(Beyond Pesticides, February 25, 2021) A University of Michigan study finds a link between elevated rates of breast cancer incidents and chemical exposure from pesticides among African American women. Breast cancer is the most common cancer among women, causing the second most cancer-related deaths in the United States. However, breast cancer outcomes differ significantly among women of various races/ethnicities, with African American women being 40 percent more likely to die from breast cancer than women of any other race. Furthermore, incidences of triple-negative breast cancer (TNBC)—an aggressive breast cancer subtype lacking remediation—is approximately three-fold higher in non-Hispanic Black women (NHBW) compared to non-Hispanic White women (NHWW). Although past studies suggest genetic and environmental factors interact to produce these differences in breast cancer outcomes, genetic factors only play a minor role while disparities (differences) in external factors (i.e., chemical exposure) may play a more notable role. This study highlights the significance of understanding how chemical exposure drives disease outcomes and increases disease risk, especially for more virulent diseases that disproportionately (unequally) impact specific communities. Prior research infers differences in chemical exposure may explain racial disparities for several illnesses, and growing evidence suggests common chemical exposure patterns influence the risk of breast cancer. […]

(Beyond Pesticides, February 18, 2021) New research published in the journal Toxicological Sciences finds extended inhalation of the common herbicide paraquat causes male mice to lose some sense of smell, even at low doses. This study highlights the significance of understanding how specific chemical exposure routes can influence disease development. Olfactory (relating to the sense of smell) impairment is a precursory feature of Parkinson’s disease (PD), and studies connect paraquat poisoning to PD risk. Hence, future pesticide management policies should assess specific disease risks with bodily chemical concentration from low-dose, chronic neurotoxic chemical exposure. The study’s researchers note, “These data support the importance of route of exposure in the determination of safety estimates for neurotoxic pesticides, such as [paraquat]. Accurate estimation of the relationship between exposure and internal dose is critical for risk assessment and public health protection.” Despite evidence demonstrating that olfactory  nerve cells transport toxic airborne particles and solutes to the brain upon inhalation, the possibility of olfactory impairment (damage) from paraquat inhalation lacks adequate assessment. To assess the impact paraquat has on olfactory function, researchers exposed a cohort of adult female and male mice to paraquat aerosols in an inhalation chamber for four hours a day, five days a week, for four weeks. Researchers investigated paraquat concentrations […]

(Beyond Pesticides. January 25, 2021) First registered in 1970 and voluntarily cancelled in 2010, aldicarb (Temik™) was being manufactured in Bhopal, India in 1984 when a leak of a precursor—methyl isocyanate (MIC)—spread over the city, ultimately killing more than 25,000 people and leaving more than 120,000 people who still suffer from severe health problems as a result of their exposure. In 1989, Union Carbide Corporation—the manufacturer of aldicarb at the time—paid $470 million (equivalent to $860 million in 2019) to settle litigation stemming from the disaster. Aldicarb has been allowed by the outgoing Trump EPA for use on oranges. >>Tell EPA to Reverse Approval of Highly Toxic Insecticide Aldicarb! No pesticide epitomizes the “cradle-to-grave” dangers of pesticides better than aldicarb. The disaster in Bhopal was followed by others, including a leak in Institute, WV in 1985 that injured at least 135 people and a 2008 explosion in Institute, WV that killed two and injured at least eight. In use, it has been implicated in poisoning of workers and their children, poisoning deer and other game consuming contaminated seeds, and notably, poisoning food grown in soil treated with the chemical. The effects don’t stop there—aldicarb is also notorious for contaminating groundwater. […]

(Beyond Pesticides, January 22, 2021) After the past four devastating years, hopes and expectations of the Biden/Harris administration abound among the environmental and public health communities. The ears and eyes of many advocates, as well as those in the agricultural community, are attuned (among myriad candidates) to the fate of the pesticide aldicarb. Although Environmental Protection Agency (EPA) registration of this terribly toxic insecticide was cancelled in 2010, various limited-use reapprovals since then have meant that the compound has found its way to increasing levels of use. On January 12, as another parting shot of midnight rulemaking, Trump’s EPA approved expanded uses (see below). The $64,000 question is whether the new administration will use its authority under the Congressional Review Act — which enables Congress to pass a joint resolution (then signed by the President) to overturn a new federal agency rule and prevent its reissuance in the future — to get this pesticide retired for good. Beyond Pesticides urges President Biden’s EPA to do so. Notably, the Trump administration used the Congressional Review Act to destroy myriad environmental rules when it came into power. This permitting of expanded aldicarb uses fits the pattern. Environmental Health News notes that, as of early […]

(Beyond Pesticides, January 8, 2021) In an eleventh-hour move, the Trump administration’s Environmental Protection Agency (EPA) announced on January 5 the finalization of its controversial, so-called “transparency” rule. The agency claims that the rule— dubbed “Strengthening Transparency in Pivotal Science Underlying Significant Regulatory Actions and Influential Scientific Information”—which mandates that researchers provide to EPA access to their raw data, will improve the credibility of its regulations because the public would be able to validate research that influences EPA regulations. In fact, as researchers and advocates recognize, this rule will significantly restrict the scientific research EPA uses in developing regulations to protect human health. This rule will mitigate against use of the best and broadest knowledge base in developing protections for the American people. In its article on the EPA announcement, The Washington Post explains that the rule would “actually restrict the EPA from using some of the most consequential research on human subjects because it often includes confidential medical records and other proprietary data that cannot be released because of privacy concerns.” Trevor Nace of Forbes magazine writes of the proposed rule: ‘It literally throws out fundamental and hallmark environmental studies the EPA paid scientists to conduct and [which it used to] build […]

(Beyond Pesticides, January 6, 2021) Long-term exposure to formulated Roundup and glyphosate results in significant harm to wildlife species that form the bottom of aquatic food chains, according to a study published in Microbiome by researchers at University of Birmingham, UK. The water flea Daphnia spp. often functions as a keystone species in lakes and ponds, and because of its ecological importance is frequently used as an indicator species in toxicity tests performed by pesticide regulators. Lead author Luisa Orsini, PhD, notes that most of this testing is flawed by limitations in its scope. “The problem is that much of the evidence is rooted in outdated toxicity tests which only look at the number of animals that die on exposure to extremely high concentrations of these chemicals,” Dr. Orsini said. “These tests also overlook the pathological effects arising from long-term exposure to low doses. What we’re proposing is that toxicity is measured by looking at what happens to the animal at a molecular and fitness level following long-term exposure, which encompasses the entire animal life cycle.” Dr. Orsini and her research team exposed populations of Daphnia magna to the maximum contaminant level (1 mg/L) of both the formulated product Roundup, […]

(Beyond Pesticides, December 17, 2020) The U.S. Environmental Protection Agency (EPA) is contemplating the reapproval of toxic, widely banned insecticide aldicarb for use on citrus fruits in Texas and Florida. A vast amount of scientific evidence reports a dramatic decline in insect population (i.e., the insect apocalypse), like pollinators and other beneficial biotas, from environmental pollution sources like pesticides. Therefore, it is important to assess regulatory decisions that can potentially jeopardize the protection of these species and, consequently, human health. Nathan Donley, PhD, a senior scientist at the Center for Biological Diversity (CBD), states, “The fact that U.S. regulators would even consider expanding use of this dangerous, widely banned pesticide is a stunning indictment of our broken regulatory system. This application vividly reaffirms why the pesticide industry considers us the dumping ground for the world’s worst pollutants. We’ll be watching closely to see whether the Biden administration steps up and puts public health before pesticide company profits.” Aldicarb is a highly toxic, systemic carbamate insecticide, with initial production beginning in 1965. The chemical is a fast-acting cholinesterase inhibitor that permanently binds to the active site of an essential enzyme for normal nerve impulse transmission, acetylcholinesterase (AChE), deactivating the enzyme. In […]

(Beyond Pesticides, October 27, 2020) The insecticide fipronil is more toxic to aquatic insects than previously thought, often present in U.S. waterways, and can trigger trophic cascades that disrupt entire aquatic ecosystems, finds new research published by the U.S. Geological  Survey (USGS). The data have important implications for waterways throughout the country, but particularly in the Southeast U.S. where the chemical was found at hazardous levels in over half of sampled steams. Despite the high quality of the findings by a U.S. government agency, pesticide regulators at the U.S. Environmental Protection Agency (EPA) do not adequately consider ecosystem-level effects when determining whether to register a pesticide. As a result, without public pressure on the agency, it is unlikely it will follow the science and take the action necessary to rein in use and safeguard the environment. Fipronil is a systemic pesticide that can travel through plant tissues and be expressed in its pollen, nectar, and dew droplets. Due to its systemic properties and similar toxicity profile, it is often targeted for restriction alongside the notorious neonicotinoid class of insecticides. Although fipronil is equally concerning, there is less data on the range of harm the chemical may cause. To better understand […]

(Beyond Pesticides, October 23, 2020) In central California, what promises to be a landmark series of lawsuits against Corteva (formerly DowAgroSciences), maker of the pesticide chlorpyrifos, is under way, spearheaded by the case Alba Luz Calderon de Cerda and Rafael Cerda Martinez v. Corteva Inc., et al. This first suit, brought by the parents of Rafael Cerda Calderon, Jr. on his behalf, charges that his lifelong disabilities were caused by chronic exposures to chlorpyrifos. The parents are suing for general damages, compensatory damages (due to Rafael, Jr.’s loss of earning capacity), medical care costs, and “punitive damages for the willful, reckless, and recklessly indifferent conduct of the Defendants” in intentionally hiding the dangers of their chlorpyrifos products from customers and the public. As with so many dangerous pesticides, absent effective federal regulation, states, cities, and other entities are taking action to protect people from this compound, and as in this case, individuals are seeking redress for harms suffered. Beyond Pesticides has long advocated for a ban on the use of chlorpyrifos because of the grave risks it poses. The case was filed in mid-September in California Superior Court, Kings County, and names not only Corteva, but also, the cities of Huron and Avenal, Woolf […]

(Beyond Pesticides, October 19, 2020) The COVID-19 epidemic has made clear to the general public what we at Beyond Pesticides have been stressing since our inception—some populations have disproportionate risk of severe outcomes, exposures to toxic chemicals can affect susceptibility to disease, comorbidity increases risk, and bad government can kill you. As Trump declares that “unborn children have never had a stronger defender in the White House,” we are reminded of Erik Jansson, who ran the National Network to Prevent Birth Defects and helped to convene the founding meeting of Beyond Pesticides, and took on then-Administrator of EPA Anne Gorsuch, calling her a “baby killer” because of policies that allowed exposures to toxic chemicals—exposures that endangered children and fetuses. Those were harsh words in the 1980s even when the Reagan administration’s environmental and toxics policies were tied to elevated harm to people, and children in particular. In today’s world, scientists and medical doctors are regularly linking elevated death rates from coronavirus to the federal government’s inadequate coronavirus policy and its attack on science. And, they are pointing to those in charge. Policies and decisions under the Trump administration that threaten the health of children and the unborn include: COVID-19 misinformation. […]

(Beyond Pesticides, October 14, 2020) Exposure to certain endocrine disrupting pesticides increases the risk men, and Hispanic men in particular, will contract testicular cancer, according to research presented at the American Association for Cancer Research Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved. The data show that living near the use of the insecticide acephate presents the greatest cancer risk. “Testicular cancer rates have been rising for decades and are rising especially quickly among Hispanics in the United States,” said Scott Swartz, an MD candidate in University of California Berkeley-UCSF Joint Medical Program, to Healio. “Given that Hispanics are disproportionately exposed to many endocrine-disrupting pesticides in California, we were interested in investigating the potential effects of nearby endocrine-disrupting pesticide application on testicular cancer among Hispanics in California.” Using public health databases, researchers assessed a group of 381 men diagnosed with testicular cancer while 15 to 19 years old, during the years 1997-2011. This cohort was compared to a control group of 762 otherwise healthy men of similar age, race and ethnicity during the same time. California’s Pesticide Use Report system was used to analyze agricultural pesticide applications within 1.8 miles of a study […]

(Beyond Pesticides, October 9, 2020) A new study demonstrates that emerging “novel” insecticides can cause significant, sublethal harm to beneficial organisms at typical “real life” exposure levels. As neonicotinoid insecticides have come under fire for their terrible impacts on a broad variety of beneficial insects — including their major contributions to the decline of critical pollinators — more such “novel” pesticides are being brought to market in response. The study results, the co-authors say, “confirm that bans on neonicotinoid use will only protect beneficial insects if paired with significant changes to the agrochemical regulatory process. A failure to modify the regulatory process will result in a continued decline of beneficial insects and the ecosystem services on which global food production relies.” Beyond Pesticides would add that the study outcome points, yet again, to the grave recklessness of the pervasive “addiction” to chemical pesticides in agriculture. The solution to this chemical morass is known, doable, and scalable: a transition to organic, regenerative agricultural practices that get everyone off the “toxic treadmill.” Neonicotinoid pesticides (neonics) are the class of chemical pesticides most commonly used worldwide, both on crops and as seed treatments. They are systemic, meaning they infiltrate all tissues of a […]

(Beyond Pesticides, September 30, 2020) Low doses of neonicotinoid (neonic) insecticides are known to disrupt insect learning and behavior, but new science is providing a better understanding of how these effects manifest at a cellular level. Published in the Proceedings of the National Academy of Sciences, this study finds that the neonic imidacloprid binds to brain receptors, triggering oxidative stress, reducing energy levels, and causing neurodegeneration. “Although many studies have shown that low doses of insecticides can affect insect behavior, they have not uncovered whether insecticides trigger changes at the cellular and molecular levels,” said lead author Felipe Martelli, PhD, of Monash University in Melbourne, Australia. “The goal of this work was to have a better understanding of the effects of low doses of the common insecticide imidacloprid at the cellular, physiological and behavioral levels.” Researchers used the fruit fly Drosophilia melanogaster, a common experimental organism, as it contains a number of nicotinic acetylchloline receptors, the primary site of action for imidaclorpid. The neonic binds to these receptors, which regulate a number of physiological processes, such muscle contraction. Binding closes these channels, leading to the range of harm researchers observed through their study. Larval fuit flies were exposed to imidacloprid […]

(Beyond Pesticides, September 18, 2020) In late August, Consumer Reports magazine (CR) issued a report titled, “Stop Eating Pesticides,” which offers consumers a rating system CR developed and employed to help them “get the health benefits from fruits and vegetables while minimizing [the] risk from toxic chemicals.” In addition to providing its analysis and ratings of the pesticide risk of a variety of produce items, CR recommends eating organically grown and raised foods whenever possible. It also makes a host of recommendations on federal pesticide policies and emphasizes the importance of maintaining the integrity of the National Organic Standards (of the USDA-housed National Organic Program). Beyond Pesticides appreciates that this mainstream publication has arrived at many shared, science-based assessments of the risks of pesticides. That said, a wholesale transition to organic and regenerative agriculture — rather than making the public figure out which fruits and vegetables are “safer” or “less safe” — is the real answer to the health risks of pesticides in the food supply, according to Beyond Pesticides. The CR analysis used data from the U.S. Department of Agriculture’s (USDA’s) Pesticide Data Program for 2014–2018. Those pesticide residue data were compiled from tests of approximately 450 pesticides across 24,000 […]

(Beyond Pesticides, September 9, 2020) Late last month the California legislature voted to ban, with limited exceptions, the use of highly toxic rat poisons. The California Ecosystems Protection Act of 2020, AB 1788, was passed after over a year of advocacy by groups and individuals concerned about the impact of second-generation anticoagulant rodenticides (SGAR) on state and local wildlife. Proponents of the legislation are advocating that lawmakers in other states follow California’s lead by passing similar legislation. The bill must be signed by Governor Gavin Newsom or allow the bill to become a law without his signature by September 30, 2020. The legislation hones in on the use of SGARs, specifically the chemicals brodifacoum, bromadiolone, difenacoum, and difethialone, which present significant hazards to non-target wildlife. Unlike the first generation of blood thinning rodenticides on the market (such as chlorophacinone, warfarin, and diphacinone, which present their own hazards), SGARs cannot be quickly excreted by the body and can deal a lethal dose to rodents in a single feeding. However, SGAR-poisoned rodents do not die immediately, and are often left lethargic and exposed to the elements. This makes them easy prey for birds and mammals. In California, SGARs gained considerable attention for […]

(Beyond Pesticides, August 21, 2020) A foundational study of the toxic insecticide chlorpyrifos left critical data out of its analysis, resulting in decades of an Environmental Protection Agency (EPA) “safe exposure limit” that is flat out wrong, new research says. That 1972 study concluded that the amount of the chemical to which a human could be exposed before adverse effects showed up (the “no observed adverse effect level,” or NOAEL) was more than twice as high as should have been determined had the study not ignored critical data. In addition, the study points to the perennial “fox and hen house” issues at EPA, which include using research commissioned, funded, or even conducted by industry as any basis for regulation. For years, Beyond Pesticides has rung the alarm on this very dangerous pesticide, and advocated for its ban nationwide. News of this omission from the 1972 “Coulston Study” comes from a team out of the University of Washington. The researchers re-analyzed that human intentional dosing study using both the original statistical methods and modern computational tools that did not exist in the 1970s. (An important side note: such a study is unethical by current research standards.) The new analysis finds two significant […]

(Beyond Pesticides, August 13, 2020) Levels of the notorious herbicide compound glyphosate in the human body are reduced by 70% through a one-week switch to an organic diet, finds a new, peer-reviewed study published in August 2020 in the journal Environmental Research. This result emphasizes both the ubiquity of this compound in the human body, and diet as the primary source of exposure for most people. It also adds to the evidence for Beyond Pesticides’ assertions that: (1) chemical-intensive agriculture must be abandoned, for a variety of reasons that include human health, and (2) in the lead-up to a transition to organic and regenerative agriculture, consuming organic foods as much as is practicable is powerful protection from glyphosate, and from the assault of multiple chemical pesticides to which most people are exposed. Glyphosate is the active ingredient in the popular weed killer RoundupTM, which has been used intensively in the U.S. and around the world, especially during the last couple of decades. It is very commonly used on crops grown from genetically engineered (GE) companion seeds for a variety of staple crops (e.g., soybeans, cotton, and corn). These GE seeds are glyphosate-tolerant, whose attribute has allowed growers to apply the herbicide and […]

(Beyond Pesticides, August 12, 2020) The herbicide atrazine can interfere with the health and reproduction of marsupials (including kangaroos and opossums) kangaroo, Virginia opossum, according to research published in the journal Reproduction, Fertility, and Development. Although the research focuses on the health of the Australian wallaby, the data is relevant for the only marsupial in the United States, the opossum. Unfortunately, the research is no surprise, as atrazine has a long history of displaying endocrine (hormone) disrupting properties, affecting sex and reproduction in a broad range of species. The study, under the auspices of University of Melbourne Animal Experimentation and Ethics Committee, exposed pregnant female adult wallabies to atrazine through gestation, birth, and lactation. Doses of the weedkiller were slightly higher than real world models, but according to researchers, “It is quite possible a wild animal could get such an exposure.” Researchers then euthanized the newborn wallabies to study atrazine’s effects. The gonads and phallus of young wallabies were analyzed for any physiological changes or impacts to gene expression. Researchers found changes to the gene expression necessary for basic function of the testis, and a significant reduction in phallus length. “These results demonstrate that [atrazine] exposure during gestation and lactation can […]

(Beyond Pesticides, August 5, 2020) Regions of Australia that use a highly toxic rodenticide are home to larger dingoes than areas where the pesticide is not used, according to research published in the Biological Journal of the Linnean Society. Over the course of roughly the last century, dingoes in rodenticide-baited regions have grown by between six and nine percent. While pesticides are well known to induce changes in insect morphology as resistance is developed, this is one of the first studies to find effects on a large vertebrate carnivore. To make their determination, researchers began measuring the size of dingo skulls, which can be used as a proximate for body size, in areas where the rodenticide compound 1080 (sodium fluoroacetate) was and was not historically used. Skull analysis relied primarily on historical specimens stored in museums throughout Australia.   “Skulls from the baited regions grew by about four millimetres since poison baiting was introduced,” says Michael Letnic, PhD, lead author of the paper and professor in conservation biology and ecosystem restoration at the University of New South Wales Science. “This equates to roughly a kilogram [2.2 lbs] in body mass.” While size increases were consistently seen in baited regions, dingoes […]

(Beyond Pesticides, July 27, 2020) Evian bottled water, produced by the French company Danone, is supposed to be so pure that scientists will calibrate their measuring devices with it. But new data from Swiss researchers finds it to be contaminated with a toxic fungicide. “The fact that even the Evian springs in the French Alps, which are hardly affected by humans, contain pesticide residues is alarming and shows the far too careless handling of these substances,” Roman Wiget, president of the international drinking water association AWBR told the German-language Swiss weekly. The answer is not to simply ban another toxic pesticide, only to be followed by another toxic pesticide, but foundational changes to agriculture and land management with a shift to organic practices.  Tell Evian to protect water quality and the integrity of its purity claim by prominently supporting a worldwide shift to organic agriculture and land management. Danone claims that the purity of Evian bottled water comes from its source in Cachat Spring at the base of the French Alps in the town of Évian-les-Bains, France, where it is “[p]rotected under a fortress of geological layers built by glaciers 30,000 years ago, it slowly travels through natural snowy, glacial […]

(Beyond Pesticides, July 24, 2020) As the novel coronavirus pandemic has heightened awareness of infectious diseases, there is increased attention to connections between environmental concerns and such diseases, including factors that may exacerbate their transmission. New research shows one such relationship: the transmission of schistosomiasis, a tropical disease caused by contact with the larvae of parasitic worms (schistosomes), is likely accelerated by the use of pesticides and other agrochemicals (such as synthetic fertilizers). The study, published in The Lancet Planetary Health, also shows that contamination of freshwater bodies with these chemicals disturbs ecological balances that can actually limit schistosome infections. This new research underscores the urgency of the needed transition, in affected tropical and subtropical areas, to agricultural approaches that do not involve synthetic agrochemicals that pollute local waterways and put people’s health at increased risk. Beyond Pesticides recently covered another study, published in Nature’s Scientific Reports in February 2020, that indicates that agricultural pesticide runoff indirectly increases rates of transmission of schistosomiasis. The transmission landscape for this disease is complex, in part because one of the parasite’s vectors are freshwater snails, which: (1) play an important role in schistosomes’ life cycle, (2) are relatively resistant to the effects of pesticides, […]

(Beyond Pesticides, July 20, 2020) Does your community spray toxic pesticides for mosquitoes? In a well-intentioned but ill-informed attempt to prevent mosquito-borne illness such as West Nile virus, many communities spray insecticides (adulticides) designed to kill flying mosquitoes. If your community is one of these, then your public officials need to know that there is a better, more-effective, way to prevent mosquito breeding. Tell your public officials to stop spraying pesticides and adopt a mosquito management plan that protects public health and the environment. The problem with mosquito pesticides. Two classes of insecticides are favored by mosquito spray programs—organophosphates and synthetic pyrethroids. In order to better target flying mosquitoes, adulticides are generally applied as ultra-low-volume (ULV) formulations that will float in the air longer than usual.  Pesticides are toxic chemicals and can exacerbate respiratory illnesses like Covid-19.Organophosphates, which include malathion (Fyfanon), naled (Dibrom), and chlorpyrifos (Mosquitomist for public health uses only) are highly toxic pesticides that affect the central nervous, cardiovascular, and respiratory systems. Symptoms of poisoning in humans include numbness, tingling sensations, headache, dizziness, tremors, nausea, abdominal cramps, sweating, incoordination, blurred vision, difficulty breathing, slow heartbeat, loss of consciousness, incontinence, convulsions, and death. Some organophosphates have been linked to […]

(Beyond Pesticides, July 14, 2020) The Mexican government announced late last month that it plans to phase out the importation and use of glyphosate in the country over the next four years. The announcement means that Mexico will join other countries, such as Luxembourg, Vietnam, Germany in prohibiting the chemical and the toxic consumer products, like Roundup, that contain it as an ingredient. International watchdogs are keeping an eye on reactions from the United States, which in recent years has worked to intervene in other countries’ decision-making over toxic pesticides. The government’s announcement cites the Precautionary Principle as part of its decision-making. According to the Wingspread Statement on the Precautionary Principle, “Where an activity raises threats of harm to the environment or human health, precautionary measures should be taken even if some cause and effect relationships are not fully established scientifically.” In the case of glyphosate, there is strong evidence, per a 2015 review by the International Agency for Research on Cancer (IARC), that glyphosate is carcinogenic. Since 2015, several more publications have added weight to glyphosate’s link to cancer. A February 2018 meta-analysis finds “a compelling link between exposures to GBH [glyphosate-based herbicides] and increased risk of NHL [non-Hodgkin […]