(Beyond Pesticides, February 1, 2024) A study published in Science of The Total Environment finds an insecticide ban would be economically beneficial in preventing Parkinson’s disease (PD). Despite differing pesticide exposure scenarios, PD risk lowers without pesticide exposure, especially insecticides that elicit neurotoxicity. In fact, a study published in 2023 notes high exposure to household pesticides, which are primarily insecticides, increases the risk of developing Parkinson’s disease (PD) two-fold.

There is a multitude of epidemiologic research on Parkinson’s disease demonstrating several risk factors, including specific genetic mutations and external/environmental triggers (e.g., pesticide use, pollutant exposure, etc.). However, several studies find exposure to chemical toxicants, like pesticides, has neurotoxic effects or exacerbates preexisting chemical damage to the nervous system. Studies suggest neurological damage from oxidative stress, cell dysfunction, and synapse impairment, among others, can increase the incidence of PD following pesticide exposure. Despite the widespread commercialized use of household pesticides among the general population, few epidemiologic studies examine the influence household pesticides, mainly insecticides or disinfectants, have on the risk of PD. Additionally, many studies demonstrate the association between PD onset and occupational (work-related) pesticide exposure patterns.

Parkinson’s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses annually. Alzheimer’s ranks first. The disease affects 50 percent more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and sleep disturbances. Over time, symptoms intensify, but there is no current cure for this fatal disease. While only 10 to 15 percent of PD incidents are genetic, PD is quickly becoming the world’s fastest-growing brain disease. Therefore, research like this highlights the need to examine alternate risk factors for disease development, especially if disease triggers are overwhelmingly nonhereditary.

The study evaluated whether the of banning specific insecticides to reduce the PD burden in three counties in Central California (CA) is cost-effective. Researchers applied a cost-effectiveness analysis to estimate the impact and costs of banning seven insecticides (methomyl, dimethoate, carbaryl, acephate, malathion, naled, or oxydemeton-methyl) linked to PD in these counties. The analysis also investigated mixed exposures of these pesticides. The cohort included 65- and 66-year-olds living in these CA counties and estimated their incidence, costs, and reduction in quality-adjusted life-years (QALY) from developing PD over 20 years. After applying various scenarios, the analysis finds banning insecticides to reduce the occurrence of PD in three Central CA counties would be cost-effective compared to not prohibiting the insecticides. For the worst-case scenario depicting exposure to one insecticide, exposure to methomyl would result in a 12 percent increase in PD cases, increasing health-related costs by $72 million, with each additional PD patient incurring $109,327 in costs per QALY loss from PD. Overall, the highest PD burden and the cost associated with PD occurs from exposure to multiple pesticides simultaneously, particularly for oxydemeton-methyl, dimethoate, and carbaryl.

Parkinson’s disease occurs when there is damage to dopaminergic nerve cells (i.e., those activated by or sensitive to dopamine) in the brain responsible for dopamine production, one of the primary neurotransmitters mediating motor function. Although the cause of dopaminergic cell damage remains unknown, evidence suggests that pesticide exposure, especially chronic exposure, may be the culprit. Data is increasingly showing that cumulative exposures over one’s life increase the risk of developing Parkinson’s disease, and other factors such as genetics and exposure to other chemicals further elevate the threat. Strong links to this chronic condition are incredibly concerning, given emerging evidence of a Parkinson’s pandemic, predicting that rates of the disease will double between now and 2040. Occupational exposure poses a unique risk, as pesticide exposure is direct via handling and application. A 2017 study finds that occupational use of pesticides (i.e., fungicides, herbicides, or insecticides) increases PD risk by 110 to 211 percent. Even more concerning, some personal protection equipment (PPE) may not protect workers from chemical exposure during application. However, indirect nonoccupational (residential) exposure to pesticides, such as proximity to pesticide-treated areas, can also increase the risk of PD. A Louisiana State University study finds that residents living adjacent to pesticide-treated pasture and forest land by the agriculture and timber industry have a higher incidence of PD. Furthermore, pesticide residues in waterways and on produce present an alternate route for residential pesticide exposure to increase the risk for PD via ingestion. In addition to PD, pesticide exposure can cause severe health problems even at low residue levels, including endocrine disruption, cancers, reproductive dysfunction, respiratory problems (e.g., asthma, bronchitis), and other neurological impacts. Nevertheless, direct occupational and indirect nonoccupational pesticide exposure can increase the risk of PD. 

This study is one of the first to assess the cost-effectiveness of banning insecticides to reduce PD burden. However, a 2021 cost-effective analysis has already shown that a ban on highly hazardous pesticides can reduce pesticide-related suicides by 28,000 deaths each year, at $0.007 per capita globally. Therefore, model-based cost-effectiveness analyses can help to estimate long-term cost benefits from reducing health effects from environmental hazards.

The analysis’s focus on insecticides is important as insecticides are the most commonly used household pesticides, and a history of high exposure to household pesticides increases the risk of PD regardless of the age at PD onset. However, herbicides like glyphosate, 2,4-D, and paraquat and fungicides like maneb can also increase the risk of PD, demonstrating that PD risk can occur regardless of pesticide category.

The cost-effectiveness analysis in this study is essential in comparing the impacts of banning pesticides according to different exposure scenarios, as it helps inform policymakers and stakeholders on regulatory decisions based on economic and long-term health consequences. Banning the seven insecticides in this analysis is a cost-effective solution when considering PD-associated costs, suggesting that reducing PD burden costs offsets the ban’s cost. However, the study may underestimate the impact of multiple insecticide exposures. Thus, the cost-effectiveness of withdrawing insecticides would be even more significant since it would reduce PD risk from single pesticide exposure while eliminating the interaction with other pesticides.

The study highlights that farmers and the agricultural industry may experience immediate financial loss when eliminating insecticide use to switch to another product, which needs to be evaluated against the long-term health benefits and the costs or burden of disease. Thus, the researchers note that “a real-world-based cost-effectiveness analysis is crucial for guiding policies that balance public health priorities and less apparent long-term benefits against economic aspects related to agricultural practices.”

The study concludes, “[T]he population-level long-term health benefits and health savings would outweigh the financial losses due to the pesticide ban. [This] study adds a financial dimension to the understanding of environmental health impacts, particularly on vulnerable populations like the elderly in rural communities. Policymakers and agricultural industries should consider healthcare costs when deciding to continue using certain pesticides and consider immediate action to reduce harm. [… The researchers would] like to highlight the necessity for further research to expand these findings to other geographic areas and pollutants to enrich and support a broader discourse concerning pesticide regulation and public health.”

Parkinson’s disease has no cure, but preventive practices, like organic agriculture or Parks for a Sustainable Future, eliminate exposure to toxic PD-inducing pesticides, especially as a 2023 study points to PD as a predominantly environmentally induced disease. Considering health officials expect Parkinson’s disease diagnosis to double over the next 20 years, mitigating preventable exposure from disease-inducing pesticides becomes increasingly essential. For more information on the effects of pesticide exposure on neurological health, see the Pesticide-Induced Diseases Database (PIDD)  pages on Parkinson’s disease, dementia-like diseases, such as Alzheimer’s, and other impacts on cognitive function. 

Organic agriculture represents a safer, healthier approach to crop production that does not necessitate toxic pesticide use. Beyond Pesticides encourages farmers to embrace regenerative, organic practices and consumers to purchase organically grown food. A complement to buying organic is contacting various organic farming organizations to learn more about what you can do. Those affected by pesticide drift can refer to Beyond Pesticides’ webpage on What to Do in a Pesticide Emergency and contact the organization for additional information. Furthermore, see Beyond Pesticides’ Parkinson’s Disease article from the Spring 2008 issue of Pesticides and You.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: Science of The Total Environment

(Beyond Pesticides, January 31, 2024) A report published in December 2023 by the European Environment Agency (EEA) details opportunities and challenges to European organic farming targets for 2030. The European Union (EU) has set ambitious targets in its environmental policy—including the Farm to Fork Strategy (F2F) and European Green Deal (EGD)—with the goal to have at least 25 percent of European farmland run on organic land management practices by 2030. The EU’s approach to organic farming and pesticide regulation on agricultural land in comparison to public and private land offers insightful lessons for advocates in the United States to apply to their campaigns.

Some countries are ahead of the 25 percent by 2030 target, such as Austria, Estonia, and Sweden, with 20 percent of agriculture organically managed as of 2021. The German government is preparing to exceed the EU goal when the new coalition government presented a strategy last November outlining a 30 percent goal for 2030. Meanwhile, some countries are vastly underperforming—with Poland adding virtually zero farmland to organic production between 2012 and 2021. Overall, approximately 9.9 percent of total EU farmland follows organic standards as of 2021. At this rate, the EU will only meet 15 percent rather than 25 percent by 2030. France has taken a leading role in pesticide bans on public landscapes and private land that is frequently employed for public use, enforcing a strict ban on all pesticides in these areas in 2022. Under previous law, which is now the EU-wide regulation via F2F, France had the target of reducing overall pesticide use by 50 percent by 2030.

In response to the introduction of pesticide bans and EU climate policies included in the EGD, news outlets such as France24 have reported a groundswell of mass protests from farmers in France, Romania, and Germany who view these policies and the associated upfront costs of transitioning away from petrochemical pesticide use as an affront to their financial stability. France24 reports, “Frustration is…. mounting among farmers across Europe. They are unhappy about bans on pesticides cleared for use in other parts of the world and what they view as unfair competition from Ukrainian grain imports.” Meanwhile, farmers in South Africa have expressed outrage at the “hypocritical tactics European agrochemical companies use to sell products in developing nations, even when those products are deemed unsafe in their home countries.” This break between the interests of farmers and climate policy goals in the European Union demonstrates the significance of U.S. reluctance to commit to a full transition in coordination with F2F in a broader organic farming strategy, as Beyond Pesticides has recently reported. For context, USDA announced its Organic Transition Initiative last year providing $300 million USD in technical, insurance, and mentoring support for existing and transitional organic farms in the United States; however, the OTI did not establish an organic farming target akin to the EU approach.

Despite the different approaches in the U.S. versus EU, public health and environmental advocates and advocacy groups generally support F2F and the Common Agricultural Policy as a vessel for advancing organic land management across all EU member states. Certain policy decisions regarding the stringency of targets and administrative roadblocks to tougher pesticide regulations are compounded by widespread pushback from pesticide-dependent farmers across the European Union, which may explain current lags to reaching the 2030 goal. For example, after hearing a petition from representatives of the European Citizens’ Initiative to establish binding targets of 80 percent overall pesticide reduction and total pesticide ban by 2035, the European Commission rejected the proposal “citing economic costs for farmers and consumers,” according to reporting by EurActiv. This move is not a surprise given the findings of a 2022 study published in the National Library of Medicine. The authors point out that the reduction of herbicide use poses a unique challenge to EGD’s stated goal of 50 percent pesticide reduction by 2030, given the decrease in alternatives in recent years and mixed understandings of concepts such as herbicidal resistance.

Additionally, Beyond Pesticides indicated in an article last year that EU and U.S. Pesticide Regulators Ignore Developmental Neurotoxicity of Pesticides as investigative journalists report that, “Of the nine undisclosed DNT [developmental neurotoxicity] studies [‘submitted to the U.S. Environmental Protection Agency (EPA) but were not disclosed to EU authorities’], three were sponsored by Bayer and performed in their own laboratory. Three studies were sponsored by Syngenta and performed in their Central Toxicology Laboratory. One study each was sponsored by Nissan Chemicals and Ishihara Sangyo Kaisha (ISK), and these were performed at Huntingdon Life Sciences. For the remaining study, the sponsor and laboratory are unknown to us.” The article continues, “In both the U.S. and the E.U., companies registering pesticides must provide evidence from toxicological studies to support their marketing plans. But in both countries, there is a built-in conflict of interest in the way the science is used to justify commercial ends, and the fox should not be the party rationalizing its presence in the henhouse.”

The groundswell of grassroots action in both the EU and the U.S. demonstrates growing public awareness of regulatory capture by the petrochemical pesticide industry and the pitfalls of these dangerous pesticides on food supply chain resilience, public health, and biodiversity protections. In the U.S. context in recent years, there has been recent movement in pesticide bans on public property, such as prohibiting day-time applications of pesticides on the grounds of Illinois public schools. State-level action on pesticide bans and actions builds upon the legacy of over 200 cities, counties, and municipalities that have some level of pesticide application restrictions on private and public land. As the Farm Bill negotiations continue, there are still opportunities to contact local elected officials as well as Congress to protect local and state authority to regulate pesticide use.

Given escalating existential crises in public health threats, biodiversity collapse, and climate, Beyond Pesticides calls for the elimination of petrochemical pesticides and fertilizers by 2032 with the transition to organic land management. (See Transformative Change: Informed by Science, Policy, an Action.) For a discussion of critical issues on the crises and their relationship to petrochemical pesticides and fertilizers, see our National Forum—Meeting the Health, Biodiversity, and Climate Crises with a Path for Livable Future (2022).

Beyond Pesticides has compiled numerous studies that indicate a plethora of benefits that emerge from the production, distribution, and consumption of organic food products. For example, research conducted by the Environmental Pollution journal, “found that children who ate organic food displayed higher scores measuring fluid intelligence and working memory. Lower scores on fluid intelligence tests were associated with children’s fast food intake, house crowding, and exposure to tobacco smoke. Lower scores on working memory tests were associated with exposure to poor indoor air quality.” For more information on the health benefits of organic farming, see our sections on Health Benefits of Organic Agriculture and Eating With a Conscience for breakdowns on the public health, environmental justice, and ecological benefits of organic food.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: European Environment Agency

(Beyond Pesticides, January 30, 2024) The City Council of Brighton and Hove (England) is preparing to expand the use of glyphosate after widespread public complaints over the growth of Japanese knotweed and a program of manual clearance. This imminent local land management decision flies in the face of substantial research on the health and ecological impacts of glyphosate-based herbicides, including from Aaron Blair, PhD—former chair of the International Agency for Research on Cancer (IARC) working group on glyphosate and former branch chief (now scientist emeritus) of the Occupational Studies Section, National Cancer Institute (NCI). Advocates are concerned that the city council is basing this rationale on the fact that the European Commission reapproved use of glyphosate in 2023 for a ten-year period and not the body of scientific literature on health and ecosystem effects as well as alternative practices and products.

According to a recent ENDS Report, “The [City of Brighton and Hove] council banned the use of glyphosate in 2019 – with an exception for killing invasive species [‘in exceptional cases’] such as Japanese Knotweed – after it was linked to health concerns and a decline in bee populations. As part of this it was agreed that the removal of weeds in parks and on hard surfaces would be undertaken manually as an alternative approach to using pesticides.” After a January 23 city council meeting, it appears that councilors are leaning toward a “controlled-droplet application of glyphosate” as of January 18, 2024. This move would broaden the existing policy of applying glyphosate to allow certain exceptions to its institution as a general practice. While the existing policy does not universally ban glyphosate, the city relied on manual weed management for the past five years.

There is much more in this piece on the specifics of the City of Brighton and Hove’s ordinance and the compelling science that has supported the elimination of glyphosate use in communities around the U.S. and around the world, in addition to large awards from jury verdicts for those exposed and harmed. Before getting to that, it should be noted that the demand for glyphosate use typically does not address the question of holistic Japanese Knotweed management strategies, which are critical to this “invasive” plant as well as all unwanted plants and the impact that control strategies have on ecosystem health and ecological balance. While eradication has been a driving force for many land managers and members of the public, those in the field have increasingly come to question the viability of that strategy. Eric Burkhart, PhD, a botanist, ethnobotanist, and agroforester from Shaver’s Creek Environmental Center (in Penn State University’s experimental forest) and associate professor at Penn State, says the following about a holistic management strategy: “After more than 25 years of trying to control this invasive species, I have acquired a great deal of respect for this herculean plant. I’m resolved not to concoct any fanciful notion of ever eradicating it. Invasive knotweed is here to stay.” From his experience using glyphosate and other elimination strategies, he learned that, “I had not carefully considered trying to restore what once grew where the knotweed intruded.” Experience has brought Dr. Burkhart to recommend the following: “. . .re-planting areas with vigorous native woody shrubs and trees such as dogwoods and willows. Live staking is reported by many sources to be a good option. Knotweed is less vigorous in shade, so establishing an overstory or other competition will help to suppress growth.” More on this can found at a Penn State Extension webpage. Beyond Pesticides notes that initial clearing of an area can be achieved with managed goat grazing, and chemicals are counterproductive to ecological balance and a restorative and regenerative strategy. While Beyond Pesticides does not recommend specific companies, Browsing Green Goats and Goat Guardian explain a strategy of clearance that is being used across the country. There are too many examples of sustainable land management with goats to list here, but a few to check out include South Portland, Maine, and Connecticut College. For more background on managed goat grazing, see Beyond Pesticides’ goat demonstration at the 36^th National Forum, Organic Neighborhoods: For healthy children, families, and ecology, Irvine, California.

The Council Committee on Weed Management in the Environment, Sea Downs, and The Sea in Brighton and Hove City Council put forward an ordinance change to consider controlled-droplet application or conventional application of glyphosate:

• Recommendation 4: Subject to approval at Budget Council, to amend the current policy to support the use of glyphosate to manage weeds on all hard surfaces and instruct the council’s City Environmental Management Services to engage with contractors to use a controlled-droplet application to manage and remove weeds from across the city in 2024, as described more fully in paragraphs 3.21 to 3.24 and 3.28 to 3.29. Further to this, Committee agrees to delegate authority to the Executive Director – Economy, Environment & Culture, in consultation with the Committee Chair, to determine the most effective approach for weed management in future years based on the outcomes achieved in 2024.

OR

• Recommendation 5: Subject to approval from Budget Council, to amend the current policy to support the use of glyphosate to manage weeds on all hard surfaces and instruct the council’s City Environmental Management Services to engage with contractors to use traditional glyphosate to manage and remove weeds from across the city in 2024, as described more fully in paragraphs 3.25 to 3.29. This will be subject to a review in winter 2024 to see if there is an option to move to a controlled-droplet application for 2025. Further to this, Committee agrees to delegate authority to the Executive Director – Economy, Environment & Culture, in consultation with the Committee Chair, to determine the most effective approach for weed management in future years based on the outcomes achieved in 2024.

While the mainstream press has focused on the cancer effects of glyphosate/Roundup and the jury verdicts against Monsanto/Bayer, the manufacturer of glyphosate/Roundup, the scientific literature on glyphosate has raised a range of serious adverse health and ecosystem effects.

As time passes since the IARC decision, a review of the science that links glyphosate/Roundup to science may be helpful. As a keynote speaker at Beyond Pesticides’ 34^th National Pesticide Forum in Portland, Maine, Dr. Blair discussed IARC’s research on the linkage between the herbicide glyphosate and cancer. Dr. Blair, who has published  over 450 scientific and medical journal articles on environmental and occupational causes of cancer, discussed in detail the methodological approach and scientific background on.”

The methodology for the 2015 study includes data from rodent bioassays, mechanistic data, and epidemiological studies. The rodent bioassays found a relationship between glyphosate exposure and the diagnosis of rare cancers, including renal tubule carcinoma, hemangiosarcoma, pancreatic islet-cell adenoma, and skin cancer. The mechanistic studies found evidence of DNA and chromosomal damage, as well as oxidative stress—all of which are indicators of cancer. Meanwhile, the epidemiological studies found an association with non-Hodgkins’s lymphoma in case-control studies from the United States, Canada, and Sweden (but not in the Agricultural Health Study that Dr. Blair was part of in Iowa and North Carolina—Dr. Blair mentioned at the Forum that “epidemiological studies….[are] not always that clear-cut [with human data]” and scientists, “have to look at the totality of what is going on.”) The IARC evaluation process includes the composition of working groups of between 15 to 30 scientists from diverse disciplines going through a literature review of publicly available research from epidemiological, bioassay, mechanistic, and exposure studies. Out of the four levels of classification, Dr. Blair’s IARC working group assigned glyphosate under category 2A, which determines the assigned pesticide or chemical as “probably carcinogenic to humans.” “You usually [get to probable cause assessment through] limited evidence in human… and sufficient evidence in animal [studies].” To listen to Dr. Aaron Blair’s full keynote, click the link here. [Timestamp: 22:00]

Understanding the scientific process that led to IARC’s 2015 assessment is important for advocates who wish to challenge claims made by the petrochemical industry, the Environmental Protection Agency (EPA), and more recently the European Union that disputes the connection between glyphosate and human health. Reports such as “Merchants of Poison” uncover Monsanto’s (now owned by Bayer) efforts to interfere in scientific analysis, media coverage, philanthropic involvement, and higher education efforts to spread disinformation and misinformation on the health impacts of glyphosate. EPA staff and managers have also been found to have an “unholy alliance” with industry actors such as Bayer. Beyond Pesticides has also reported on industry efforts on dicamba and atrazine in which Bayer and BSF, “engaged in a variety of deceitful, unethical, and possibly fraudulent practices to enable [their] use.” In 2022, the EPA revisited their 2017 decision declaring their conclusion that glyphosate is not carcinogenic after, “the Court of Appeals for the Ninth Circuit handed down a ruling that held EPA’s 2020 approval of glyphosate was unlawful.“ According to an “independent evaluation of available data for glyphosate”, the EPA found “no risks of concern to human health from current uses of glyphosate,” “no indication that children are more sensitive to glyphosate,” “no evidence that glyphosate causes cancer in humans,” and “no indication that glyphosate is an endocrine disruptor.”

Advocates are concerned that the use of glyphosate is a self-fulfilling prophecy in that this approach aims to create ecosystem imbalance to address ecosystem imbalance. Beyond IARC’s work, there is extensive scientific evidence linking glyphosate to a range of human and ecological health effects. Regarding human health, see the article Scientists Express Concern Over Widespread Use of Glyphosate-Based Herbicides where, “Following the carcinogenic classification by IARC, a research study published in Environmental Health linked long-term, ultra-low dose exposure to glyphosate in drinking water to adverse impacts on the health of liver and kidneys.” Adding to the body of science, more studies in the last year corroborate the health risks posed by glyphosate exposure to male reproductive systems, behavioral and gut health, and neurodegenerative disease and sleep function.

Beyond Pesticides—through ManageSafe, ManageSafe’s resources on Japanese Knotweed, and previous reporting on glyphosate health, safety, and environmental justice impacts across the supply chain— has a plethora of resources underscoring the danger of pesticide application exemptions in creating wiggle room for state and local authority to spray glyphosate and harmful petrochemical pesticides in local communities.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.  

Source: ENDS Report

(Beyond Pesticides, January 29, 2024) With its draft Biological Evaluation of the impacts of rodenticides open for public comment until February 13, advocates are warning the U.S. Environmental Protection Agency (EPA) that its inadequate review is unconscionable in view of the looming biodiversity collapse. “This is not a moment for business as usual and weak reviews that lead to wholly inadequate regulations in a time of crisis,” said Jay Feldman, executive director of Beyond Pesticides. Beyond Pesticides has tracked the scientific literature on the threat of rodenticides to wildlife, including an important study on contamination of eagles with rodenticides. Central to the concern about the deficiencies in EPA’s biological evaluation is the inadequate focus on secondary poisoning of listed endangered species fish and aquatic reptiles associated with predation of animals poisoned with rodenticides. In 2020, California passed the California Ecosystems Protection Act, AB 1788, which mostly bans on state lands rodenticides associated with secondary poisonings and initiated a broader review.

Tell EPA to improve its protection of endangered species from rodenticides.

In announcing the  2022 COP15 conference — the United Nation’s (UN’s) Conference of the Parties to the Convention on Biological Diversity (CBD), the UN Development Programme set out the context for the summit: “Despite ongoing efforts, biodiversity is deteriorating worldwide, and this decline is projected to worsen with business-as-usual. The loss of biodiversity comes at a great cost for human well-being and the global economy.” Mr. Feldman said, “EPA either wants to be a part of the solution or a part of the problem. Unfortunately, this biological evaluation clearly exemplifies the agency is a part of the problem.” Meanwhile, the U.S. has never joined the world community in ratifying a national commitment to protecting biodiversity as a signatory to the United Nations Convention on Biological Diversity (CBD), signed by 196 nations. [In addition to commenting on the rodenticide biological evaluation, the public can continue to: Tell Congress to ratify the Convention on Biological Diversity. Tell EPA to incorporate CBD targets into its programs.]

The rodenticide comments due by February 13, EPA’s Draft Biological Evaluation (BE), Effects Determinations, and Mitigation Strategy for Federally Listed and Proposed Endangered and Threatened Species and Designated and Proposed Critical Habitats for 11 Rodenticides, are an opportunity for the public to urge the agency to evaluate pesticide impacts on the environment more holistically under its statutory mandate. Beyond Pesticides has stated, “The BE is inadequate, both in its evaluation of risk and measures to mitigate risk and should not be used as the basis for registration of these rodenticides.” A detailed examination can be found in draft comments by Beyond Pesticides.

The rodenticide biological evaluation is to be conducted under the Endangered Species Act (ESA), one of the most effective conservation laws globally, protecting 1,662 species in the U.S. and 638 species elsewhere on Earth. Over the past five decades, the ESA has played a pivotal role in preventing these extinctions by safeguarding the most critically endangered species within biological communities. The ESA establishes a framework to categorize species as “endangered” or “threatened,” granting them specific protections, but the goal of the ESA is to address the broader issue of biodiversity loss by protecting habitats of species most at risk, or, as stated in the ESA, to “Provide a means whereby the ecosystems upon which endangered species and threatened species depend may be conserved, to provide a program for the conservation of such endangered species and threatened species, and to take such steps as may be appropriate to achieve the purposes of the treaties and conventions set forth in subsection (a) of this section.”

Under the ESA, EPA is required to consult with relevant agencies when registering chemicals to assess their impact on endangered species. Unfortunately, according to advocates, EPA has consistently fallen short in fulfilling this statutory obligation, as highlighted over years of reporting by Beyond Pesticides. EPA admits that its Pesticide Program “has been unable to keep pace with its ESA workload, resulting not only in inadequate protections for listed species but also litigation against the Agency.”

Pesticide use is a major cause of declining biodiversity, which is manifested in extinctions, endangered species, and species vulnerable to environmental disturbances—including climate change, habitat fragmentation, and toxic chemicals. If EPA is serious about protecting biodiversity, it must look first to the ways it has created the crisis in the first place.

In this BE, EPA predicts the potential likelihood of future jeopardy for only 73 of the 136 species it judged may be affected and the potential likelihood of future adverse modification for only four of the 38 “likely to be adversely affected” critical habitats. It predicted potential jeopardy for 24 mammal species for bait station use, 31 for burrow use, and 35 for broadcast applications. For birds, EPA predicts jeopardy for six species from bait station use, one for burrow use, and 30 for broadcast applications. For reptiles, EPA predicts jeopardy for just four species from bait station use, and just one species for broadcast applications. EPA made “no effect” determinations for all aquatic and terrestrial plants, aquatic and terrestrial invertebrates, and aquatic vertebrates for which no direct effects or effects on prey, pollination, habitat, or dispersal are expected from the use of the 11 rodenticides.

Tell EPA to improve its protection of endangered species from rodenticides.

Despite data to the contrary, EPA has made no effect (NE) determinations for all species under the jurisdiction of the National Marine Fisheries Service (NMFS) because no consequences relevant to direct toxicity of these species or their prey, pollination, habitat, or dispersal are expected by EPA from the use of these rodenticides. These categorical NE determinations by EPA for all aquatic vertebrates, including those under the jurisdiction of NMFS, are not warranted. Anticoagulant rodenticides (ARs), contrary to the agency’s assertions, can be transported to the aquatic environment (freshwater and marine). Recent detections in raw and treated wastewater, sewage sludge, estuarine sediments, suspended particulate matter, and liver tissue of sampled fish demonstrate that the aquatic environment experiences a greater risk of anticoagulant rodenticide exposure than previously thought. One AR, brodifacoum, revealed an enduring persistence (>3 years) in a marine environment after broadcast treatment in an island eradication project. Monitoring studies have also demonstrated that second-generation ARs bioaccumulate in fish liver under environmentally realistic conditions and exposure scenarios. Island eradication programs also provide for increased drift and runoff potential due to the broader treatment area and amplified application rates. Fish sampled after broadcast applications of AR bait pellets during monitored island eradication operations (Palmyra Atoll and Lehua Island, Hawaii) were found to have consumed treated pellets. The fish, as well as other animals that consumed the bait, were killed.

Secondary poisoning in listed endangered species fish and aquatic reptiles is similarly possible from ingesting poisoned animals. Some invertebrates (e.g., insects, mollusks, and annelid worms) can consume poisoned baits and transfer the poison via food web to various susceptible vertebrates. Target and nontarget small mammals that have consumed poisoned baits will not always stay sedentary or concealed—many roam openly and often seek water. Those who become moribund or die in sewers, culverts, drainage ditches, or similar conduits can be swept into riparian zones or directly into water bodies (streams, rivers, lakes, tidal basins, estuaries) where they can be consumed by aquatic predators and scavengers. Encounter and ingestion of a poisoned and sickened rodent could prove fatal to aquatic vertebrate species. Mice have been reported to be consumed by listed species such as alligator snapping turtle, bull trout, Atlantic salmon, and steelhead trout. These four listed species should be considered “may be affected” and their potential jeopardy considered by the Services (U.S. Fish and Wildlife Services-USFWS and NMFS) in the required formal consultation. Additionally, marine mammals may be at serious risk from existing and planned island eradication projects and should be considered in a revised BE.

As discussed above, fish are exposed through primary routes in the consumption of bait pellets/grains that may be washed or transported into waters. They may also consume invertebrates or small mammals that have ingested poisoned baits and moved into their habitat. However, EPA lacks dietary toxicity data for fish and cannot confidently assess the extent of risk from this route of exposure in these aquatic vertebrates. EPA must seek additional toxicity data from registrants to better evaluate rodenticide toxicity from dietary exposures of fish. In addition to lacking dietary toxicity data for rodenticides, the agency also lacks reproduction and chronic (life cycle) toxicity data on aquatic vertebrates.

In conclusion, the draft BE is unsatisfactory and must be revised before proceeding to formal ESA §7(a)(2) consultations with the Services (Fish and Wildlife Service and National Marine Fisheries Service). The flawed draft BE erroneously disregards potential aquatic exposure and fails to identify additional listed species (alligator snapping turtle, bull trout, Atlantic salmon, steelhead trout) that may be adversely affected. Aquatic animals, including fish are exposed, as previously discussed, through primary routes in the consumption of bait pellets/grains that may be washed or transported into waters from broadcast application or improperly disposed bait stations. Secondary routes are also possible from consuming invertebrates or small mammals that have ingested poisoned bait and moved into their habitat. However, EPA lacks dietary toxicity data for fish and cannot confidently assess the extent of risk from this route of exposure.

EPA must seek additional toxicity data from registrants to better evaluate rodenticide toxicity from dietary exposures of fish. In addition to lacking dietary toxicity data for rodenticides, the agency also lacks reproduction and chronic (life cycle) toxicity data on aquatic vertebrates. Since this draft BE is intended to be a comprehensive review and analysis of all currently registered uses of 11 rodenticides, the island eradication programs special use labels should also be considered in the rodenticide BE and not solely dependent on expected USDA Animal Plant Health Inspection (APHIS) ESA consultations.

Source document: Document ID EPA-HQ-OPP-2023-0567-0001.

Tell EPA to improve its protection of endangered species from rodenticides.

Comment to EPA

The Draft Biological Evaluation (BE) is inadequate and should not be used to support the registration of the 11 rodenticides under review. Pesticide use is a major cause of declining biodiversity, which is manifested in extinctions, endangered species, and species vulnerable to environmental disturbances—including climate change, habitat fragmentation, and toxic chemicals. EPA must reverse these trends.

The BE predicts the potential likelihood of future jeopardy for only 73 of the 136 species that “may be affected” and the potential likelihood of future adverse modification for only 4 of the 38 “likely to be adversely affected” critical habitats. EPA made “no effect” determinations for all aquatic and terrestrial plants, aquatic and terrestrial invertebrates, and aquatic vertebrates for which it expects no direct effects or effects on prey, pollination, habitat, or dispersal from the use of the 11 rodenticides.

EPA made “no effect” (NE) determinations for species under the jurisdiction of the National Marine Fisheries Service (NMFS). These categorical NE determinations by EPA for all aquatic vertebrates are not warranted. Anticoagulant rodenticides (ARs) can be transported to freshwater and marine environments—as shown by recent detections in raw and treated wastewater, sewage sludge, estuarine sediments, suspended particulate matter, and liver tissue of fish. One AR, brodifacoum, persisted at least 3 years in a marine environment after broadcast treatment in an island eradication project (Palmyra Atoll and Lehua Island, Hawaii). Studies also show that second-generation ARs bioaccumulate in fish liver. Island eradication programs provide increased drift and runoff potential due to the broad treatment area and high application rates. Fish sampled after broadcast applications of AR bait pellets during monitored island eradication operations were found to have consumed treated pellets. The fish and other animals that consumed the bait were killed.

Secondary poisoning in listed endangered species aquatic species may occur by ingesting poisoned animals. Invertebrates such as insects, mollusks, and annelid worms can consume poisoned baits and transfer the poison via food web to susceptible vertebrates who may end up in water bodies where they can be consumed by aquatic predators and scavengers. Ingestion of a poisoned and sickened rodent could prove fatal to aquatic vertebrates. Mice are consumed by listed species such as alligator snapping turtle, bull trout, Atlantic salmon, and steelhead trout. These four listed species should be “may be affected” and their potential jeopardy considered by the Services (USFWS and NMFS) in the required formal consultation. Additionally, marine mammals may be at serious risk from existing and planned island eradication projects and should be considered in a revised BE.

In conclusion, the draft BE is flawed and must be revised before proceeding to formal consultations with the Services. The draft BE erroneously disregards potential aquatic exposure and fails to identify additional listed species (alligator snapping turtle, bull trout, Atlantic salmon, steelhead trout) as well as marine mammals that may be adversely affected. Aquatic animals are exposed through primary routes and secondary routes. EPA must seek additional data from registrants on dietary and chronic toxicity to aquatic vertebrates, which it currently lacks. Since this draft BE is intended to be a comprehensive review and analysis of all currently registered uses of 11 rodenticides, the island eradication programs special use labels should also be considered in the rodenticide BE and not wait on expected APHIS consultations.

Thank you for considering these comments.

(Beyond Pesticides, January 26, 2024) In addition to maternal (mothers) exposure, children experience exposure to pyrethroid insecticides earlier in life as levels significantly increase post-natal (after birth), according to a study published in Frontiers in Public Health. This study is one of the few studies to investigate pyrethroid exposure concentrations in the urine of newborns and children within their first year of life. However, this research reiterates what many other studies demonstrate on pyrethroids’ impacts on children’s health, primarily due to their notorious neurotoxic properties. The findings indicate that exposure to pyrethroids during pregnancy and early childhood exposure has links to adverse health effects, including neurodevelopmental delays (e.g., autism), behavioral issues (e.g., attention deficit [hyperactivity] disorder), and endocrine disruption (e.g., delay in puberty). Pesticide exposure during pregnancy is of specific concern as health effects for all life stages can be long-lasting. Just as nutrients are transferable between mother and fetus, so are chemical contaminants. Studies find pesticide compounds in the mother’s blood can transfer to the fetus via the umbilical cord. Therefore, pesticide exposure during pregnancy affects both the mother and child’s health.

Beyond Pesticides has covered a variety of pregnancy risks from pesticides and other toxic chemicals, including these in just the last three years: pesticides and children’s sleep disorders; prenatal exposures to a multitude of chemicals; insecticides and childhood leukemia; and insecticides and Attention Deficit/Hyperactivity Disorder.

The study evaluated concentrations of pyrethroid insecticides from exposure among 142 pregnant women in Rio de Janeiro, Brazil, and their children during birth and in the first, third, and sixth months of life. Researchers measured pyrethroid concentrations in urine via metabolites (breakdown products) of the insecticides 3-phenoxy benzoic acid (3-PBA) and 4-fluoro-3-phenoxybenzyl acid (4-FPBA). The results find 3-PBA more frequently in the urinalysis of pregnant women (47 percent) as it is the metabolite of more common pyrethroids used in Brazil, like cypermethrin, cyhalothrin, deltamethrin esfenvalerate, and permethrin, compared to 4-FPBA, a metabolite of cyfluthrin, in 11 percent of pregnant women. Ten percent of children’s urine samples have detachable 3-PBA levels after birth. However, the levels of 3-PBA increase with age, as 21 percent of the children’s urine samples during the third and sixth months of life contain detectable levels of pyrethroids.

The study highlights that the presence of pyrethroids in newborn urine indicates exposure through the mother during gestation (pregnancy), and continued exposure through the first year of the child’s life can be due to exposure through breast milk, food consumption, and the use of pyrethroid-based insecticides indoors.

Prenatal and early-life exposure to environmental toxicants increases susceptibility to disease, as women living near agricultural areas experience higher exposure rates that increase the risk of birthing a baby with abnormalities, including brain malformations. A 2011 study found that children exposed to higher levels of synthetic pyrethroids are three times as likely to have mental delays compared to less exposed children. Additionally, a 2014 study associates proximity to pesticide-treated agricultural fields in pregnancy with an increased risk of autism in children of exposed mothers. Two studies published in 2015 found that deltamethrin increases the risk of attention-deficit/hyperactivity disorder (ADHD) in children, with one study finding impacts specifically on boys. Studies published in 2017 found that synthetic pyrethroid exposure increases the risk of premature puberty in boys, and another associated the chemicals with externalizing and internalizing disorders. The impacts seen are not all developmental. A 2012 study associates pyrethroid exposure before, during, and after pregnancy with an increased risk of infant leukemia, with a 2013 finding exposure to permethrin (a pyrethroid) in utero is linked to an increased risk of infant leukemia diagnosed before age two. More recently, a 2022 study finds that synthetic pyrethroid exposure during mosquito control operations increases the risk of respiratory disease and specific allergies.

This study highlights that people living within the study area have used household pesticides within the previous year, with over 80 percent of those household pesticides containing pyrethroids. Thus, the rampant use of these chemicals can account for their presence in breast milk, transferring from mother to child through nursing. With this study being one of the few to assess urinary concentrations of pyrethroids in newborns and children during the first year of life, the results are relatively concerning. The increase in pyrethroid metabolite concentrations in urine after birth highlights the potential adverse impacts on newborns, who are more vulnerable to the toxic effects of pollutants due to their immature immune systems. This conclusion supports long-known concepts regarding the hazards of pesticides to children’s health. Early life exposures during “critical windows of vulnerability” can predict the likelihood or otherwise increase the chances of an individual encountering a range of pernicious diseases. 

There is a strong consensus among pediatricians that pregnant mothers and young children should avoid pesticide exposure during critical windows of development. However, the general population should follow this advice as the effects of pesticide exposure can affect every individual. Beyond Pesticides tracks the most recent studies on pesticide exposure through the Pesticide Induced Diseases Database (PIDD). This database supports the need for strategic action to shift away from pesticide dependency. For more information on the multiple harms of pesticide exposure, see PIDD pages on learning/developmental disorders, Birth/Fetal Effects, Sexual and Reproductive Dysfunction, Body Burdens, and other diseases. Additionally, learn more about the hazards to children’s health through Beyond Pesticide’s Pesticide and You Journal article, “Children and Pesticides Don’t Mix.”

Fortunately, the wide availability of non-pesticidal and nontoxic alternative strategies allows for choices in residential and agricultural management to promote a safe and healthy environment, especially among chemically vulnerable individuals. For instance, buying, growing, and supporting organic land management reduces human and environmental contamination from pesticides. Organic agriculture has many health and environmental benefits, which curtail the need for chemical-intensive agricultural practices. Numerous studies find that pesticide metabolite levels in urine significantly decrease when switching to an all-organic diet. For more information on how organic is the right choice for consumers and the farmworkers that grow our food, see the Beyond Pesticides webpage on the Health Benefits of Organic Agriculture.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: Frontiers in Public Health

(Beyond Pesticides, January 25, 2024) Legislative efforts to curtail some life-threatening pesticides associated with birds and bees (and other pollinators) decline were weakened in New York State at the end of December 2023 as the governor negotiated and stripped elements of a bill relating to agriculture that had passed the legislature—again illustrating the grip of the agrichemical industry on public policy intended to begin to address the crisis in ecosystem collapse. (See “Study Cites Insect Extinction and Ecological Collapse.”) In passing the Birds and Bees Protection Act, New York joined New Jersey, Nevada, and Maine in banning most nonagricultural uses of neonicotinoid (neonic) insecticides, but, in last-minute changes to avoid the governor’s veto, failed to phase out corn, soybean, and wheat seeds coated with these chemicals. [Pointing to an exemption in federal law that has been challenged by advocates, the U.S. Environmental Protection Agency (EPA) does not regulate treated or coated seeds as pesticides despite their toxic pesticidal properties.] In New York State, the governor can, in consultation with the leadership of the legislative branch, negotiate language changes (called Chapter Amendments) in legislature-passed legislation (originally enacted) before deciding to sign it into law or can simply choose to veto the legislation. In the case of S. 1856-A and A. 7640, the Birds and Bees Protection Act, the governor stripped out major legislative advances and crafted a negotiation process for determining the status of coated seed use that runs through 2029. [Note: The changes can be seen in the linked (above) line-edited version of the new law—green text is law and red text is the originally enacted legislation.]

“Clearly, while the Senate and Assembly of New York State recognize the importance of removing from the agricultural market seeds coated with deadly pesticides that are wreaking havoc with the ecosystem at a crucial time when scientists have warned us about ecosystem collapse, the governor is playing politics with environmental systems essential to sustaining life,” said Jay Feldman, executive director of Beyond Pesticides. “The delay and waiver provisions for continued ecosystem-toxic chemical use through 2029 and beyond unfortunately do not meet the challenge of our time to eliminate petrochemical pesticides that are known to be harmful and unnecessary in light of the availability of productive and profitable organic agricultural practices,” Mr. Feldman continued, saying, “These chemicals are the poster children for a failed EPA pesticide regulatory process.” Like New York, state and local governments are increasingly stepping in to restrict pesticides given what they view as inadequate protection from EPA.

Advocates note that the major difference between the originally enacted Birds and Bees Protection Act and the governor-amended law is the stripping out of unequivocal statutory mandates that are intended to force institutional change to meet a crisis—and their replacement with language deferential to regulatory bodies with a history of advancing pesticide dependency. Agencies like these that are given broad discretionary power (and thus under pressure from those regulated) tend to maintain the status quo. The fact that the law signed by the governor opens the door to the regulation of seeds coated with ecosystem-toxic pesticides is in theory an important step. However, advocates argue that key to addressing the life-threatening petrochemical pesticide threats of the current day are statutory mandates that are unequivocal in eliminating known toxics without broad waiver provisions and are implemented in reasonable time frames with a serious investment in alternatives practices and products.

Starting January 1, 2027, New York will join Nevada, New Jersey, and Maine, with the strongest state laws that eliminate all outdoor (nonagricultural) uses of bee-toxic neonicotinoid (neonic) insecticides, except for outdoor uses around structures for structural pests. Previously, New York Department of Environmental Conservation (NY DEC) took action to limit certain products containing the neonicotinoid (neonic) insecticides imidacloprid, thiamethoxam, and acetamiprid by reclassifying their use to “restricted use,” meaning applications were limited to trained pesticide applicators in specific situations. In 2023, Minnesota banned neonicotinoid use on state lands and granted its home-rule subdivisions the authority to ban “pollinator-lethal pesticides” (those with bee warning labels) under its state law, which otherwise preempts local authority to restrict pesticides.

An analysis of the Birds and Bees Protection Act can be divided into two parts, its restrictions on residential and agricultural use. In the area of typical residential use, the bill incorporates language, adopted in numerous states across the U.S., that prohibits people generally from applying five neonicotinoids and related compounds (clothianidin, imidacloprid, thiamethoxam, acetamiprid, and dinotefuran). A provision added by the governor exempts from the law ”structural commercial applications within one foot of a building foundation perimeter to manage structural pests provided that the application is not conducted on any blooming plant.” Because the neonicotinoids are systemic pesticides that move through the vascular system of plants and because of the adverse impact of the chemical on soil organisms, this provision has broad implications for destructive ecosystem exposure. The language contains a one-year (without restrictions on renewals) use exemption for an “environmental emergency,” which is defined as “an occurrence of any pest which presents a significant risk of harm or injury to the environment. . . , including, but not limited to, any exotic or foreign pest.” The Department of Environmental Conservation (DEC) is required to determine efficacy of the neonicotinoid to be used and make a finding that “no other, less harmful pesticide or pest management practice would be effective in addressing the environmental emergency.” Certified applicators, or those operating under their supervision, are permitted to use the chemicals on “invasive species affecting woody plants.”

On the agricultural provisions, delayed until 2029, DEC, in consultation with the Department of Agriculture and Markets, is given broad mandated authority to promulgate any appropriate regulations” in implementing a two-year renewable waiver  “to sell, offer for sale or use, or distribute within the state any corn, soybean or wheat seeds coated or treated” with clothianidin, imidacloprid, thiamethoxam, or any other neonicotinoid as determined by the department in regulation. The originally enacted legislation included two related compounds, acetamiprid and dinotefuran, whose uses in agriculture will continue under the law. Prerequisites for the waiver include: farm owners must complete an integrated pest management (IPM) training and complete a “pest risk assessment” and report. Agricultural uses are also covered by the “environmental emergency” provision cited above in the case of “significant harm, injury, or loss to agricultural crops.” Advocates point out that chemical-intensive agriculture that ignores ecosystem services leads to crops threatened with “significant harm” from pests and disease and a cycle of chemical dependency to sustain yields. In this context, statutory support is needed to assist farmers in getting off the chemical treadmill to eliminate reliance on neonicotinoids and other pesticides. Otherwise, emergency provisions like that in the law will be triggered repeatedly.

Recordkeeping for coated seed use is required and subject to DEC review. This waiver process dramatically changes the originally enacted version of the bill, which provided for a temporary one-year waiver period only in the case of a finding by the DEC and Department of Agriculture and Markets that untreated seeds are not commercially available or the purchase of untreated seeds “would result in undue financial hardship to agricultural producers.” Commercial availability clauses in law tend to incentivize the market to increase availability of the alternative to the banned chemical, so the expectation is that the language jettisoned by the governor would have increased the market for untreated seed.

The fingerprints of the agrichemical industry on this bill, although obvious throughout, is especially clear in the deletion of the “State University of New York College of Environmental Science and Forestry” (according to their website: “focused on the study of the environment, developing renewable technologies, and building a sustainable future”) from the list of consultants on a mandated alternatives study. The law requires the DEC and Department of Agriculture and Markets “to identify practicable and feasible alternatives” to the use of clothianidin, imidacloprid, thiamethoxam, dinotefuran, or acetamiprid, only with the New York state’s land grant university.

As reported in the Wellsville Sun, New York State Farm Bureau President David Fisher lauded Governor Hochul for the changes she negotiated to the legislation, stating that “the new legislation is a product of good faith negotiations between NY agricultural interests and the Governor.” Despite scientific findings of no benefit associated with treated soybean seed (see here and here), the ranking member of the Senate Agriculture Committee said the bill “dealt another blow to struggling New York farmers,” saying that seed treatment technology has “helped farmers optimize crop yield and quality.” 

The longest-running—four-decade—investigation comparing organic and conventional grain-cropping approaches in North America is reporting impressive results for organic. The Rodale Institute’s Farming Systems Trial—40-Year Report, released in 2022, highlighted these outcomes: (1) organic systems achieve 3–6 times the profit of conventional production; (2) yields for the organic approach are competitive with those of conventional systems (after a five-year transition period); (3) organic yields during stressful drought periods are 40% higher than conventional yields; (4, 5, and 6) organic systems leach no toxic compounds into nearby waterways (unlike pesticide-intensive conventional farming), use 45% less energy than conventional, and emit 40% less carbon into the atmosphere. Beyond Pesticides reported in 2019 on similar results, from the institute’s 30-year project mark, which have been borne out by another three years of trials. (See Daily News.)

For additional discussion on the importance of ecosystem health and organic agriculture, view a talk by David Goulson, PhD, and André Leu, DSc, at the 40^th National Forum, Forging a Future with Nature.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: Birds and Bees Protection Act, S. 1856-A and A. 7640

(Beyond Pesticides, January 24, 2024) A study published in Environmental Sciences Europe finds that 2,4-D, pyrethroid (PRY), and organophosphate (OP) pesticides increase the risk of cancer through oxidative stress (OS). The study highlights that pesticides that increase cancer risk also raise inflammation biomarkers that indicate damage to organs (e.g., liver) via oxidative stress. Additionally, different cancers show different sensitivities to pesticides; thus, cancer risk changes with exposure concentration and pattern. Despite a plethora of studies linking cancer and pesticide exposure, very few cover the mechanisms involved in cancer development, including OS.

Only five to ten percent of cancers are hereditary. However, environmental or lifestyle factors, like chemical exposure, can make an individual more susceptible to cancer development through gene mutation. In fact, a vast amalgamation of research links cancer risk to pesticide exposure, which augments the risk of developing both common and rare cancers. Therefore, studies like this highlight the importance of understanding how pesticide use can increase the risk of latent diseases, which do not readily develop upon initial exposure.

Using data from the National Health and Nutrition Examination Survey (NHANES), researchers investigated the link between the risk of several cancers and pesticide exposure. The researchers also thoroughly evaluated the mechanism’s impact on cancer development and oxidative stress. The study focuses on six types of cancers: breast, colon, cervical, prostate, melanoma, and non-melanoma skin cancer. Individuals who have cancer were the case group, while individuals without cancer were the control. To determine pesticide exposure, researchers measured the concentration of pesticide metabolites in urine, with the most detectable being used in the study, including metabolites of OPs (oxypyrimidine [diazinon], paranitrophenol [parathion], and dichlorovnl-dimeth prop carboacid [dichlorvos]), pyrethroids (4-fluoro-3-phenoxybenzoic acid, 3-phenoxybenzoic acid), and 2,4-D. From blood samples, oxidative stress measurements used eight biological markers (biomarkers), and inflammatory measurements used two biological markers. The results find that each pesticide increases the risk of at least three of the six cancers. Markers for oxidative stress from pesticide exposure, including iron, aspartate aminotransferase (AST—an enzyme found in the liver, muscle, and other organs), and gamma-glutamyl transferase (GGT—another enzyme found in the liver and throughout the body), have a positive association with cancer risk.

The connection between pesticides and associated cancer risks is not a new finding. Many pesticides are “known or probable” carcinogens (cancer-causing agents), and widespread uses only amplify chemical hazards, adversely affecting human health. Several studies link pesticide use and residue to various cancers, from the more prevalent breast cancer to the rare kidney cancer, nephroblastoma (Wilms’ tumor). Sixty-six percent of all cancers have links to environmental factors, especially in occupations of high chemical use. At least 45 different cancers have associations with work-related chemical exposure. Although the link between agricultural practices and pesticide-related illnesses is stark, over 63 percent of commonly used lawn pesticides and 70 percent of commonly used school pesticides have links to cancer. Many cancer-causing substances are endocrine disruptors, directly affecting traditional endocrine glands and their hormones and receptors (e.g., estrogens, anti-androgens, thyroid hormones) while greatly influencing hormone cancer incidents among humans (e.g., unrein, breast, prostate, and thyroid cancers). Moreover, several studies and reports, including U.S. Environmental Protection Agency (EPA) data, identify hundreds of chemicals as influential factors associated with hormone-related cancer risk. 

All chemicals in this study produce different biological markers of oxidative stress, and the concentrations of oxidative stress biological markers can indicate an increased risk of cancer. Many of the study’s patients with cancer had a history of exposure to 2,4-D, PYRs, and OPs (like parathion), with prostate cancer being the most significant. However, the oxidative stress biological marker AST demonstrated an increased cancer risk of colon, prostate, breast, and cervical cancers among patients exposed to 2,4-D and melanoma, prostate cancer, and breast cancer among patients exposed to the OP diazinon. This study considers the role oxidative stress from pesticide exposure plays a role in cancer development, highlighting how previous studies tend to focus on the endocrine-disrupting effects of pesticide exposure on cancer development. Discovering additional mechanisms involved in pesticide-mediated cancers can give researchers a holistic understanding of disease risk from chemical exposure.

There is a limited understanding of the etiology of pesticide-induced diseases, including predictable lag time between chemical exposure, health impacts, and epidemiological data. Exposure to pesticides can increase the risk of developing chronic illnesses. Cancer is one of the leading causes of death worldwide, with over eight million people succumbing to the disease every year. Notably, IARC predicts an increase in new cancer cases from 19.3 million to 30.2 million per year by 2040. Therefore, studies related to pesticides and cancer will aid in understanding the underlying mechanisms that cause the disease. Consequently, it is essential to understand the health implications of pesticide use and exposure for humans, particularly when pesticides increase chronic disease risk. Beyond Pesticides tracks the most recent news and studies on pesticides and related topics through the Daily News Blog and Pesticide-Induced Diseases Database (PIDD). For more information on the adverse effects of pesticides on human health, see PIDD pages on cancer, endocrine disruption, and other diseases.

Moreover, proper prevention practices, like buying, growing, and supporting organics, can eliminate exposure to toxic pesticides. Organic agriculture has many health and environmental benefits, as it curtails the need for chemical-intensive agricultural practices. Regenerative organic agriculture nurtures soil health through organic carbon sequestration, preventing pests and generating a higher return than chemical-intensive agriculture. For more information on why organic is the right choice, see the Beyond Pesticides webpage, Health Benefits of Organic Agriculture. 

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: Environmental Sciences Europe

(Beyond Pesticides, January 23, 2024) Earlier this month, a coalition of over 140 local and state elected officials from over 30 states sent a letter to ranking members of the House and Senate Agriculture committees to reject the proposed Agricultural Labeling Uniformity Act (H.R. 4288), which would preempt local governments’ authority to protect their constituents from toxic pesticides. Members of Congress are negotiating language in the Farm Bill that would preempt local and state authority to restrict pesticides.

“We write to express our strong opposition to any efforts to limit longstanding state and local authority to protect people, animals, and the environment by regulating pesticides,” says the signatories. “As Congress considers legislation related to agriculture, including the reauthorization of the Farm Bill and Fiscal Year 2024 appropriations bills, we urge you to ensure that state, county, and local governments retain the right to protect their communities and set policies that best suit our local needs.”

The question of local rights to adopt more stringent restrictions on pesticide use has historically been left to the states. However, after the U.S. Supreme Court (Wisconsin v. Mortier, 1991) affirmed the rights of local communities under the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA), most states stepped in to take away local pesticide control authority. However, multiple state legislatures have been grappling with state preemption reform with mixed results, including in Colorado, Illinois, Wisconsin, and West Virginia, underscoring what advocates see as an important citizen-led advocacy movement to hold elected officials in state legislatures accountable to the local democratic process.

In 2023, Illinois successfully passed SB 171, establishing the Pesticide Application at Schools Act (PASA). PASA prohibits schools “serving students grades kindergarten through 8th grade… from scheduling pesticide applications on school grounds during the school day, including during a partial day, when students are in attendance at school for instructional purposes.” This is a big change to state policy that did not enforce any requirements for pesticide spraying within school zones. PASA will enter into force starting July 1^st, 2024.

Last year, the Wisconsin legislature deliberated over several legislative items that would expand exemptions to state law that currently prevent local pesticide ordinances. Senate Bill 359 and Assembly Bill 358 would provide an additional exemption permitting local governments to prohibit pesticide spraying “for the purpose of protecting pollinator or pollinator habitats.” Senate Bill 322 and Assembly Bill 289 would permit local governments to ban pesticide use on private lawns. These bills did not get to a vote and expired as the 2024 legislative session begins, but they both represent a decades-long commitment by local elected officials to regulate pesticide use under their jurisdictions. Pesticide industry group Responsible Industry for a Sound Environment (RISE), an agrichemical industry-aligned association, sued Dane County back in December 2005 (See court finding.) over its decision to institute a ban on the use of synthetic lawn fertilizers that contain phosphorus due to its pollution of local lakes—what is considered the restricted the use of “weed and feed” products that combine synthetic fertilizers and herbicides. The U.S. 6th Circuit Court of Appeals upheld Dane County’s fertilizer ordinance in December 2005, finding that the law does not preempt local authority to regulate fertilizers containing pesticides. Jurisdictions in states that preempt local authority to restrict pesticides can in most cases institute synthetic fertilizer restrictions that limit “weed and feed” products containing pesticides.

Colorado legislators recently failed to reverse state preemption when enacting Senate Bill 192, allowing the state to continue preventing counties from issuing pesticide ordinances, rules, and actions through 2034. A similar move had previously failed to authorize local governments to regulate pesticides at the county level in 2020.  

Democracy is under attack in West Virginia with the rushed passage of SB 171, which would prevent county commissions from setting more stringent standards, ordinances, rules, or other actions that “prohibits the purchase, or alters the permissible use or application, of any federally or 40 state-registered pesticide, herbicide, or insecticide product.” The Senate Bill was initially introduced in the 2023 legislative session but failed because it was held up in the House of Delegates Judiciary Committee. State senators reintroduced the bill on the first legislative day of the 2024 calendar year and voted unanimously in favor just two days later without going through the Senate Agriculture and Natural Resources Committee, disregarding any input from local elected officials. The Charleston Gazette-Mail interviewed Hardy County officials, including Commissioner Steven Schetrom, who expressed his concerns “about the implications of this bill.” Mr. Schetrom hopes to continue discussions with state elected officials before the next vote so “that the key decision makers are able to make choices that lead to the best health outcomes for West Virginians.” West Virginia had previously adopted preemption of local pesticide control authority in its state pesticide law.

Was Congress not supposed to pass the Farm Bill in 2023? History seems to repeat itself as yet another continuing resolution (CR) passed last week to keep the government from shutting down in March. This has significant implications for the fate of the preemption regulatory paradigm that stifles community ownership of their own health outcomes. Please see “Pesticide Lobby Pushes Farm Bill Amendment to Strip Localities and States From Restricting Pesticides” on the legacy of federal deference of pesticide management to state agencies through the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). This article discusses the impact of state preemption language on the longstanding legacy of local governments to regulate related issues, including dog waste and trash cleanup.

Local governance of pesticide regulation has been vital to community health because of concerns such as pesticide drift from private to public land. Beyond Pesticides has extensively explored the heightened impact of chemical exposure to sensitive populations, including children, pregnant women, and immunocompromised individuals. There is a history of studies tying pesticide drift to increased rates of childhood leukemia, neurodevelopmental challenges, and various forms of cancer. Pesticide drift into riverways, groundwater, and soil has also jeopardized the health of birds, amphibians, and tropical mammals.

Beyond Pesticides has provided numerous resources on the history of insidious state preemption efforts conducted by the petrochemical industry. Some of these resources include a detailed map of distinctions between all 50 states and their relevance to state lawn pesticide notification laws. There are also many ways to act that are proven to mobilize grassroots momentum. The recently released letter represents the culmination of community leaders such as you who successfully reached out to public officials through a previous call to action to protect local democracy in the upcoming Farm Bill. You can still share these resources with your elected officials in the lead-up to the Farm Bill.

There is still time to contact your U.S. Representative or Senator directly to oppose inclusion in the Farm Bill of the Agricultural Labeling Uniformity Act (H.R. 4288), which would amend FIFRA to mandate, “uniformity in national pesticide labeling, and prohibit any State, instrumentality or political subdivision thereof, or a court from directly or indirectly imposing or continuing in effect any requirement… different from the labeling or packaging approved by the Administrator.” Rather than treat FIFRA as the minimum level of protection guaranteed by the federal government, H.R. 4288 provisions would alter the standards to treat FIFRA language as a ceiling for pesticide management under the guise of concern over labeling consistency.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: Environmental Working Group

(Beyond Pesticides, January 22, 2024) Today, Monday, January 22, is the last day for public comment on a three-year extension of U.S. Department of Agriculture’s (through its Agricultural Marketing Service’s National Organic Program (NOP)) authority to collect information from certifiers entrusted with ensuring compliance with organic standards. Beyond Pesticides, along with allied organizations and organic advocates, is urging USDA to use this process to clarify the need for USDA to collect key information needed to verify compliance with key language in OFPA (Section 6513(b))—a provision that requires farming practices that “foster soil fertility.”

Advocates maintain that information on organic farmers’ practices to foster soil fertility, required in the law, is critical to organic integrity, public trust in the organic label, and certifier responsibility. As USDA states, “The Organic Foods Production Act of 1990 (OFPA), as amended (7 U.S.C. 6501–6524), authorized the Secretary of Agriculture to establish the National Organic Program (NOP) and accredit certifying agents to certify that farms and businesses meet national organic standards. Under OFPA, the purpose of the NOP is to: (1) establish national standards governing the marketing of certain agricultural products as organically produced products; (2) assure consumers that organically produced products meet a consistent standard; and (3) facilitate interstate commerce in fresh and processed food that is organically produced (7 U.S.C. 6501).”

Advocates cite a failure of NOP to consistently require the collection of information on soil-building practices for certification of organic farms, which they say presents a serious threat to organic integrity and compliance with organic law. As a result of this failure, some growers using hydroponic and other practices that do not build the soil are allowed to sell produce as organic. And, consumers are not able to distinguish growing practices because produce is not required to be labeled as “hydroponic” or “container-grown.”

Organic farming and soil are inextricably linked. The microorganisms in healthy soils interact in a symbiotic manner with plant roots, strengthening the plant, enabling it to resist diseases and facilitating water and mineral uptake. The essence of organic production is maintaining and enhancing the organic matter content of soil by relying on environmentally beneficial methods such as green manure, crop rotation, and biological pest management.

Tell USDA to protect organic integrity and follow organic law by fostering soil fertility for ALL organic labeled products.

The Earth needs many more real organic farms that support soil health, help sequester carbon dioxide, and avoid the use of materials like soluble nitrogen fertilizers that contribute many times as much warming potential as carbon dioxide. By a decisive vote in 2010, the USDA National Organic Standards Board determined that hydroponic and aquaponic operations are inconsistent with OFPA and do not qualify for organic certification.

At the present time, the NOP accredits certifying agents that certify soil-based crop producers who comply with the soil fertility requirements of OFPA and regulations. Simultaneously, the NOP accredits certifying agents that certify hydroponic, container, and other soilless crop production systems that do not comply with the soil fertility requirements of OFPA and NOP regulations.

Soil-based organic production systems sequester carbon, fix nitrogen, build soil health, increase the water-holding capacity of soils, prevent soil erosion, foster the cycling of resources, promote ecological balance, conserve biodiversity and provide numerous ecological services. Hydroponic, aquaponic, and other soilless container growing systems do not sequester carbon, fix nitrogen, increase the water-holding capacity of soils, recycle nutrients, prevent erosion, enhance biological diversity, or protect ecological balance, yet the USDA currently allows such operations to be certified “organic.”

There are significant differences between soil-based and soilless crop production systems, but there is no data available to determine how much of the U.S. organic market is comprised of the products from these two different production systems, since the products of both systems are labeled “organic” and allowed to carry the “USDA Organic” logo. Likewise, USDA has no data to research and compare the environmental and health impacts of these systems, since the products of both systems are labeled the same.

This comment period provides an opportunity to tell USDA that its failure to require data that can support an organic farm’s compliance with the soil-building requirements of OFPA undermines organic consumers’ trust in the integrity of the organic market.

Tell USDA to protect organic integrity and follow organic law by fostering soil fertility for ALL organic labeled products.

Letter to USDA, National Organic Progam

The Earth needs many more real organic farms to support soil health, help sequester carbon dioxide, and avoid the use of materials that contribute many times as much warming potential as carbon dioxide. USDA’s failure to require information to ensure consistent application of the Organic Foods Production Act (OFPA) threatens the integrity of organic products upon which I depend.

At 6513(b)(1), OFPA states, “An organic plan shall contain provisions designed to foster soil fertility, primarily through the management of the organic content of the soil through proper tillage, crop rotation, and manuring.” OFPA 6513(g) states, “An organic plan shall not include any production or handling practices that are inconsistent with this chapter.”

NOP now accredits certifying agents that certify soil-based crop producers who comply with the soil fertility requirements of OFPA 6513(b)(1) and 7 CFR sections 205.2, Natural Resource Protection; 205.203 Soil Fertility and Nutrient Management; and 205.205 Crop Rotation. NOP also accredits certifying agents that certify hydroponic, container, and other soilless crop producers who do not comply with those same requirements.

Soil-based organic production systems sequester carbon, fix nitrogen, build soil health, increase the water-holding capacity of soils, prevent soil erosion, foster the cycling of resources, promote ecological balance, conserve biodiversity, and provide numerous ecological services, while hydroponic, aquaponic, and other soilless container growing systems do not, yet USDA allows such operations to be certified “organic.”

Despite significant differences between soil-based and soilless crop production systems, USDA has no data to determine or research how much of the U.S. organic market is comprised of the products from these two different production systems, since the products of both systems are labeled “organic” and allowed to carry the “USDA Organic” logo and compare the environmental and health impacts of these systems.

NOP must collect data on the type of production system used by certified organic crop producers to determine the number of soil-based vs soilless crop production operations and products, both foreign and domestic, that are being certified as “organic” under NOP. Accredited certifying agents must ask specific questions to assess all crop operations’ compliance with OFPA 6513(b)(1), since the law states that organic crop plans “shall contain provisions designed to foster soil fertility.”

In order to “assure consumers that organically produced products meet a consistent standard,” NOP must require that accredited certifying agents who certify hydroponic, aquaponic, and other soilless container systems provide data to NOP—and make it publicly available—on the number of such operations that they certify; the amount of acreage or square footage in soilless production; the types and quantities of crops produced using soilless production methods; the expected vs actual yields from soilless operations; the value of the crops produced using soilless production methods; the labels and brand names used on all such products; the countries of origin; and the markets where these products are sold.

The U.S. is the only country where soilless crop production systems are being certified as “organic,” so collection of the information cited above is needed to verify compliance with trade agreements in international organic markets. 

USDA has issued no rules governing the soilless production of “organic” crops, so it is incumbent on USDA to collect accurate and detailed information on both soil-based and soilless crop production systems that are being certified as “organic,” in order to comply with OFPA Sections 6501(2), 6513(b), and 6513(g), and 7 CFR Part 205.2, 205.203, and 205.205.

Thank you.

Source: Notice of Intent to Extend and Revise a Previously Approved Information Collection (2024)
Document ID: AMS-NOP-23-0052-0001

(Beyond Pesticides, January 19, 2024) A study published in Environmental Health Perspective is one of the first to indicate a link between exposure to the herbicides 2,4-D and glyphosate and the impairment of behavioral performance (i.e., attention/inhibitory control, memory/learning, language, visuospatial processing, and social perception). These adverse effects associated with the neurotoxic impacts of pesticides on behavior have been previously documented. For example, a study in August 2023 finds oral intake (e.g., eating contaminated foods), inhalation, and dermal exposure to glyphosate lowered cognitive function scores, increased the likelihood of severe depressive symptoms, and impaired auditory (hearing) function. Although previous studies find neurotoxic effects from exposure to these herbicides, very few until now have evaluated how this neurotoxic exposure impacts neurotypical behavior among youth (children and teenagers).

The ubiquitous use of glyphosate and 2,4-D use in agriculture—which leaves residues of the toxic chemicals in food and in public areas (e.g., parks and walkways) creates a creates a significant risk for exposure. Glyphosate is already implicated in or proven to lead to the development of numerous health anomalies, including cancer, while 2,4-D also has a range of potential hazards, including cancer. Therefore, studies like this help local and government officials make holistic decisions regarding the use of pesticides that adversely affect human health, especially among adolescents.

Principal investigator José Ricardo Suarez-Lopez, MD, PhD, associate professor at the Herbert Wertheim School of Public Health and Human Longevity Science at the University of California, San Diego (UCSD), expresses the importance of studying these pesticides for other effects like hormone disruption, mental health, inflammation, and additional health systems, and says, “Our study will allow us to evaluate the toxicity potential of these and other chemicals assessed from childhood through adulthood.”

The neurological system, including the brain, spinal cord, and a vast network of nerves and neurons, is responsible for many bodily functions—from behavior to movement. However, pesticides play various roles in causing or exacerbating adverse health outcomes, including neurotoxic effects and chemical damage to the brain. Numerous pesticides impair neurological function, especially for chronically exposed individuals (e.g., farmworkers) or during critical windows of vulnerability and development (e.g., childhood, pregnancy).

The study evaluates 519 adolescent individuals between the ages of 11 and 17 years, living in Ecuadorian agricultural communities for concentration of glyphosate, two N, N-diethyl-meta-toluamide (DEET), 2,4-D, and their metabolites (breakdown products) in urine samples. Upon collection of samples, researchers also assess the neurobehavioral performance of the adolescent participants through five areas: attention/inhibitory control, memory/learning, language, visuospatial processing, and social perception. Overall, glyphosate is detectable in 98.3 percent of participant urine samples, 2,4-D in 66.2 percent of participants, and DCBA (the metabolite of DEET) in 63.3 percent of participants. Although DEET lacks an association with neurobehavioral performance in this study, 2,4-D and glyphosate are negatively associated with neurobehavioral performance. 2,4-D has the highest association with negative neurobehavioral performance for all five areas, with the most significant impacts on attention/inhibition control, language, and memory/learning, respectively. On the other hand, glyphosate only has a significant negative association with social perception. Unlike previous studies, these chemicals do not impact neurobehavioral differences among gender and adrenal hormone function.

Glyphosate is the most commonly used active ingredient worldwide, appearing in many herbicide formulations and readily contaminates soil, water, food, and other resources. Decades of extensive glyphosate herbicide use (e.g., Roundup) have put human, animal, and environmental health at risk. Four out of five U.S. individuals over six years of age have detectable levels of glyphosate in their bodies. Exposure to glyphosate has implications for the development of various health issues, like cancer, Parkinson’s disease, developmental and birth disorders, and autism. Although the U.S. Environmental Protection Agency (EPA) classifies glyphosate herbicides as “not likely to be carcinogenic to humans,” stark evidence demonstrates links to various cancers, including non-Hodgkin lymphoma. EPA’s classification perpetuates adverse impacts, especially among vulnerable individuals, like pregnant women, infants, children, and the elderly. Like glyphosate, 2,4-D is ubiquitous in the environment from decades of extensive use in agricultural and residential areas. Current research describes a range of serious hazards from 2,4-D exposure, including the International Agency for Research on Cancer (IARC) finding that the chemical is a possible human carcinogen (e.g., soft tissue sarcoma and non-Hodgkin lymphoma). Moreover, exposure to 2,4-D can cause neurotoxic health issues like the development of amyotrophic lateral sclerosis (ALS) and loss of smell, as well as kidney/liver damage and endocrine disruption. The U.S. Environmental Protection Agency (EPA) finds babies born near areas of high 2,4-D use, such as farming communities, have higher rates of birth abnormalities, respiratory and cardiovascular issues, and developmental defects.

Although glyphosate replaced much 2,4-D herbicide use during the late 1990s and early 2000s, increasing glyphosate resistance is shifting the market back to heavy 2,4-D use. However, 2,4-D has striking similarities to glyphosate with growing weed resistance to the chemical and its contribution to the growth of antibiotic resistance in human pathogenic bacteria. Scientists even note 2,4-D’s similarities to glyphosate as the commercial formulation presented more severe health outcomes than the technical grade or pure chemical alone. Moreover, products containing glyphosate and 2,4-D to combat growing herbicide resistance are becoming increasingly popular, as 2,4-D, like glyphosate, has become integral to genetically engineered crops. Considering the agricultural industry is now heading toward multi-herbicide-tolerant cropping systems, public and environmental health is at greater risk from chemical input threats from this cropping system.

This study is among the first to find a significant association between negative neurobehavioral performance and the two herbicides 2,4-D and glyphosate among youth. This research also highlights an increased rate of toxic body burden among adolescents, especially as prior studies note adolescents have higher bodily concentrations of glyphosate than adults, a significant concern for the onset of chronic disease. Moreover, studies like this are essential because 2,4-D and glyphosate are often formulated together in the market herbicide products. This study highlights that combined concentrations of 2,4-D and glyphosate are associated with worsened neurobehavioral performance among all five areas (i.e., attention/inhibitory control, memory/learning, language, visuospatial processing, and social perception). However, the researchers urge further assessments of herbicide mixtures’ joint (synergistic) effects among various pediatric and adult populations.

There is a lack of complete understanding of the etiology of pesticide-induced diseases, including predictable lag time between chemical exposure, health impacts, and epidemiological data. Pesticides themselves can possess the ability to disrupt neurological function. Pesticides’ effect on the brain is mainly of concern for chronically exposed individuals or during critical windows of vulnerability and development. Therefore, studies related to pesticides and neurological disorders can help scientists understand the underlying mechanisms that cause neurodegenerative diseases. Although occupational and environmental factors, like pesticide exposure, adversely affect human health, regulatory reviews are plagued by numerous limitations in defining real-world poisoning, as captured by epidemiologic studies in Beyond Pesticides’ Pesticide-Induced Diseases Database (PIDD) and Daily News Blog. Pesticides’ adverse health effects, exposure, and aggregate or cumulative risk showcase a need for a precautionary approach to regulating pesticides, as more precise research is conducted on occupational and residential pesticide exposure—allowing more complete determinations. Existing information, including this study, supports the clear need for a strategic shift away from pesticide dependency. For more information on the effects of pesticide exposure on neurological health, see Beyond Pesticides’ PIDD pages on brain and nervous system disorders and other impacts on cognitive function. 

Organic agriculture represents a safer, healthier approach to crop production that does not necessitate pesticide use. Beyond Pesticides encourages farmers to embrace regenerative, organic practices, consumers to purchase organic, and gardeners and municipalities to adopt organic land management practices. A complement to buying organic is contacting various organic farming organizations to learn more about what you can do. 

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: Environmental Health Perspective (study), Environmental Health Perspective (article)

(Beyond Pesticides, January 18, 2024) Research continues to raise alarms about the hazards associated with the use of plastic, including the microplastic particles that are distributed in alarming amounts throughout the environment and taken up by organisms, including humans. A study published by researchers at Columbia and Rutgers universities (see article in the Proceedings of the National Academy of Sciences, January 2024) reports that the average liter of three brands of bottled water in the U.S. contains almost a quarter of a million tiny plastic pieces, of which 90 percent are at the nanoscale. The other ten percent are slightly larger, at microscale. Last December, researchers at Norway’s MicroLEACH project published a study that analyzes the components of 50 items in common use—plastic bags, disposable cups, dishwashing gloves, car tire granules, children’s toys and balloons. (See summary.)

The researchers found, like in previous studies, that many hazardous chemicals in the plastics as well as many that could not be identified because they were not listed in the major chemical substance databases. Only 30 percent of the chemical compounds identified in the study were present in two or more products. This suggests that most plastics contain many unidentified chemicals, far beyond the known impurities, metabolites and degradation products. Further, it suggests that in the environment plastics are chemically reactive and forming new compounds no one has anticipated and whose toxicity is unknown.

Like pesticides, plastics—mostly derived from fossil fuels—are exerting a heavy drag on the health of ecosystems and human beings. An estimated 8,300 million metric tons have been created since plastic production skyrocketed during World War II. Annual global production of plastic has reached 400 million metric tons, according to one estimate, with some 13,000 chemicals used in their manufacture, of which only one percent is regulated. In a January report, Consumer Reports, in The Plastic Chemicals Hiding in Your Food, reports that, “Our tests of nearly 100 foods found that despite growing evidence of potential health threats, bisphenols and phthalates remain widespread in our food.” Key among the chemicals found in plastics are plasticizers (most commonly phthalates used to increase flexibility and softness) and bisphenols (including BPA used in can liners, bottle caps, and water bottles). Phthalates and BPA are endocrine disruptors, linked to developmental problems and cancer. In improving organic production and processing to address current use of plastic, Beyond Pesticides has called for an end to use of plastics in certified organic.

Recent concern has turned to microplastics, including those at nanoscale—measuring billionths of a meter, or 70 times smaller than the width of a human hair. Microplastics are tiny particles broken up and ground very fine by natural processes like friction and heat. Their small size enables easy travel in air and water. Nanoplastics are now distributed over the entire globe. They are found in sandy beaches and in ocean sediments, as fibers floating in the stratosphere, in bottled water, and in the tissues of living creatures. Whereas numerous adverse effects of fossil-derived pesticides and plastic exposures at the macroscale are relatively well known, very little research has focused on those of microplastics.

The rapid spread of macroscale plastic trash has been unintentional. But agricultural and pharmaceutical interests are also intentionally researching nanoscale materials, including plastics, as the next big thing in their respective technological revolutions. Development of nanomaterials to distribute pesticides and deliver drugs and other medical treatments is proceeding at breakneck pace with very little oversight or public awareness. Agricultural and medical innovators see mostly the wondrous applications nanomaterials promise, but seem unaware of the risks.

Most plastics are polymers—long chains of often identical or very similar smaller molecules called monomers. Humans naturally make a number of polymers, including collagen, DNA and fibrinogen. The molecular structure of a polymer makes it flexible and able to maintain structural integrity under mechanical stress. Synthetic polymers also have those qualities, which is why plastic is so popular. One medical review of nanomaterials described polymers optimistically as “biocompatible, biodegradable, non-toxic, and popular in medical applications such as drug delivery, wound plug dressings, stents, and tissue engineering.”

Nanoplastics are attractive to pesticide proponents as a way to increase bioavailability, reduce product degradation, and increase water solubility. Timed release of the pesticide from the nanoparticle can be controlled, and some methods can make release contingent on exposure to light. These qualities are presented as advantages and purportedly reduce the amount of pesticide needed to control pests, helping the pesticide “exhibit extended pest control capabilities.”

Of course, while pesticide volume may be reduced using nanoparticle delivery, the payload is still usually a highly toxic substance derived from fossil fuels. Further, little is known about how the delivery medium, especially plastic, will affect the environment, but there is already evidence that micro- and nanoscale plastics can increase the toxicity of some pesticides. They can also carry other contaminants into the bodies of organisms, a process called the “Trojan horse effect.” Studies of micro- and nanoplastics have shown associations with damage to genes, neurotransmission, development and reproduction, feeding, and predatory competence.

Policymakers have yet to face up to the presence of nanoplastics leaching from packaging into many other products. The process of leaching begins as soon as a plastic is exposed to water—but because the plastic particles are so small, they go undetected by consumers.

In the Columbia/Rutgers study, the researchers checked for seven types of plastic, but they were only able to identify about ten percent of the nanoparticles they found. Polyethylene terephthalate (PET) was a common ingredient, probably because many water bottles are made of it. However, they also found polyamide, polystyrene, polyvinyl chloride, and polymethyl methacrylate. (Tap water also contains microplastics in many places, although in much lower concentrations.) The team found that the number of individual chemical compounds varied wildly among products, ranging from 114 to 2,456, leading them to conclude that “assessing the toxicity of plastic chemicals present in a product based on testing individual target chemicals has limited value.” The Norwegian scientists also exposed cod eggs, embryos and larvae to water containing microplastics. The toxic effects they observed include spinal deformities reminiscent of scoliosis in humans.

Beyond Pesticides covered a 2022 Danish study of reusable plastic sports bottles. The researchers tested two groups of plastic bottles: one set of newly purchased bottles and another of bottles that had been used for about a year, with a control group of glass bottles. They rinsed the new bottles with tap water and discarded it before refilling with tap water and storing for 24 hours. Next they ran all the bottles through a dishwasher for an hour, during which the water temperature reached about 150 degrees Fahrenheit. Finally, they put all the bottles through two more rounds of rinsing, refilling and storing for a day.

The results were dramatic. When they tested the final stored water, they found more than 400 substances associated with the plastic and more than 3,500 dishwashing compounds. Water from the new bottles held 350 unique chemicals, 230 of which were removed by the dishwasher and by rinsing. The used bottles contained 3,436 chemicals, about two-thirds of which were removed by dishwashing. It was clear that the dishwashing produced far more leached chemicals than simply rinsing with tap water and left an enormous residue of its own chemicals. In addition to the expected chemicals from the plastic and the dishwasher soap, the researchers found a number of chemicals they were unable to precisely identify and had never been reported in plastic.

There are many other problems inherent in nanoscale materials that should act as red flags in the development of nanoscale pesticides and their modes of delivery. Nanoscale objects have some qualities owing to their physical characteristics and others stemming from their chemistry. In fact, one group of researchers proposed that nanoscale plastics in the environment must be treated as distinct from both natural and engineered nanomaterials because of their “high particle heterogeneity and their potential for rapid further fragmentation in the environment. These characteristics impact environmental fate, potential effects on biota and human health, sampling and analysis.”

Nanoscale objects can go anywhere. In the environment, plastic clothing fibers spread even farther and faster than spherical particles. When inhaled, nanoplastics can penetrate lung and intestinal tissue and reach the circulatory system quickly. They can cross the blood-brain barrier, one of the strongest protections the body provides to protect the brain. They can also travel up the olfactory nerve from the nose to the brain.

3-D printing is a prime example of the failure to anticipate and control nanoplastic exposure. In many high-end research and manufacturing contexts, a variety of materials such as metal powders are used to build machines and parts according to specified digital instructions. But down at the low end of the cost spectrum, consumer 3-D printers use primarily ABS plastic: Acrylonitrile-butadiene-styrene filaments. There are even plastic children’s 3-D printers printing ABS plastic objects. Each component of ABS plastic is a either a known or probable carcinogen in its own right. Further, ABS, like most plastics, is a mixture rather than a compound of its ingredients, meaning the components are not chemically bonded and are easily separated. In 3-D printers, ABS heats up enough to separate into its component parts. The 3-D process releases nanoscale particles into the room unless the printer is enclosed, which many are not. In the best-case scenario, the nanoscale plastic particles are vented to the outside air.

Another problem with nanomaterials is their surface area. The smaller something is, the more surface area it has compared to its volume. Thus, a nanoparticle of a pesticide or a nanoparticle of a plastic medium for pesticide delivery will have much greater surface area than a macroscale unit. This makes nanoparticles much more chemically reactive than macroscale materials. The chemical reactivity of nanomaterials may be one reason why the studies discussed above found so many unidentified chemicals in water and water bottles.

The Norwegian researchers tested whether it was the shape and size of the particles or their chemistry that was responsible for the damage to their aquatic test animals. They exposed the cod to particles of the same shape and size but without known toxic effects and found that with plastics, it is definitely the chemistry that does the damage. Flexible plastics and combinations of toxic compounds seemed to have the worst effects.

There are a few lights on the horizon hinting that we may eventually be able to capture and render harmless the trillions of tons of plastic already blanketing the globe. In 2022, for the first time, the United Nations Environment Assembly adopted a resolution entitled “End plastic pollution: Towards an international legally binding instrument.” The Assembly hopes to reach a final agreement by the end of this year. In April 2023 the U.S. EPA produced a similar Draft National Strategy to Prevent Plastic Pollution.

A major step forward both nationally and internationally would be a public policy and legal structure that would prevent the chemical industry from merely making small changes to problematic formulas and declaring the result a new, safe chemical. The Endocrine Society published a statement on the UN resolution noting that once bisphenol A (BPA) was shown to be an endocrine disrupter, the industry switched to bisphenol B and several other closely related compounds, resulting in what became a “regrettable substitution” that was not an improvement on the original problem.

Mother Nature may eventually provide a little help. Knowable Magazine reports that there are numerous efforts around the world to develop enzymes, insects, and bacteria into useful ways to cope with the Sorcerer’s Apprentice plague of plastics threatening human and ecosystem survival.

In the meantime, let your elected officials know that the combined problem of pesticides and plastics stems from the vast use of fossil fuels, that organic agriculture can feed the world without these scourges, and that it is past time to regulate them honestly. See Beyond Pesticides webpage on organic agriculture, as well as our advocacy efforts to continually improve organic standards at our Keeping Organic Strong page.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Sources: Researchers surprised at levels of toxicity in standard plastic products, Christina Benjaminsen, Norwegian University of Science and Technology, https://phys.org/news/2023-12-toxicity-standard-plastic-products.html; MicroLEACH (Microplastics – Long-term Effects of plastics and Additive Chemicals on marine organisms), https://www.niva.no/en/projects/microleach; Bottled water can contain hundreds of thousands of previously uncounted tiny plastic bits, study finds A new microscopic technique zeroes in on the poorly explored world of nanoplastics, which can pass into blood, cells and your brain COLUMBIA CLIMATE SCHOOL, https://www.eurekalert.org/news-releases/1030312; Exposure to petroleum-derived and biopolymer microplastics affect fast start escape performance and aerobic metabolism in a marine fish,  https://www.sciencedirect.com/science/article/pii/S0048969723060503?via%3Dihub; The living things that feast on plastic https://knowablemagazine.org/content/article/food-environment/2023/how-to-recycle-plastic-with-enzymes, The Global Plastics Treaty: An Endocrinologist’s Assessment Marina Olga Fernandez, Leonardo Trasande, https://academic.oup.com/jes/article/8/1/bvad141/7420190.

(Beyond Pesticides, January 17, 2024) Science continues to find a link between mental health and occupational (work-related) chemical exposure, with a study published in Toxicology finding an increased risk of depression among farmers exposed to pesticides. Conventional, chemical-intensive farming is a profession notorious for higher-than-average pesticide exposure occurrences, thus explaining why the study concludes that individuals within this occupation can suffer from chemically induced oxidative stress, inflammation, and lower education-based cognition that exacerbate depressive symptoms. However, besides psychological symptoms, the study indicates potential physiological issues from pesticide exposure, such as renal (kidney) and hepatic (liver) issues. Studies like this one can directly pinpoint risks of developing depression, especially among agricultural workers and landscapers who use pesticides.

Usually, research on pesticide-induced diseases commonly investigates pesticide exposure concerning the development of various physical illnesses. However, previous studies show that occupational risks of developing depression are high in agriculture, where pesticide use is rampant. Acute exposure to chemicals, including organophosphate, organochlorine, triazine, and carbamate pesticides, tends to put farmers at greater risk of suicide than the general population. There is a lack of information connecting pesticide exposure to the subsequent psychological (psychiatric) effects on the general population.

Although the etiology of depression—and many other psychiatric disorders—is often genetic, studies suggest that other etiological factors, like pesticide exposure, play a role in depression incidents. Poor mental health has a tangible influence on physical health (e.g., depression and cardiovascular disease); therefore, the combination of pesticide exposure and mental illness worsens the adverse effects on human health. Since pesticide exposure can exacerbate psychiatric symptoms, it is essential to evaluate how pesticide exposure affects mental health in addition to physical health. This research highlights the significance of researching potential mental health detriments resulting from pesticide exposure, especially as society tends to rank mental health risks second to physical health. 

The study notes, “…[T]he impact of occupational pesticide exposure on the mental health of rural workers… [the] underuse of PPEs [personal protective equipment] and the link between depressive symptoms, inflammation, and oxidative stress underscore the urgent need for improved safety measures in agricultural practices. Addressing these issues will contribute to a deeper understanding of the intricate relationship between environmental exposures and mental health outcomes.”

The study assesses the oxidative and inflammatory profiles and mental health of Brazilian farmers exposed to pesticides and compares the results to the control group lacking occupational exposure to pesticides. Researchers gathered data on sociodemographic factors (i.e., age, race, ethnicity, language, economic status), work history, and medical records. Using the State-Trait Anxiety Inventory (STAI) and Beck Depression Inventory (BDI), the researchers evaluate emotional states to determine mental health status. Researchers collected blood samples from the participants to measure redox (oxidative) and inflammatory profiles. The physiological results identify that BDI scores are higher among the pesticide-exposed group (farmers), with these individuals experiencing more severe cases of depression. Physically, the same farmers have increased lipid peroxidation and superoxide dismutase activity, among other oxidative stress markers, and elevated levels of inflammatory signaling cells (cytokines) indicating inflammation. The study notes that the herbicide glyphosate is the most commonly used pesticide among farmers, which may play a role in elevating the enzyme levels in the liver and kidneys of pesticide-exposed participants. Additionally, the results highlight a particularly stark issue concerning the underuse of PPE among farmers and the disparity in education among farmers. Education is pivotal in fostering safety practices, comprehending technical information about pesticide handling, and using PPE.

Within the past two and a half decades, research concerning pesticide exposure and psychiatric disorders, such as depression, has grown, especially for farmworkers. Exposure to agricultural pesticides puts farmers at a six times greater risk of exhibiting depressive symptoms, including chronic anxiety, irritability, restlessness, and sadness. For instance, exposure to organochlorines and fumigants (highly toxic, gaseous pesticides) heighten an individual’s risk of depression by 90% and 80%, respectively. Linear models reveal an association between lifelong pesticide poisoning episodes and the increased risk of developing mental disorders among tobacco farmers, with farmers using organophosphate pesticides (notorious for neurotoxicity) having a higher prevalence of minor psychiatric disorders. Although individuals suffering from occupational pesticide exposure face a disproportionate risk of developing depression, pesticide exposure from nearby agricultural fields remains a threat to residential (nonoccupational) human health. Previous studies find that populations living near farms are more likely to have high depressive symptoms. Similarly, a 2019 study found that teens and adolescents living in agricultural areas, where organophosphate exposure is prevalent, are at higher risk of depression. Uniquely, gender (female), physical health, and age (young adult) indicate the likelihood of having depressive symptoms, with the most adverse effects on women, those in poor physical health, and children under 14. Regardless of pesticide exposure frequency, duration, intensity, type, and location, the development of depression symptoms remains of concern.

The study highlights the interplay of multiple factors contributing to the prevalence of depression among pesticide-exposed farmers. Despite the study location being in Brazil, the results have implications for farmers across the globe, especially in regions where pesticide policies and practices do little to protect workers. Understanding the mental health implications of conventional pesticide exposure can help identify the various physiological mechanisms attributed to psychiatric disorders. Notably, this study calls for the continued investigation of pesticide neurotoxicity mechanisms and the association between mental health disorders. This and other studies indicate that farmers and those in agricultural communities are at disproportional risk of mental health problems due to pesticide use. Therefore, the study advocates “for comprehensive strategies to improve the mental and physical well-being of rural workers exposed to pesticides, including education, preventive measures, and ongoing research efforts to safeguard the health of those who play a vital role in our agricultural communities.”

Mental health is just as—if not more–important than physical health, and reviews such as this highlight the importance of knowing pesticide implications beyond physical ailments. According to the World Health Organization (WHO), depression affects 322 million people globally, with the number of diagnosed patients increasing by 18.4% from 2005 to 2015. Annually, only half of Americans with a depression diagnosis seek treatment for symptoms. Untreated symptoms of depression can increase the risk of suicide, a severe sign of depression. Commonalities between occupational and household pesticide exposure are suicidal thoughts and pesticide provocation as a suicide agent. WHO scientists recognize pesticide self-poisoning as one of the most significant global methods of suicide, as increases in pesticide toxicity make them potentially lethal substances. 

Beyond Pesticides tracks the most recent news and studies related to pesticide exposure through our Daily News (DN) Blog and Pesticide Induced Diseases Database (PIDD). For more information on the multiple harms of pesticides, see our DNs on Pesticides and Depression and PIDD pages on brain and nervous system disorders, endocrine disruption, and other diseases.  Additionally, buying, growing, and supporting organic can help eliminate the extensive use of pesticides in the environment. It also reduces demand for toxic pesticides in areas where farmer suicides are alarmingly high. Coupled with evidence from past studies that link pesticide exposure to suicidal ideations and depression, even in developed countries, this research strongly supports a ban on toxic pesticides in favor of organic practices. Our choices encourage the protection of the people who help put food on our table daily by purchasing organic products. For more information on how organic is the right choice for consumers and the farmworkers that grow our food, see the Beyond Pesticides’ webpage, Health Benefits of Organic Agriculture. 

Lastly, suicide is the tenth leading cause of death among adults (3rd for adolescents) in the U.S., with more than 34,000 individuals succumbing to the disease annually. Suicidal thoughts and behaviors are dangerous and harmful and are therefore considered a psychiatric emergency. An individual experiencing these thoughts should seek immediate assistance from a health or mental health care provider. If you or someone you know is in an emergency, call the National Suicide Prevention Lifeline at 1-800-273-TALK (8255) or 911 immediately.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: Toxicology

(Beyond Pesticides, January 16, 2024) The U.S. Environmental Protection Agency (EPA) has long been criticized for its failure to evaluate the effectiveness (or efficacy) of all the pesticides it registers. A petition, for which there is now an open public comment period (submit comments by January 22, 2024), challenges what advocates call a basic failure of the agency to evaluate the claimed benefits of pesticides. Because of this long-standing situation, those who purchase pesticides do not know that the pesticides they buy will meet expectations for control. For farmers, that means that EPA has not evaluated whether the pesticide’s use actually increases productivity of the treated crops and/or whether over time the target pest (weed, insect, fungus) will become resistant. For consumers, it also means that there is not an independent analysis of whether the pesticide products work. As EPA implements the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), not only is there no agency assessment of whether the pesticide’s use will achieve its intended purpose, there is not a determination as to whether there is a less toxic way of achieving the pest management goal.

As Beyond Pesticides cited last year, a piece published in the Proceedings of the National Academy of Sciences Journal (2020) sums it up well: “[N]eonicotinoid [widely used insecticide] exposure is far higher than necessary to achieve plant protection and yield objectives. Neonicotinoid seed coatings rarely improve crop yield, and neonicotinoids are applied preventively to vast areas of turf, which cover more land in the United States than any other irrigated crop, even when pests are absent or below thresholds. . . . Risks to many terrestrial, aquatic, and detrital organisms and ecosystems have been documented. Considering these risks, advocacy groups have frequently promoted outright bans on all neonicotinoids in all circumstances, and this stance seems easy to justify.” Nearly ten years agon, “Heavy Costs—Weighing the Value of Neonicotinoid insecticides in Agriculture” (Center for Food Safety, 2014) concluded that, “EPA should suspend all existing registrations of neonicotinoid seed treatment products whose costs and benefits have not been adequately weighed until this accounting is completed.

The petition open for public comment is requesting the adoption of rules that require efficacy data be submitted for systemic insecticides by manufacturers registering these pesticides with EPA.   

>>EPA must require submission of efficacy data and make findings based on evidence that benefits outweigh risks before registering a pesticide.

Petitioners ask that manufacturers of neonicotinoids (neonics) or other systemic insecticides be required to prove that they work as intended and do not “subject species, ecosystems, and people to abject devastation with no benefit to users.” In fact, Section 3(c)(5) of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) requires that EPA determine whether the pesticide will perform its intended function, when used “in accordance with widespread and commonly recognized practice,” without “unreasonable adverse effects on the environment.” “Unreasonable adverse effects on the environment” means “any unreasonable risk to man or the environment, taking into account the economic, social, and environmental costs and benefits of the use of any pesticide.” 

The petitioners submit support for their contention that systemic insecticides are not effective and that they cause widespread harm to the environment, including birds, honey bees, aquatic ecosystems, and wildlife. The petition says, “The species impacted include all amphibians, and the majority of endangered fish, birds, and mammals, as well as pollinators and the plants they pollinate.”  

The petitioners also point to results showing lack of benefits—including a report by EPA’s Biological and Economic Analysis Division (BEAD) showing that systemic insecticides generally do not provide benefits when used to protect soybeans. 

Thus, the petitioners make a case that registration should be denied to these systemic insecticides, since FIFRA Section 3(c)(6) requires EPA to deny registration if “the Administrator determines that the requirements of paragraph (5) for registration are not satisfied.” 

But how can EPA make any determination without efficacy data? The petitioners say that because the case they make shows that systemic insecticides do not meet the criteria for registration, EPA must request efficacy data for those pesticides. However, the same is true for all pesticides. EPA cannot meet the statutory prerequisite for registration without weighing data on both risks and benefits. Instead, as pointed out by the petitioners, EPA says, “rather than require efficacy data the Agency presumes that benefits exceed risks.” 

In 2021, a coalition of groups, including PEER and Beyond Pesticides, issued a scathing critique of the performance of EPA’s Office of Pesticide Programs — embedded in the groups’ advocacy for a series of 25 reforms. The petition tackles one specific aspect of EPA’s process on one class of insecticides. The agency’s track record, on so many pesticides, is to deal with one compound (under a narrow range of circumstances and/or narrow time frame and/or specific exposure levels) at a time. Beyond Pesticides has dubbed this the “whack-a-mole” struggle on pesticides. 

Each regulatory baby step at EPA represents small, incremental advances on a pesticide problem that is vast in scope—an approach that is wholly inadequate to the devastation that toxic pesticides are causing, and it continues the “collision course” we are on re: human health and well-being, biodiversity collapse, and the climate crisis. A precautionary approach—captured in organic, regenerative agriculture and land management protocols—is far more suited to the task of genuinely protecting public health and the environment than EPA’s current, industry-friendly, piecemeal approach. 

The availability of alternative materials and practices that prevent (or vastly reduce) toxic hazards, as are used in organic management, makes the dependence on synthetic chemical pesticides even more reprehensible. A genuinely protective approach to pests (floral or faunal) in agriculture and land management starts with transitioning from chemical dependency to organic land management in food production, and parks, playing fields, and all recreational and public spaces. In the meantime, efforts to push EPA will continue to move the needle, however slowly and haltingly. EPA should take seriously its mission: to protect human health and the environment. 

>>EPA must require submission of efficacy data and make findings based on evidence that benefits outweigh risks before registering a pesticide.

The target for this Action is the U.S. Environmental Protection Agency via Regulations.gov.  

Letter to EPA

I am writing to support the petition  asking that manufacturers of neonicotinoids (neonics) or other systemic insecticides be required to prove that they work as intended and do not “subject species, ecosystems, and people to abject devastation with no benefit to users.” In fact, Section 3(c)(5) of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) requires that EPA determine whether the pesticide will perform its intended function, when used “in accordance with widespread and commonly recognized practice,” without “unreasonable adverse effects on the environment.” “Unreasonable adverse effects on the environment” means “any unreasonable risk to man or the environment, taking into account the economic, social, and environmental costs and benefits of the use of any pesticide.”

It has been shown that systemic insecticides are not effective in soybean production and that they cause widespread harm to the environment, including birds, honey bees, aquatic ecosystems, and wildlife. The petition says, “The species impacted include all amphibians, and the majority of endangered fish, birds, and mammals, as well as pollinators and the plants they pollinate.” The petitioners point to results showing lack of benefits—including a report by EPA’s Biological and Economic Analysis Division (BEAD) showing that systemic insecticides generally do not provide benefits when used to protect soybeans.

Thus, the petitioners make a case that registration should be denied to these systemic insecticides, since FIFRA Section 3(c)(6) requires EPA to deny registration if “the Administrator determines that the requirements of paragraph (5) for registration are not satisfied.”

But how can EPA make any determination without efficacy data? The petitioners say that because the case they make shows that systemic insecticides do not meet the criteria for registration, EPA must request efficacy data for those pesticides. The same is true for all pesticides. EPA cannot meet the statutory prerequisite for registration without weighing data on both risks and benefits. Instead, as pointed out by the petitioners, EPA says, “rather than require efficacy data the Agency presumes that benefits exceed risks.”

Each regulatory baby step at EPA represents small, incremental advances on a pesticide problem that is now vast in scope—an approach that is wholly inadequate to the devastation that toxic pesticides are causing, and it continues the “collision course” we are on re: human health and well-being, biodiversity collapse, and the climate crisis. A precautionary approach — captured in alternatives like organic, regenerative agriculture and land management protocols — is far more suited to the task of genuinely protecting public health and the environment than EPA’s current, industry friendly, piecemeal approach. This approach is viable under the “unreasonable adverse effects” standard of review under FIFRA.

The availability of alternative materials and practices that prevent (or vastly reduce) toxic hazards, as are used in organic management, makes the dependence on synthetic chemical pesticides even more reprehensible and “unreasonable.” A genuinely protective approach to pests (floral or faunal) in agriculture and land management starts with transitioning from chemical dependency to organic land management in food production, and parks, playing fields, and all recreational and public spaces. In the meantime, the petitions request for efficacy review will push the pesticide registration review process to move the needle, however slowly and haltingly. EPA should take seriously its mission: to protect human health and the environment.

Thank you for your consideration of these comments.

(Beyond Pesticides, January 12, 2024) As we commemorate Dr. Martin Luther King Jr.—an inspiration for taking on the challenges of justice, equity, and safety as a central part of all our work for a sustainable future—through a day that stands for equality, justice, and the pursuit of a better world, it is crucial to reflect on issues that impact the health and well-being of communities. One such issue that echoes the spirit of Dr. King’s vision is the pervasive use of pesticides and the associated health risks. Drawing insights from prior articles on Beyond Pesticides’ Daily News, we delve into the intersection of environmental justice, public health, and the ongoing struggle for a safer and healthier world. 

The Invisible Threat with Visible Consequence: Pesticides and Health. 

Beyond Pesticides sheds light on the hidden dangers of pesticide exposure and the disproportionate impact it has on marginalized communities. Communities of color and economically disadvantaged areas bear a heavier burden of pesticide exposure, leading to higher rates of health issues, including respiratory problems, developmental disorders, and certain cancers.  From agricultural workers to residents of low-income neighborhoods, the adverse health effects of pesticides are not evenly distributed. The use of pesticides without adequate consideration for their health impacts constitutes a form of environmental injustice. This resonates with Dr. King’s vision of equity, as these communities often face the brunt of environmental injustices. Dr. King said, “Injustice anywhere is a threat to justice everywhere.”  

Connecting the Dots: MLK’s Legacy and Environmental Advocacy.  

Dr. King’s legacy extends beyond civil rights, encompassing a vision of justice that encompasses all aspects of life. The Beyond Pesticides article underscores the importance of connecting MLK’s teachings with environmental advocacy. By advocating for alternatives to harmful pesticides and promoting sustainable practices, we honor Dr. King’s call for justice and equality. 

Community-Led Initiatives for Social Justice. 

Community-led initiatives featured on Beyond Pesticides’ blog, where individuals and groups have taken the initiative to address pesticide-related health risks. From local activism to policy advocacy, these stories showcase the power of grassroots movements in effecting positive change, aligning with Dr. King’s belief in the strength of communities to drive transformation. 

Beyond Pesticides works to advance systemic change seeks to identify underlying policies that codify dispropor­tionate harm, such as federal pesticide law that is built on a foundation that allows elevated and disproportionate risk to workers. They are excluded from EPA’s cumulative risk assessment (under the Food Quality Protection Act amendments to the Fed­eral Food, Drug and Cosmetic Act and the Federal Insecticide, Fungicide, and Rodenticide Act), which aggregates dietary and non-dietary, but explicitly not occupational, exposure to pesticides, while in­cluding a mandate to protect children. With this, the law effectively requires EPA to allow higher rates of harm for workers, particularly farmworkers, land­scapers (workers who are disproportionately people of color), and others occupationally exposed to pes­ticides. In response, Beyond Pesticides is reimagin­ing legislative proposals that effect a transformation to an organic society that eliminates toxic pesticides, respects the complexity of life and the ecosystems that sustain us, and put an end to institutional biases that codify environmental racism.  

Beyond Pesticides also works with grassroots groups, like The Black Institute and other grassroots organizations, across the nation to ban toxic pesticides in city, town, and county parks, playgrounds, and playing fields, as part of an organic transition. Children and people of color face disproportionate harm from pesticide exposure. To make matters worse, the hazards associated with the toxic chemicals inflict multi-generational diseases like diabetes, asthma and respiratory illness, and learning disabilities. 

Educating: A Cornerstone of Change.  

Here are some of the pieces covered by Beyond Pesticides over the last year that paint a stark picture of disproportionate harm to people of color, translating to a pattern of injustice that must be corrected in the adoption of a transformative path forward. 

—A study published on April 18 finds that people in U.S. BIPOC (Black, Indigenous and People of Color) communities, as well as those living in low-income communities, endure a very disproportionate rate of exposure to pesticides, and of subsequent risks of harm. It finds that such disparities exist in both urban and rural communities, and at all points in the pesticide “life cycle,” from manufacture to application. A section of Beyond Pesticides’ recent mega-issue of Pesticides and You, “Retrospective 2021: A Call to Urgent Action,” is devoted to such inequities. Section IV, “Disproportionate Pesticide Harm Is Racial Injustice: Documenting Victimization: Structural Racism,” reprises Beyond Pesticides’ 2021 coverage of environmental injustices. It also calls for urgent action re: federal and state “evaluations that go into toxic chemical regulation . . . to reform and replace the current regulatory decision-making process, which is empirically racist, with one that acknowledges and cares for those with the highest real-world vulnerabilities and exposure[s].” [See Black, Indigenous, and People of Color Community at Disproportionate Risk from Pesticides, Study Finds] 

On Juneteenth Day, we commemorate the abolition of slavery and celebrate human freedom. At the same time, we recognize that we have significant work to do to eliminate systemic racism and advance environmental justice. We strive to ensure that people of color are not disproportionately harmed by pesticides and other toxic chemicals—from production, use, to disposal—and that all people have access to sustainable and organic food and organically managed communities. Acute and chronic exposure to chemicals like pesticides cause a plethora of harmful effects, including (but not limited to) brain and nervous system disorders, birth abnormalities, cancer, developmental and learning disorders, endocrine disruption, immune disorder, and reproductive dysfunction, among others. However, people of color may experience more severe health effects from exposure, resulting in elevated rates of diseases. Communities of color and those living in low-socioeconomic conditions experience an inequitable number of hazards, including toxic waste plants, garbage dumps, and other sources of environmental pollution and odors that lower the quality of life. Therefore, these populations experience greater exposure to harmful chemicals and suffer from health outcomes that affect their ability to work and learn. When discussing health disparities and environmental justice, we need to focus on those most impacted by toxic chemical use. [See This Juneteenth, We Celebrate Those Who Made this Country] 

Beyond Pesticides’ Daily News serves as a valuable resource for educating individuals and communities about the risks associated with pesticides and the viability of organic practices that eliminate petrochemical pesticides and fertilizers. By empowering people with knowledge, we can foster a collective commitment to healthier alternatives and advocate for policies that prioritize both human health and environmental sustainability. 

As we reflect on Martin Luther King Jr. Day, it is crucial to recognize the interconnectedness of social justice, environmental advocacy, and public health. Beyond Pesticides’ Daily News provides a platform for understanding and addressing the health risks posed by pesticides, aligning with Dr. King’s vision of a just and equitable world. Let us draw inspiration from his teachings to work toward a future where everyone, regardless of their background, can enjoy the benefits of a healthy and sustainable environment. 

Beyond Pesticides continues to emphasize its commitment to advancing systemic change that can address the depth and extent of the institutional biases that allow environmental racism to continue, as well as the complexity of the “moving parts” of the food, health, environmental, and governance sectors that allow the persistence of disproportionate impacts. For example, campaigns to eliminate individual pesticides (or other chemicals) are insufficient to the gravity and extent of the threats; a precautionary approach and standards are needed to meet and remedy ongoing and escalating threats. 

We at Beyond Pesticides are looking forward to working with people and organizations in communities nationwide to tackle what often seems like insurmountable problems, but problems that have real solutions that are within our reach, when we tap into the power of working together. Please join, reach out, act locally and regionally, and — in honor of Dr. King — help build a healthy and thriving “network of mutuality, tied into a single garment of destiny” for all people. 

Thank you, Martin Luther King, Jr. 

Sign up for Beyond Pesticides Action of the Week and Weekly News Update to stay informed on these issues and take action. 

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

(Beyond Pesticides, January 11, 2024) In a move to safeguard public and animal health, the U.S. Food and Drug Administration (FDA) warned nine manufacturers and distributors in December last year to stop selling unapproved and misbranded antimicrobial animal drugs, with the director of FDA’s Center for Veterinary Medicine, Tracey Forfa, explaining to the public that “inappropriate use of medically important antimicrobials contributes to the development of antimicrobial resistance, which affects both human and animal health.”  This action and announcement exhibit a higher degree of concern about antimicrobial resistance—understood as a growing worldwide pandemic—than the history and ongoing inaction by the U.S. Environmental Protection Agency (EPA)—resulting in the allowance of widespread nonmedical uses of antibiotics in agriculture and on synthetic (or artificial) turf. Contrary to broad scientific understanding, EPA told a federal appeals court last year that, “There is no data that antibiotic use in agriculture leads to the presence of antibiotic resistance in bacteria of human health concern,” and that “[a]t the present time, there is little evidence for or against the presence of microbes of human health concern in the plant agricultural environment.” The issue of resistance discussed in the scientific literature concerns reduced susceptibility to clinically important antimicrobials, including antibiotics, due to either cross-resistance or co-resistance mechanisms. 

The FDA enforcement action highlights the growing concern over antimicrobial resistance (AMR), a critical issue that Beyond Pesticides has reported on extensively, especially as related to horizontal gene transfer (the movement of antibiotic-resistant bacteria throughout the environment, ultimately making their way to people, as medically necessary drugs become ineffective).  The illegal marketing of these drugs for minor species, including aquarium fish and pet birds, featuring medically important antimicrobials such as amoxicillin, penicillin, tetracycline, and erythromycin, violates FDA regulations. 

While the uses in the FDA warning are limited, the agency used the opportunity to highlight the importance of the AMR issue. AMR is an escalating global health crisis that affects humans and animals alike. When pathogenic microorganisms become resistant to antimicrobials designed to kill them, the consequences can be severe, leading to infections that are harder to treat and more likely to spread. Previous coverage of this issue by Beyond Pesticides has discussed how the use of antimicrobials, including antibiotics, in agriculture, synthetic turf management, and medicine contribute to this resistance, turning what were once easily treatable infections into serious health threats. The use of antimicrobials in artificial turf exemplifies a nonmedical use that results in frequent exposure to children and others playing on antimicrobial-treated surfaces. In November, Beyond Pesticides reported, “A builder of sports facilities, American Athletic, states, “Beyond surface cleaning, the artificial turf should be sanitized weekly or monthly to protect the players’ and coaches’ health. This disinfection requires special solvents, cleansers, and anti-microbial products to remove invisible particles and bacterial growth. You should strive to sanitize the field after every game and throughout the school day if it’s used for physical education classes.” 

A 2020 scientific peer-reviewed article in Revista Panamericana de Salud Publica (Pan American Journal of Public Health)—a publication of the Pan American Health Organization,  From environment to clinic: the role of pesticides in antimicrobial resistance, finds the following: “This report draws attention to molecules, rather than antibiotics, that are commonly used in agrochemicals and may be involved in developing AMR in non-clinical environments, such as soil. This report examines pesticides as mediators for the appearance of AMR, and as a route for antibiotic resistance genes and antimicrobial-resistant bacteria to the anthropic environment. Available evidence suggests that the natural environment may be a key dissemination route for antibiotic-resistant genes. Understanding the interrelationship of soil, water, and pesticides is fundamental to raising awareness of the need for environmental monitoring programs and overcoming the current crisis of AMR.”  

The study goes on: “Soil microbiota serves as an early contributor to AMR and a reservoir of genes for resistance to clinical pathogens. Metagenomics studies have identified an exchange of antibiotic resistance genes (ARG) between environmental bacteria and clinical pathogens (5). Multidrug-resistant (MDR) soil bacteria also contain genes for resistance to the main classes of antibiotics, such as aminoglycosides, amphenicols, β-lactams, sulfonamides, and tetracycline.” 

As the American Society for Microbiology (ASM) noted in its December 13, 2023 letter to Environmental Protection Agency, ASM Responds to Environmental Protection Agency on Antimicrobial Resistance Assessment Framework about EPA’s proposed  Antimicrobial Resistance Assessment Framework, “Antimicrobial resistance (AMR) is a top public health threat and one of our most daunting challenges. AMR is associated with the deaths of 4.95 million people in 2019 and is projected to cause 10 million deaths by 2050. Each use of an antimicrobial drug or agent, whether used to treat disease in humans, animals, or crops, contributes to antimicrobial resistance. As existing antimicrobial agents decline in effectiveness, infections will be more difficult and expensive to treat and epidemics harder to control.” 

The FDA, in its announcement, links to its simply stated page entitled Antimicrobial Resistance: “When microorganisms become increasingly resistant to antimicrobial drugs, the drugs become less effective at slowing or stopping the growth of the microorganisms. This makes it more difficult to treat infections in people and animals. When antimicrobials are used excessively or inappropriately, the rate of this resistance grows.” 

The scientific literature and many recommendations abound for strategies and progress on AMR, including banning medically important antibiotics in agribusiness and promoting consumer (and business) awareness and action. Beyond Pesticides endorses these strategies, but insists that a genuine solution must include a systemic change through the transition to organic agriculture, recognizing the health benefits it provides. Beyond Pesticides’ databases, including Gateway on Pesticide Hazards and Safe Pest Management and Pesticide-Induced Diseases Database, provide advocates with science-based information that informs the urgent need to shift to organic management practices in addressing existential health, biodiversity, and climate crises. 

All unattributed positions and opinions in this piece are those of Beyond Pesticides. 

Sources:

FDA NEWS RELEASE: FDA Warns Nine Manufacturers, Distributors of Unapproved Antimicrobials for Animals; FDA warns Chewy, others about antimicrobials in pet drugs

Agricultural Uses of Antibiotics Escalate Bacterial Resistance: Organic leads in prohibiting antibiotic use, Beyond Pesticides’ Pesticides and You, Winter 2016-2017; American Society for Microbiology letter to Environmental Protection Agency

(Beyond Pesticides, January 10, 2024) Exposure to endocrine-disrupting chemicals (EDCs) negatively impacts testicular function and may cause sperm count declines over time, according to a 2022 review published in Endocrine. The findings indicate that this occurs regardless of whether exposure is prenatal (before birth) or postnatal (after birth). More recent work from October 2023 confirms the connection between male reproductive health and exposure to organophosphate and carbamate insecticides and the weed killer glyphosate—as many pesticide products containing these chemicals are classifiable as endocrine disruptors (ED). Just last year, a meta-analysis from researchers at Mount Sinai Medical Center, the Hebrew University of Jerusalem, and the University of Copenhagen, among others, finds that the drop in global sperm count is accelerating, dropping by 51.6 percent from 1973 through 2018.

The U.S. regulatory system, under the authority of the U.S. Environmental Protection Agency (EPA), has not kept pace with the science and does not fully evaluate pesticides in wide use for endocrine disruption, despite a requirement in 1996 law (the Food Quality Protection Act) to begin that testing and evaluation nearly three decades ago. In 2021, Beyond Pesticides reported that the Office of the Inspector General (OIG) for EPA issued a damning report on the agency’s progress in protecting the population from potentially damaging endocrine disruption impacts of exposure to synthetic chemical pesticides (and other chemicals of concern). For more context on EPA’s failure to regulate endocrine-disrupting pesticides, see When France Bans Common Endocrine Disrupting Pesticide, EPA Goes Silent. For more background, see here.

Endocrine disruptors are xenobiotic (i.e., chemical substances like toxic pesticides foreign to an organism or ecosystem). Many reports demonstrate that exposure to endocrine-disrupting chemicals can adversely affect human, animal—and thus environmental—health by altering the natural hormones responsible for conventional reproductive, physical, and mental development. Scientists and health officials already associate pesticide exposure with a decrease in male fertility, including reduced sperm count, quality, and abnormal sperm development. Furthermore, Beyond Pesticides has long highlighted the relationship between reproductive anomalies and toxic pesticides, particularly the role of endocrine-disrupting (ED) compounds. Therefore, reviews like this emphasize the importance of understanding how chemical exposure threatens reproductive health, not just for the current generation but for future generations, as these reproductive harms can prompt genetic changes.

The researchers reviewed animal and human studies on the effects of EDC exposure on testicular development, spermatogenesis (sperm production and development), malformations of the male genital tract, testicular tumors, and the mechanisms involved in testicular damage mediated by EDCs. After reviewing the scientific literature, the review confirms that EDCs harm the male reproductive system, ultimately compromising male fertility. The study notes explicitly that EDCs can bind to hormone receptors, dysregulating hormone receptor expression, disrupting the production and metabolism of the steroid hormone (steroidogenesis), and altering the epigenetic (heritable traits) mechanisms. The resulting reproductive outcomes from EDC exposure include poor semen quality, increased sperm DNA fragmentation, increased gonadotropin levels, a slightly increased risk of hereditary malformations (e.g., cryptorchidism and hypospadias), and testicular tumor development. Regarding prenatal exposure, maternal exposure to EDCs increases the predisposition for testicular tumor development, as well.  

The ubiquity of pesticides in the environment and food supply is concerning, as current measures restricting pesticide use and exposure do not adequately detect and assess total environmental chemical contaminants. The scientific literature demonstrates pesticides’ long history of severe adverse human health effects (i.e., endocrine disruption, cancer, reproductive/birth problems, neurotoxicity, loss of biodiversity, etc.). Most concerning is exposure to past and current-use pesticides, as these chemicals display endocrine-disrupting effects. The World Health Organization (WHO), European Union (EU), and endocrine disruptor expert (deceased) Theo Colborn, Ph.D., classify over 55 to 177 chemical compounds as endocrine disruptors, including various household products like detergents, disinfectants, plastics, and pesticides. Endocrine disruption can lead to several health problems, including hormone-related cancer development (e.g., thyroid, breast, ovarian, prostate, testicular), reproductive dysfunction, and diabetes/obesity that can span generations. Therefore, studies related to pesticides and endocrine disruption help scientists understand the underlying mechanisms that indirectly or directly cause infertility, among other health issues.

Like this review, other studies highlight many pesticides can impact male sperm production (and reproduction broadly) through endocrine disruption. This disturbance may happen in several ways, including mimicking a natural hormone and fooling the body into over-responding to a stimulus, responding at inappropriate times, blocking the effects of a hormone from specific receptors, and/or directly stimulating or inhibiting the endocrine system, cause over- or under-production of hormones. The National Institutes of Health explainer says that exposures to ED chemicals can cause “deleterious effects on human reproductive health by interfering with the synthesis and mechanism of action of sex hormones. Any change during the synthesis or action of the sex hormones may result in abnormal reproductive functions, which includes developmental anomalies in the reproductive tract and decline in semen quality.”

In addition to the downward trend in sperm quality, the evidence highlighted by this review is sufficient enough to cause concern. Moreover, science has recognized for years the significant role pesticide exposures likely play in degraded sperm quantity and quality and impaired reproductive functions. Pesticides are ubiquitous — they are found in many industrial products and consumer products, such as plastics, furniture, clothing, canned food, water bottles, toys, cosmetics, electronics, food packaging, fertilizers, and pesticides. People are exposed to pesticides through these products, occupationally and dietarily.

Although this study explicitly evaluates EDCs’ impacts on male fertility, it is not the first to demonstrate the sex-specific effect of pesticide exposure. In 2017, scientists presented a study at the 99th meeting of the Endocrine Society, showing instances of early onset puberty in boys after exposure to common pyrethroid insecticide, which exhibits endocrine-disrupting properties that interfere with the proper regulation of the human body’s hormonal system. Furthermore, a 2021 study demonstrates that exposure to current-use pesticides, like organophosphates, poses a greater health risk to women. In addition to impacts on fertility, the study warns, “Testicular GJIC and connexin dysregulation, especially during critical early stages of development, could partly participate in the etiopathology of human subfertility and infertility and testicular cancer.”

Pesticides and other chemicals undermine the ability of reproduction. Furthermore, studies regarding pesticides reveal mechanisms that show how specific chemical toxicants can alter fertility, including endocrine disruption. Therefore, advocates urge that policies strengthen pesticide regulations and increase research on the long-term impacts of pesticide exposure. Beyond Pesticides tracks the most recent studies related to pesticide exposure through our Pesticide Induced Diseases Database (PIDD). This database supports the clear need for strategic action to shift away from pesticide dependency. For more information on the multiple harms of pesticide exposure, see PIDD pages on Sexual and Reproductive Dysfunction, Endocrine Disruption, Body Burdens, and other diseases.

The ubiquity of pesticides in the environment and food supply is concerning, as current measures restricting pesticide use and exposure do not adequately detect and assess total environmental chemical contaminants. For instance, 90 percent of Americans have at least one pesticide biomarker (including parent compound and breakdown products) in their body. However, one way to reduce human and environmental contamination from pesticides is to buy, grow, and support organic. Numerous studies find that levels of pesticides in urine significantly drop when switching to an all-organic diet. Furthermore, given the wide availability of non-pesticidal alternative strategies, families, from rural to urban, can apply these methods to promote a safe and healthy environment, especially among chemically vulnerable individuals or those with health conditions. For more information on how organic is the right choice for consumers and the farmworkers that grow our food, see the Beyond Pesticides webpage, Health Benefits of Organic Agriculture.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: Endocrine

(Beyond Pesticides, January 9, 2024) A “landscape-level” study finds that typical risk assessment studies used by the U.S. Environmental Protection Agency (EPA) and European regulators fail to “safeguard bees and other pollinators that support agricultural production and wild plant pollination.” The study, published in Nature (November 2023), evaluates the health of bumble bees (Bombus terrestris) as a sentinel species placed in 106 agricultural landscapes across Europe. The authors’ conclusions challenge “the current assumption of pesticide regulation—that chemicals that individually pass laboratory tests and semifield trials are considered environmentally benign”—calling into question EPA’s persistent failure to adequately regulate mixtures of chemicals to which organisms are exposed in the real world.

This study adds to the body of science on pesticide mixtures adversely affecting bee and pollinator health. See here, here, and here. The failure to capture real-world exposure to pesticide mixtures in its regulatory assessments extends to EPA’s systemic failure to evaluate a range of serious adverse impacts, as noted by the agency’s Office of Inspector General (OIG) report. And, aquatic environments also have documented mixtures of pesticides, with the U.S. Geological Survey finding 90 percent of water samples containing at least five or more different pesticides.

“We can take no comfort in a regulatory system that continuously ignores, despite a plethora of studies over decades, the reality of pesticide exposure and adverse effects, yet continuously claims to the public that pesticides are adequately regulated, and business-as-usual dependency on pesticides is just fine,” said Jay Feldman, executive director of Beyond Pesticides. “This latest study in Nature reminds us yet again, at the beginning of this new year, that we are not doing enough to expedite and escalate the transition to organic land management,” he continued.

The study found a combination of insecticides and fungicides, including ten compounds found in colony pollen stores, which the authors consider to present the highest risk, based on acute toxicity. The ten pesticides (nine insecticides and one fungicide) include indoxacarb, spinosad, chlorpyrifos-ethyl, deltamethrin, dimethoate, imidacloprid, cyfluthrin, dithianon, etofenprox, and chlorpyrifos-methyl. Concern about impacts on bees extends beyond acute effects to a range of adverse impacts, including disorientation, other sublethal effects, reproductive effects and development delays, and vulnerability to disease and mite infestation.

The study authors, Charlie Nicholson, PhD (post-doctoral fellow at Lund University, Lund, Sweden), et al., show a reduction in “bee colony performance.” This is especially true in what the authors call “simplified landscapes,” characterized by a predominance of non-flowering plants, “potentially stressing colonies and interacting with pesticide effects.” The authors conclude, “Our results show that ambitious sustainability goals related to pesticide reduction—objectives of the COP 15 meeting on the Convention on Biological Diversity and the European Farm to Fork strategy—would benefit bee populations and potentially the pollination services they provide.

The United Nations Convention on Biological Diversity (CBD) is the international legal instrument for “the conservation of biological diversity, the sustainable use of its components and the fair and equitable sharing of the benefits arising out of the utilization of genetic resources.” It has been ratified by 196 nations—all the members of the United Nations except the United States and the Vatican. The CBD includes 21 action targets to be achieved by 2030, including reducing pesticide use by two-thirds, eliminating plastic waste, and “fully integrating biodiversity values into policies, regulations, planning, development processes, poverty reduction strategies, accounts, and assessments of environmental impacts at all levels of government and across all sectors of the economy, ensuring that all activities and financial flows are aligned with biodiversity values.”

In a 2017 Science magazine article, “Toward pesticidovigilance,” authors Alice Milner, PhD, professor in the Department of Geography at the University of London, Surrey, and Ian Boyd, PhD, professor in the School of Biology, University of St. Andrews, Scotland, argue, “Without knowledge of safe environmental limits, the total pesticides used—and therefore the total environmental dose—is governed by market demand rather than by a limit on what the environment can endure.” Standard toxicity tests on individual pesticides, according to the authors, is of “limited use” when considering wide, “diffuse environmental effects that arise from ecosystem connectivity at a landscape scale.” The study in Nature adds to the empirical evidence of devastation wrought by pesticides and the ineffectiveness of current European as well as U.S. regulatory approaches. 

Beyond Pesticides has agreed with the conclusion of Drs. Milner and Boyd that there is a lack of “effective global governance of pesticides and their use” and advocates for the urgent need to adopt organic land management practices in agricultural and nonagricultural settings, including an immediate ban, like in France, on the use of lawn and landscape pesticides in both public and private areas frequently used by the public. 

The failure of EPA to consider the effect of pesticide mixtures in the environment extends to the formulation of pesticide products. While the Nature study identifies active pesticide ingredients, advocates and scientists have long asked EPA to evaluate and regulate full formulations of pesticides. Last year, EPA rejected a citizen petition filed in 2017 requesting that the agency evaluate complete formulations of pesticide products, not just the ingredients the manufacturer claims attack the target pest (so-called “active” ingredients). The citizen petition [see more background] was followed by a lawsuit for the same purpose in 2022.

Because of the three existential crises of health threats, biodiversity collapse, and the climate emergency, Beyond Pesticides has called for a broad phase out of all petrochemical pesticides and fertilizers and a shift to organic land management by 2032.

For more information on hazards and alternatives, see Beyond Pesticides, Gateway on Pesticide Hazards and Safe Pest Management, the Pesticide-Induced Diseases Database, and the Organic Agriculture webpage. For communities that would like to partner with Beyond Pesticides in shifting community land management to organic, see Parks for a Sustainable Future.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: Pesticide use negatively affects bumble bees across European landscapes; Toward pesticidovigilance

(Beyond Pesticides, January 8, 2024) Despite successful litigation that stopped the unnecessary use of an antibiotic (streptomycin) in citrus production in December 2023, the court’s reasoning fails to grasp the science behind the biggest emerging threat to U.S. and global health—antibiotic resistance. What is most disturbing and challenging is that the U.S. Environmental Protection Agency (EPA), responsible for applying science in the protection of the public’s health, misled the court on the overwhelming worldwide scientific consensus on the contribution of agricultural antibiotic use to the human death and disability rate linked to antibiotic resistance. On this subject, Beyond Pesticides has written extensively about horizontal gene transfer, which explains the movement of antibiotic resistant bacteria throughout the environment, ultimately making their way to people, as medically necessary drugs become ineffective. As we’ve written, “The human pathogenic organisms themselves do not need to be sprayed by the antibiotic because movement of genes in bacteria is not solely “vertical,” that is from parent to progeny—but can be “horizontal”— from one bacterial species to another.”

[Regarding the reliance of the court on EPA’s misrepresentation of the science, the court found, ”EPA emphasized that ‘there is no data that antibiotic use in agriculture leads to the presence of antibiotic resistance in bacteria of human health concern,’ and that ‘[a]t the present time, there is little evidence for or against the presence of microbes of human health concern in the plant agricultural environment.'” And yet, on May 19, 2019, The New York Times reported, “The agency [EPA] approved the expanded use [of streptomycin] despite strenuous objections from the Food and Drug Administration and the Centers for Disease Control and Prevention, which warn that the heavy use of antimicrobial drugs in agriculture could spur germs to mutate so they become resistant to the drugs, threatening the lives of millions of people.”]

Tell EPA and Congress that antibiotic pesticides must be eliminated.

We like victories, so let’s soak up the victory of the court decision and the protection it affords farmworkers in the short-term. Of note is the court finding, for procedural reasons, that EPA review of direct streptomycin exposure to pollinators “does not pass muster.” We have always said that when we protect pollinators and ecosystems, we protect people. But, now we must urgently zero in on how the nation’s pesticide law, the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA), and the chemical-intensive agricultural practices it effectively promotes, is contributing to what can already be considered a worldwide pandemic. Yes, antibiotic resistance is another pandemic that some call the “silent pandemic,” but the numbers belie that characterization.

Let’s look at the numbers and the threat and then ask ourselves whether our federal agencies should be doing everything they can, from every perspective, to take action. It certainly is true that there is a confluence of factors that contribute to this worldwide pandemic, which will be the focus of a United Nations General Assembly (UNGA) High-Level meeting on antimicrobial (e.g. bacterial and fungal) resistance (AMR) in September, 2024 in New York. However, we cannot afford to ignore any cause of resistance, given the health implications of ineffective treatments for bacterial and fungal diseases. While there are many statistics with a range of numbers that we cite, according to the Centers for Disease Control and Prevention (CDC), “More than 2.8 million antimicrobial-resistant infections occur in the U.S. each year, and more than 35,000 people die as a result. When Clostridioides difficile—a bacterium that is not typically resistant but can cause deadly diarrhea is associated with antibiotic use—is added to these, the U.S. toll of all the threats in the report exceeds 3 million infections and 48,000 deaths.” According to a 2021 article in Current Research in Microbial Sciences, “Antibiotic resistance in agriculture: Perspectives on upcoming strategies to overcome upsurge in resistance,” the leading consumers of antibiotics in developed countries are U.S. consumers. So, it would appear that the U.S. population may have the most to lose from antibiotic resistance.

A report evaluating 204 countries published by the University of Washington’s Institute of Health Metrics and Evaluation, “Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis,” generated the following statistics:

13.66 million people who died globally had sepsis as an immediate cause of death or in the chain of events leading to their death (intermediate cause).

4.95 million people who died in 2019 suffered from drug-resistant infections, such as lower respiratory, bloodstream, and intra-abdominal infections.

1.27 million deaths in 2019 were directly caused by AMR [antimicrobial resistance].

1 in 5 people who died from AMR was a child under 5 years old, often from previously treatable infections.

For those who prefer to talk about public health in economic terms, according to the Food and Agriculture Organization of the U.N., the Global Research on Antimicrobial Resistance study found, “If action is not taken, the rise of AMR cumulatively may result in over 3.4 trillion USD loss in the world’s annual gross domestic product (GDP) in ten short years.

ReAct, an independent worldwide network focused on antibiotic resistance, founded in 2005, has characterized the problem from perspectives around the world.

ReAct Africa Director Mirfin Mpundu says:

“Addressing antibiotic resistance effectively will require big changes – to governance, financing, systems transformation and the change of behaviors and practices. But at the end of the day the end goal must be to ensure that everyone who has a resistant infection, or requires surgery, or needs cancer treatment, or is born premature can in fact access effective antibiotics in the future – this is the expectation that we should all voice to governments from now to September next year.”

ReAct Europe Director Anna Sjöblom says:

“The UNGA High-level meeting must be a turning point in the global response to AMR – and more specifically to antibiotic resistance. Enough with the talk of ‘a silent pandemic’ –  antibiotic resistance is here now and is a global leading cause of suffering and unnecessary loss of lives across the world. The global response must finally start to reflect this fact.”

Ultimately, EPA must get out in front and start thinking and acting holistically in its analyses and restrictions of pesticides. The challenge of antimicrobial resistance is an example of the agency moving along with a limited focus that undermines the protection of the environment and people, as existential crises continue to emerge—whether it’s the chemical-induced or exacerbated human health crises, biodiversity collapse, or the climate emergency. Even under existing law, EPA has the opportunity and responsibility to deem the adverse effects associated with petrochemical pesticide use related to these existential crises “unreasonable” (the statutory standard under FIFRA), given the availability of alternative practices, principally organic land management, that are viable, accessible, productive, profitable, and, most importantly, enabling of a livable future.

Tell EPA and Congress that antibiotic pesticides must be eliminated.

Letter to EPA:

Antimicrobial resistance is rising to dangerously high levels. In the May 1, 2022, issue of the Bulletin of the World Health Organization, Samira Choudhury, PhD, et al. write, “Often referred to as the silent pandemic, antimicrobial resistance claims the lives of over 700,000 people annually.” They continue, “A study suggests that if no actions are taken, antimicrobial resistance will cause 10 million deaths per year by 2050 and an economic impact of over 100 trillion United States dollars.”

A federal district court decision blocked EPA’s decision to register the antibiotic streptomycin for use in Florida citrus to control Huanglongbing (HLB), also known as “citrus greening,” a plant disease spread by the Asian citrus psyllid, finding, “[EPA] admits it did not comply with the ESA.” The court also found that EPA failed to show that streptomycin would achieve benefits in preventing the disease. However, the court was not convinced that EPA fails to protect against the spread of antibiotic resistance and assumed that the restrictions that EPA required for personal protective equipment (PPE) and drift control would adequately mitigate risks.

When antimicrobial pesticides are sprayed on a crop, they induce resistance in bacteria that are present by killing susceptible bacteria—which may or may not be pathogenic—allowing resistant bacteria to proliferate. The resistant bacteria move off the site on crops, workers, and the wind. Prevention of chemical drift is thus inadequate to protect against the spread of antibiotic resistant bacteria. The fact of horizontal gene transfer means that antibiotic resistance genes in those (possibly harmless) bacteria can move to pathogens.

In 2017, EPA permitted use of these antibiotics in Florida citrus crops. In January 2019, EPA moved to make the authorization permanent, despite, according to the New York Times, “strenuous objections from the Food and Drug Administration and the Centers for Disease Control and Prevention, which warn that the heavy use of antimicrobial drugs in agriculture could spur germs to mutate so they become resistant to the drugs, threatening the lives of millions of people.” Two years prior oxytetracycline was approved for use on the same citrus crops.

In addition to crops, antimicrobials are used to manage synthetic turf. A builder of sports facilities, American Athletic, states, “Beyond surface cleaning, the artificial turf should be sanitized weekly or monthly to protect the players’ and coaches’ health. This disinfection requires special solvents, cleansers, and antimicrobial products to remove invisible particles and bacterial growth. You should strive to sanitize the field after every game and throughout the school day if it’s used for physical education classes.”

Finally, focusing on materials sold as antibiotics or antimicrobials is too shortsighted. First, science shows that use of any antibiotics anywhere can increase antibiotic resistance everywhere. Second, many pesticides not intended to kill microbes—such as the herbicides glyphosate, 2,4-D, and dicamba—also induce antibiotic resistance in deadly human pathogens. Thus, we must stop broadcasting pesticides in the environment. The crisis in antibiotic resistance, which creates a threat of another pandemic, is ignored in the registration of pesticides. The antibiotic impacts of pesticides cited above were discovered only after the pesticides had been disseminated in the environment for decades.

EPA must not register pesticides unless they have been demonstrated not to contribute to antibiotic resistance and must cancel the registration of those that do.

Thank you.

Letter to U.S. Representative and Senators:

Antibiotic resistance is rising to dangerously high levels. In the May 1, 2022, issue of the Bulletin of the World Health Organization, Samira Choudhury, PhD, et al. write, “Often referred to as the silent pandemic, antimicrobial resistance claims the lives of over 700,000 people annually.” They continue, “A study suggests that if no actions are taken, antimicrobial resistance will cause 10 million deaths per year by 2050 and an economic impact of over 100 trillion United States dollars.”

A federal district court decision blocked EPA’s decision to register the antibiotic streptomycin for use in Florida citrus to control Huanglongbing (HLB), also known as “citrus greening,” a plant disease spread by the Asian citrus psyllid, citing failure to comply with the ESA and to show benefits. However, the court was not convinced that EPA fails to protect against the spread of antibiotic resistance and assumed that the restrictions that EPA required for personal protective equipment (PPE) and drift control would adequately mitigate risks.

When antimicrobial pesticides are sprayed on a crop, they induce antimicrobial resistance in bacteria that are present by killing susceptible bacteria—which may or may not be pathogenic—allowing resistant bacteria to proliferate. The resistant bacteria move off the site on crops, workers, and the wind. Prevention of chemical drift is thus inadequate to protect against the spread of antibiotic resistant bacteria. The fact of horizontal gene transfer means that antibiotic resistance genes in those (possibly harmless) bacteria can move to pathogens.

In 2017, EPA permitted expanding use of these antibiotics in Florida citrus crops. In January 2019, EPA moved to make the authorization permanent, despite, according to the New York Times, “strenuous objections from the Food and Drug Administration and the Centers for Disease Control and Prevention, which warn that the heavy use of antimicrobial drugs in agriculture could spur germs to mutate so they become resistant to the drugs, threatening the lives of millions of people.” Two years prior oxytetracycline was approved for use on the same citrus crops.

In addition to crops, antimicrobials are used to manage synthetic turf. A builder of sports facilities, American Athletic, states, “Beyond surface cleaning, the artificial turf should be sanitized weekly or monthly to protect the players’ and coaches’ health. This disinfection requires special solvents, cleansers, and anti-microbial products to remove invisible particles and bacterial growth. You should strive to sanitize the field after every game and throughout the school day if it’s used for physical education classes.”

Finally, focusing on materials sold as antibiotics or antimicrobials is too shortsighted. First, science shows that use of any antibiotics anywhere can increase antibiotic resistance everywhere. Second, many pesticides not intended to kill microbes—such as the herbicides glyphosate, 2,4-D, and dicamba—also induce antibiotic resistance in deadly human pathogens. Thus, we must stop broadcasting pesticides in the environment. The crisis in antibiotic resistance, which creates a threat of another pandemic, is ignored in the registration of pesticides. The antibiotic impacts of pesticides cited above were discovered only after the pesticides had been disseminated in the environment for decades.

Please ensure EPA does not register pesticides unless they have been demonstrated not to contribute to antibiotic resistance and cancels the registration of those that do.

Thank you.

(Beyond Pesticides, January 5, 2023) The 28^th United Nations Climate Change Conference of the Parties (COP28) wrapped up in Dubai on December 13 with what some hailed as a breakthrough agreement among almost 200 countries to reduce fossil fuel consumption that signals “the eventual end of the oil age.” To be successful and assure human survival, eliminating oil, gas, and coal use, Beyond Pesticides is calling for the elimination of petrochemical pesticides and fertilizers and support for organic, regenerative agriculture around the world.

Because of the insurmountable crises that are caused or exacerbated by petrochemical pesticides and fertilizers, the adoption of organic land management practices and the need for foundational change in federal, state, and local policies and practices has come into focus. Under organic management, healthy soil can absorb and store 1,000 pounds of carbon per acre foot of soil annually. This translates to about 3,500 pounds of carbon dioxide per acre drawn down from the air and sequestered into organic matter in soil. (It is noteworthy that use of synthetic fertilizers actually compromises the carbon-capture ability of some kinds of terrain, such as salt marshes.) A fact often overlooked by policy makers in generating climate strategies is that carbon-sequestering soil practices are federally mandated in certified organic agriculture.

As reported by Beyond Pesticides in October 2021 before COP26, the use of synthetic fertilizers is a particular and noxious contributor to the rising planetary temperature. This happens largely through these products’ emissions of nitrous oxide, or NO_x — another potent greenhouse gas that also pollutes the air and feeds the development of ozone. NO_x is roughly 300 times as potent in trapping heat as CO₂. (In addition, runoff of high-nitrogen, synthetic fertilizers contaminate water bodies and contributes to eutrophication.) Nitrous oxide levels have increased, compared to pre-industrial levels, by 20% from all sources. Earlier in 2021, Beyond Pesticides asserted, “The excess nitrogen in these fertilizers is . . . driving global nitrous oxide emissions dangerously high, exacerbating the climate crisis.” For more on climate-friendly organic agriculture, see Daily News and the groundbreaking work of the Rodale Institute, as captured in its Farming Systems Trial — 40-Year Report. California Certified Organic Farmers Association’s Roadmap to an Organic California provides a policy framework for advancing agricultural programs that combat climate change. 

COP28’s call for an end to fossil fuels aligns with Beyond Pesticides’ call for the elimination of petrochemical pesticides and fertilizers by 2032. This grows out of the experience with the viability of organic land management as a productive and profitable alternative to chemical-intensive land management (including agriculture, parks, playing fields, schoolyards, and home landscapes and gardens).

At the Beyond Pesticides November 2022 National Forum session on climate, scientists discussed the science and the urgent need for a strategic response to the climate crisis as part of a constellation of crises that intersect. Whether talking about a health crisis borne out of chemical-induced diseases, the collapse of life-sustaining biodiversity, or the dramatic catastrophes caused by greenhouse gases and rising temperatures—the interconnectedness of the crises, advocates say, requires solutions that are holistic and nurturing of humans’ relationship with nature—interrelationship that have been neglected as a matter of policy and practice.

Leading up to COP28, in October, 2023, an editorial in the Journal of the American Medical Association (JAMA) captures the urgency of the climate and biodiversity crisis in Time to Treat the Climate and Nature Crisis as One Indivisible Global Health Emergency. The authors state: “Over 200 health journals call on the United Nations, political leaders, and health professionals to recognize that climate change and biodiversity loss are one indivisible crisis and must be tackled together to preserve health and avoid catastrophe. This overall environmental crisis is now so severe as to be a global health emergency.”

There is a particularly noxious feedback loop involving climate and pesticides. Beyond Pesticides covered a Nature Communications study in 2021 showing that as the climate warms, pests form a permanent population in places where they were formerly seasonal. Permanent or endemic pests are often repeatedly exposed to the same pesticide and become resistant. Seasonally abundant pests are not exposed year-round and tend to be less resistant. Warmer temperatures enable larger year-round pest populations that can expand into new habitats, resulting in more pesticide use. It is essential to restrict warming as much as possible while adopting agricultural coping methods that do not involve pesticides. The temptation to use them will be powerful: For every degree of global surface warming, crop losses from insects are projected to increase some 10-25 percent, primarily in temperate regions where rice, maize and wheat are grown.

The problem of pests benefiting from warmer temperatures to expand their ranges and their food sources has been starkly evident in western Canada, where the boreal forest has been harvested for two centuries. The mountain pine beetle, endemic to western British Columbia, was historically killed off every year by cold weather. Further, healthy trees could fight off the beetles with toxic resin if the beetle population was low. But in the early 1990s, as British Columbia temperatures rose, the beetle population grew and expanded its range northward and eastward. By 2007 the pests in British Columbia reached epidemic proportions and crossed the Continental Divide into Alberta. Millions of trees died, contributing to ever more dire wildfires, with dense smoke from the conflagration in 2023 joining that of U.S. wildfires and covering much of the United States and Canada. To make matters worse, climate change has transformed much of Canada’s boreal forest from a sink to a source of atmospheric carbon. The beetle has also become a problem in U.S. forests. The primary insecticide used in futile attempts to control the beetle is carbaryl, a carcinogen and acetylcholinesterase inhibitor with neurotoxic effects.

It seems obvious that the rationales underpinning fossil fuel extraction and use in myriad ways is a case of humans shooting themselves in the foot. There is no solution to this wide array of crises that includes continued fossil fuel use. Beyond Pesticides has a rich archive of information and action plans to bring to bear on these entwined crises. The organization established the Parks for a Sustainable Future program, which underwrites horticultural consultation to plan the transition to organic land management in communities across the U.S. It also strives to maintain the integrity of organic standards through Keeping Organic Strong campaign and historical work to transition agriculture to organic practices. In 2022, Beyond Pesticides sponsored a Climate Change Calls for Phase Out of Fossil Fuels Linked to Petrochemical Pesticides and Fertilizer series of national virtual seminars (with archived videos) covering health, biodiversity and climate. And Rodale Institute’s work to show the efficacy and benefits of organic agriculture is cited.

The primary document emerging from COP28, called the “First Global Stocktake,” released at the end of the meeting, mentions the phrase “fossil fuels” just once, and the word “food” occurs only six times. But the fact that the phrase “fossil fuels” is used at all reflects a triumph over the resistance of the fossil fuel industry. More importantly, the agreement is the first time the parties have explicitly stated the intention to transition away from fossil fuels entirely. This is remarkable considering the intense wrangling that went on before agreement on the wording was reached.

On the other hand, the fossil fuel sector—including the host of the conference, the United Arab Emirates—continued to drag its feet, reprising old arguments for carbon capture rather than a complete phaseout of fossil fuels. Carbon capture has been studied, discussed and tested for two decades at least, but has yet to be implemented on anywhere near the scale necessary to prevent catastrophic warming. In fact, according to the Institute for Energy Economics and Financial Analysis, “Failed/underperforming projects considerably [outnumber] successful [carbon capture] experiences,” and the technology exists mostly as an excuse to continue extracting oil and natural gas.

Yet focusing on the fossil fuel undertow and the less-than-perfect commitment to ending the fossil fuel era may obscure other encouraging developments. In a further sign of forward momentum, COP28 was the first time a full day was devoted to food and agriculture at a U.N. climate conference. The U.S. delegation said many of the right things—a change from the Trump administration’s abrupt withdrawal from the 2015 Paris Agreement. U.S. Department of Agriculture (U.S.D.A.) Secretary Tom Vilsack touted President Biden’s Inflation Reduction Act (IRA), which provides close to $20 billion to help reduce greenhouse gas emissions in agricultural production and protect communities vulnerable to climate change impacts. The U.S.D.A. share of the IRA also includes more than $13 billion to “provide rural America with clean, affordable energy,” according to a U.S.D.A. press release.

The COP28 executive issued a call to develop “resilient food systems” in its UAE Declaration on Sustainable Agriculture, Resilient Food Systems, and Climate Action. There were 153 national government signatories to the declaration, with some 200 non-party stakeholder organizations signing a companion Call to Action for Transforming Food Systems for People, Nature and Climate. Next year, at COP29 in Azerbaijan, there will be an opportunity to evaluate progress on these declarations’ stated commitments.

Given the number of countries that participated and the number and variety of other organizations, including non-governmental organizations and nonprofits, that held side meetings and observed, COP28 can be considered a success. Across many climate and agriculture activist constituencies, there is strong grassroots motivation to change what can be changed as soon as possible. Keeping the pressure up on the entwined issues of climate and food protection will lift all ships—that is, advancing the cause of organic agriculture will also be advancing the goal of net zero carbon emissions.

As noted  Beyond Pesticides’ 2022 post about the insect apocalypse, “While the solutions are in reach, tremendous public action is needed to stop the fossil fuel and agrichemical industries from their short-sighted pursuit of profit at any cost….Arguments are made that high intensity, industrial chemical agriculture is the only way to feed the world, and the fossil fuels are the only way to provide energy. Scientific data is now spelling out exactly what we are in for if we continue to endorse these dangerous myths.”

Ironically, the fossil fuel industry may not be considering a major possibility—that not only is continued fossil fuel use the highway to catastrophe, but in a drastically warming world, high intensity agriculture as currently practiced may not even be possible. On the present course pollinators and other helpful insects are being lost, along with water, topsoil, soil microbes and fungi, and all the other natural contributors to food production. No amount of fertilizer or pesticides can overcome these losses. Nor are high-tech, complex industrial processes likely to solve these problems. It is recognizing the dependence on the species, landscapes and natural processes of the planet that will deflect oncoming collapse.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Sources:
Conference of the Parties serving as the meeting of the Parties to the Paris Agreement Fifth session United Arab Emirates, 30 November to 12 December 2023
https://unfccc.int/sites/default/files/resource/cma2023_L17_adv.pdf

Nations strike deal at COP28 to transition away from fossil fuels
https://www.reuters.com/business/environment/countries-push-cop28-deal-fossil-fuels-talks-spill-into-overtime-2023-12-12/

The carbon capture crux: Lessons learned|https://ieefa.org/resources/carbon-capture-crux-lessons-learned

(Beyond Pesticides, January 4, 2024) A review published in the Journal of Neurosciences in Rural Practice finds an association between farmers’ pesticide exposure and cognitive impairment. Specifically, farmers suffer from attention deficit, lack of information processing, non-comprehension of verbal cues, slow processing speed, memory loss, sluggishness, speech difficulties, and impaired motor function. Additionally, the risk of adverse effects from exposure increases with time spent around pesticides, like in other occupational (work-related) settings. Although pesticide exposure may not be the only factor involved in cognitive impairment, exposure can work synergistically (together) with other factors, triggering neurotoxicity.

Pesticides play various roles in causing or exacerbating adverse health outcomes like neurotoxic effects and chemical damage to the brain. Numerous pesticides impair neurological function, especially for chronically exposed individuals (e.g., farmworkers) or during critical windows of vulnerability and development (e.g., childhood, pregnancy). Mounting evidence over the past years shows that chronic exposure to sublethal (low) levels of pesticides adversely affects the central nervous system (CNS) and neural receptors, such as connections between nerves, the brain, enzymes, and DNA. Specifically, researchers identify agricultural chemical exposure as a cause of many adverse CNS impacts and neurological diseases, including Alzheimer’s, amyotrophic lateral sclerosis (ALS), and Parkinson’s disease.

The researchers reviewed scientific articles published in the Scopus, Web of Science, ScienceDirect, and PubMed databases between 2000 and 2021, all related to “pesticides and cognition” and “pesticides and memory.” The review follows the preferred reporting methodology for systematic reviews and meta-analyses (PRISMA) guidelines. The review results find that ten studies match the specific criteria, with researchers highlighting the lack of comprehensive scientific literature on cognition (or the process of understanding and thought) and pesticide exposure. Half of the studies in the review measure organophosphate (OP) exposure impact on cholinesterase (enzymes necessary for the transmission of nerve impulses), confirming neurotoxicity.

Numerous occupational hazards are associated with chemical exposure, especially among individuals with occupations that involve regular exposure to xenobiotic (foreign substance) compounds. The agricultural sector has a long-standing history of synthetic chemical use, which disproportionally affects farmworkers’ health. Furthermore, farmworkers’ children are at greater risk as their immune system response is immature and especially vulnerable to stressors from pesticide exposure. Synthetic chemicals in pesticides can accumulate in bodies, causing an amalgamation of health effects. These effects can range from heightened risks of various cancers (e.g., prostate, hepatic, liver, etc.) and endocrine disruption to mental health problems (e.g., depression), respiratory illnesses (asthma), and many other pesticide-induced diseases. However, pesticide exposure is ubiquitous and not confined to where the chemicals are applied. Pesticides and other toxic chemicals can enter homes from the workplace via clothes, shoes, and home-based personal protective equipment (PPE) and accumulate residues on laundry, on carpets, and in art/house dust. Some cases demonstrate that levels of chemicals transported into the house can be high enough to cause an adverse health effect in a resident child or spouse.

Many pesticide compounds remain in soils, water (solid and liquid), and the surrounding air at levels exceeding U.S. Environmental Protection Agency (EPA) standards. These compounds have a global distribution, with evaporation and precipitation facilitating long-range atmospheric transport, deposition, and bioaccumulation of hazardous chemicals in the environment. The continuing ubiquity of pesticides concerns public health advocates as current measures safeguarding against pesticide use do not adequately detect and assess total environmental chemical contaminants. Therefore, individuals will continuously encounter varying concentrations of pesticides and other toxic chemicals, adding to the body’s burden of current-use chemicals.

Although studies demonstrate developmental and learning-based deficiencies from prenatal and early life exposure, this review is one of the few to highlight how pesticides can induce neurological issues that manifest over time, especially in chemical-intensive occupations like farming. However, many studies find a stark association between pesticide exposure and neurotoxic impacts that manifest as physical ailments like Alzheimer’s Disease, Dementia, Parkinson’s Disease, brain tumors, and more. Additionally, the notes state that anticholinesterase compounds like OPs are found in farmers and individuals close to agricultural areas, suggesting that direct and indirect chronic low-level exposure influences cognitive functioning. Overstimulation and continued activation of muscarinic and nicotinic receptors from acetylcholine accumulation are potential mechanisms involved in cognitive impairment from OP exposure. The review suggests “that future studies engage in similar projects, addressing the aspects mentioned above and assessing the specific categories of pesticides most harmful to cognition and the toxicological mechanisms by which they act. Finally, [they review] consider[s] the monitoring of the mode of pesticide application to be important, favoring lower occupational exposure of farmers to pesticides and, consequently, lower cognitive impairment.”

There is a lack of complete understanding of the etiology of pesticide-induced diseases, including predictable lag time between chemical exposure, health impacts, and epidemiological data. Pesticides themselves can possess the ability to disrupt neurological function. Pesticides’ impact on the brain is mainly of concern for chronically exposed individuals or during critical windows of vulnerability and development. Therefore, studies related to pesticides and neurological disorders can help scientists understand the underlying mechanisms that cause neurodegenerative diseases. Although occupational and environmental factors, like pesticide exposure, adversely affect human health, regulatory reviews are plagued by numerous limitations in defining real-world poisoning, as captured by epidemiologic studies in Beyond Pesticides’ Pesticide-Induced Diseases Database (PIDD) and Daily News Blog. The adverse health effects of pesticides, exposure, and the aggregate risk of pesticides showcase a need for a precautionary approach to regulating pesticides as more precise research is conducted on occupational and residential pesticide exposure—allowing more complete determinations. Existing information, including this study, supports the clear need for a strategic shift away from pesticide dependency. For more information on the effects of pesticide exposure on neurological health, see Beyond Pesticides’ PIDD pages on brain and nervous system disorders and other impacts on cognitive function. 

Organic agriculture represents a safer, healthier approach to crop production that does not necessitate pesticide use. Beyond Pesticides encourages farmers to embrace regenerative, organic practices, consumers to purchase organic, and gardeners and municipalities to adopt organic land management practices. A complement to buying organic is contacting various organic farming organizations to learn more about what you can do. 

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: Journal of Neurosciences in Rural Practice

(Beyond Pesticides, January 3, 2024) A study published in Environmental Health Perspectives finds elevated, chronic exposure to glyphosate throughout one’s lifetime increases the risk of mosaic loss of chromosome Y (loss of chromosome Y occurs to many men in some cells due to aging [mLOY]) that impacts a noticeable fraction of cells. Although the loss of this sex chromosome does not cause cell death, like the loss of autosomal chromosomes, the risk of mLOY is a biomarker for genotoxicity (the damage of genetic information within a cell causing mutations from chemical exposure, which may lead to cancer) and expansion of cellular response to glyphosate, resulting in the precursor for hematological (blood) cancers. This study is one of the first to identify sex-specific chromosome degradation, with stark evidence demonstrating links to various cancers, including non-Hodgkin lymphoma. The International Agency for Research on Cancer (IARC) has classified the glyphosate as a probable carcinogen or cancer-causing chemical. However, the U.S. Environmental Protection Agency’s (EPA) allowance of widespread use of glyphosate allows for adverse impacts, especially among vulnerable individuals, like pregnant women, infants, children, and the elderly. Glyphosate exposure levels and resulting residues in urine has been documented with recent data showing that four out of five (81.6%) U.S. residents have detectable levels of glyphosate in their bodies. Despite these concerning data, evidence of widespread exposure to a carcinogen has so far failed to influence regulators at EPA, which puts increasing responsibility on local elected officials and consumers, according to advocates, to stop glyphosate use in their community’s land management.

The study notes, “Although future studies are needed to confirm the observed associations, our findings for glyphosate add to the limited literature on occupational and environmental exposures as contributors to mLOY, the most common acquired chromosomal alteration in men, and provide novel mechanistic evidence supporting the potential carcinogenicity of this widely used herbicide.”

The study analyzes blood-derived DNA from 1,606 farmers to detect mLOY using genotype assessments of the sex chromosomes in the cells. Researchers gathered self-reported pesticide exposure from the farmers and estimated the association between mLOY and glyphosate use, employing a multivariable logistic regression. The results find that mLOY is detectable in 21.4 percent of farmers, with mLOY expanding throughout most cells in 9.8 percent of farmers. Most farmers with mLOY expanding throughout most cells are older in age, with a greater lifetime exposure and intensity of exposure to glyphosate. However, these individuals are non-smokers and non-obese, which are other risk factors for mLOY.

Glyphosate is the most commonly used active ingredient worldwide, appearing in many herbicide formulas, including Bayer’s (formerly Monsanto) Roundup®. The use of this chemical has been increasing since the inception of crops genetically modified to tolerate glyphosate over two decades ago. Glyphosate is often promoted by industry as a “low toxicity” chemical and “safer” than other chemicals, yet it has been shown to have detrimental impacts on humans and the environment. The toxic herbicide readily contaminates the ecosystem, with residues pervasive in food and water commodities. In addition to this study, decades of accumulated scientific literature commonly associates glyphosate with human, biotic, and ecosystem harm. Additionally, glyphosate’s ubiquity threatens 93 percent of all U.S. endangered species, resulting in biodiversity loss and ecosystem disruption (e.g., soil erosion, loss of services, and trophic cascades). Moreover, chemical use has been increasing since the inception of crops genetically modified to tolerate glyphosate. Not only do health officials warn that continuous use of glyphosate will perpetuate adverse health and ecological effects, but that use also highlights recent concerns over antibiotic resistance. Thus, glyphosate has been extensively controversial about its safety for humans, nonhuman organisms, and ecosystems. For instance, the presence of glyphosate in human bodies has risen dramatically during the past three decades. Research at the University of California San Diego found that, between two data collection periods (1993–1996 and 2014–2016), the percentage of people testing positive for the presence of glyphosate (or its metabolites) in urine rose by an average of 500 percent, peaking at 1,208 percent.

Although the EPA classifies glyphosate herbicides as “not likely to be carcinogenic to humans, glyphosate exposure has implications for the development of various health anomalies, including the distortion of DNA function, leading to several chronic diseases like cancer, Parkinson’s disease, metabolic disorders, gut dysbiosis, nervous system disorders, and neurodevelopment disorders like autism. In recent years, numerous lawsuits have targeted Monsanto (now Bayer), which contains glyphosate, alleging that the herbicide contributes to the plaintiffs’ cancers. Beyond Pesticides has reported on EPA’s ongoing failures to protect people and the environment from glyphosate-based herbicide (GBH) compounds. Therefore, advocates say it is crucial to comprehend the full spectrum of glyphosate’s effects on human health from its potential carcinogenicity.

This study is one of the first to investigate mLOY as a biomarker for genomic instability (loss of sex chromosome), providing new insight into the biological mechanism involved in carcinogenicity beyond general genotoxicity (i.e., DNA damage) and oxidative stress. However, considering the co-occurring effects of glyphosate exposure, including the chemical’s breakdown product AMPA, is essential. Since glyphosate and its formulations have long been associated with oxidative stress and strong evidence of genotoxicity, multiple biological mechanisms can work synergically (together) to increase the risk, time of onset, or disease severity.

It is essential to understand the effects of widely used pesticides and their breakdown products on the health of current and future generations. Beyond Pesticides challenges the EPA registration of chemicals like glyphosate in court due to their impacts on soil, air, water, and health. However, emphasis on converting to regenerative-organic systems and using least-toxic pest control can mitigate harmful exposure concerns. Public policy must advance this shift rather than allow unnecessary reliance on pesticides. Considering glyphosate levels in the human body can decrease by 70% through a one-week switch to an organic diet, purchasing organic food whenever possible—which never allows glyphosate use—can help curb exposure and adverse health effects. Learn more about pesticides’ impacts on human health by visiting Beyond Pesticides’ Pesticide-Induced Diseases Database. This database supports the clear need for strategic action to shift away from pesticide dependency. Moreover, Beyond Pesticides provides tools, information, and support to take local action: check out our factsheet on glyphosate/Roundup and our report, Monsanto’s Roundup (Glyphosate) Exposed. Contact us for help with local efforts and stay informed of developments through our Daily News Blog and our journal, Pesticides and You. Additionally, check out Carey Gillam’s talk on Monsanto’s corruption on glyphosate/Roundup at Beyond Pesticides’ 36th National Pesticide Forum.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: Environmental Health Perspectives

(Beyond Pesticides, January 2, 2024) [photo credit: Alessandro Marongui, Bhopal Medical Appeal, Bhopal, 2009] The new year begins with numerous critical decisions before the U.S. Environmental Protection Agency (EPA) and its Office of Pesticide Programs, along with other federal agencies and the U.S. Congress, that determine whether the agency will continue to erode its leadership position in meeting the existential crises that threaten health, biodiversity, and climate. Given these crises, EPA under its current authority could take the action necessary to advance a transition away from the use of petrochemical pesticides, since under the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA) the hazards associated with pesticides are “unreasonable”—given the availability and viability of organic systems that do not utilize toxic pesticides.

As EPA fails to meet the catastrophic environmental and health challenges of the day, communities and states across the U.S. are increasingly exercising their authority to restrict pesticides more stringently than the federal government. FIFRA, as affirmed by the U.S. Supreme Court in Wisconsin Public Intervenor v. Mortier (1991), does not prohibit or preempt local municipalities from adopting more stringent pesticide restrictions throughout their jurisdictions than the federal government. The U.S. Congress over the next several weeks will continue debating the inclusion in the Farm Bill statutory language that will preempt local authority.

One of the more outrageous proposals now under consideration by EPA is a chemical industry proposal to register the use of the highly neurotoxic, carbamate, insecticide aldicarb on citrus. While the adverse impact of pesticides often remains hidden from public view, especially in communities where pesticides are produced or used, the catastrophic explosion involving the chemical used in aldicarb production cannot be ignored. Forty years ago this year (December 1984), a Union Carbide plant in Bhopal, India released a cloud of highly toxic methyl isocyanate (MIC) gas, the precursor chemical used in carbamate manufacture, in the middle of the night, killing thousands of people immediately—estimates range from 1,754 to 10,000—and up to 20,000 subsequently. Estimates of the number suffering permanent disabilities or chronic disease range up to 95% of the affected population of 531,881. Continuing research released this year (June 2023) has found that fetuses in the womb during the disaster exhibited lower birth weights and remained more susceptible to respiratory problems, cognitive impairments, and other health issues later in life. Moreover, those born just after the gas leak were found to have lower educational attainment and reduced earning potential as adults. (For background on the Bhopal explosion and immediate and long-term effects, see Daily News.)

In 2021, the use of aldicarb on citrus was rejected  by the Florida Department of Agriculture and Consumer Services (April 2021) and the U.S. Court of Appeals (June 2021). Both EPA and the World Health Organization (WHO) classify the chemical in the highest toxicity category. Over 100 countries have banned aldicarb under the Rotterdam Convention, an international agreement on toxic chemicals that the United States has signed but not ratified.    

>>Tell EPA not to revive the use of aldicarb. Tell your Congressional Senators and Representative to ensure that EPA decisions are not dictated by the chemical industry.

Less than a year after the Bhopal tragedy, a cloud containing aldicarb oxime—which is combined with MIC to make aldicarb—leaked from a Union Carbide plant in Institute, WV. This time, at least 135 residents were treated for eye, throat, and lung irritation. In 1991, seven cars of a freight train derailed near Dunsmuir, CA. A tank car ruptured, dumping 19,000 gallons of the soil sterilant metam sodium into the Sacramento River. Several hundred people were hospitalized after inhaling fumes. The chemical causes birth defects and fetal death and is a known mutagen, so the total impact on human health is unknown. However, the chemical sterilized a 41-mile stretch of the river, killing over a million fish and thousands of trees. Such events are not in the distant past, as shown by the derailment of about 50 out of 141 cars on the Norfolk Southern train that exploded in a towering fireball over the town of East Palestine, OH in February 2023. Among the compounds on board those cars were “inert” pesticide ingredients (vinyl chloride, ethylhexyl acrylate, and isobutylene), an antimicrobial compound (ethylene glycol monobutyl ether [EGBE]), benzene (a carcinogenic solvent), and butyl acrylate. In 2022, train accidents resulted in releases of hazardous chemicals 11 times.

These examples of injuries to humans and the environment show that the harm caused by pesticides goes far beyond the impacts to consumers, farmworkers, other organisms, air, water, and soil caused by the application of those poisons, which are also extensive. We are all potentially affected. In some cases—including aldicarb—the damages caused by use alone have been shown many times to be, in the words of FIFRA, “unreasonable adverse effects.”

In fact, no pesticide epitomizes the “cradle-to-grave” dangers of pesticides better than aldicarb. In short, it is a suspected endocrine disruptor and is linked to neurotoxic and reproductive effects, asthma, and learning behavior problems. It has been detected in groundwater, is a potential leacher, and is toxic to birds and fish/aquatic organisms. In use, it has been implicated in poisoning of workers and their children, poisoning deer and other game consuming contaminated seeds, and notably, poisoning food grown in soil treated with the chemical. The effects don’t stop there—aldicarb is also notorious for contaminating groundwater. 

Aldicarb may persist in groundwater for decades due to its long half-life between 200 to 2,000 days, and ingestion of aldicarb-contaminated groundwater by residents adversely affects immune system function. Furthermore, aldicarb is a systemic pesticide that plant roots and leaves readily uptake, leading to toxic chemical residues in pollen and guttation droplets, poisoning pollinators like bees. Evidence demonstrates that past use of the aldicarb product Temik 15G on citrus fruit crops exclusively posed the highest risk to children and infants, ultimately leading to its 2010 cancellation.

Organic growers know that soil biology and soil health is important to protection from diseases like citrus greening. The use of aldicarb, on the other hand, destroys healthy soil biota.

This revival of consideration of aldicarb use demonstrates the danger of regulating pesticides through negotiated voluntary cancellations, which do not produce a record on which EPA or the public can depend for future decisions. See the Daily News of December 14, 2023 for more about aldicarb.

EPA must not revive the use of aldicarb, which is responsible for so much death and destruction, beginning with its manufacture and continuing through its use.

>>Tell EPA not to revive the use of aldicarb. Tell your Congressional Senators and Representative to ensure that EPA decisions are not dictated by the chemical industry.

Letter to EPA:

Thirty-nine years ago last month, a Union Carbide plant in Bhopal, India released a cloud of highly toxic methyl isocyanate (MIC) gas in the middle of the night, killing thousands of people immediately—estimates range from 1754 to 10,000—and up to 20,000 subsequently. Estimates of the number suffering permanent disabilities or chronic disease range up to 500,000. MIC is a precursor used in the manufacture of carbamate insecticides, including aldicarb, carbofuran, and carbaryl. In spite of this history and the many adverse effects of aldicarb, EPA is now considering reviving the pesticide’s use.

Less than a year later, a cloud containing aldicarb oxime—which is combined with MIC to make aldicarb—leaked from a Union Carbide plant in Institute, WV, and at least 135 residents were treated for eye, throat, and lung irritation. In 1991, seven cars of a freight train derailed near Dunsmuir, CA, dumping 19,000 gallons of the soil sterilant metam sodium into the Sacramento River, resulting in the hospitalization of several hundred people, with unknown future impacts from birth defects, fetal death, and mutations. Miles of the river were sterilized, killing over a million fish and thousands of trees. In February 2023, about 50 out of 141 cars on a Norfolk Southern train exploded in a towering fireball over East Palestine, OH. Among the compounds on board those cars were “inert” pesticide ingredients, an antimicrobial compound, benzene, and butyl acrylate.

Thus, the harm caused by pesticides goes far beyond the impacts caused by the application of those poisons, which are also extensive. We are all potentially affected. In fact, no pesticide epitomizes the “cradle-to-grave” dangers of pesticides better than aldicarb. It is a suspected endocrine disruptor, linked to neurotoxic and reproductive effects, asthma, and learning behavior problems. It has been detected in groundwater, is a potential leacher, and is toxic to birds and fish/aquatic organisms. It is a systemic pesticide readily taken up by plant roots and leaves, leading to toxic chemical residues in pollen and guttation droplets, poisoning pollinators like bees.

It has been implicated in poisoning of workers and their children, game consuming contaminated seeds, and notably, food grown in soil treated with the chemical. Aldicarb is also notorious for contaminating groundwater, where it may persist for decades due to its long half-life between 200 to 2,000 days. Ingestion of aldicarb-contaminated groundwater by residents adversely affects immune system function. Aldicarb is a highly toxic, systemic carbamate insecticide banned by over 100 countries under the Rotterdam Convention. Both EPA and the World Health Organization (WHO) classify the chemical in the highest toxicity category.

Evidence demonstrates that past use of aldicarb on citrus fruit crops exclusively posed the highest risk to children and infants, ultimately leading to its 2010 cancellation. In 2017 and 2018, the Florida Department of Agriculture denied “Special Local Needs” approval for use on Florida citrus because the registrant was unable to demonstrate that aldicarb is safer than alternatives.

Organic growers know that soil biology and soil health are important to protection from diseases like citrus greening. The use of aldicarb, on the other hand, destroys healthy soil biota.

I am appalled that despite previous cancellations due to unreasonable adverse effects, particularly on the health of children, EPA is now considering approving the use of aldicarb for use on Florida oranges and grapefruits. This reconsideration of aldicarb use demonstrates the danger of regulating pesticides through negotiated voluntary cancellations, which do not produce a record on which EPA or the public can depend for future decisions.

EPA must not revive the use of aldicarb, which is responsible for so much death and destruction, beginning with its manufacture and continuing through its use.

Thank you.

Letter to U.S. Senators and Representative:

Thirty-nine years ago last month, a Union Carbide plant in Bhopal, India released a cloud of highly toxic methyl isocyanate (MIC) gas in the middle of the night, killing thousands of people immediately—estimates range from 1754 to 10,000—and up to 20,000 subsequently. Estimates of the number suffering permanent disabilities or chronic disease range up to 500,000. MIC is a precursor used in the manufacture of carbamate insecticides, including aldicarb, carbofuran, and carbaryl. In spite of this history and the many adverse effects of aldicarb, the Environmental Protection Agency (EPA) is now considering reviving the pesticide’s use.

Less than a year later, a cloud containing aldicarb oxime—which is combined with MIC to make aldicarb—leaked from a Union Carbide plant in Institute, WV, and at least 135 residents were treated for eye, throat, and lung irritation. In 1991, seven cars of a freight train derailed near Dunsmuir, CA, dumping 19,000 gallons of the soil sterilant metam sodium into the Sacramento River, resulting in the hospitalization of several hundred people, with unknown future impacts from birth defects, fetal death, and mutations. Miles of the river were sterilized, killing over a million fish and thousands of trees. In February 2023, about 50 out of 141 cars on a Norfolk Southern train exploded in a towering fireball over East Palestine, OH. Among the compounds on board those cars were “inert” pesticide ingredients, an antimicrobial compound, benzene, and butyl acrylate.

Thus, the harm caused by pesticides goes far beyond the impacts caused by the application of those poisons, which are also extensive. We are all potentially affected. In fact, no pesticide epitomizes the “cradle-to-grave” dangers of pesticides better than aldicarb. It is a suspected endocrine disruptor, linked to neurotoxic and reproductive effects, asthma, and learning behavior problems. It has been detected in groundwater, is a potential leacher, and is toxic to birds and fish/aquatic organisms. It is a systemic pesticide readily taken up by plant roots and leaves, leading to toxic chemical residues in pollen and guttation droplets, poisoning pollinators like bees.

Aldicarb has been implicated in poisoning of workers and their children, game consuming contaminated seeds, and notably, food grown in soil treated with the chemical. It is also notorious for contaminating groundwater, where it may persist for decades due to its long half-life between 200 to 2,000 days. Ingestion of aldicarb-contaminated groundwater by residents adversely affects immune system function. Aldicarb is a highly toxic, systemic insecticide banned by over 100 countries under the Rotterdam Convention. Both EPA and the World Health Organization (WHO) classify the chemical in the highest toxicity category.

Evidence demonstrates that past use of aldicarb on citrus fruit crops exclusively posed the highest risk to children and infants, ultimately leading to its 2010 cancellation. In 2017 and 2018, the Florida Department of Agriculture denied “Special Local Needs” approval for use on Florida citrus because the registrant was unable to demonstrate that aldicarb is safer than alternatives.

Organic growers know that soil biology and soil health are important to protection from diseases like citrus greening. The use of aldicarb, on the other hand, destroys healthy soil biota.

I am appalled that despite previous cancellations due to unreasonable adverse effects, particularly on the health of children, EPA is now considering approving the use of aldicarb for use on Florida oranges and grapefruits. This reconsideration of aldicarb use demonstrates the danger of regulating pesticides through negotiated voluntary cancellations, which do not produce a record on which EPA or the public can depend for future decisions.

Please ensure that EPA does not revive the use of aldicarb, which is responsible for so much death and destruction, beginning with its manufacture and continuing through its use.

Thank you.

On behalf of the Beyond Pesticides team, we wish you and your loved ones a happy and healthy holiday season! We deeply appreciate the vital community-based work taking place across the country as we join together to confront the existential health and environmental challenges of our time.

Meeting the challenges ahead with a transformative strategy 

Beyond Pesticides shares the vision of people and communities that are striving to ensure a future that protects health and sustains life. We are facing existential crises—the climate crisis, biodiversity collapse, and severe public health threats—from cancer to neurological, reproductive, and endocrine system effects, including brain and behavioral impacts. To reverse these threats —which we can do— we advance model organic solutions that eliminate billions of pounds of fossil fuel-based pesticides and synthetic fertilizers and nurture biological systems that take dangerous pollutants out of our environment, protecting health and the ecosystems that sustain life.    

• Our audacious goal: to phase out petrochemical pesticides and fertilizers by 2032.
• Our solution: to provide hands-on assistance, funded by our supporters, to assist in the transition to organic land management in community parks, playing fields, and schoolyards. 
• The path moving forward: Advancing sustainable, organic practices and policies to solve the pesticide poisoning and contamination problem and the range of existential adverse effects in partnership with local communities and governments.

Over this past year, the urgency of our work has never been more palpable. Our daily collaboration with communities across the country—via the Parks for a Sustainable Future program—to adopt organic land management policies and practices in public spaces (parks, playing fields, and schoolyards) defined the path forward as a model to eliminate toxic pesticides and fertilizers, protect children, pets, and families, and sustain local ecosystems. 

Our program bridges policy and practice—reframing strategies that go after an endless list of toxic chemicals—and advancing a holistic approach that recognizes complex biological communities, the importance of soil microbiota, complex biological communities, and ecosystem services in the context of broader human health and environmental protection. By developing organic systems plans and training parks and public works departments on organic-compatible practices and products, we engage in a systems approach that works with soil biology, enriches nutrient cycling, and cultivates more resilient landscapes that meet community expectations while delivering long-term cost savings. 

It is imperative that, as we focus national attention on meaningful systemic change, we address the disproportionate risk to people of color communities and workers, from landscapers to farmworkers. 

Elevating science that calls for the urgent need to act 

Local science-based advocacy is vital, in tandem with practical hands-on support, to drive the changes critical to a livable future as scientific facts coupled with action advance the adoption of solutions within our reach. Believing in the empowerment of advocates and decision-makers, our team provides up-to-date information on the independent, peer-reviewed scientific literature on our website and on a daily basis, five days a week, published in our Daily News blog in articles that analyze complex scientific findings, judicial rulings, regulatory decisions, and legislative action.  

In addition, our unique databases offer tools to empower local activists and more to take action in their communities, schools, workplaces, and homes—including our Gateway on Pesticide Hazards and Safe Pest Management, Eating with a Conscience (on ecological and worker effects), What the Science Shows (pollinators), Pesticide-Induced Diseases Database, and ManageSafe (how to manage homes and gardens without pesticides). Our updated resources, such as the health and environmental effects in our 40 Most Commonly Used Lawn Pesticides, are “tools for change.”    

Elevating our voice and networking for change 

In the face of the chemical industry and related service providers wielding tremendous power across levels of government, and agencies not keeping pace with the escalating environmental and public health challenges, it is the communities and their elected officials that have chosen to actively engage in democratic decision making to protect the health of their residents.  

As a key example, during the 2023 National Forum in November—Forging a Future with Nature—a mom and advocate from Maine spoke side-by-side with a parks supervisor from Colorado to share what change looks like—from two of dozens of our partner communities!

Our work in collaboration with these communities is a bright spot at a time when solutions may seem out of reach. In these perilous times, your support helps us to elevate these voices and empower grassroots-based strategies that lead the way in the face of federal and state inaction.  

Online, our Action of the Week platform provides our network with one concrete action that can be taken each week to have our collective voice heard to advance specific actions that are protective of public and worker health, eliminate toxic pesticide use, and put in organic, sustainable, and regenerative practices and policies. 

Taking a stand 

Having worked with organic systems since our founding in 1981, we know that this change can be achieved. We continue—through campaigns such as Keeping Organic Strong—to push for the growth of organic agriculture as the only acceptable and foundational form of land management for the future.    

[Plus, with a 43-year+ history of successfully advancing systemic change, we know the solutions are within our grasp!] 

Our team at Beyond Pesticides looks forward to continuing to partner with you in the new year to meet the existential environmental and public health challenges with truly organic solutions through policy, science, and action—one day at a time for ourselves and for future generations.  

For more information and to discover actions that have defended democratic decision making to adopt organic land management on public land, informed action, and met the challenges of 2023, please click on the image above or the link to access our Year in Review page for 2023.

It’s a fact. Your support makes our work possible. 

A special thank you to all our donors and supporters this year. Without your engagement and incredible generosity, it would not be possible to lead the transition to a world free of toxic pesticides. Our team provides up-to-date information about the health and environmental hazards of pesticides, pesticide regulation and policy, holistic nontoxic management systems, and cutting-edge science—free of charge to the public. This program is not possible without the generosity of people like you!  

Please make your secure tax-deductible donation at bp-dc.org/donate2023 or by clicking/scanning the QR code below!