(Beyond Pesticides, April 14, 2021) Litigation on the highly toxic herbicide paraquat may soon move into its next phase as lawyers representing victims recently requested cases be consolidated in the federal district court of Northern California. Over a dozen lawsuits have been filed against the Swiss-based agrichemical corporation Syngenta in several states throughout the U.S. The complaints allege that exposure to Syngenta herbicides containing paraquat resulted in their diagnosis of Parkinson’s Disease. Paraquat dichloride (paraquat) is a highly toxic herbicide that has been registered for use in the United States since 1964. Although not permitted for residential use, the product is registered on a wide range of agricultural land, from row crops to vegetables and trees, and on non-farm areas, including airports, certain industrial sites and commercial buildings. It can be used as a preemergent, post-emergent, and post-harvest as a desiccant or harvest aid in the field. The lawsuits target both Syngenta and Chevron corporation, which previously held the rights to sell paraquat in the 1960s under an agreement with a company that was eventually purchased by Syngenta. Syngenta itself, while still headquartered in Switzerland, is now owned by the Chinese National Chemical Corporation (ChemChina) after a 2016 merger. Despite […]

(Beyond Pesticides, February 18, 2021) New research published in the journal Toxicological Sciences finds extended inhalation of the common herbicide paraquat causes male mice to lose some sense of smell, even at low doses. This study highlights the significance of understanding how specific chemical exposure routes can influence disease development. Olfactory (relating to the sense of smell) impairment is a precursory feature of Parkinson’s disease (PD), and studies connect paraquat poisoning to PD risk. Hence, future pesticide management policies should assess specific disease risks with bodily chemical concentration from low-dose, chronic neurotoxic chemical exposure. The study’s researchers note, “These data support the importance of route of exposure in the determination of safety estimates for neurotoxic pesticides, such as [paraquat]. Accurate estimation of the relationship between exposure and internal dose is critical for risk assessment and public health protection.” Despite evidence demonstrating that olfactory  nerve cells transport toxic airborne particles and solutes to the brain upon inhalation, the possibility of olfactory impairment (damage) from paraquat inhalation lacks adequate assessment. To assess the impact paraquat has on olfactory function, researchers exposed a cohort of adult female and male mice to paraquat aerosols in an inhalation chamber for four hours a day, five days a week, for four weeks. Researchers investigated paraquat concentrations […]

(Beyond Pesticides, November 5, 2020) Research at the University of California San Francisco (UCSF) finds that pesticide exposure increases the risk of developing Parkinson’s disease (PD), regardless of whether disease onset is idiopathic (spontaneous) or genetic (GBA genetic risk variant). Although the exact etiology of PD remains unknown, epidemiological and toxicological research repeatedly identifies exposure to pesticides, as well as specific gene-pesticide interactions, as significant adverse risk factors that contribute to PD. Furthermore, this study, “Gene Variants May Affect PD Risk After Pesticide Exposure,” suggests that environmental triggers like occupational exposure to pesticides can prompt PD in individuals with or without the genetic precursor. This research demonstrates the importance of assessing disease etiology concerning occupational pesticide exposure, especially if disease triggers are overwhelmingly non-hereditary. Since not all individuals genetically predisposed to the disease develop PD, with only 10 to 15 percent of PD cases being genetic, government officials need to consider alternate etiological pathways that include environmental risk factors. Study researchers note, “‘Environmental exposures may have differential effects in different genotypes’ and may predispose people with PD to different symptom burden.”  Parkinson’s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about […]

(Beyond Pesticides, July 14, 2020) The Mexican government announced late last month that it plans to phase out the importation and use of glyphosate in the country over the next four years. The announcement means that Mexico will join other countries, such as Luxembourg, Vietnam, Germany in prohibiting the chemical and the toxic consumer products, like Roundup, that contain it as an ingredient. International watchdogs are keeping an eye on reactions from the United States, which in recent years has worked to intervene in other countries’ decision-making over toxic pesticides. The government’s announcement cites the Precautionary Principle as part of its decision-making. According to the Wingspread Statement on the Precautionary Principle, “Where an activity raises threats of harm to the environment or human health, precautionary measures should be taken even if some cause and effect relationships are not fully established scientifically.” In the case of glyphosate, there is strong evidence, per a 2015 review by the International Agency for Research on Cancer (IARC), that glyphosate is carcinogenic. Since 2015, several more publications have added weight to glyphosate’s link to cancer. A February 2018 meta-analysis finds “a compelling link between exposures to GBH [glyphosate-based herbicides] and increased risk of NHL [non-Hodgkin […]

(Beyond Pesticides, July 7, 2020) One’s zip code plays an important role in the likelihood of developing Parkinson’s disease (PD), according to data published by Louisiana State University researchers in the International Journal of Environmental Research and Public Health. With genetics and exposure to agricultural pesticide use identified as the main factors affecting PD, proximity to certain cropland and its effluent had a major impact on disease risk. As with most environmentally related diseases, this study highlights the disproportionate risk and environmental racism low income, indigenous and people of color communities endure. Researchers received access to over 23,000 PD diagnoses in Louisiana between 1999 and 2012, and mapped these data by zip code. Risk was determined calculating the number of diagnoses per 10,000 people in a given zip code, based on census data. To flesh out the role agriculture was playing in PD diagnoses, additional data derived from water quality samples taken by the Louisiana Department of Health and Hospitals, and the U.S. Geological Survey pesticide use estimates were compared against reported disease incidence. Results show that certain zip codes faced significantly higher incidence of PD than others in the state. Further, “The PD high-risk areas match closely the arbor-pastoral […]

(Beyond Pesticides, May 15, 2020) New research out of Japan’s Chiba University suggests that exposure to glyphosate, the active ingredient in the most commonly used pesticide worldwide (Roundup), may be a risk factor in the development of Parkinson’s Disease. The ubiquity of glyphosate use in agriculture — which leaves residues of the toxic chemical in food — may mean that exposures to it represent a significant risk factor for the disease. Glyphosate is already implicated or proved in the development of numerous health anomalies, including cancer. Beyond Pesticides recognizes that pesticides play a variety of roles in causing or exacerbating negative health outcomes, including Parkinson’s Disease (PD). Transitioning pest management — in agriculture, land management, and household and personal care contexts — to nontoxic and organic approaches is the critical step away from bathing humans and the Earth in harmful chemicals. The researchers in this subject study, out of the Chiba University Center for Forensic Mental Health’s Division of Clinical Neuroscience, sought to investigate whether exposures to glyphosate could impact dopaminergic neurotoxicity in the brains of mice. They found that exposures to glyphosate in adult mice intensified a type of neurotoxicity associated with PD. [The abstract for the research paper, titled […]

(Beyond Pesticides, October 17, 2019) The U.S. Environmental Protection Agency (EPA) is downplaying the connection between exposure to the herbicide paraquat and the development of Parkinson’s disease, per registration review documents released by the agency this week. Although unsurprising given the current administration’s track record of defending some of the most heinous chemicals still on the market, the review nonetheless marks a low point for scientific integrity within EPA’s Office of Pesticide Programs, according to advocates. Health and environmental advocates have already discounted EPA’s industry-biased review, and are instead pushing hard for Congressional action – namely HR 3817, the Protect Against Paraquat Act, introduced by Congresswoman Nydia Velazquez (D-NY). Under federal law, pesticides are required to undergo reevaluation every 15 years. Paraquat is a potent restricted use herbicide, not available to be applied by residential users, but permitted for use on multiple agriculture crops. Over the last decade, independent peer-reviewed scientific studies have repeatedly found strong associations between paraquat to the development of Parkinson’s disease. Many of these studies have been covered in Beyond Pesticides’ Daily News or are recorded in the Pesticide-Induced Diseases Database. In response to this growing body of literature, EPA conducted an epidemiological evaluation of published […]

(Beyond Pesticides, July 23, 2019) Last week, U.S. Representative Nydia M. Velazquez introduced legislation to cancel all uses of the pesticide paraquat, which is acutely toxic and strongly linked to Parkinson’s disease. The move is supported by the Unified Parkinson’s Advocacy Council – a group led by The Michael J. Fox Foundation for Parkinson’s Research – as well as other health and environmental groups such as Beyond Pesticides. Paraquat, which is a dangerous, fast-acting nonselective herbicide that kills by burning living tissues, is also unnecessary. Organic agriculture provides an alternative that does not depend on toxic chemicals like paraquat. Tell your U.S. Representative to support H.R. 3817 to cancel the use of paraquat. According to the EPA, “one small sip [of paraquat] can be fatal, and there is no antidote.” Advocates are pushing for its elimination from the American agriculture system for many reasons, including acute toxicity and organ failure by inhalation, oral intake and dermal absorption; chronic toxicity affecting the eyes, lungs, liver, kidneys and endocrine system; and a higher incidence of various cancers after exposure. The EPA characterizes paraquat as “extremely biologically active and toxic to plants and animals.” The agency has previously determined that exposure to this herbicide […]

(Beyond Pesticides, December 20, 2018) Using low doses of the herbicide paraquat and common proteins found in food called lectins, researchers were able to recreate the symptoms of Parkinson’s disease in rats. Results of this study, published in the journal Parkinson’s disease, provide scientists with fresh insights into the development of the disease, and a new model to test potential remedies. Paraquat, a neurotoxic herbicide with a well-established body of literature linking it to Parkinson’s disease, is currently undergoing a registration review by the U.S. Environmental Protection Agency, and groups like the Michael J Fox Foundation are calling for its ban. Researchers based their study on the Braak Staging hypothesis of Parkinson’s, which posits that the disease is brought on by foreign agents entering the body through the gut or nose and making their way to the brain. Rats were exposed to low doses of paraquat combined with lectin every day for a week. After two weeks, the animals’ motor function was tested and compared to an unexposed control group. Rats exposed to lectin and paraquat exhibited Parkinson-like symptoms. Primary author R. Alberto Travagli, PhD, notes, “After observing that these animals did indeed show symptoms of Parkinsonism, we wanted to […]

(Beyond Pesticides, February 1, 2018) Scientists at the European Institute for the Biology of Aging are finding new information about how Parkinson’s disease manifests itself after exposure to the herbicide paraquat, in hopes of finding ways to prevent the progression of the disease. Despite a well-established body of scientific literature linking the paraquat to Parkinson’s, and a ban on the use of the chemical in the European Union that dates back to 2007, its use is still permitted in the U.S. Many health groups, including Beyond Pesticides and organizations like the Michael J Fox Foundation are calling on the U.S. Environmental Protection Agency stop the use of paraquat by denying its upcoming reregistration. Published in the journal Cell Reports, this new research on Parkinson’s investigates the impact of “senescent” cells in the body. Senescent cells are those which, despite being able to divide, stop doing so in response to stress. This is an anti-cancer mechanism, as stress would otherwise cause the cells to multiply unchecked and create malignancies. Researchers suspected that despite the benefit of stopping cancer, senescent cells may be causing other problems in the body. Rather than dying, these cells can cause inflammation in the area around where […]

(Beyond Pesticides, November 9, 2017) Vietnam veterans suffering from certain Agent Orange-related health conditions will continue to wait for compensation. U.S. Department of Veteran Affairs (VA) Secretary David Shulkin announced last week he intends to delay a decision to expand coverage to new illnesses. Despite a robust review by the National Academy of Medicine, which recommended expanding disability compensation for bladder cancer, hyopothyroidism, high blood pressure, and Parkinson’s-like tremors due to past exposure to the toxic herbicide cocktail, the VA decided to take no action. “After thoroughly reviewing the National Academy of Medicine (NAM)’s latest report regarding Veterans and Agent Orange, and associated data and recommendations from the NAM Task Force, I have made a decision to further explore new presumptive conditions for service connection that may ultimately qualify for disability compensation,”  Secretary Shulkin said in a press release last week.  “I appreciate NAM’s work and the commitment and expertise of VA’s NAM Task Force, and look forward to working with the Administration on the next steps in the process.” Given a promise from VA Secretary Shulkin to provide a decision on the new ailments by November 1st, Veterans groups are crying foul, and placing blame on the Trump administration, […]

(Beyond Pesticides, December 11, 2015) Milk contaminated with the long-banned and toxic organochlorine pesticide heptachlor in Hawaii has been found  in the brains of men that were more likely to develop Parkinson’s disease, according to a new study. This study adds to a large body of evidence linking pesticide exposure to Parkinson’s disease. Researchers of the study, titled “Midlife milk consumption and substantia nigra neuron density at death” and published in the journal Neurology, collected milk intake data from 1965 to 1968 for 449 men aged 45-68 years withpostmortem examinations from 1992 to 2004. Neuron density was measured in an area of the brain called substantia nigra (SN). As Parkinson’s develops, cells are destroyed in certain parts of the brain stem, particularly in the SN, a crescent-shaped cell mass. Measurements of brain residues of heptachlor epoxide, a heptachlor metabolite that is persistent and more toxic than its parent chemical, were also taken. “Among those who drank the most milk, residues of heptachlor epoxide were found in 9 of 10 brains as compared to 63.4%…for those who consumed no milk,” the researchers wrote. Neuron density was lowest in subjects who consumed the highest amounts of milk. The researchers looked at milk […]

(Beyond Pesticides, June 23, 2015) After years of denial and obstruction, Air Force and Air Force Reserve veterans now have the chance to receive compensation for their exposure to the highly toxic herbicide Agent Orange on contaminated aircraft used after the Vietnam War. Affected veteran’s health issues stem from their time spent on UC-123 transport planes, which during the war were outfitted with spray equipment in the American military’s attempt to eliminate forest cover for Vietcong fighters. After the war, these aircraft were returned to use in the United States for basic transport operations such as cargo shipping and medical evacuation missions. However, these planes never underwent any form of decontamination or testing before being repurposed. Though the Agent Orange Act of 1991 stipulated medical care and disability coverage for sick veterans who  served in the Vietnam War and were exposed to Agent Orange, those who flew in contaminated post-war planes were deemed ineligible. Prior to this recent announcement from the Department of Veteran’s affairs, government officials asserted that the “dried residues” of Agent Orange were not likely to pose a health threat to aircraft crew. However, a study published by the National Academy of Sciences Institute of Medicine in […]

(Beyond Pesticides, December 23, 2014) The U.S. Department of Agriculture’s (USDA) Agricultural Marketing Service (AMS) has posted a report on its data from the 2013 Pesticide Data Program (PDP) Annual Summary, concluding that although over half of the food tested by the agency for pesticide residues last year showed detectable levels of pesticides, these levels are below the tolerances established by the Environmental Protection Agency (EPA) and do not pose a safety concern. The residues reflect a pesticide use and exposure pattern that raises hazard scenarios that are not fully evaluated by EPA for chemical mixtures, synergistic effects, impacts  on  people and environments  with high risk factors, and certain critical health endpoints, such as endocrine disruption  . Excluding water, of the 9,990 samples analyzed, 23.5 percent had one pesticide detected and 36 percent had more than one pesticide. Residues exceeding tolerances were detected in 0.23 percent (23 samples out of 9,990) of the samples tested. Of these 23 samples, 17 were imported and 6 were domestic. Residues with no established tolerances were found in 3.0 percent of samples, of which 50.2 percent were domestic and 49.2 percent imported. According to USDA, “The Pesticide Data Program provides reliable data through rigorous […]

(Beyond Pesticides, December 10, 2013) A former steward for Australian-based Quantas airlines is suing the Australian government claiming that frequent insecticide use in airplane cabins resulted in his Parkinson’s disease diagnosis. Australia is among 49 countries that require pesticide spraying on some or all flights. Pesticide use on flights into the United States is not required, but is permitted under international law. (See here for a breakdown of pesticide use in American-based airlines, and here for information from the U.S. Department of Transportation on pesticide use in aircrafts.) Brett Vollus, former Quantas airline steward, worked for the company for 27 years until this past May when he was diagnosed with Parkinson’s and a malignant brain tumor. “He [my doctor] asked me what I did for living and when I told him he just nodded and said: ‘Another one, I am seeing a lot of you’,” Mr. Vollus said to The Australian. “This is a nightmare that has ruined my life. I am very keen to start a legal action and if it can help others I am happy to lead the way.” This case puts an international spotlight on growing evidence that pesticide use is linked to Parkinson’s disease. Parkinson’s […]

(Beyond Pesticides, December 6, 2013) In a new study exploring gene-environment interactions, researchers find that individuals with a genetic mutation linked to Parkinson’s disease are more likely to develop the neurodegenerative disease if they are exposed to pesticides. The study, Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF 2-PGC1α Transcription, identifies the molecule that protects neurons from pesticides, ties genetic mutation to pesticide exposure, and demonstrates that low dose exposure can cause Parkinson’s disease. The study, conducted by researchers at the Massachusetts Institute of Technology and the Sanford-Burnham Medical Research Institute in La Jolla, CA, supports previous epidemiological and animal studies that demonstrate the link between pesticide exposure and neurological damage, using human stem cells as a model. “For the first time, we have used human stem cells derived from Parkinson’s disease patients to show that a genetic mutation combined with exposure to pesticides creates a ‘double hit’ scenario, producing free radicals in neurons that disable specific molecular pathways that cause nerve-cell death,” says lead author Stuart Lipton, M.D., Ph.D., professor and director at the Sanford-Burnham’s Medical Research Institute. Using skin cells from Parkinson’s patient who already possess the genetic mutation linked to the disease, researchers transformed […]

(Beyond Pesticides, May 30, 2013) New research published in the journal Neurology further supports the causative link between pesticide exposure and Parkinson’s disease. Emanuel Cereda, M.D., Ph.D., of the IRCCS university Hospital San Matteo Foundation in Pavia, Italy, and coauthor Gianni Pezzoli, M.D., analyzed 104 studies published between 1975 and 2011 to determine the link between pesticides and solvents to Parkinson’s disease. The researchers analyzed exposure using information on proximity to large farms likely to use pesticides, likelihood of well water consumption, and occupations that cause greater exposure to pesticides and solvents used to kill weeds, insects, fungus, and rodents. Overall, researchers found exposure to pesticides increased the risk of developing the disease by 33%  to 80%.   Some pesticides were considered to be of higher risk than others, with weed killers like paraquat and fungicides maneb and mancozeb causing twice the risk for development of Parkinson’s disease. While risk increased the longer people were exposed to pesticides, researchers indicate there is still a need for further research on the chemical threshold for harm to the brain. The study builds on recent research that has linked Parkinson’s disease to pesticide exposure. In a 2011 article published in the journal Molecular […]

(Beyond Pesticides, May 9, 2013) A review of the scientific literature of the toxic effects of glyphosate, one of the most popular weed killers in the U.S. and the active ingredient in Roundup, links the herbicide  to a wide range of diseases and suggests  that more research is needed. The review, conducted by a scientist at Massachusetts Institute of Technology (MIT), looks at the mechanisms through which the adverse effects may be happening and points to  the chemical’s inhibition of cytochrome P450 (CYP) enzymes, which plays the crucial role of detoxifying xenobiotics. Thus, glyphosate can enhance the negative effects of other environmental toxicants on the body. Authors argue that this has been a critically overlooked component in research on glyphosates’ toxicity to mammals. We “have hit upon something very important that needs to be taken seriously and further investigated,” Stephanie Seneff, PhD, lead author and research scientist at MIT, told Reuters. Not surprisingly, Monsanto, the developer of Roundup, the leading product containing glyphosate, has attempted to discredit the study, claiming that its product has a long track record of being safe – read Another Bogus “Study.” However, Beyond Pesticides has assembled  extensive documentation on the human health and environmental risks […]

(Beyond Pesticides, January 8, 2013) Neurologists at the University of California, Los Angeles (UCLA) have published their latest research linking pesticide exposure to Parkinson’s disease. Appearing in the online edition of PNAS, the UCLA scientists’ work details the series of events that can occur after individuals are exposed to the pesticide benomyl, which was phased out in 2001. Researchers believe their findings on the series of events the pesticide sets in motion could be applicable even to Parkinson’s patients who have not been exposed to benomyl. According to scientists, exposure to benomyl prevents the enzyme aldehyde dehydrogenase (ALDH) from keeping in check a naturally occurring toxin in the brain called 3,4-Dihydroxyphenylacetaldehyde (DOPAL). Without ALDH regulating DOPAL, the toxin accumulates, damages neurons, and increases an individual’s risk of developing Parkinson’s disease. Researchers postulate that this process may be occurring in people with Parkinson’s who were never exposed to pesticides. The findings of this research provide insight into possible treatments to slow the disease, such as developing new drugs to protect ALDH activity. Although the exact cause of Parkinson’s is still unknown, until this research scientists were focusing in on the protein a-synuclein as a pathway to the disease. The protein, present […]

(Beyond Pesticides, November 14, 2012) For years, scientists have shown that pesticide exposures are linked to the onset of Parkinson’s disease. Now a new study by researchers at University of California, Los Angeles, (UCLA) finds that exposure to pesticides and suffering a head injury are associated with a three-fold increase in one’s chances of developing Parkinson’s disease. Parkinson’s disease is the second most common neurodegenerative disease, and occurs when nerve cells in the substantia nigra region of the brain are damaged or destroyed and can no longer produce dopamine, a nerve-signaling molecule that helps control muscle movement. People with Parkinson’s disease have a variety of symptoms, including loss of muscle control, trembling and lack of coordination. Over time, symptoms intensify. At least one million Americans have Parkinson’s and about 50,000 new cases are diagnosed each year. The study, “Traumatic brain injury, paraquat exposure, and their relationship to Parkinson disease,” published in the journal Neurology surveyed more than 1,000 adults ages 35 and older who lived in central California. Some 357 of the participants were diagnosed with Parkinson’s disease. Participants with the disease were nearly twice as likely as those without the disease to report having had a head injury in […]

(Beyond Pesticides, June 29, 2012) New research from the McGill University Health Centre (MUHC) in Montreal suggests that pesticide exposure, as well as smoking, head injury, farming, and less education, may be a risk factor for a rare sleep disorder that causes people to kick or punch during sleep, according to a study entitled “Environmental risk factors for REM sleep behavior disorder: A multicenter case-control study” published in the June 27, 2012, online issue of Neurology, the medical journal of the American Academy of Neurology. People with the disorder, called REM sleep behavior disorder, do not have the normal lack of muscle tone that occurs during rapid eye movement (REM) sleep, causing them to act out their dreams. The movements can sometimes be violent, causing injury to the person or their bed partner. The disorder is estimated to occur in 0.5 percent of adults. “Until now, we didn’t know much about the risk factors for this disorder, except that it was more common in men and in older people,” said study author Ronald B. Postuma, MD, MSc, with the Research Institute at MUHC and a member of the American Academy of Neurology. “Because it is a rare disorder, it was […]

(Beyond Pesticides, June 28, 2011) Recent studies have linked Parkinson’s disease to pesticide exposure. In a new article published in the journal Molecular Neurodegeneration, researchers at the University of Missouri School of Medicine take some of the first steps toward understanding this link and unraveling the molecular dysfunction that occurs when proteins are exposed to environmental toxins. The study, “Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation,” helps further explain recent NIH findings that demonstrate the link between Parkinson’s disease and two particular pesticides — rotenone and paraquat. “Fewer than 5 percent of Parkinson’s cases are attributed to genetics, but more than 95 percent of cases have unknown causes,” said Zezong Gu, MD, PhD, assistant professor of pathology and anatomical sciences. “This study provides the evidence that oxidative stress, possibly due to sustained exposure to environmental toxins, may serve as a primary cause of Parkinson’s. This helps us begin to unveil why many people, such as farmers exposed to pesticides, have an increased incidence of the disease.” Scientists previously understood that Parkinson’s is associated with oxidative stress, which is when electronically unstable atoms or molecules damage cells. The MU study yields […]

(Beyond Pesticides, May 31, 2011) A study has found that people whose workplaces were close to fields sprayed with chemicals — not just those who live nearby — are at higher risk of developing Parkinson’s disease (PD). The pesticide chemicals in question include two fungicides -maneb (in the ethylene bisdithiocarbamate (EDBC) family and ziram (in the dimethylthiocarbamate family)- and the herbicide paraquat that appear to raise the risk of developing the movement disorder. In a study published in the European Journal of Epidemiology, entitled, “Parkinson’s disease risk from ambient exposure to pesticides,” a team of researchers led by UCLA neurologist Beate Ritz, PhD found that exposures to the trio of pesticides are actually higher in workplaces located near sprayed fields than they were in residences. And the combination of exposure to all three pesticides, which act in different ways to harm brain cells involved in Parkinson’s disease, appears to be cumulative, the team led by Dr. Ritz concludes. The study found that the combined exposure to pesticides ziram, maneb and paraquat near any workplace increased the risk of Parkinson’s disease threefold, while combined exposure to ziram and paraquat alone was associated with an 80% increase in risk. The researchers estimate […]