(Beyond Pesticides, November 27, 2018) The U.S. Environmental Protection Agency (EPA) ignored the input of an expert weed scientist on the controversial herbicide dicamba, bending to Bayer’s Monsanto and the pesticide industry, according to emails obtained by the Arkansas Democrat and Chronicle (ADC) through a Freedom of Information Act request. The scandal centers on the recent re-approval of the pesticide, a highly volatile and drift-prone herbicide that has become a serious problem for many farmers and state regulators. As top-level EPA officials continue to work with industry to subvert their own agency’s scientific findings, more and more consumers are moving to organic products in order avoid the pesticide risks government regulators ask consumers to accept. Emails ADC received indicate that Jason Norsworthy, PhD, a weed scientist with the University of Arkansas, worked closely with Bayer’s Monsanto in conducting field trials this past summer, but found high volatility and drift of the company’s new dicamba-based herbicide XtendiMax. The product was developed in the face of widespread resistance to glyphosate-based herbicides in genetically engineered (GE) farm fields. However, recent accounts from farmers in the south and midwest indicate that, not only is the switch to dicamba unhelpful  in eliminating drift and reversing escalating weed resistance, its […]

(Beyond Pesticides, November 21, 2018) A study published last month in the Journal of Apicultural Research finds significant numbers of U.S. honey bees at risk after exposure to hazardous synthetic pesticides intended to control mosquitoes. With many beekeepers rarely given warning of insecticide spraying, researchers say the risk of losing colonies could increase. Advocates say fear of Zika and other mosquito-borne illnesses could result in counterproductive and reactionary insecticide spraying that will add further stress to managed and native pollinators already undergoing significant declines. Researchers aimed to determine whether neighboring honey bee colonies could be similarly affected by aerial insecticide spraying. To calculate the percentage of colonies that could be affected, density of honey bee colonies by county was compared with projections of conditions thought to be prone to regional Zika virus outbreaks. Researchers found 13 percent of U.S. beekeepers at risk of losing colonies from Zika spraying. In addition, it was determined that many regions of the U.S. best suited for beekeeping are also those with favorable conditions for Zika-prone mosquitoes to proliferate. These regions include the southeast, the Gulf Coast, and California’s Central Valley. “[Considering] all the threats facing bees,” says study lead author Lewis Bartlett of the […]

(Beyond Pesticides, November 16, 2018) Pesticides and biocides used to control bacterial infections in humans and weeds and pests in agriculture are surpassing ‘planetary boundaries’ within which human civilization can continue to rely on these biocides, according to a review by an international team of scientists working on the Living with Resistance project. While the study reinforces the role of susceptible populations in managing resistance, it fails to distinguish essential differences between antibiotic resistance and resistance to pesticides that is identified by Beyond Pesticides. The study focuses on six different forms of resistance. Researchers looked at antibiotic resistance in gram negative bacteria (such as E. coli, P. aeruginosa, Salmonella) and gram positive bacteria (such as S. aureus, Clostridium) separately, due to their divergent resistance mechanisms. Pesticide resistance was divided among herbicides in general, herbicide resistant crops, insecticides in general, and genetically engineered (GE) crops that produce their own insecticide. Resistance to antibiotics and pesticides are similar in that they are both evolved responses to substances toxic to the organism. However, lumping them together in evaluating their importance to human health and survival does not recognize important differences in context. “Without new approaches, going to hospital in the future will increasingly become […]

(Beyond Pesticides, November 8, 2018) Two months after publishing its first series of tests, part two of an Environmental Working Group (EWG) study finds residues of Roundup’s active ingredient, glyphosate, in all General Mills’ Cheerios and PepsiCo’s Quaker Oats products sampled. Health advocates are expressing concern about the consequences of chronic glyphosate exposure, and say U.S. federal agencies must limit the herbicide’s use on oat-based breakfast foods regularly marketed to children. In addition, organic itself is under threat, as chemical-intensive management practices undermine the future of the growing organic movement. In this second round of testing, EWG scientists purchased products around San Francisco and Washington DC. 28 samples of conventional and 16 samples of organic oat products were collected. Approximately 300 grams of each General Mills and PepsiCo product were packaged and shipped to Anresco Laboratories, in San Francisco. Detected glyphosate residues were compared to EWG’s own health benchmark of 160 parts per billion (ppb). This benchmark is based on risks of lifetime exposure and what EWG scientists consider allowable and protective of children’s health with an adequate margin of safety.  EWG’s results detected glyphosate residues in all 28 samples of conventionally grown oat products. The vast majority (all but two) […]

(Beyond Pesticides, October 16, 2018) Bacteria exposed to widely used herbicides like Roundup develop antibiotic resistance 100,000 times faster than average, according to new research published by New Zealand scientists in PeerJ. The results have ominous implications for the modern world’s ability to avert a post-antibiotic era. Even if new antibiotics are discovered, or existing compounds used more judiciously, scientists say that will not be enough to prevent the ongoing crisis – the world is also confronting bacterial exposure to herbicides and other non-antibiotic agents that have the ability to rapidly induce resistance. “Herbicides are among the most widely used and dispersed manufactured products on Earth. Some form of exposure for people, pets and livestock can be routinely expected,” study author Jack Heinemann, PhD, told Newsweek. “Meanwhile, antibiotics are used at high rates particularly on people, pets and livestock. Therefore, the combination of exposures for bacteria that live on us is all but guaranteed.” This current round of research by Dr. Heinemann and his team is the outgrowth of previous studies (1, 2) that established the ability of common herbicides to induce antibiotic resistance in strains of pathogenic bacteria Salmonella eterica and Escherichia coli. Now, the scientists are drilling into […]

(Beyond Pesticides, August 2, 2018) Weed scientists from the University of Missouri (UM) have just published evidence of a water hemp population resistant to six different herbicides. The study is sending shock waves throughout the chemical-intensive agricultural community, particularly in light of the plant’s resistance to 2,4-D. In its reporting on the study, KTIC Rural Radio begged the question, “If we’re already seeing 2,4-D resistance now, what will happen when use of the herbicide becomes even more commonplace?” KTIC is referring to the impending commercialization of products like Enlist Duo, developed by DowDupont in an attempt to address widespread weed resistance to glyphosate. Enlist Duo is an herbicide containing both glyphosate and 2,4-D, and is intended to be sprayed only on crops genetically engineered (GE) to tolerate exposure to both chemicals. However, with growing reports like this, many farmers may begin to rethink their approach. In 2014, a farmer contacted UM indicating that water hemp was not responding to 2,4-D during a regular ‘burndown’ the farmer conducted before planting a new crop. (Chemical-intensive farmers will often use a synthetic herbicide to clear their field for new plantings.) The farmer had also used other herbicides, fomesafen and glyphosate, in this process […]

(Beyond Pesticides, May 9, 2018) An insect’s gut microbiome plays an important role in conferring pesticide resistance, according to a new review published in the Annals of the Entomological Society of America. “Whether you’re looking at agricultural pests, household pests like cockroaches, or medical pests like disease-carrying mosquitoes, insects are great at adapting to whatever we throw at them, especially when it comes to different chemicals,” said lead author Jose Pietri, Ph.D to Entomology Today. The review adds to the numerous ways pests can evade the effects of chemical agriculture, reinforcing calls from recent studies showing that the best method of addressing this issue is to simply stop using synthetic pesticides and employ alternative pest management practices. The authors identify two overarching methods through which microbes help confer resistance to toxic pesticides. The first involves the pest accepting a physiological trade-off, where a pest is able to better withstand an insecticide at the cost of losing its ability to regulate certain gut bacterium. For instance, diamondback moths resistant to fipronil and chlorpyrifos are found to contain higher levels of Lactobacillales, Pseudomonadales, and Xanthomonadales bacteria than non-resistant moths. While this trade-off affects the fitness of the organism, alterations of the bacterial […]

(Beyond Pesticides, April 10, 2018) Current strategies aimed at managing herbicide resistant weeds in agriculture are not effective and may exacerbate weed problems, according to research published earlier this year by scientists at University of Sheffield in the United Kingdom (UK). While the conventional wisdom in farming, promoted strongly by the chemical industry, is that resistance can be adequately managed by rotating the herbicides used, researchers did not find evidence to support this strategy. In an ode to Occam’s razor, a philosophical theory that hypotheses with the fewest assumptions may be the correct one, researchers found the best method to reduce weed resistance to herbicides was to reduce the overall use of herbicides. Sheffield scientists focused their research on the occurrence of a common weed in the UK called black-grass. This weed was found to occur on 88% of the farmland tested in the study, and has recently been spreading into new areas it had never before colonized. Rob Freckleton, PhD, a population biologist and co-author of the study indicated to Science Daily, “The driver for this spread is evolved herbicide resistance: we found that weeds in fields with higher densities are more resistant to herbicides.” Thus, the more abundant […]

(Beyond Pesticides, July 12, 2017) In a move that threatens to further the spread of antibiotic resistance, researchers at the University of Western Australia (UWA) mining a collection of antimalarial drugs for potential new herbicides. Joshua Mylne, PhD, a senior lecturer in the School of Molecular Sciences (SMS) who directs the project, got started based on work he did while in the Australian Army Reserve. There he discovered that “malarial parasites are actually closely related to plants.” Due to widespread resistance of weeds to the popular herbicide glyphosate, Dr. Mylne began investigating antimalarial drugs as potential replacements. Malaria parasites are actually protozoans in the genus Plasmodium. Their crucial connection with plants is that the parasite contains a plastid similar to the chloroplast in plants. Like the chloroplast in plants, this plastid is critical for the survival of the parasite. Along with organic chemist Keith Stubbs, PhD, associate professor in SMS, Dr. Mylne began screening chemicals in the “Malaria Box,” an open source collection of potential anti-malarial drugs that have never been commercialized. Of the 20 chemicals tested on the small weed Arabidopsis thaliana, 11 were found to have some herbicidal activity. They were then compared to the herbicides glyphosate, glufosinate, asulam, […]

(Beyond Pesticides, June 26, 2017) A new report released last week by the U.S. Environmental Protection Agency’s (EPA) Office of the Inspector General finds that the agency must collect and assess information on chemical mixtures and potential synergistic effects in order to improve oversight over pesticide registrations and management of developing herbicide resistance. Synergy results when the mixture of chemicals creates effects greater than the aggregation of individual effects, leading to underestimated toxic impacts on human and environmental health. EPA’s Office of Chemical Safety and Pollution Prevention states it will consider how best to use synergistic effects data for pesticide registration decisions by 2019. The report, released June 21, 2017, EPA Can Strengthen Its Oversight of Herbicide Resistance With Better Management Controls, is the result of an assessment into EPA’s management and oversight of resistance issues related to herbicide-resistant genetically engineered (GE) crops. The report finds, “EPA uses the pesticide registration process to collect information on human health and environmental risks from pesticides used on herbicide-resistant weeds, but no information is collected regarding synergism.” It states that information on synergy is important because it allows EPA “a greater ability to assess human health and environmental risks combined with real-world pesticide […]

(Beyond Pesticides, June 21, 2017) More than 200 international scientists and medical professionals have signed the Florence Statement on Triclosan and Triclocarban, which states that triclosan and its chemical cousin triclocarban pose a risk to human health, and urges the international community to limit use of these antimicrobials, which are associated with bacterial resistance and no more effective than soap and water. In 2016 after manufacturers failed to prove efficacy, the U.S. Food and Drug Administration (FDA), which regulates cosmetic triclosan products, announced that manufacturers must, by September 2017, remove triclosan from over the counter hand soaps. The agency still allows the chemical in toothpastes and other products, such as hand wipes. The Environmental Protection Agency (EPA), which regulates triclosan in household items, textiles and plastics, still permits wide use of the chemical in a range of products. The Florence Statement on Triclosan and Triclocarban is “based on extensive peer-reviewed research,” and “concludes that triclosan and triclocarban are environmentally persistent endocrine disruptors that bioaccumulate in and are toxic to aquatic and other organisms.” The statement includes evidence of human health threats, and provides recommendations intended to mitigate harm from triclosan, triclocarban, and other similar antimicrobials. The recommendations are listed below: “Avoid […]

(Beyond Pesticides, June 7, 2017) Fruit flies that developed a genetic resistance to the insecticide DDT have lower success at mating than those without similar changes, according to a study published last month in the journal Behavior Genetics. The results were surprising to researchers, given that the resistance developed through changes to a single allele (a variation of a single gene). “It is amazing that even if all the genes are exactly the same, having this one gene expressed at a higher level has all these effects,” said Professor Nina Wedell, PhD, of the Centre for Ecology and Conservation on Exeter’s Penryn Campus in Cornwall, UK to Phys.org. The study raises possible concerns about the effect of pesticide exposure to non-target (not the focus of pesticide use) insects that are integral to a healthy ecology and food web. In conducting their investigation, researchers studied the biological fitness costs associated with the development of an insecticide resistance gene. After scientists bred resistant flies in the lab, they set up a series of “competitive mating trials,” comparing both courtship behavior and the impact of size on male fruit flies’ mating success. In general, resistant males were found to be smaller than flies that […]

(Beyond Pesticides, March 22, 2017) Today, a coalition of farmers and environmental and public health organizations filed a lawsuit against the Environmental Protection Agency (EPA) for approving agrochemical giant Dow Chemical’s toxic pesticide combo, Enlist Duo, among the newer more highly toxic pesticide mixtures used in genetically engineered (GE) herbicide-tolerant crops. Comprised of glyphosate and 2,4-D (50% of the mixture in the warfare defoliant Agent Orange), Enlist Duo is typically marketed alongside commercial crops like corn, cotton and soybeans that are engineered to withstand pesticide exposure, leading to problems of resistance and driving the evolution of super weeds. This is the third lawsuit challenging EPA approval of Enlist Duo by petitioners, which include Beyond Pesticides, National Family Farm Coalition, Family Farm Defenders, Pesticide Action Network North America, Center for Food Safety, and Center for Biological Diversity, represented jointly by legal counsel from Earthjustice and Center for Food Safety. The lawsuit charges that approval of Enlist Duo “will lead to sharply increased spraying of toxic pesticides, harming farmers, neighboring crops, and wildlife.” Specifically farmers’ health and financial positions stand to be heavily impacted by the approval of Enlist Duo, as increased use will result in increased pesticide drift, an alarming concern especially […]

(Beyond Pesticides, March 20, 2017) Last week, the Environmental Protection Agency (EPA) announced it is allowing residues of antibiotics in Florida orange juice, after approving an emergency exemption for the antibiotics streptomycin and oxytetracycline –allowing their use for a bacterial disease, citrus greening (Candidatus Liberibacter asiaticus (CLas) bacterium that causes Huanglongbing), in Florida citrus crops through December of 2019, and further exacerbating bacterial resistance. The World Health Organization has called bacterial resistance “one of the biggest threats to global health, food security, and development today.” The agency announced March 15, “EPA is issuing these tolerances without notice and opportunity for public comment as provided in FFDCA section 408(l)(6).” EPA states “time-limited tolerances are established for residues of streptomycin in or on fruit, citrus, group 10-10, at 2 ppm, and the dried pulp of these commodities at 6 ppm.” For oxytetracycline, EPA is allowing residues ” in or on all commodities of fruit, citrus, group 10-10, at 0.4 ppm.” [See below; organic standards do not allow antibiotic use.] In its review, EPA has determined that the toxicological endpoints of dietary exposure under the allowed tolerances meet the safety standard of the Federal Food, Drug and Cosmetic Act, but does not consider the public health impact of bacterial resistance to […]

(Beyond Pesticides, March 9, 2017) A recent European Parliament (EP) report concludes that organic agriculture and food offer clear human health benefits over chemical-intensive agriculture. The report, Human health implications of organic food and organic agriculture, which was written by scientists from universities across Europe, used existing scientific literature to assess the human health effects from organic agricultural systems. The authors determined that organic agriculture has considerable benefits, including reduction in antibiotic resistance, lowered levels of cadmium in organic crops, and decreased dietary pesticide exposure levels. According to the EP report, “Overall, consumption of organic food substantially decreases the consumer’s dietary pesticide exposure, as well as acute and chronic risks from such exposure.” Organic farming is a systems approach that values healthy, biologically active soils to support plant life and provide critical environmental benefits, such as improved water infiltration, pest suppression, and carbon storage. It is through this preventive, systems approach that organic agriculture eliminates the necessity for pesticides, and instead relies upon soil health to prevent the problems that chemical-intensive agriculture cannot. This report adds to the growing body of evidence on impaired learning and lowered IQs in children prenatally exposed to low levels of certain pesticides, such as organophosphates. The […]

(Beyond Pesticides, January 27, 2016) Last week, farmers, environmentalists, and conservation groups filed a federal lawsuit that challenges the U.S. Environmental Protection Agency’s (EPA) approval of a new formulation of the toxic herbicide dicamba. The new formulation is called Xtendimax with Vapor Grip Technology, which is claimed to have lower volatility. The petitioners claim that EPA violated its duties under the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA) in issuing a conditional registration, and that it did not adhere to duties under the Endangered Species Act that require EPA to consult with the U.S. Fish and Wildlife Service to ensure registration would not harm any listed species. The organizations involved in the lawsuit are National Family Farm Coalition, Pesticide Action Network North America, Center for Food Safety, and Center for Biological Diversity, represented by legal counsel from Earthjustice and Center for Food Safety. Dicamba has caused a lot of controversy in the past. In August 2016, farmers in Missouri, Arkansas, and Tennessee confronted widespread crop damage and braced for lower yields as a result of agrichemical giant Monsanto’s botched roll-out of GE soybean and cotton crops. The company, whose current line of glyphosate-tolerant crops are failing to control weeds throughout […]

(Beyond Pesticides, January 18, 2017) Despite science affirming its hazards, the U.S. Environmental Protection Agency (EPA) has expanded the registration of the toxic herbicide mixture, Enlist Duo, which contains 2,4-D and glyphosate, for use on genetically engineered (GE) cotton and extended its use on GE corn, soybean, and cotton from 15 to 34 states. This approval late last week comes at a time when widespread chemical use is threatening public health and the environment and weed resistance continues to grow, threatening farmers’ productivity and profitability. Over 600 public comments were submitted to EPA on this issue, with many comments vehemently opposing the current uses and the proposed expansion of uses. In its decision, EPA stated that Enlist Duo “meets the safety standard for the public, agricultural workers, and non-target plants and animal species.” However, as Beyond Pesticides stated in comments to the agency, EPA has not fully considered all the environmental costs, including the cost of tackling increased 2,4-D resistant weeds, crop and non-target damages from uncontrolled drift, as well as unanswered questions regarding synergistic chemical effects in non-plant species. Advocates predict weed resistance to Enlist Duo and have urged EPA to reject its continued use and incentive sustainable organic practices. Additionally, […]

(Beyond Pesticides, January 5, 2017) Winegrowers in the Texas High Plains region are concerned that approval of new herbicides by the U.S. Environmental Protection Agency (EPA) will devastate their profitable industry due to chemical damage from pesticide drift. Wine producers in this region of Texas have witnessed chemical damage to their vineyards that they blame on the toxic herbicides, dicamba and 2,4-D, used on cereal crops and pastures on surrounding agricultural land. A new herbicide formulation containing dicamba, XtendiMax with VaporGrip Technology, was approved by EPA, and the agency has recently proposed to register and expand the use of Enlist Duo, a herbicide that contains 2,4-D. EPA’s final decision on registration of Enlist Duo is expected in early 2017. According to Paul Bonarrigo, owner of Messina Hof Winery in Texas, the “approval of these formulations will wind up affecting every vineyard up there.” This will have ramifications across Texas, as the wine industry contributed $1.88 billion to the state’s economy in 2013. Advocates say that the new herbicide formulations present unreasonable adverse risks to humans and the environment in addition to harming the livelihood of farmers. Following on these concerns, Garrett Irwin, owner of Cerro Santo vineyard, stated,“If we get […]

(Beyond Pesticides, December 24, 2016) Beyond Pesticides thanks our members and supporters for being a part of a critical movement to advance sustainable and organic land and building management in 2016. As our Daily News takes a holiday break, returning Tuesday, January 3, 2017, we hope you will join us in reflecting on the progress made this year, and the critical challenges that lie ahead. The road ahead We are entering a period in our nation’s history with many serious concerns about the protection of public health and the environment. We have heard the President-elect’s rhetoric about the overreach of the Environmental Protection Agency (EPA), the burden of regulatory compliance, and the need to dismantle environmental programs. The nominee for EPA Administrator is on record as challenging science and the value of environmental protection. In contrast, we have learned over the last several decades that protection of the environment contributes to a productive economy and healthier people. Beyond Pesticides’ databases track the scientific literature on pesticide hazards and alternatives, which clearly document the value of healthy ecosystems in providing ecosystem services that translate to reduced costs for farmers and land managers. Whether we’re talking about bees and other pollinators or predator insects, […]

(Beyond Pesticides, December 2, 2016) Last week, the Arkansas Plant Board voted 12-0 to push measures that would ban or limit the use of certain forms of the toxic herbicide dicamba in the state. The hearing was called to address proposals that the board released for public comment on September 30, such as banning certain formulations of dicamba outright, creating restrictions on the time of year that other formulations of the herbicide can be used, and creating buffer zones in certain situations. This decision comes on the heels of a newly registered formulation of dicamba by the Environmental Protection Agency (EPA), and widespread reports of crop damage across the Midwest and Southeast due to the illegal use of dicamba before it was registered. According to DTN Progressive Farmer, the three-hour public meeting was packed with almost 200 people, and approximately 20 of those testified. The testimonies highlighted the disputes and tensions that have arisen over the use of dicamba, as many remembered and spoke about Mike Wallace, a farmer who was tragically murdered on October 27 during an argument with a fellow farmer in Missouri over the illegal use of the chemical and subsequent crop damage. “We’ve seen exactly what […]

(Beyond Pesticides, November 11, 2016) The U.S. Environmental Protection Agency (EPA) has registered a new formulation of dicamba to control weeds in cotton and soybean crops that have been genetically engineered (GE) to tolerate the chemical. The new formulation is called Xtendimax with VaporGripâ Technology, which is claimed to be specifically designed to have lower volatility. The registration, which is time-limited, will automatically expire after two years. According to the Center for Biological Diversity, EPA ignored the legal requirement to explore threats to endangered species, approving this new formulation without considering impacts to species protected under the Endangered Species Act. This decision comes directly after EPA announced that it is reapproving the toxic herbicide mixture Enlist Duo, and proposed to expand the number of crops and states in which it can be used. Dicamba has been linked to damage of the kidney and liver, neurotoxicity, and developmental impacts. The chemical has a strong propensity to volatilize small particles of the herbicide into the air and drift far off-site. Sensitive crop species can be damaged by dicamba at levels in the parts per million.  A study published by Pennsylvania State scientists in late 2015 found dicamba drift was “frequently responsible for […]

(Beyond Pesticides, November 4, 2016) After withdrawing in January its registration approval for the toxic herbicide mixture Enlist Duo, for use in genetically engineered (GE) crops, the Environmental Protection Agency (EPA)  announced  this week that it is not only reapproving  the chemical combination, but it is proposing to expand the number of crops and states in which it can be used. The expanded registration will allow the use of Enlist Duo on GE cotton and extend use to GE corn, soybean, and cotton from 15 states to 34 states. This follows an EPA review triggered by manufacturer claims that Enlist Duo ingredients have synergistic effects, which EPA had not evaluated. According to EPA, its latest review of the data found no synergistic effects. Ironically, this EPA-proposed expansion of pesticide use in GE crops across the U.S. comes on the heels of a front page Sunday New York Times exposé  that concludes “genetically engineered crops fail to increase yields and reduce pesticide use,” despite continuing claims to the contrary. Developed by Dow AgroSciences (Dow), Enlist Duo is an herbicide that incorporates a mix of glyphosate and a new formulation of 2,4-D, intended for use on GE Enlist-Duo-tolerant corn and soybean crops. […]

(Beyond Pesticides, September 22, 2016) Yesterday, the United Nations (UN) gathered to address the alarming rise of antibiotic resistance at a day-long meeting in New York. The UN General Assembly, made up of delegates from 193 countries, has only convened health-related meetings on three other issues: Ebola, HIV, and noncommunicable diseases. According to the World Health Organization, which collaborates with the UN on health-related priorities, “Antimicrobial resistance has become one of the biggest threats to global health, such as human development.” At this high-profile meeting, Heads of State and Heads of Delegations addressed the urgency of the situation and discussed multisectoral approaches to addressing antimicrobial resistance. This UN meeting elevated the discussion to a historic level and led to the approval of a declaration, but did not result in legally binding actions and failed to include language to eliminate excessive antibiotic use in animal agriculture. In an interview with Vox, Kevin Outterson, Professor of Law at Boston University, stated that “it has taken 15 years to get [antimicrobial resistance] back on the global agenda” since the UN last tried to take action in September 2001. Experts are warning that we may be entering or have already entered a post-antibiotic era […]