. The findings, published earlier this month in Environmental Health Perspectives, have important implications for the hundreds of thousands of American service members suffering from a constellation of chronic symptoms without a true understanding of how they became sick. “Quite simply, our findings prove that Gulf War illness was caused by sarin, which was released when we bombed Iraqi chemical weapons storage and production facilities,” said Robert Haley, MD, lead author of the study and epidemiologist at University of Texas Southwestern. “There are still more than 100,000 Gulf War veterans who are not getting help for this illness and our hope is that these findings will accelerate the search for better treatment.” Sarin was first synthesized in the late 1930s by Nazi chemists working for IG Farben (a consortium that included Bayer) in an attempt to create stronger and more powerful insecticides. Sarin is a G-series organophosphate (named after the scientists that created them), characterized by high acute toxicity and […]

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23
May

Broadscale Devastating Ecological and Health Effects Associated with Herbicide Indaziflam; Ask To Go Organic

(Beyond Pesticides, May 23, 2022)  The climate change-induced increase in wildfire frequency and intensity has lent new urgency to efforts to manage so-called “invasive” plants. Unfortunately, the herbicide-based approach favored by many is both counterproductive and hazardous. It must be replaced by an organic system, incorporating biological control agents like goats and establishing a more resilient ecology.    Tell your county/city officials to replace herbicides with organic vegetation management. Tell EPA and Congress that herbicides must be evaluated in the context of the availability of organic systems. Use of the herbicide indaziflam is an example of the ineffectiveness of management based on herbicides. While indaziflam is considered a “selective” herbicide, it actually kills and prevents germination of a wide range of broad-leaved plants and grasses and comes close to being a soil sterilant. The action on seedlings is long-lasting, thus inhibiting the growth and establishment of a resilient plant community that is resistant to invasion. Given its persistence and nonselective action and the extent of the damage it causes to native soil seed banks and plant biodiversity, indaziflam could contribute to the eventual ecological collapse of ecosystems where it’s applied, similar to the cascading impacts of the systemic insecticides, fipronil and […]

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19
May

Contaminated Environment and Chemical Exposure Puts Firefighters at Elevated Risk for Adverse Heart and Brain Effects

(Beyond Pesticides, May 19, 2022) A study published in the Journal of the American Heart Association finds a correlation between the number of fires fought annually and atrial fibrillation (AF), one of the most common medical arrhythmias that increases the risk of stroke, heart failure, and other cardiovascular health issues. In the firefighting occupation, firefighters can experience exposure to chemicals and particulate matter in smoke, pollutants, volatile organic compounds, and polycyclic aromatic hydrocarbons (PAHs) that increase cardiovascular (heart) and respiratory distress risk through oxidative stress and autonomic function disruption. However, firefighters encounter both personal and occupational (work-related) risk factors for cardiovascular diseases, making this subset of the population particularly vulnerable to heart-related fatalities. Considering firefighters live 10 to 15 years less than non-firefighters, studies like these are significant for understanding how chemical exposure contributes to health and wellness disparities. Lead author Paari Dominic, Ph.D., notes, “Clinicians who care for firefighters need to be aware of the increased cardiovascular risk, especially the increased risk of [AF], among this unique group of individuals… The conditions that elevate their risk further, such as high blood pressure, type 2 diabetes, lung disease and sleep apnea, should be treated aggressively. In addition, any symptoms of [AF], such as […]

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28
Apr

Glyphosate Breakdown Product Associated with Oxidative Stress and DNA Damage Among Children

(Beyond Pesticides, April 28, 2022) A study in Environmental Research finds that glyphosate’s primary metabolite (breakdown product), aminomethylphosphonic acid (AMPA), induces DNA damage through oxidative stress among subpopulations of primary school children. Although pyrethroid and chlorpyrifos metabolites can induce oxidative stress, this study is the first to investigate AMPA’s association with adverse health effects, rather than solely the effects of the active ingredient, glyphosate, in Roundup and other formulations. Glyphosate is the most commonly used active ingredient worldwide, appearing in many herbicide formulations, readily contaminating soil, water, food, and other resources. Chemical use has been increasing since the inception of crops genetically modified to tolerate glyphosate. However, studies demonstrate glyphosate is among the most prevalent pesticide contributors to human, biotic, and ecosystem harm. According to research, herbicide toxicity to invertebrates has doubled since 2004. Although research links glyphosate exposure to cancer, specifically non-Hodgkin lymphoma, much less research considers the effects that metabolites have on children who are more vulnerable to chemical exposure. Ecological and health risk assessments primarily focus on active ingredients in pesticide products, overlooking the potential impacts of metabolites. Thus, studies like these highlight the need to assess the implications of metabolite exposure to protect human, animal, and environmental health. The study notes, “Our […]

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20
Apr

Mother’s Exposure to Pesticides during Pregnancy Results in Sleep-Related Problems among Daughters

(Beyond Pesticides, April 20, 2022) A University of Michigan study is the first to highlight that maternal pesticide exposure during pregnancy adversely affects sleeping patterns for offspring later in life, specifically for females. Prenatal development is one of the most vulnerable periods of exposure as the fetus is most susceptible to the harmful effects of chemical contaminants. Many studies indicate that prenatal and early-life exposure to environmental toxicants increases susceptibility to diseases, from learning and developmental disabilities to cancer. However, the toxicity of pesticide exposure ad its full impact on the nonagricultural population in the U.S., especially women. Given research links to sleep-related disorders and neurological and cognitive development, studies like this can help government and health officials identify how pesticides’ impact on the brain elevates health concerns. The authors note, “Overall, these results are of public health importance considering the continued widespread agricultural and possibly residential use of pyrethroids and chlorpyrifos [in Mexico]…Thus, our results underline the importance of additional research studies that include both larger samples and assessment of unregulated pesticides, as well as studies that consider the underlying mechanisms explaining sex differences.” Levels of inadequate sleep patterns are rising among children and adolescents. Reports find variability in sleep duration results in higher rates of depression, anxiety, and […]

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