(Beyond Pesticides, August 1, 2012) New research is adding to the evidence that some pesticides and industrial chemicals may increase women’s risk of uterine and ovarian diseases, such as endometriosis. The research supports the decades old theory that hormone-mimicking chemicals impact human reproductive systems. Scientists have long suspected a link between estrogen-mimicking pollutants and gynecological diseases. According to Environmental Health News, research investigating a link between hormone-disrupting chemicals in the environment and gynecological diseases has had mixed results. But a new study, “Persistent Lipophilic Environmental Chemicals and Endometriosis: The ENDO Study,” from researchers at the National Institutes of Health and others, found that two groups of women in the Salt Lake City and San Francisco areas — one group with pelvic pain and the other with no symptoms — were more likely to be diagnosed with endometriosis if they had high blood levels of the estrogen-like pesticide hexachlorocyclohexane (HCH) than women with low levels. HCH, a persistent organic pollutant (POP), and a byproduct of the production of the insecticide lindane (head lice treatments), has been banned as a crop pesticide in the United States but it persists in the environment and remains in some food supplies. Endometriosis is a female […]

(Beyond Pesticides, July 5, 2012) After a 2006 cancellation of uses due to unreasonable risks to farmworker health and the environment, and a 6-year phase out scheduled to conclude this September, the U.S. Environmental Protection Agency (EPA) is conducting a risk-benefit analysis to make a determination whether to keep in place or amend the cancellation order for the organophosphate azinphos-methyl (AZM), citing new information on the economic costs of using alternatives. In 2001, EPA found that insecticides azinphos-methyl (AZM) posed unacceptable risks to farmworkers and announced that 28 crop uses were being canceled, seven crop uses were to be phased-out over four years, and eight crop uses were to be allowed to continue under a “time-limited” registration for another four years. Farmworker advocates challenged that decision in federal court citing that EPA failed to take into account the costs of poisoning workers, exposing children, and polluting rivers and streams. A settlement agreement effectively stayed the legal challenge pending EPA’s reconsideration of the “time limited” uses of AZM. In November 2006, EPA decided that AZM poses unreasonable adverse effects and issued a final decision to cancel AZM, but allowed continued use on some fruit crops (apples, cherries, pears) for six more […]

(Beyond Pesticides, June 29, 2012) New research from the McGill University Health Centre (MUHC) in Montreal suggests that pesticide exposure, as well as smoking, head injury, farming, and less education, may be a risk factor for a rare sleep disorder that causes people to kick or punch during sleep, according to a study entitled “Environmental risk factors for REM sleep behavior disorder: A multicenter case-control study” published in the June 27, 2012, online issue of Neurology, the medical journal of the American Academy of Neurology. People with the disorder, called REM sleep behavior disorder, do not have the normal lack of muscle tone that occurs during rapid eye movement (REM) sleep, causing them to act out their dreams. The movements can sometimes be violent, causing injury to the person or their bed partner. The disorder is estimated to occur in 0.5 percent of adults. “Until now, we didn’t know much about the risk factors for this disorder, except that it was more common in men and in older people,” said study author Ronald B. Postuma, MD, MSc, with the Research Institute at MUHC and a member of the American Academy of Neurology. “Because it is a rare disorder, it was […]

(Beyond Pesticides, June 21st, 2012) A new study details the toxic effects of long-term exposure to commonly used agricultural pesticides. Results indicate an increased likelihood of moderate to severe blood toxicity and a reduced total number of bone marrow cells, which can lead to degenerative diseases like aplastic anemia. The study, entitled “Pesticide Induced Alterations in Marrow Physiology and Depletion of Stem and Stromal Progenitor Population: An Experimental Model to Study the Toxic Effects of Pesticide” is published in the online version of the Journal of Environmental Toxicology . The experiment, led by researchers at the Calcutta School of Tropical Medicine’s Department of Biochemistry and Medical Biotechnology, exposed a group of mice to a mixture of organochlorine, organophosphate and pyrethriod pesticides, including a preponderance of the chemicals cypermethrin, and chloropyrofos. The exposed mice showed an overall reduction in the ability of their bodies to produce bone marrow cells. Bone marrow, the soft flexible tissue found in the interior of bones, is a storehouse for stem cells. While the exact mechanism is unknown to researchers, the study reveals that the microenvironment in which stem cells develop is somehow deranged by pesticides. This derangement prevents the maturation of stem cells into every […]

(Beyond Pesticides, June 15, 2012) Researchers at the Duke University School of Medicine have developed a laboratory screening system for detecting neurotoxic chemicals and successfully tested it on more than 1,400 potential toxicants. The study confirms the high toxic activity of the chemical piperonyl butoxide (PBO), a chemical “synergist” used to increase the potency of more than 700 insecticides, including synthetic pyrethroids widely used in mosquito and community spray programs and for home use. The study, entitled “The Insecticide Synergist Piperonyl Butoxide Inhibits Hedgehog Signaling: Assessing Chemical Risks,” was published in the May 2012 edition of the journal Toxicological Sciences. The testing shows that PBO disrupts a biological signaling system that is “critical in neurological development,” the researchers reported in the abstract of their paper. The study finds that the disruption of this critical pathway “may be the molecular basis for profound developmental defects in children exposed in utero to PBO.” Piperonyl butoxide is not itself classified as a pesticide, but companies combine it with insecticides to increase their potency. PBO came into widespread use when the U.S. Environmental Protection Agency (EPA) phased out chlorpyrifos and other organophosphate pesticides nearly a decade ago after determining that they posed a risk […]

(Beyond Pesticides, June 5, 2012) A new study finds that children exposed to high levels of naphthalene, a common air pollutant and the active ingredient in mothballs, are at increased risk for chromosomal aberrations (CA’s) that have been associated with increased cancer risk in adults. These include chromosomal translocations, a potentially more harmful and long-lasting subtype of CAs, which are of special concern as they result in a portion of one chromosome being juxtaposed to a portion of another chromosome, potentially scrambling the genetic script. Researchers from the Columbia Center for Children’s Environmental Health (CCCEH) at the Mailman School of Public Health, Columbia University Medical Center, and the Centers for Disease Control and Prevention (CDC) published the findings in Cancer, Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. “Translocations can persist for years after exposure. Some accumulated damage will be repaired, but not everyone’s repair capacity is the same. Previous studies have suggested that chromosomal breaks can double an adult’s lifetime risk for cancer, though implications for children are unknown,” says first author Manuela A. Orjuela, MD, ScM, assistant professor of clinical environmental health sciences and pediatrics (oncology) at Columbia University Medical Center and a […]

(Beyond Pesticides, May 30, 2012) A settlement between plaintiffs and the manufacturer of the endocrine disrupting herbicide atrazine, Syngenta, will pay $105 million to settle a nearly 8-year-old lawsuit and could help reimburse community water systems (CWS) in 45 states that have had to filter the toxic chemical from its drinking water, according to news reports. It will provide financial recoveries for costs that have been borne for decades by more than 1,887 CWSs that provide drinking water more than one in six Americans across at least 45 states. “The scope of this historic settlement is enormous and its protection of the health of millions of Americans across the country is a huge benefit to the public, the environment, and the taxpayers,” the lead plaintiffs’ lawyer Stephen M. Tillery told the media. The individual amounts that eligible CWSs will recover will be calculated based on the levels of atrazine and frequency of atrazine contamination measured in the water of impacted CWSs and the population served by each CWS. The 300 CWSs with the highest contamination levels will recover 100 percent of their costs. Atrazine Settlement Details ”¢ Under the reported settlement, Syngenta will pay $105 million to pay the claims […]

(Beyond Pesticides, May 22, 2012) The Spanish-based Inesfly company announced recently its plans to release commercially pesticide encapsulated paint, Inesfly 5A IGR, containing two neurotoxic organophosphates (OPs), chlorpyrifos and diazinon, and the insect growth regulator (IGR), pyriproxyfen, which it hopes will combat malaria in sub-Saharan Africa. The company’s owner Pilar Mateo, PhD, calls her product “a vaccine for houses and buildings” and explains that because the insecticides are released slowly from the paint, it remains effective for two to four years. This formulation of Dr. Mateo’s paint could not be registered for use in the U.S. because both indoor residential uses of chlorpyrifos and diazinon have been banned because of risks posed to children’s health, although the company has another formulation that substitutes pyrethroids for the organophosphates. Though probably well-intentioned —Dr. Mateo has already invested $6 million of her family’s money and $12 million in grants from nonprofits, on research, creating educational programs about hygiene, and donating paint to more than 8,000 homes in Latin America and Africa””the product puts the people it is supposed to protect from disease at risk for other health problems. Organophosphate insecticides have been linked to a host of neurodevelopmental problems, especially in children. Because […]

(Beyond Pesticides, May 17, 2012) Rather than investing in safe, long-term solutions to prevent malaria mortality, the World Health Organization (WHO) has issued a strategic plan that calls for multiple toxic pesticides to combat mosquito resistance to insecticides that is showing up in sub-Saharan Africa. Insecticide resistance, according to the WHO report, is already rampant in 64 malaria-ridden countries and may result in as many as 26 million more cases of malaria a year, which could end up costing between $30 and $60 million annually for tests and medication. Mosquitoes in sub-Saharan African countries are becoming resistant to pyrethroid insecticides, which are used extensively for household spraying and treating bed nets, as well as to the organochloride compound DDT -which is still used in many parts of the world to control mosquitoes. In Somalia, Sudan and Turkey, resistance has spread to carbamates and organophosphates in addition to pyrethroids and organochloride pesticides. Rather than reducing the reliance on these products, WHO is recommending rotating classes of pesticides used to spray inside homes and developing a new non-pyrethroid insecticide to treat bed nets. Implementation for these suggestions are estimated to cost around $200 million, which is in addition to the $6 billion […]

(Beyond Pesticides, May 2, 1012) New research published online at the Proceedings of the National Academy of Sciences reports that babies exposed in the womb to a commonly used insecticide have brain abnormalities after birth. The insecticide, chlorpyrifos (used in agriculture, mosquito control, and golf course management) , is well documented as inducing neurodevelopmental abnormalities in infants exposed in their mother’s womb, including ADHD, cognitive deficits, and serious learning, behavioral or emotional disorders. Entitled, “Brain anomalies in children exposed prenatally to a common organophosphate pesticide,” the study investigated associations between chlorpyrifos exposure and brain morphology using magnetic resonance imaging in 40 New York City children. It found significant associations of prenatal exposure, at standard use levels, with structural changes in the developing human brain, including enlargement of superior temporal, posterior middle temporal, and enlarged superior frontal gyrus, gyrus rectus, cuneus, and precuneus along the mesial wall of the right hemisphere. These areas of the brain impacted are related to attention, language, reward systems, emotions and control may be affected by the chemical. Twenty high-exposure children (upper third of chlorpyrifos concentrations in umbilical cord blood) were compared with 20 low-exposure children. The children, ages 6-11 years, considered to have a high […]

(Beyond Pesticides, April 13, 2012) A study has found that the children of flower plantation workers in Ecuador are neurologically affected by the pesticide residues that their parents unwittingly carry home on their clothes, tools, and skin. The study documents significantly reduced activity for the essential enzyme acetycholinesterase (AChE) in children whose parents work on flower plantations compared to others whose parents do not. The two main classes of pesticides that the researchers identify as used in the region’s flower production, organophosphates and carbamates, are known to suppress the enzyme’s activity. AChE activity is crucial to healthy neurological functioning in humans and its suppression during childhood can hinder nervous system and cognitive development causing immediate and long-term impairment. In the study, Lower acetylcholinesterase activity among children living with flower plantation workers (Environ Res. 2012 Apr;114:53-9. Epub 2012 Mar 10), children whose parents work on a flower plantation are more than three times more likely to be in the group of lowest AChE activity. Additionally, the children who live the longest with a flower plantation worker are four times more likely to have lower enzyme activity than children who never live with a plantation worker. The researchers obtained their results by […]

(Beyond Pesticides, April 9, 2012) A new study finds that exposure of pregnant women to organophosphate (OP) pesticides —a widely used class of pesticides in North American agriculture— may affect both length of pregnancy and birth weight. Environmental Health Perspectives published the paper, “Associations of Prenatal Exposure to Organophosphate Pesticide Metabolites,” last Thursday, April 5, 2012. The study, by a Simon Fraser University researcher, finds that the population of 306 women in Cincinnati, Ohio, is representative of the type of exposures most North American women and their children experience. Although the use of OPs in Canada and the U.S. has declined in recent years, exposures remain widespread, and these findings add to growing evidence about the harmful effects of low-level exposures to environmental toxicants. The researchers collected urine from each of the women in Cincinnati twice during their pregnancies for organophosphate metabolites as well as other factors that could influence the fetus’ health, including exposure to second hand smoke, race, and poverty. Women with higher levels of organophosphates were found to have pregnancies that were three to four days shorter and babies that were about â…“ pound lighter on average than women with lower levels of pesticides. “For an individual […]

(Beyond Pesticides, April 4, 2012) The world’s most popular weed killer can induce morphological changes in vertebrate animals, U.S. biologists studying its effect on amphibians say. University of Pittsburgh researchers have found that the weed killer Roundup, in sub-lethal and environmentally relevant concentrations, causes two species of amphibians to change their shape by interfering with the hormones of tadpoles and potentially many other animals. The study, “New effects of Roundup on amphibians: Predators reduce herbicide mortality; herbicides induce antipredator morphology” is the first to show that a pesticide can induce morphological changes in a vertebrate animal, biological sciences Professor Rick Relyea, PhD, said in a university release. The study was undertaken using simple created wetlands and introducing tadpoles from three species of amphibians —the leopard frog, American toad, and wood frogs. After three weeks, the tadpoles were examined. The impact of Roundup on the shape of tadpole tails was most noticeable in both the wood frog and leopard frog tadpoles. According to the study, “In wood frog and leopard frog tadpoles, Roundup induced relatively deeper tails in the same direction and of the same magnitude as the adaptive changes induced by dragonfly cues… [T]his is the first study to show […]

(Beyond Pesticides, March 16, 2012) A report published online this week in the journal Endocrine Reviews documents extensive scientific research showing that endocrine disrupting chemicals, or endocrine disruptors, can be toxic to humans even in minutely small doses. The report, three years in the making, was published Wednesday by a team of 12 scientists who study hormone-altering chemicals. Authors include the University of Missouri’s Frederick vom Saal, PhD., who has linked low doses of bisphenol A (BPA) to a variety of effects, Theo Colborn, PhD., who is credited with first spreading the word about hormone-disrupting chemicals in the late 1980s, and University of California at Berkeley’s Tyrone Hayes, PhD., who has documented the effects of the pesticide atrazine on frogs. Drs. Colborn, Hayes, and vom Saal are all former speakers at the National Pesticide Forum. One of the reporrt’s authors is Pete Myers, PhD, the founder of Environmental Health News and chief scientist of Environmental Health Sciences. Dozens of substances that can mimic or block estrogen, testosterone and other hormones are found in the environment, the food supply and consumer products, including plastics, pesticides and cosmetics. One of the biggest, longest-lasting controversies about these chemicals is whether the tiny doses […]

(Beyond Pesticides, March 9, 2012) With Members of Congress attempting to gut pesticide protections from the Clean Water Act and state legislators threatening to repeal Connecticut’s historic pesticide ban on school grounds, environmentalists from the Northeast and beyond are joining with researchers, authors, beekeepers, organic business leaders, elected officials, and others to discuss strategies for protecting health and the environment. Healthy Communities: the 30th National Pesticide Forum will take place March 30-31 at Yale University in New Haven, CT. Register online. Fees start at $35 ($15 for students) and include all sessions, conference materials, and organic food and drink. A limited number of partial scholarships are available, contact Beyond Pesticides for details. Conference Highlights: Pesticide-Free Lawns and Landscapes With the Connecticut General Assembly’s considering legislation that would repeal the state’s ban on toxic pesticide use on school grounds by replacing it with a weak “integrated pest management” (IPM) system, this issue will be a central theme at the conference. Speakers on this topic include: Warren Porter, PhD, professor of Zoology and Environmental Toxicology at the University of Wisconsin at Madison with expertise in lawn chemicals, especially low doses and mixtures; Chip Osborne, national organic turf expert and president of Osborne […]

(Beyond Pesticides, March 6, 2012) New research conducted in New Bedford, Massachusetts suggests that organochlorine chemicals, which were first linked to learning problems in children more than two decades ago, may play a role in attention-deficit hyperactivity disorder (ADHD), especially in boys. Previous research has reported associations between organochlorines and ADHD-related behaviors, but this research found sex-specific effects in children born to mothers who lived near the contaminated harbor and dumpsites in low-income communities. This study adds to a growing body of literature associating learning disorders with prenatal chemical exposures. According to the study, Neuropsychological Measures of Attention and Impulse Control among 8-Year-Old Children Exposed Prenatally to Organochlorines, boys who were exposed to higher levels of the organochlorines -polychlorinated biphenyls (PCBs) and DDE (a metabolite of DDT)- in the womb scored lower on focus and concentration tests, which indicates they are more likely to have attention problems often related to ADHD. In the study, umbilical cord blood was collected from 788 newborns born between 1993 and 1998 from four towns near New Bedford Harbor, Mass., to see what they were exposed to in the womb. Roughly eight years after they were born, almost 600 of these children underwent two tests. […]

(Beyond Pesticides, February 13, 2012) Acclaimed ecologist and Living Downstream author, Sandra Steingraber, will be speaking at the 30th National Pesticide Forum. With Connecticut and communities throughout the country facing threats to existing environmental laws, as well as opportunities for greater protection and increased local control, this conference will have a strong focus on organic land management and protective policies. Join Dr. Steingraber and other researchers, authors, beekeepers, organic business leaders, elected officials, activists, and others to discuss the latest science, policy solutions, and grassroots action. Registration Register online. Fees start at $35 ($15 for students) and include all sessions, conference materials, and organic food and drink. Speaker Highlights Sandra Steingraber, PhD – An acclaimed ecologist and author, Dr. Steingraber explores the links between human rights and the environment, with a focus on chemical contamination. She takes a personal and scientific look at these issues and offers insights into how we can protect our environment and ourselves. She brings a clear, lyrical voice to the complex evidence of biology. The author of several books, including her latest, Raising Elijah, Dr. Steingraber has been called “a poet with a knife” by Sojourner magazine, and received many honors for her work as […]

(Beyond Pesticides, February 1, 2012) Pesticides could be suppressing vitamin D levels in people, leading to deficiency and disease, say scientists. This comes from a new study which discovered that adults with high serum concentrations of organochlorine pesticides, such as DDT, have lower vitamin D levels, further proving that these chemicals have a long-lasting impact on human health. While not widely appreciated, some organochlorine pesticides continue to be used in the U.S., resulting in exposure through our diet, environment, and prescription drugs, while most organochlorine pesticides have been banned in the U.S. and much of the world. Exposure to low doses of organochlorine pesticides has been previously linked to common diseases like type 2 diabetes, metabolic syndrome and cardiovascular disease. Vitamin D deficiency has similarly been associated with a rise in chronic diseases, but the two have been studied separately by researchers in different fields. The study, “Associations between Organochlorine Pesticides and Vitamin D Deficiency in the U.S. Population,” compared serum concentrations of organochlorine (OC) pesticides with serum concentrations of 25-hydroxyvitamin D (25(OH)D), a vitamin D pre-hormone, which is used to assess vitamin D levels in the body. It concludes that background exposure to some OC pesticides can lead to […]

(Beyond Pesticides, January 31, 2012) The Environmental Protection Agency (EPA) has proposed an expansion in pyrethrins/pyrethroid insecticide uses as part of its cumulative risk assessment for this neurotoxic class of chemicals. In the cumulative risk assessment, EPA concludes that pyrethroids “do not pose risk concerns for children or adults,” ignoring a wealth of independent data that links this class of chemicals to certain cancers, respiratory and reproductive problems, and the onset of insect resistance. It went as far as to state that its cumulative assessment supports consideration of registering additional new uses of these pesticides, potentially opening the flood gates for manufacturers to bombard the market with more pyrethroid pesticides, endangering the health of the public. The agency is accepting public comments through February 8, 2012. Tell EPA that it has ignored numerous health effects and that these pesticides do pose unacceptable risks to human health given the availability of alternatives. Submit comments directly to the EPA docket or sign-on to Beyond Pesticides’ comments. In its comments to EPA, Beyond Pesticides states: There are several major concerns and flaws plaguing this cumulative assessment, which therefore does not meet the regulatory burden in fully evaluating synthetic pyrethroids’ effect on public and […]

(Beyond Pesticides, January 19, 2012) Although organic farming and land management continue to grow, policies to protect people from pesticides are threatened in the Northeast and around the country. At the same time, cutting-edge science links pesticide exposure to health problems, honey bee colony collapse, and other environmental issues. Join researchers, authors, beekeepers, organic business leaders, elected officials, activists, and others at Beyond Pesticides’ 30th National Pesticide Forum to discuss the latest science, policy solutions, and grassroots action. This national conference, Healthy Communities: Green solutions for safe environments, will be held March 30-31 at Yale University in New Haven, CT. Registration Register online. Fees start at $35 ($15 for students) and include all sessions, conference materials, and organic food and drink. Speakers Confirmed speaker highlights include: Gary Hirshberg is chairman and co-founder of Stonyfield Farm, the world’s leading organic yogurt producer, and the author of Stirring It Up: How to Make Money and Save the World. Previously, he directed the Rural Education Center, the small organic farming school from which Stonyfield was spawned. Before that, Gary had served as executive director of The New Alchemy Institute, a research and education center dedicated to organic farming, aquaculture and renewable energy. He […]

(Beyond Pesticides, December 9, 2011) A recent study published in the journal NeuroToxicology has found a positive link between exposure to the pesticide propoxur and poor motor development in infants. At the age of two, children exposed to propoxur in the womb experience poor development of motor skills, according to a test of mental development. The study joins numerous others that consistently show birth defects and developmental problems when fetuses and infants are exposed to pesticides. The study, undertaken by researchers at Wayne State University in Michigan, the University of the Philippines, and Davao Regional Hospital in the Philippines, is entitled “Fetal exposure to propoxur and abnormal child neurodevelopment at 2 years of age.” It examines levels of exposure to multiple pesticides in pregnant women living in areas of high pesticide use in the Philippines. Pesticide exposure was monitored by measuring the pesticide content of hair and blood for both mothers and children. The researchers then compare these exposure levels to adverse outcomes regarding the health of the infants once they were born. To accomplish this, the team used a method called path analysis modeling in order to determine what effects the pesticides might have on fetal development. The striking […]

(Beyond Pesticides, December 5, 2011) On December 3, the 27th anniversary of the Bhopal pesticide plant disaster in Bhopal, India, a trial began in an international people’s court in India involving the world’s six largest pesticide companies: Monsanto, Syngenta, Bayer, BASF, Dow and Dupont. These companies, collectively known as the “Big 6,” are cited by prosecutors for their human rights violations, including internationally recognized rights to life, livelihood and health. Beyond Pesticides joined Pesticide Action Network (PAN) and others in signing a joint statement demanding that these companies be held accountable for their human rights violations, which was presented at the trial. The trial, hosted by PAN International, is facilitated by the Permanent People’s Tribunal (PTT), an international opinion tribunal independent from State authorities. The prosecution’s 230-page indictment outlines the global threats to human rights. It begins: The victims and survivors of [pesticide industry] aggression are the poor peasants, small-scale farmers, agricultural workers, rural women, children, and indigenous and agricultural communities around the world. They are at the mercy of the expanding power of the agrochemical [corporations] and are losing their control over their seeds and knowledge, and suffering debilitating physical and chronic effects due to pesticide poisoning, including coping […]

(Beyond Pesticides, November 29, 2011) New research shows that women who drink water containing the widely used herbicide atrazine may be more likely to have irregular menstrual cycles and low estrogen levels, even at concentrations far below federal drinking water standards considered safe by the U.S. Environmental Protection Agency (EPA). Researchers compared women living in Illinois farm towns where atrazine is used regularly to women living in Vermont where the herbicide is used sparingly, and found that the women in Illinois were almost five times more likely to report irregular menstrual cycles, including more than six weeks between periods. Consumption of over two cups of unfiltered Illinois water daily was associated with increased risk of irregular periods. The study, entitled “Menstrual cycle characteristics and reproductive hormone levels in women exposed to atrazine in drinking water,” was published in the journal Environmental Research earlier this month, and is based on municipal tap water tested between July and September of 2005. In the study, participants maintained menstrual cycle diaries, answered a questionnaire, and provided daily urine samples for analyses of luteinizing hormone and estradiol and progesterone metabolites. To measure exposure, analysts looked at the state of residence, concentrations of atrazine and chlorotriazine […]