(Beyond Pesticides, October 12, 2016) German chemical company Bayer said it would not introduce genetically engineered (GE) crops in Europe after its historic takeover of U.S. seed and pesticide producer Monsanto. The European Union (EU) has been skeptical of GE crops, with many countries refusing to approve certain varieties of them. However, in the U.S., where GE crops make up about half of the crops grown, the merger will probably have little to no effect on GE use. Last month, St. Louis-based agrichemical giant  Monsanto Co. agreed to sell the company  to German pharmaceutical and chemical conglomerate, Bayer, in  an unprecedented $66 billion dollar deal. This takeover of the U.S. firm is the biggest ever by a German company. The combination would create a global agricultural and chemical giant ””and bring Bayer together with a leading producer of genetically engineered seeds that are engineered to resist pesticides, particularly Monsanto’s flagship product, Roundup. Roundup, whose active ingredient is glyphosate, is used alongside various GE crops including corn and soybeans. In 2015, the World Health Organization’s International Agency for Research on Cancer (IARC) released a landmark  report naming glyphosate as  “probably carcinogenic to humans.” Glyphosate’s EU license was set to expire this […]

(Beyond Pesticides, October 4, 2016) Chemicals previously used as  inert ingredients in pesticide formulations have been detected in a wide range of North American wildlife species, according to research published in the journal Environmental Science and Technology. The compounds, perfluroalkyl phosphinic acids (PFPIAs), were widely used as anti-foaming agents in pesticide formulations until 2006, when the U.S. Environmental Protection Agency took regulatory action to cancel  their use, citing “human health and environmental risks of concern.” However, the chemicals continue to be used today in consumer goods, including carpet cleaning formulas. While scientists did not find what they would consider high concentrations of the chemicals in wildlife, the ubiquity of the detections was found to be most concerning. Researchers detected the presence of PFPIAs in the blood of 100% of animals sampled. This includes northern pike in Montreal, Canada, cormorants from the Great Lakes, and bottlenose dolphins from Sarasota Bay, Florida. “We aimed for diversity: air-breathing versus water-breathing, differences in habitat, different taxonomic groups,” Amila O. De Silva, PhD, coauthor of the study, said to CNN. Part of the reason for the wide range of detection lies with the properties of these chemicals. They are highly stable and resist degradation from […]

(Beyond Pesticides, September 21, 2016) The U.S. Environmental Protection Agency’s (EPA) Office of Pesticide Programs released last week  its Glyphosate Issue Paper in which the agency is proposing to classify glyphosate as “not likely to be carcinogenic to humans at doses relevant for human health risk assessment.” Glyphosate, the controversial active ingredient in Roundup, was classified in 2015 by the World Health Organization (WHO) as a “probable carcinogen” and numerous studies have associated the chemical with cancer and other human health issues. However, EPA’s proposed a classification that is contrary, not only to WHO’s, but also a position  it had previously held. The issue paper was released in preparation for the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) Scientific Advisory Panel (SAP) meeting, October 18-21, which convenes to review EPA’s evaluation of the carcinogenic potential of glyphosate. Glyphosate, produced by Monsanto, is one of the most popular weedkillers in the U.S., and the active ingredient in Roundup. Glyphosate is often promoted by industry as a “low toxicity” chemical and “safer” than other chemicals, yet has been shown to have  detrimental impacts  on humans and the environment. Given its widespread use on residential and agricultural sites, its toxicity is of increasing […]

(Beyond Pesticides, September 14, 2016) According to a recent study by the U.S. Geological Survey (USGS), high concentrations of dioxins and furans have been detected in tree swallow eggs collected near several sites around the Great Lakes. Other chemicals detected include polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), which were at background levels. The study is part of efforts to clean up a toxic chemical legacy around the Great Lakes, and the researchers believe their results are critical to regulators to assess “bird or animal deformity or reproductive problems” The study, “Concentrations and spatial patterns of organic contaminants in tree swallow (Tachycineta bicolor) eggs at United States and binational Great Lakes Areas of Concern, 2010—2015,” used tree swallows to quantify current exposure to organic contaminants across all five Great Lakes including 59 sites within 27  Areas of Concern (AOCs)  and 10 nearby  locations. The Great Lakes Areas of Concern refers to a U.S.-Canada  Great Lakes Water Quality Agreement  (Annex 1 of the 2012 Protocol) that  defines AOCs as “geographic areas designated by the Parties where significant  impairment of beneficial uses  has occurred as a result of human activities at the local level.” An AOC is a location that has […]

(Beyond Pesticides, September 7, 2016) Industry giant Bayer has increased its offer to acquire Monsanto to $65 billion, making it the largest all-cash takeover bid in history. Bayer is now offering $127.50 per share- up two percent from its earlier bid of $125. The pharmaceutical giant has been pursuing Monsanto in an attempt to become the world’s largest biotechnology and pesticide manufacturer. But many are concerned that should this merger be successful, farmers would have even fewer choices for acquiring seed, ensuring that the American food supply is dominated by a few mega-corporations. According to The Guardian, Bayer’s proposal will create a global pharmaceutical and farm supplies giant, just as  rival firms are also consolidating. ChemChina earlier this year offered  to buy Switzerland’s Syngenta for $43bn, after the latter rejected takeover approaches from the St. Louis-based Monsanto. This ChemChina-Syngenta merger is all set to move forward after getting approval from the regulatory agency, Committee on Foreign Investment in the U.S. (CFIUS). U.S. firms Dow Chemical and DuPont are pursuing a $130bn merger, to be followed by a breakup into three businesses. Bayer’s previous offers for Monsanto were rejected, but Monsanto remains open to further discussion. However, Monsanto has faced financial […]

(Beyond Pesticides, August 16, 2016) Young children are disproportionately poisoned by toxic pesticides used indoors, according to a study published in the Australian and New Zealand Journal of Public Health. Data analyzed from the Queensland, Australia Poisons Information Centre (QPIC) finds that 49% of 743 insecticide-related calls in 2014 concerned young children. Given that children are more sensitive to pesticide exposure than adults because they take in more of a chemical relative to their body size and have developing organ systems, this data underscores the importance of educating the general public about alternatives to the use of toxic pesticides in and around the home. A significant share of childhood pesticide poisonings occurred in very young children. “Children in the one-year age group were at greatest risk — as they’re at that stage where they spend a lot of the time on the floor and put things in their mouth,” said Karin English, PhD candidate at the University of Queensland. As a result of children’s propensity for hand to mouth motion, cockroach baits and ant liquid were found to be the most common source of insecticide exposure for kids under five, covering 39% of calls. However, Ms. English notes that enclosing […]

(Beyond Pesticides, August 14, 2016) According to recent reports, the illegal misuse of pesticides in Dubai has left ten people dead within the last year. The culprit? Domestic use of a pesticide containing highly toxic aluminum phosphide sold on the black market, touted as a way to fight bed bugs for low-income families that may not have the education level or means to research and pursue other options. While the government acknowledges a significant problem given the common occurrence of these  deaths, those in positions of power are admittedly at a loss when it comes to finding a solution, with some calling for a crack down on those selling the pesticides illegally, and others wanting to punish those that buy and use it. Regardless of the actions, elected officials decide to pursue, embracing organic pest management systems, as well as a robust education campaign, will be critical in curbing these deaths. Given the availability of greener, safer alternatives, Beyond Pesticides opposes any registration or allowance of phosphide fumigants and other highly toxic chemicals that can be easily misused. Phosphide fumigants, including aluminum phosphide, are known to be acutely toxic when ingested or inhaled. Symptoms of mild to moderate acute exposure […]

(Beyond Pesticides, July 28, 2016)   Led by the Institute of Bee Health at the University of Bern, new research finds evidence that two commonly used neonicotinoid (neonic) insecticides have a significant adverse effect on the reproductive ability of male honey bees (drones) and queen bees in managed and wild colonies. The study,  Neonicotinoid insecticides can serve as inadvertent insect contraceptives, published in  Royal Society Journal Proceedings B, focuses on the differences in lifespan and viability of sperm throughout exposed and unexposed drones. Since 2006, honey bees and other pollinators in the U.S. and throughout the world have incurred ongoing and rapid population declines from hive abandonment and bee die-off in a phenomenon known as colony collapse disorder (CCD).  Neonicotinoids, such as imidacloprid, thiamethoxam and clothianidin, have been found by  a growing body of scientific literature  to be linked to the CCD phenomenon and  pollinator decline in general. While science has become increasingly clear that these  pesticides  play a critical role in contributing to  the ongoing decline of bee health, this is one of the first to look at how these chemicals specifically effect the fertility of male honeybees. In the study, scientists randomly assigned honeybee colonies consisting of drones […]

(Beyond Pesticides, July 27, 2016) In South America, Colombia has officially declared an end to its Zika epidemic. The country, which previously had the highest cases of suspected Zika virus infection after Brazil, with a total of more than 99,721 people infected since September 2015 have registered a drop in the number of infections to 600 new cases a week, down significantly from a peak of more than 6,000 cases a week in February, according to health officials. Fernando Ruíz, M.D., Deputy Minister of Health and Service Provision in Colombia, said the numbers signaled that the epidemic had given way to an endemic phase of the disease, in which it continues to be present but spreads much more slowly. This news arrives following the publication of Zika Virus Disease in Colombia —Preliminary Report, which suggests that infe ctions late in pregnancy may pose less risk to the fetus than widely feared. The report follows thousands of women in Colombia who have had symptoms consistent with Zika virus disease during pregnancy to try to better understand the risk the virus poses. At the time of the report, the country had only seven official cases of microcephaly, a birth defect marked by […]

(Beyond Pesticides, July 26, 2016)  Health Canada’s Pest Management Regulatory Agency (PMRA) announced this week it will cancel certain  formulations  of boric acid-based pesticides. The announcement reflects the latest science showing that certain products, such as those in dust formulations or open baits, put residents at inhalation and ingestion exposure risk, respectively, to the naturally occurring element  boron and borate compounds. PRMA’s decision  is part of the Health Canada’s registration review of boric acid, which, like that of the U.S. Environmental Protection Agency (EPA), is conducted every 15 years. PRMA is cancelling the following uses of boric acid and similar compounds All domestic dust formulation products All domestic granular formulation products Domestic solution formulation products, with the exception of enclosed bait stations and spot treatment with gel formulations For other uses, PRMA has amended label requirements to better protect handlers and users of the pesticide. For example, the agency will update label directions to specify that boron products can only be applied to areas inaccessible to children and pets. Jane Philpott, Minister of Health in Canada said in a press release, “even natural ingredients like boric acid can pose a risk to Canadians. That’s why Health Canada looks at all […]

(Beyond Pesticides, July 12, 2016) Canadian environmental organizations sued the  Canadian Pest Management Regulatory Agency (PRMA) last week in a bid to overturn the approval of two neonicotinoid pesticides linked to the decline of honey bees and wild pollinators. The move comes amid growing awareness, action, and scientific evidence linking this widely used class of insecticides to the global decline of pollinator populations. The lawsuit, filed  by Ecojustice on behalf of  The David Suzuki Foundation, Friends of the Earth Canada, Ontario Nature, and the Wilderness Committee, argues that pesticide products containing two neonicotinoids, clothianidin and thiamethoxam, are unlawfully registered in Canada. The groups allege that PMRA failed to ensure that it had the data necessary to determine the environmental risks, particularly those concerning pollinators, posed by the chemicals. “The PMRA has taken a see-no-evil, hear-no-evil, speak-no-evil approach by repeatedly registering these neonicotinoid pesticides without important scientific information on their risks to pollinators,” said Charles Hatt, staff lawyer at Ecojustice. Under Canada’s Pest Control Products Act, PMRA must have “reasonable certainty” that a pesticide will not cause harm to the environment before it is registered. The groups also note that several thiamethoxam-based products have been registered by the agency for years […]

(Beyond Pesticides, July 6, 2016) Unable to come to a formal decision on glyphosate, the European Commission has issued a limited license extension for  glyphosate,  the pesticide in Monsanto’s flagship product Roundup. The decision also comes with some restrictions, including obligations for member states to minimize use on playgrounds, and a ban on formulations with the ingredient POEA. The  18-month interim license will allow glyphosate-containing products to remain on the market until the European Chemicals Agency rules  on glyphosate’s safety, an action  due by the end of 2017. According to the European Commission, “Despite repeated efforts from the Commission to address concerns expressed about the re-approval of glyphosate, Member States were not prepared to take responsibility for a decision  as no qualified majority was reached”¦” Debate has been raging in Europe about the continued use of glyphosate in light of the 2015 classification by the World Health Organization’s (WHO) International Agency for Research on Cancer (IARC) of glyphosate as a “probable human carcinogen.” However, confusion peaked when a few short months later the European Food Safety Authority (EFSA) published its report finding that glyphosate is  “unlikely to pose a carcinogenic hazard to humans.” However, EFSA’s report is  limited in that […]

(Beyond Pesticides, June 21, 2016) New regulations issued by the European Commission (EU) last week to regulate endocrine disruptors in pesticide products are being criticized by public interest groups and scientists as undermining the precautionary legal standard governing pesticide use in Europe. Previous  investigations and reports  have uncovered  industry’s attempt to quash efforts to enact robust protections from these harmful chemicals, despite their likely contribution to billions of dollars in lost revenue due to health effects. EC’s new rules endorse the World Health Organization’s definition of endocrine disrupting chemicals (EDC). The WHO defines an endocrine disruptor as “an exogenous substance or mixture that alters function(s) of the endocrine system and consequently causes adverse health effects in an intact organism, or its progeny, or (sub)populations,” However, the proposed regulations go little beyond defining the term. “The WHO definition is not a criteria, it is just a definition,” said Andreas Kortenkamp, PhD to The Guardian. “In effect, the commission has decided to place the burden of deciding how to regulate endocrine-disrupting chemicals onto the assessors on a case-by-case basis.” Of concern is the level to which the rules reflect a hazard or risk-based criteria. While EC asserts that its rules will follow […]

(Beyond Pesticides, June 10, 2016) A proposal for a temporary ‘technical extension’ of the EU approval of the herbicide glyphosate failed to secure the support of a majority of EU governments at a meeting of the EU standing committee on plants, animals, food and feed on Monday. This action may force the withdrawal of the herbicide, widely sold as Monsanto’s Roundup, from shelves if no decision is reached by the end of the month, when its license expires. After a proposal to renew the license for glyphosate for up to 15 years failed to win support in two meetings earlier this year, the EU executive offered a limited 12 to 18 month extension to allow time for further scientific study. Yet, despite this compromise, the proposal failed to win the support of member states representing at least 65% of the EU’s population, which is needed for adoption, an EU official told The Guardian. Seven member states abstained from Monday’s vote, 20 backed the proposal and one voted against, a German environment ministry spokeswoman said. According to the news source, Germany was among those that abstained from Monday’s vote. Of note is that Bayer, the German chemical company, recently offered to […]

(Beyond Pesticides, April 27, 2016) The  European Union (EU)  has placed a moratorium on two endocrine-disrupting herbicides that are linked to thyroid cancer, infertility, reproductive problems and fetal malformations. The chemicals, amitrole and isoproturon, will be banned as of September 30, 2016, after the European Commission voted unanimously, for the first time, to ban the two endocrine disruptors. Earlier this month, the European Commission’s Standing Committee on Phytopharmaceuticals voted to ban the uses of amitrole and isoproturon in accordance with 2009-EU pesticide rules,  which state that endocrine disrupting pesticides should not be allowed on the European market. The committee finds that amitrole is capable of causing malformations in offspring and inducing thyroid cancer, while isoproturon can cause adverse effects to reproduction and lower fertility. In 2013 amitrole was voluntarily cancelled by the registrant, while isoproturon is not registered for use in the U.S. According to the Guardian, amitrole is widely used in 10 EU countries, including the UK, in industrial farming. But  a European Food Safety Authority (EFSA) analysis concluded  that it was an endocrine disruptor that could damage unborn children, and have toxic effects on the thyroid and reproductive organs. Similarly, EFSA recommended classifying  isoproturon as toxic for reproduction […]

(Beyond Pesticides, April 14, 2016) Two-thirds of Europeans support a ban on glyphosate, the  most widely used agricultural chemical in the world, according to a new poll. This as Germany plans to formally support a European Union (EU) plan to re-license the use of the chemical. Monsanto’s glyphosate, the active ingredient in the popular weedkiller, Roundup, has been classified as a probable carcinogen by the World Health Organization’s (WHO) International Agency for Research on Cancer (IARC), is detected in food, breast milk, and urine, and is increasingly used on genetically engineered (GE) crops, leading to the proliferation of resistant “superweeds” and environmental contamination. The poll conducted by Yougov, an international internet-based market research firm, surveyed more than 7,000 people across the EU’s five biggest countries and find  three-quarters of Italians, 70% of Germans, 60% of French and 56% of Britons support a ban on glyphosate. Despite this, the EU is moving forward on whether to approve a European Commission proposal to extend the authorization of glyphosate for another 15 years until 2031. The existing authorization is due to lapse in June 2016. The decision was delayed after the IARC classified glyphosate as a  Group 2a “probable” human carcinogen  based on […]

(Beyond Pesticides, April 4, 2016) Pesticides widely used in rice paddies in Japan are harming  dragonflies. The study, conducted by researchers at Japan’s National Institute for Environmental Studies, finds that the insecticide fipronil significantly reduces the population of adult dragonflies, more so than any other pesticide treatment. The study, titled Fipronil application on rice paddy fields reduces densities of common skimmer and scarlet skimmer  and published in the journal Scientific Reports, investigated the impact of neonicotinoids, which have been linked to bee die-offs around the world, and chlorantraniliprole, which, like neonicotinoids and fipronil, is a systemic pesticide that is taken up by the plant and subsequently expressed in pollen, nectar, and guttation droplets. Plankton species were adversely  affected by clothianidin, a neonicotinoid, and chlorantraniliprole, but they recovered after concentrations of the chemicals decreased. Koichi Goka, Ph.D., a senior researcher at the institute, said nymphs living near the soil are particularly vulnerable to toxic chemicals, according to The Asahi Shimbun. “The density of insecticidal components in the water drops quickly after they are dissolved,” Goka said. “But such components long remain in the soil. Nymphs at the bottom of water could have been affected.” Dr. Goka is calling for more testing […]

(Beyond Pesticides, March 18, 2016) One of the world’s largest community kitchens, will soon be serving organic food. Guru Ramdas Langar Hall at Sri Harmandir Sahib (popularly known as the Golden Temple) in Amritsar, India feeds 100,000 people daily for free. Shiromani Gurdwara Parbandhak Committee (SGPC), which administers the gurdwaras (places of worship for people of the Sikh faith) across the country, has decided to adopt organic farming, foregoing the use of use of synthetic pesticides, herbicides, and fertilizers. “Organic farming is the new mission of SGPC to inspire farmers to cut down on the use of chemicals and pesticides and switch to sustainable agricultural practices,” an SGPC official said. Grains, fruits and vegetables like carrot, reddish, cauliflower, spinach and fenugreek are now being grown at farms in Patiala and Gurdwara Gurusar Satlani Sahib near Amritsar, the official said, adding that they have now started receiving supply of 10 quintals (about 2,200 pounds) of organic produce every 1-2 days which is being used to prepare nourishing vegetarian meals. While applauding this landmark decision, Dr. Rajwant Singh, founder and president of EcoSikh, a non-profit organization working to raise awareness about environmental issues and inspiring farmers to focus on producing food through […]

(Beyond Pesticides, March 8, 2016) A vast majority of German citizens are contaminated with the herbicide glyphosate, according to a report from the Heinrich Boll Foundation. The findings come just one week after another environmental group in Germany, the Munich Environmental Institute, found traces of the popular weed killer in popular German beers. The results of this study add concern to EU-wide deliberations regarding the renewal of glyphosate’s registration. According to the study, 99.6% of the 2,009 German citizens monitored have some level of glyphosate found in their urine. Over 75% of these individuals have  concentrations that are higher than the EU’s legal level for glyphosate in drinking water. Further, children up to age 19 are found to exhibit  higher levels of urinary glyphosate than older adults. Individuals living near agricultural areas also show elevated concentrations compared to those that did not. Given recent data finding glyphosate to be the most widely used herbicide on the globe, it is not surprising that the chemical is near ubiquitous in human bodies. Similar results are expected in the United States. A pilot study conducted by the group Moms Across America in 2014 found that glyphosate may also bioaccumulate in the human body, […]

(Beyond Pesticides, March 4, 2016) Honey bees experience a learning and memory deficit after ingesting small doses of the insecticide  chlorpyrifos, potentially threatening their success and survival, according to a study in  New Zealand. Chlorpyrifos is a highly neurotoxic organophosphate pesticide used worldwide on crops to protect against insects and mites. The study,  Measurements of Chlorpyrifos Levels in Forager Bees and Comparison with Levels that Disrupt Honey Bee Odor-Mediated Learning Under Laboratory Conditions,  published in  Ecology, examines chlorpyrifos levels in  bees collected from 17 locations in Otago, New Zealand and compared doses of the pesticide that cause sub-lethal effects on learning performance under laboratory conditions with amounts of chlorpyrifos detected in bees in the field. Researchers found chlorpyrifos in 17% of the sites sampled and 12% of the colonies examined. Honey bees are found to experience harmful effects to smell memory and learning, and reduction in specificity of memory recall. Chlorpyrifos is just one of many pesticides that have frequently been detected in honey bees. According to a study conducted last year by the U.S. Geological Survey (USGS), 72% of bees tested positive for pesticide residues, raising concerns about  unintended pesticide exposures where land uses overlap or are in proximity […]

(Beyond Pesticides, February 29, 2016) Last Thursday, the Munich Environmental Institute stated that it had found traces of glyphosate, the widely used and controversial weed-killer, in 14 of Germany’s most popular beers. These findings are a potential blow to Germany’s Beer Purity Law, which is highly regarded in German beer culture. Industry and German government immediately sought to downplay the results, saying that the levels found did not pose a risk to humans. However, according to the study’s results, all levels found were above the glyphosate residue level allowed in drinking water. Consumers have a right to be worried about the findings, as glyphosate was classified in March 2015  as a probable carcinogen by the International Agency for Research on Cancer (IARC). The results, published  in German, are broken down by beer and by micrograms per liter in picture format. The researchers cite the laboratory test results of the 14 beers, which found glyphosate levels  between 0.46 and 29.74 micrograms per liter. The highest reading is 300 times the legal limit for drinking water in Germany, which is 0.1 microgram per cubic meter. Hasseroeder, a beer brewed in Saxony-Anhalt in eastern Germany and owned by Anheuser Busch Inbev, contained the […]

(Beyond Pesticides, February 25, 2016) Feminine care products sold in France may contain “potentially toxic residues,” according to a study conducted by 60 Millions de Consommateurs, a French consumer rights group. The study finds  traces of chemicals, such as dioxins and insecticides, in 5 of 11 products tested. A separate analysis conducted by Corman, a manufacturer of feminine care products, also finds  residues of the weedkiller glyphosate, which was classified in March 2015  as a probable carcinogen by the International Agency for Research on Cancer (IARC). Researchers at 60 Millions  reported finidng traces of halogenated waste, a by-product related to the processing of raw materials, in Tampax Compak Active Regular Fresh tampons. The researchers also detected residues of organochlorine and pyrethroid pesticides, linked to a wide range of adverse health impacts, in some Always sanitary towels. Highly toxic dioxins, which can be cause cancer, reproductive and developmental problems and damage the immune system, according to the World Health Organization, were also found in products by OB and the European Nett brands. Corman, which makes Organyc panty liners, told the Agence France-Presse (AFP) news agency that it conducted its own analysis that confirmed the trace amounts of glyphosate, the active ingredient […]

(Beyond Pesticides, February 17, 2016) After reviewing a prolific scientific database, researchers find that organic meat and milk have 50 percent more important nutrients like omega-3 fatty acids that are important in human nutrition. Organic meat has slightly lower concentrations of saturated fats, while organic milk contains 40 percent more linoleic acid, and carries slightly higher concentrations of iron, vitamin E and some carotenoids. While this new information certainly adds to the debate over the benefits of organic, it strengthens the argument that there is a nutritional advantage to eating organic that complements the  environmental benefit of    avoiding toxic pesticide use. The new findings, reported in two studies by scientists from the United Kingdom, Poland, Norway, Italy, Denmark, Switzerland, Greece and Turkey, “  Higher PUFA and omega-3 PUFA, CLA, a-tocopherol and iron, but lower iodine and selenium concentrations in organic milk: A Systematic Literature Review and Meta- and Redundancy Analyses” and “Composition differences between organic and conventional meat; a systematic literature review and meta-analysis,” both published in the British Journal of Nutrition, compare the compositional differences between organic and conventional (non-organic) milk and dairy, as well as organic and conventional meat.   The researchers reviewed 196 research studies of […]