(Beyond Pesticides, July 29, 2019) A research study, published in March in Scientific Reports, uncovers a pesticide effect on a sugar-metabolizing enzyme common to all cells that has broad health ramifications ignored by the U.S. Environmental Protection Agency’s (EPA) safety testing protocol. This finding raises a larger question regarding the need for EPA to test for the synergistic effects of pesticides, whereby pesticides and chemicals in combination have an even greater effect than they do by themselves. The research, by T. Tristan Brandhorst, PhD, Iain Kean, PhD, and others in the lab of Bruce Klein, PhD, of the University of Wisconsin–Madison and UW School ofMedicine and Public Health, specifically sheds light on the mode of action of the fungicide fludioxonil. Fludioxonil, a phenylpyrrole fungicide, was developed to treat seeds during storage, and has come to be used commonly on grains, vegetables, fruits, and ornamental plants during cultivation, and produce after harvest to extend “shelf life.” As reported by the American Association for the Advancement of Science publication, EurekAlert, “The ability of [the fungicide] fludioxonil to act on a sugar-metabolizing enzyme common to all cells, and to produce the damaging compound methylglyoxal, may mean that the pesticide has more potential to harm non-fungal cells than previously […]

(Beyond Pesticides, July 3, 2019) A disturbing association between urinary triclosan concentrations and osteoporosis has been identified in an epidemiological study. Drawing from the National Health and Nutrition Examination Survey (NHANES) results for 1,848 U.S. adult women, the authors conclude that higher concentrations of urinary triclosan are associated with lower bone mass density and higher prevalence of osteoporosis among U.S. adult women. The study, published in the Journal of Clinical Endocrinology and Metabolism, adds weight to previous laboratory results, which showed that endocrine-disrupting chemicals such as triclosan can interfere with bone metabolism. Triclosan and its byproducts are known endocrine disruptors and have been shown in laboratory studies to interfere with collagen and bone structure. Taken together with previous findings, the new epidemiological results demonstrate that the ubiquitous endocrine disruptor triclosan “could lead to lower BMD [benchmark dose] and increased prevalence of osteoporosis in U.S. adult women.” Triclosan is used as an antimicrobial agent in products regulated by both the Environmental Protection Agency (EPA) and the Food and Drug Administration (FDA), and cumulative exposure to triclosan registered by both agencies pose unacceptable risks to human health and the environment. Triclosan exposure has become so common that it has shown up in […]

(Beyond Pesticides, July 1, 2019) France made a decision in May to ban a widely-used fungicide because it damages the endocrine system. In contrast, there has been a stark failure to protect health in the U.S. Despite a Congressional mandate, EPA is not acting on endocrine disruptors linked to infertility and other reproductive disorders, diabetes, cardiovascular disease, obesity, and early puberty, as well as attention deficit hyperactivity disorder (ADHD), Parkinson’s, Alzheimer’s, and childhood and adult cancers. This is a tragedy. Ask your elected members of Congress to demand that EPA tests and acts on regulatory endocrine disruptors as required by law. In 1998, following a mandate in the Food Quality Protection Act (FQPA) of 1996, EPA established a program to screen and test pesticides and other widespread chemical substances for endocrine disrupting effects. Despite operating for 21 years, the Endocrine Disruptor Screening Program (EDSP) has made little progress in reviewing and regulating endocrine-disrupting pesticides.  As of 2019, the program has stalled entirely. To ensure appropriate follow-through, Congress gave EPA a timeline to: develop a peer-reviewed screening and testing plan with public input not later than two years after enactment (August 1998); implement screening and testing not later than three years after […]

(Beyond Pesticides, June 7, 2019) Fruit orchards and vineyards endure some of the most intensive chemical management in all of agriculture. What has not been investigated — until now — is how pesticide drift from such agricultural sites may be affecting nearby public spaces. A recent, first-of-its-kind study out of northern Italy tested 71 public playgrounds near to apple orchards and vineyards in four valleys of the North Tyrol, and finds that 45% are contaminated with a single pesticide, and 24% by more than one. Study authors note that the playground contamination will likely grow worse over the course of the growing season. This would likely amplify the impacts of such chemical trespass on nearby public spaces, never mind the varieties of harm to the sites themselves and the food produced on them. Organic agriculture, of course, remedies all these concerns. The study randomly chose 71 public playgrounds in the four South Tyrolean regions, and analyzed grass samples for potential contamination by 315 different pesticides. Because pesticides applied to agricultural fields, orchards, and vineyards are easily volatized, carried aloft by wind, and/or washed by rain off of the target site, the study also evaluated the impacts of those (and other) factors […]

(Beyond Pesticides, May 2, 2019) Researchers have documented an increase in food and drinking water residues of neonicotinoids, insecticides linked to breast cancer. Using the Pesticide Data Program (PDP), 1999-2015, of the U.S. Department of Agriculture, the researchers identified near-peak detection frequencies in 2015, after a decline from 2008-2013. Imidacloprid remains the most common neonicotinoid detected across imported commodities, while the neonicotinoids clothianidin, thiamethoxam, acetamiprid, and flonicamid are replacing imidacloprid in domestic production. Authors note that these newer neonicotinoids are potentially more toxic than imidacloprid, raising concerns for understudied human health and environmental impacts. The study, Trends in neonicotinoid pesticide residues in food and water in the United States, 1999–2015, published in the journal Environmental Health, finds the highest detection frequencies for neonicotinoids in drinking water, with 30% of treated drinking water turning out positive for imidacloprid in 2011. Certain fruits and vegetables are also frequently contaminated by neonicotinoids, with detection frequencies ranging from 20% to as high as 57% in the case of imidacloprid on cauliflower. While the study points to specific fruits and vegetables as posing higher risk, the main message reaches beyond individual commodity or individual neonicotinoid results. Authors uncover a systematic increase in detection of neonicotinoid […]

(Beyond Pesticides, May 1, 2019) Evidence of the dangers of glyphosate continues to mount: researchers at Washington State University have identified, in research that exposed pregnant rats to the compound, significant disease and pathology in subsequent generations. The rats were exposed, from day 8 through day 14 of gestation, to half the observable adverse effect level (NOAEL) of glyphosate. Although this study found negligible impacts on the pregnant rats themselves or on their first-generation offspring, dramatic increases in incidence of pathology showed up in the two subsequent generations, including reproductive (prostate and ovarian) and kidney diseases; obesity; and birth anomalies. The study, published in the journal Scientific Reports (an open access, multidisciplinary journal from Nature Research), and conducted by Michael Skinner, Ph.D. and five colleagues, is the first to assess the potential transgenerational impacts of glyphosate in mammals. Its results point to an emerging frontier in assessing the risks of glyphosate and other toxic chemicals, and add to the urgent and growing demand that the use of this particular toxic — and pervasive — pesticide be halted. The research team was interested in looking at possible transgenerational impacts of glyphosate in part because of its ubiquity: it is one of the […]

(Beyond Pesticides, April 26, 2019) Research by the youth participatory action team of the CHAMACOS of the Salinas Evaluating Chemicals in Homes and Agriculture (COSECHA) reveals that teenagers in the Salinas Valley, California are routinely exposed to concerning levels of multiple toxic pesticides, several of them known endocrine disruptors. In an interview with Kion News, COSECHA research director Kimberly Parra remarked that the study is especially important because teenagers are in a stage of rapid reproductive development. As the study authors emphasize, it is their developmental stage that makes teenagers more vulnerable to the effects of endocrine disrupting pesticides, with potentially devastating consequences for lifelong health. The COSECHA study quantifies exposure to 72 pesticides, captured through volatile-trapping silicone wristbands, across 97 teenage girls living in various areas of the Salinas Valley region. Of the 72 pesticides analyzed, authors report that subjects are exposed to as many as 20 and an average of 8 pesticides over one week of routine indoor and outdoor activity. Given the well-documented dangers of pesticide co-exposures, these multiple-exposure findings are particularly concerning. Ranking the highest for prevalence among the studied pesticides is fipronil sulfide, a breakdown product of the insecticide fipronil, detected in 86.6% of the analyzed wristbands. […]

(Beyond Pesticides, March 7, 2019) A publication in the journal Environmental Health Perspectives highlights findings from a recent study showing that environmental concentrations of the neonicotinoid insecticides thiacloprid and imidacloprid increase expression of a gene linked to hormone-dependent breast cancer. Authors of the featured study uncovered a pathway through which neonicotinoids stimulate excess estrogen production, known to occur during the development of progressive hormone-dependent breast cancer. In the words of the authors, “Our findings highlight the need for further research to assess the potential impacts of low-dose and chronic exposure to neonicotinoids on endocrine processes affecting women’s health.” The study, published in Environmental Health Perspectives in April 2018 by researchers at the University of Quebec, is not the first to point to a potential link between neonicotinoid exposure and breast cancer. A 2015 study by the same research group revealed that the neonicotinoids thiacloprid and thiamethoxam, along with the herbicide atrazine, induce similar effects in breast cancer cells. In both studies, exposure to neonicotinoids alter promoter activity to induce heightened production of the enzyme aromatase, which is known to stimulate estrogen production and thereby cancer cell proliferation. The recently published study, authored by Silke Schmidt, PhD, brings greater urgency to […]

(Beyond Pesticides, March 1, 2019) The costs of pesticide use extend far beyond the invoices farmers pay for purchase of the chemicals to use on their crops. The real costs related to pesticide use and exposure include those of health care, lost productivity and income, and environmental damage (loss of environmental services and biodiversity; compromised air, water, and soil quality). There has been relatively little research focused on those real and extensive costs; this Daily News Blog turns its attention to several that have made the attempt. January 2019 saw the publication of a new book, Sicker Fatter Poorer: The Urgent Threat of Hormone-Disrupting Chemicals to Our Health and Future … and What We Can Do About It, by Leonardo Trasande, MD, MPP, which examines how some chemicals — including organophosphate and organochlorine pesticides — disrupt human endocrine (hormonal) function, and damage health, sometimes irreparably. The book further investigates the economic costs of associated diseases and other health problems to the U.S. economy — on the order of 2.3% of GDP (gross domestic product), or $340 billion, annually. As Dr. Trasande notes, “The reality is that policy predicts exposure, exposure predicts disease and disease ultimately costs our economy.” Dr. Trasande is […]

(Beyond Pesticides, February 20, 2019) Women exposed to DDT during ‘early windows of susceptibility’ in their childhood are at increased risk of developing breast cancer, according to new research published in the Journal of the National Cancer Institute. Nearly 75 years after the chemical was first used in the U.S., and 50 years after its ban, DDT is continuing to adversely affect the health of Americans. The data brings needed attention to the dangers of early-life pesticide exposure, and underlines the need to take a precautionary approach to the introduction of biocides in our environment so that future generations do not suffer from the same mistakes of the past. “What we have learned is that timing really matters. We know that if harmful exposures occur at times when breast tissue is rapidly changing, such as during puberty, they impact breast development in ways that can later result in cancer,” said lead author Barbara A. Cohn, PhD, of the Public Health Institute’s (PHI) Child Health and Development Studies. “The research published today suggests that DDT affects breast cancer as an endocrine disruptor, that the period of time between first exposure and cancer risk seems to be around 40 years–and that other […]

(Beyond Pesticides, January 2, 2019) The “indoor microbiome” of yoga studios and other athletic facilities often contain significant levels of antibacterial chemicals like triclosan, which show up in dust and breed antibiotic resistance, according to research published last month in the journal mSystems. Triclosan may be banned from hand soaps, but its continued use in a myriad of other products, from disinfectant sprays to impregnated clothing, yoga mats, and other work-out equipment makes it difficult to avoid this now-ubiquitous chemical. This is a public health concern because these antibacterial or antimicrobial chemicals are link to antibiotic-resistant bacteria. Antibiotic resistance kills over 23,000 people each year, according to the Centers for Disease Control and Prevention (CDC). In addition to the CDC, the World Health Organization has cited this escalating problem as become one of the biggest public health challenges of our time. Many people may suspect their gym or yoga study is not a germ-free location, but attempts to address these germs through antibacterial sprays or impregnated yoga mats and other surfaces, may be exacerbating the issue—doing much more harm than good. The continued detection of triclosan and its impacts at new and unexpected locations are feeding renewed calls for a complete ban on […]

(Beyond Pesticides, December 6, 2018) A recent analysis of annual drinking water quality reports has revealed that many community drinking water systems in the Midwest have seasonal exceedances of the allowable limit for the herbicide atrazine. Atrazine, linked to endocrine disruption, neuropathy, and cancer, is the second most widely used pesticide in corn growing areas, with over 73 million pounds applied to agricultural fields each year.  A 2009 study by Paul Winchester, MD, professor of clinical pediatrics at Indiana University School of Medicine and a neonatologist at St. Francis Hospital in Indianapolis, linked birth defects to time of conception, with the greatest impact on children conceived when concentrations of atrazine and other pesticides are highest in the local drinking water. (See Reproductive Effects Peak with Pesticide Exposure.) During peak use, atrazine levels in drinking water have been recorded at three to seven times above the legal limit. In addition to the well documented impact on the environment, recent  studies have linked prolonged pesticide exposure to not only shortened gestation and preterm birth for women, but also neurodevelopment delays in children. Ultimately, these unreported seasonal peaks may result in persistent adverse health impacts in impacted communities. The Safe Drinking Water Act (SDWA), enacted in 1974, […]

(Beyond Pesticides, November 9, 2018) A Tunisian study (published in January 2018) on the effects in pre-pubertal mice of exposure to malathion — an organophosphate pesticide first registered for use in the U.S. in 1956 — demonstrates significant distortion of liver and kidney biochemistry and function in the animals. Deleterious effects include compromise of feeding ability, metabolism performance, neurologic deficits, reduction of overall body weight, and simultaneous increases in the weights of livers and kidneys, with structural anomalies and lesions in those organs. Organophosphates (OPs) have raised alarm bells for years. Some, such as chlorpyrifos and diazinon, have had their registrations cancelled for household uses because of the extreme health risks to children, but agricultural, golf course, and “public health” (mosquito control) uses remain commercially available and in use. Recently, Beyond Pesticides reported on research whose investigators support — and called publicly for — a worldwide ban on the compounds because of the serious health and environmental risks they pose, particularly for children. Beyond Pesticides has written extensively on OP pesticides, including malathion and chlorpyrifos. Both are used widely in agriculture. Chlorpyrifos has been the subject of quite a ping-pong match in recent years: a scheduled ban by the Environmental Protection […]

(Beyond Pesticides, November 1, 2018) A new study offers fresh evidence that wild bumblebee pollinators are particularly vulnerable to the impacts of neonicotinoid (neonic) insecticides, finding that exposure to these compounds interferes with mating success and population stability. Researchers from Worcester Polytechnic Institute in Massachusetts, measuring real-world harms of neonicotinoids, indicate that the impacts they found to bumblebee “reproducers,” namely queen and drone (male) bees, does not bode well for the array of plant species that relies on them. Though advocates warn that destabilizing managed pollinators could threaten U.S. food production and exports, with food prices increasing as cost of bringing pollinators to farms increases, the study’s authors and advocates insist that the impacts of such widespread poisoning of wild bees could be felt well beyond agriculture. Researchers in the lab compare behavioral and psychological responses of virgin queens, workers, and male Bombus impatiens from multiple colonies to field-realistic doses of the neonicotinoid clothianidin. While every bee was given a replenishing supply of pollen based on body weight and energy demands, four distinct concentrations of diluted analytical-grade (pure) clothianidin (including a control with no pesticide added) were mixed into a nectar-like solution and fed to the bumblebees orally for 5 […]

(Beyond Pesticides, July 27, 2018) The American Academy of Pediatrics (AAP) has issued new guidelines for measures to lower children’s exposures to chemicals in food and food packaging that are tied to health problems such as obesity, metabolic changes, decreased birth weight, and endocrine disrupting effects, including reduced fertility. Exposures to these chemicals–added to food during processing or in food packaging–are disproportionately high among minority and low-income populations, according to the report, especially given inadequate federal regulation and oversight. The guidelines, issued in both a statement and technical report by the AAP entitled, Food Additives and Child Health, came after the group decided to review and highlight emerging child health concerns related to “the use of colorings, flavorings, and chemicals deliberately added to food during processing (direct food additives) as well as substances in food contact materials.” Food additives, in particular, have been documented to be linked to endocrine disruption and other adverse health effects. According to AAP, “regulation and oversight of many food additives is inadequate because of several key problems in the Federal Food, Drug, and Cosmetic Act. Current requirements for a “generally recognized as safe” (GRAS) designation are insufficient to ensure the safety of food additives and do not […]

(Beyond Pesticides, March 21, 2018) According to a new study published this month in Environment Health, women with high levels of glyphosate in their bodies are more likely to have shorter pregnancies. Shorter pregnancies can lead to children with reduced learning and brain development. This is the first study to suggest that exposures to glyphosate can influence the long-term well-being of children. The study, Glyphosate exposure in pregnancy and shortened gestational length: a prospective Indiana birth cohort study, obtained both urine and drinking water samples from 71 women with pregnancies living in Central Indiana while they received routine prenatal care, and analysed the relationships of glyphosate levels in mother’s urine with fetal growth indicators and gestational length. The researchers found that more than 90 percent of pregnant women had detectable levels of glyphosate where higher glyphosate levels were significantly correlated with shortened gestational lengths, even though the drinking water samples had little to no detectable levels of glyphosate. Women living in rural areas were found to have higher glyphosate levels. The authors note their study is significant because it is the first U.S. study designed specifically to measure prenatal glyphosate exposure in pregnant women to determine its association with adverse fetal […]

(Beyond Pesticides, October 31, 2017) Scientists warn that inadequate federal testing, disproportionate industry influence, and subverted regulatory oversight threaten decades of progress on protecting people from hormone disrupting chemicals. This from a new paper with findings that regulators face a critical need to fully understand and address the hazards from these dangerous substances. Hormone disrupting chemicals, also known as endocrine disruptors, are substances that have been shown to interfere with the hormone system, leading to long-term health impacts ranging from cancer to neurological developmental impairments. Even small alterations in hormone concentrations, particularly during “critical windows” of embryonic development and developmental phases of life, can have lasting and significant effects. Mounting science is showing that disruptions to the hormone system can occur at very low doses that are lower than those used in traditional toxicity testing. Now, commentary from scientists at Rutgers University and North Carolina State University, “Endocrine disrupting chemicals and behavior: Re-evaluating the science at a critical turning point,” states that inefficient federal testing and outsized industry influence in Washington threaten decades of progress. “The significant progress made over the past couple of decades to understand endocrine disrupting chemical-related effects and mitigate exposures is now at serious risk,” write the authors […]

(Beyond Pesticides, September, 2017) A recently released report, Gallup-Sharecare State of Well-Being: The Face of Diabetes in the United States, looks at high diabetes rates across various U.S. demographic groups, including those in farming. People working in the transportation sector registered the highest incidence of diagnosed diabetes at 10.6%. But those working as farmers and fishermen came in second, with 8.5% reporting a diagnosis of the disease. Based on a self-reporting survey, The Face of Diabetes in the United States did not differentiate between Type 1 diabetes (which typically manifests in childhood or young adulthood) and Type 2 diabetes (which commonly emerges in adulthood). It did, however, consider lifestyle risk factors that can influence development of each form of the disease. The “farmer and fisher” folks placed more-or-less in the mid-range among all occupations vis-à-vis several of the lifestyle factors that can impact development of the disease (smoking, diet, and obesity), and a bit higher in alcohol consumption, but in fact, reported more exercise than any other category of worker. These data points would seem to suggest that farmers would be at less risk than those in some other occupational categories. For instance, those working in “installation and repair” reported […]

(Beyond Pesticides, July 24, 2017) A new report by the National Academies of Sciences, Engineering, and Medicine (NAS) is recommending to the U.S. Environmental Protection Agency (EPA) a strategy to evaluate the evidence of adverse human health effects from low doses of exposure to chemicals that can disrupt the endocrine system. NAS believes that EPA’s current process, which utilizes traditional toxicity testing, would miss some effects that occur at doses lower then what EPA evaluates. EPA’s Endocrine Disruption Screening Program (EDSP) is currently screening chemicals for their potential to interact with the endocrine system, but the program is years behind schedule and has been criticized for using outdated methods. Endocrine disruptors are substances that can cause a variation in normal hormone function. Even small alterations in hormone concentrations, particularly during embryonic development and developmental phases of life, can have lasting and significant effects. Mounting science is showing that disruptions to the hormone system can occur at very low doses that according to NAS, are lower than those used in traditional toxicity testing by EPA. This means that some effects may be missed. EPA’s methodologies have been criticized over the years for failing to adequately capture impacts at low doses. EPA requested NAS […]

(Beyond Pesticides, June 29, 2017) On June 16, the European Chemicals Agency (ECHA) decided to classify bisphenol A (BPA) as an endocrine disruptor, and as a substance of “very high concern” due to “probable serious effects to human health.” The classification follows a proposal by the French food security agency (ANSES), which was made earlier this year. The committee, comprised of representatives from all 28 European Union EU countries, agreed to the classification unanimously. With pressure from environmental groups and others, the European Commission (EC) is working to define scientific criteria that will be used to identify endocrine disrupting chemicals (EDCs), and lead to more effective regulation in EU countries. In June 2016, the EC issued weak regulations on endocrine disruptors in pesticide products, undermining the precautionary legal standard that governs pesticide usage in Europe. Many scientists and advocacy organizations criticized the proposed regulations for creating an impossibly high burden of proof for defining harm from endocrine disrupting pesticides and other products. EDCs contained in common household products such as detergents, disinfectants, furniture, plastics, and pesticides, interfere with the body’s hormone system either by mimicking naturally produced hormones, blocking hormone receptors in cells, or effecting the transport, synthesis, metabolism or excretion […]

(Beyond Pesticides, June 21, 2017) More than 200 international scientists and medical professionals have signed the Florence Statement on Triclosan and Triclocarban, which states that triclosan and its chemical cousin triclocarban pose a risk to human health, and urges the international community to limit use of these antimicrobials, which are associated with bacterial resistance and no more effective than soap and water. In 2016 after manufacturers failed to prove efficacy, the U.S. Food and Drug Administration (FDA), which regulates cosmetic triclosan products, announced that manufacturers must, by September 2017, remove triclosan from over the counter hand soaps. The agency still allows the chemical in toothpastes and other products, such as hand wipes. The Environmental Protection Agency (EPA), which regulates triclosan in household items, textiles and plastics, still permits wide use of the chemical in a range of products. The Florence Statement on Triclosan and Triclocarban is “based on extensive peer-reviewed research,” and “concludes that triclosan and triclocarban are environmentally persistent endocrine disruptors that bioaccumulate in and are toxic to aquatic and other organisms.” The statement includes evidence of human health threats, and provides recommendations intended to mitigate harm from triclosan, triclocarban, and other similar antimicrobials. The recommendations are listed below: “Avoid […]

(Beyond Pesticides, June 8, 2017) On Monday, numerous organizations filed an administrative appeal to the U.S. Environmental Protection Agency (EPA), seeking to reverse Scott Pruitt’s order to continue allowing the toxic organophosphate insecticide chlorpyrifos in agriculture, and revoke all tolerances (allowed food residues) of the chemical. On the same day, Attorneys General (AGs) from seven states announced legal objections to Scott Pruitt’s order, also calling for a reversal of the decision and a revocation of all tolerances. Allowing the continued use of chlorpyrifos runs counter to findings of independent science and EPA’s own scientists, which establish unacceptable risks to humans and the environment. The administrative appeal, filed by Earthjustice on behalf of 12 environmental, labor, and civil rights organizations, resulted from the decision by EPA to allow the use of chlorpyrifos while it studies the safety of the chemical. The seven AGs, in their filing, are charging that EPA wrongfully approved the continued use of chlorpyrifos in agriculture without first gathering and assessing the full safety data, as required by the U.S. Food, Drug, and Cosmetic Act. Many environmental groups spoke out in favor of these filings. “There’s a good reason this dangerous toxin has been banned from indoor use for more […]

(Beyond Pesticides, June 2, 2017) According to a new study, levels of triclosan spike in the bodies of children after they brush their teeth or wash their hands. Triclosan, a controversial antimicrobial, is frequently added to consumer care products. Last year, the Food and Drug Administration (FDA) banned the use of triclosan in hand soaps, but it is still allowed in toothpaste and numerous plastic and textile products regulated by the U.S. Environmental Protection Agency (EPA). Many companies had previously decided, due to consumer pressure, to remove triclosan from hand soaps years ahead of the FDA decision. Researchers collected and tested the urine of 389 mothers and their children –three times during pregnancy, and then took between 1-6 samples from children between the ages of 1 and 8 years old. The researchers found triclosan in over 70% of samples taken. In the group of 8 year olds, they report that levels were 66% higher in the children that used hand soap. For those that wash their hands over five times a day, the levels increase more than four times in comparison to children who wash their hands once or less per day. For toothpaste, researchers find that children who had […]