(Beyond Pesticides, March 8, 2019) Researchers from the U.S. and Switzerland have published their findings, a beginning assessment of how use of a new category of pesticides — dsRNA (double stranded RNA), which is less a traditional pesticide than a genetically based pesticide “technology” — might impact soils and non-target microorganisms in the soil. The co-authors (Kimberly M. Parker, PhD, et al.) note that, “The ecological risk assessment of these emerging pesticides necessitates an understanding of the fate of dsRNA molecules in receiving environments, among which agricultural soils are most important.” Their research appeared in late January 2019 in Environmental Science & Technology.

Previously, technical hurdles in measuring dsRNA had stymied scientists’ ability to quantify the genetic material and its degradation products in soil, but these investigators were able to attach a radioactive atom to the molecule, “tagging” it so it could be followed through a series of simulated soil systems representative of those in the “real” world. Researchers were able to measure the presence of the material at concentrations as low as a few nanograms of dsRNA per gram of soil. The work of these researchers represents the beginning of understanding the ecological risks of these emerging dsRNA pesticides.

They demonstrated that dsRNA molecules in soil suspensions “undergo adsorption to soil particle surfaces, degradation in solution, and potential uptake by soil microorganisms.” In addition, they found that in some soils, enzymes can degrade, or break down, the pesticide, and that some organisms actually “eat” the pesticide and the post-enzymatic fragments. One hypothesis the scientists are considering is that the soil particles may actually be protective of the molecules by slowing down their degradation, and that this effect may be more pronounced in finer, rather than coarser, soils.

How do these dsRNA pesticides work? They impede the expression of essential proteins in target pest insects via a cellular mechanism called RNA interference (RNAi). In RNAi, long dsRNA is “sliced” into small fragments, which then bind to “Argonaute” proteins. When that happens, one of the double strands of the dsRNA is removed, leaving the remaining strand available to bind to messenger RNA targets. Once bound, the Argonaute protein can cleave the messenger RNA, destroy it, or recruit other factors to regulate the target sequence in other ways. The target organism is left either stunted or dead. RNAi is widely used by researchers to silence genes in order to learn something about their function.

In the biochemical genetic engineering (GE) sector, it is hoped that such “gene silencing” technology can be engineered into plants so that they can, functionally, produce their own pesticides. The Environmental Protection Agency (EPA) registered the first four products using dsRNA technology in the summer of 2017. These products were developed in large part to help farmers control corn rootworm, a pest that has developed resistance to several other pesticides. When the rootworm ingests the dsRNA in the corn plant’s tissue, a gene in the insect called Snf7, which is essential for rootworm survival, gets turned off. The first expected commercial product will be a line of GE corn seeds called SmartStax Pro, which will contain both Bt (Bacillus thuringiensis, a bacterium that is toxic to some pests) and a dsRNA called DvSnf7; it is expected to show up on the market by 2019 or 2020. This “stacking” of pesticide technologies by the agrochemical and agrogenetic industries is increasingly common, as they attempt to tackle issues of resistance to chemical pesticides by pairing them with GE approaches — even in the same product, as with the coming SmartStax Pro.

Mamta and M.V. Rajam wrote, in that same summer of 2017 in the journal Physiology and Molecular Biology of Plants, about this new approach to pest control. The authors generally touted the potential of this new GE approach — RNAi silencing, saying that the “ideal pest control strategy . . . should be specific in its action and should target [a] large number of pests without affecting non-targeted organisms.” However, they also identified that “off-target effect is one of the major limitations associated [with] RNAi technology. Off-target effects are describe[d] as the silencing of non-target genes in the same organism or in non-target organisms.

The Atlantic magazine’s 2017 coverage of this emerging technology, by Sarah Zhang, noted that RNAi is considered useful because of its specificity: it can turn off one gene in one species while, theoretically, leaving others unaffected. Organisms use this “gene silencing” on their own all the time. Scientists have created genetically modified crops, such as those grown from Monsanto’s Roundup Ready soy, corn, and alfalfa seeds, and industry scientists have previously used RNAi to create GE crops (such as apples and potatoes that do not brown because their browning gene is silenced). The difference in the case of this emerging technology, to be launched in Dow’s (formerly Monsanto’s) DvSnf7 dsRNA product, is that it silences a gene in another living organism. Ms. Zhang says: “Rather than modifying itself, it modifies its environment.”

Among the concerns about this dsRNA/RNAi pesticide technology becoming “operational” in plants are hazards identified in an article in the August 2013 issue of the journal BioScience, by Jonathan G. Lundgren and Jian J. Duan. The authors acknowledge that “the creation of RNAi-based GM [genetically modified] crops that are lethal to pests or that deleteriously affect interactions of the pests with other organisms (including the crop) is a very real technology that has potential for limiting the impact of pests on crops.” They note that for “traditional” chemical and microbial pesticides and Bt crops, the modes of action are reasonably well understood, and that “laboratory nontarget toxicity assays can be focused and optimized on the basis of predictable effects.” They contrast that with assessing nontarget toxicity for RNAi pesticide technology, which produces those small “bits” of genetic material (small RNAs) from the source dsRNA: “Small RNAs often have off-target binding elsewhere in a nontarget species’ genome that makes predicting toxic effects and designing maximum-hazard dose assays challenging for the wide range of species potentially exposed.”

The authors further note that when these small RNAs, or siRNAs (small interfering RNAs) silence unintended (nontarget) genes, the hazards include: “off-target gene silencing, silencing the target gene in nontarget organisms, immune stimulation, and saturation of the RNAi machinery,” and that, “Knowledge gaps in the genomics and physiologies of highly exposed nontarget organisms currently preclude our ability to assess the activity spectrum of RNAi, determine whether toxicity assays will be sufficient in predicting the risks of RNAi-based crops, and explain how these risks may affect food webs associated with agroecosystems.” An additional unknown is how persistent siRNAs may be in the environment.

Adding to concern is the fact that, unlike traditional pesticides, which pose no risk to nontarget organisms if there is no physical or physiologic exposure to these toxicants in the environment, this GE technology represents unknown levels of potential exposure. If the technology is broadly adopted, the scale of the “unknown” is truly daunting, given the amount of land in the U.S. that is planted in corn, never mind its potential use in other commodity crops (soybeans, cotton, e.g.). Further, there is little-to-nothing yet understood about effects on ecosystems where this technology could be deployed, or effects on people (or other animals) after specific dsRNA/RNAi is ingested dietarily.

The subject study is a beginning look at the interaction of this GE pesticide technology in soils, but there are huge gaps in understanding about the organismic and environmental implications of this GE “pesticide.” One of the authors, Dr. Parker says, “Now that we have identified the major processes controlling pesticide degradation in soils, we will next investigate in detail the variables that control these processes to enable accurate ecological risk assessment of double-strand RNA pesticides. This will allow us to understand whether or not these new pesticides pose a risk to ecosystems.”

Beyond Pesticides wrote about RNAi technology back in 2015, when the GE (via RNAi) Arctic apple was on the horizon. It noted at that time that, as always, GE crops can represent threats to organic food production through cross-contamination, usually via bee pollen. Keep current on developments on this emerging GE pesticide technology via the Beyond Pesticides Daily News Blog, which tracks developments in research, policy making, and advocacy.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: https://www.scienceAll unattributed positions and opinions in this piece are those of Beyond Pesticides.daily.com/releases/2019/03/190301084910.htm

(Beyond Pesticides, March 7, 2019) A publication in the journal Environmental Health Perspectives highlights findings from a recent study showing that environmental concentrations of the neonicotinoid insecticides thiacloprid and imidacloprid increase expression of a gene linked to hormone-dependent breast cancer. Authors of the featured study uncovered a pathway through which neonicotinoids stimulate excess estrogen production, known to occur during the development of progressive hormone-dependent breast cancer. In the words of the authors, “Our findings highlight the need for further research to assess the potential impacts of low-dose and chronic exposure to neonicotinoids on endocrine processes affecting women’s health.”

The study, published in Environmental Health Perspectives in April 2018 by researchers at the University of Quebec, is not the first to point to a potential link between neonicotinoid exposure and breast cancer. A 2015 study by the same research group revealed that the neonicotinoids thiacloprid and thiamethoxam, along with the herbicide atrazine, induce similar effects in breast cancer cells. In both studies, exposure to neonicotinoids alter promoter activity to induce heightened production of the enzyme aromatase, which is known to stimulate estrogen production and thereby cancer cell proliferation.

The recently published study, authored by Silke Schmidt, PhD, brings greater urgency to the group’s findings, quoting first author Elyse Caron-Beaudoin as stating, “This provides in vitro evidence that neonicotinoids can be endocrine disruptors and that aromatase may be one of their targets. Importantly, the promoter switch occurs at concentrations that are highly relevant to humans.” Indeed, authors were careful to test concentrations of thiacloprid and imidacloprid “similar to those found in urine samples of farmers and women from the general population in Japan (Nomura et al. 2013; Ueyama et al. 2015).”

These findings add to a growing body of scientific evidence suggesting that neonicotinoids cause unreasonable harm to the environment and human health. Neonicotinoids are infamously known for their central role in pollinator decline, but as more and more studies reveal, that is just the tip of the iceberg. Because these chemicals are broad-spectrum insecticides, beneficial soil dwelling insects, benthic aquatic insects, grain-eating vertebrates, along with pollinators are also victims of these systemic chemicals. Even slight deviations in exposure levels take a heavy toll on vulnerable wildlife. University researchers have found that tiny amounts of neonicotinoids are enough to cause migrating songbirds to lose their sense of direction and become emaciated.

The newfound evidence suggesting neonicotinoids as potential endocrine disruptors is of particular concern given that these insecticides are ubiquitous in the environment, found across land types and waterbodies, regardless of individual management decisions and practices. A recent study in Switzerland found neonicotinoids in sparrow feathers sampled from all 47 farms studied, including a range of organic, integrated-production and conventional farms. A 2018 study by U.S. Geological Survey (USGS) researchers found neonics widespread in the Great Lakes at levels that harm aquatic insects—the foundation of healthy aquatic ecosystems.

Unsurprisingly, human exposure to neonicotinoids is also on the rise. A recent study by researchers at the U.S. Geological Survey (USGS) and the University of Iowa found two metabolites of imidacloprid in drinking water that have never been detected previously, nor evaluated for their potential risks to human and environmental health. Experts warn that these metabolites may morph further into new forms of chlorinated disinfection byproducts (DBPs) during routine water treatment processes, with potential for high toxicity to humans due to loss of insect-specificity. The authors warn, “Because of their pervasiveness in source waters and persistence through treatment systems, neonicotinoids are likely present in other drinking water systems across the United States.”

With significance at known exposure levels, the newest findings linking neonicotinoids to endocrine disruption and breast cancer highlight yet another unacceptable hazard wrought by pesticide use. Beyond Pesticides holds the position that nothing short of a complete transformation to organic, least-toxic practices can begin to reverse the damage wrought by decades of unchecked poisoning. Stay abreast of new public health findings by reading Beyond Pesticides’ Daily News Blog and Pesticide-Induced Diseases Database. Join the movement to end destructive pesticide use by engaging at the local, state and federal levels to transform our agricultural system.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Sources: Environmental Health Perspectives

(Beyond Pesticides, March 6, 2019) After a brief hiatus, Florida Fish and Wildlife Conservation Commission (FWC) is continuing use of aquatic herbicides, including glyphosate, for invasive species management. Public pressure and feedback caused FWC to take a temporary pause from spraying while the commission collected public comment  through public hearings and emails from late January through February. FWC ultimately decided to resume spraying invasive species, and points to its improved integrated management system as reducing overall herbicide use.

Glyphosate, one of the 17 aquatic herbicides that FWC uses regularly has sparked opposition from environmentalists and the general public due to its wide usage and known adverse effects. According to FWC data, 12,263 pounds of glyphosate-based herbicides were used on Florida’s Lake Okeechobee in 2017.

About 175,000 people have signed North Palm Beach photographer and wildlife advocate Jim Abernathy’s petition titled “Stop The State-Sanctioned Poisoning of Our Lakes and Rivers!”. The petition decries the use of glyphosate to kill invasive aquatic plants and warns of subsequent nutrient pollution caused by decay. An excess of nutrients (e.g. nitrogen and phosphorus) in water bodies contribute to algal blooms. Eutrophication can eventually result in oxygen depletion and thereby decrease biodiversity. FWC denies that the invasive species management program contributes to either red tide (discoloration caused by an explosion of algae) or blue/green algae build up, citing lack of evidence and asserting that keeping low populations of the plant reduces buildup of decaying plant material.

Invasive aquatic plants, such as water hyacinth and hydrilla, plague Florida’s waterways. They displace native plant communities and disrupt recreation – particularly waterhyacinth, which can get so thick as to be impassable. Water hyacinth is a free-floating aquatic plant native to Amazon River in Brazil. Mature plants reproduce rapidly through horizontal stolons; populations can double in as little as 6-18 days. Mechanical means of management are difficult, as dense populations can weigh as much as 400 tons per acre. The plant then needs to be taken away from the waterway, and disposal can be expensive and time consuming. In response to the question, “Why can’t the FWC just use mechanical control and eliminate the use of herbicides?,” FWC noted:

“Research and tests conducted on Lake Okeechobee and other waterways throughout the state have consistently shown that mechanical harvesters alone are ineffective for large-scale control of these fast-growing exotics. In past tests, when harvesters replaced chemicals on Lake Okeechobee, the plants multiplied faster than they could be harvested, lake conditions became unsuitable for navigation and recreation, and there was a significant loss of native habitat. One crew applying herbicide can cover approximately 10 acres a day, whereas a crew operating a harvester can typically clear only .5 acre a day. Some biological controls can have moderate success on some types of plants but, despite many research efforts, we have not found a biological control agent that provides good results on floating plants such as water hyacinths.”

Those who use alternatives say that employing nonchemical strategies requires different approaches than chemical-intensive strategies. For example, timing of harvesting and the use of biological controls becomes an important factor in efficacy of these non-chemical approaches. Additionally, economists evaluating the cost of pesticide use in comparison with nonchemical approaches have evaluated secondary costs, such as those associated with adverse health effects, contamination, clean-up costs, weed resistance, and more. In most cases, chemical-intensive approaches are inherently more expensive.

Florida residents are concerned about the impact on people and wildlife of chemicals used, while FWC responds to this apprehension with the position that, “Herbicides registered for use in aquatic environments undergo years of rigorous evaluation with the U.S. Environmental Protection Agency (EPA).” Additionally, FWC states that it works with universities and research institutions for “environmentally compatible and cost-effective strategies to apply herbicides to control target vegetation while conserving or enhancing non-target plants and animals.” However, with industry-influenced research and a history of negligence regarding the potential harm associated with undisclosed pesticide product ingredients (inerts), independent critiques have found EPA’s pesticide evaluation process to be inadequate.

While not ending herbicide use entirely, FWC is “recommitting to employing methods that minimize the quantity of herbicides needed to achieve the desired level of control.” A news release from March 1, 2019 details their improvements as:

• Accelerating the development of habitat management plans for individual lakes.
• Forming a Technical Assistance Group consisting of staff, partners and stakeholders.
• Improving the timing of herbicide-based invasive aquatic plant treatments.
• Exploring ways to better integrate and increase the strategic use of mechanical aquatic plant harvesting.
• Exploring new methods and technologies to oversee and increase accountability of aquatic plant control contractors.
• Developing pilot projects to explore better integrated plant management tools.
• Improving agency communication regarding plant management activities.

FWC is still accepting comments through [email protected]. You can read Beyond Pesticides’ 2018 article “Meeting the ‘Invasive Species’ Challenge” or our “Least-toxic Control of Weeds” for more information about Beyond Pesticides’ approach to weed management.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Sources: Naples News, News-Press, Florida Fish and Wildlife Conservation Commission

(Beyond Pesticides, March 5, 2019) Wild, edible plants subject to drift from the herbicide glyphosate during forestry operations can be contaminated with the chemical an entire year after an initial application, according to a new study published in the Canadian Journal of Forest Research. Glyphosate is often used in forestry to knock down unwanted trees, shrubs, and other plants after clear-cutting to provide room for the regrowth of trees deemed valuable. However, this new research shows that “non-target” species, such as raspberries and blueberries, eaten by wildlife and sometimes wild foraged by humans can retain significant levels of glyphosate contamination due to drift and overspray.

Forester Lisa Wood, PhD, from the University of Northern British Columbia began this research based on input and requests from Canadian indigenous First Nations communities. Back in 2013, shrubs foraged by traditional berry-pickers in northeastern British Columbia were sampled and found to contain glyphosate residues, leading to the need for a broader investigation. Dr. Wood sampled the roots and shoots of 10 plant species from an area that had been aerially sprayed with glyphosate a year prior as part of forestry operations to clear aspen and make room for coniferous re-plantings. The 10 plants, which included highbush cranberry, prickly rose, bunchberry, pink wintergreen, blueberries and red raspberries, among others, were compared against those chosen from a control region where glyphosate was not applied.

Results show that 12 of 23 plant shoots (new growth) sampled contain detectable levels of glyphosate one year after application, with some levels ranging over 1 ppm. The roots of plants contain higher levels on average, ranging from .1 ppm to over 4 ppm. Researchers specifically analyzed the fruit of raspberries and blueberries, finding average glyphosate levels of roughly .14 ppm.

“If a plant dies from an application it falls to the soil and there are microbes that gobble up the glyphosate,” Dr. Wood told the Vancouver Sun. “When they don’t die, they have interesting ways of coping, often by storing and isolating the glyphosate.” In general, plants appear to store glyphosate in their roots during dormancy, but translocate the chemical to shoots during the growing season. Dr. Wood found that lower growing plants appear to contain higher levels of glyphosate contamination than those farther from the ground.

Many of the plants sampled have levels of contamination over the maximum residue limit of glyphosate the U.S. Environmental Protection Agency sets for some food commodities. Wild foragers and hikers will need to think about past chemical use in an area where wild fruiting berries occur. The study also has important ethnobotanical implications for North American indigenous First Nations, which use or have used the sampled plants for a variety of traditional means. As the study indicates, “Glyphosate may cause a disruption to the medicinal quality of plants harvested; there is evidence that glyphosate disrupts some plant secondary metabolites, and these metabolites could be the phytochemicals responsible for a given medicinal effect.”

Progressive forestry practices that forgo the use of toxic herbicides like glyphosate are gaining steam. In Canada, the Herbicides Alternative Project, a collaborative group consisting of the Tembec, Mushkegowuk Environmental Research Centre and other First Nations are working to reduce and eliminate forestry herbicides.

Eating pesticide-contaminated food does lead to higher levels of pesticides in one’s body, as a recent report found. Reduce pesticide contamination in your body by purchasing foods that are certified organic, which never allow glyphosate to be used on crops. Also, given the years-long contamination noted from this study, prohibits glyphosate in or near edible garden vegetables, particularly edible perennials. For more information on growing an organic garden, see Beyond Pesticides webpage on growing your own organic food.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: Vancouver Sun,  Canadian Journal of Forest Research

(Beyond Pesticides, March 4, 2019) Last week, U.S. Representative Earl Blumenauer (D-OR) reintroduced the Saving America’s Pollinators Act (H.R.1337) to cancel specific bee-toxic pesticides and establish a review and cancellation process for all pesticides that are potentially harmful to pollinators. The specific pesticides targeted in the bill include the systemic insecticides imidacloprid, clothianidin, thiamethoxam, dinotefuran, acetamiprid, sulfoxaflor, flupyradifurone, and fipronil. The bill also establishes requirements for review of other potentially bee-toxic chemicals by an independent pollinator protection board, and requires annual reports on the health and population status of pollinators. The bill creates a sustainable model for pollinator protection in the face of ongoing obstruction by an increasingly industry-influenced EPA. There are 29 cosponsors to date.

The current bill is the fifth version of Saving America’s Pollinators Act (SAPA), which was first introduced by U.S. Representative Conyers (D-MI) in 2013. The newest version differs from previous bills in its bold definition of who should have responsibility for assessing harm to pollinators. SAPA 2019 calls for the establishment of a Pollinator Protection Board, to be composed of expert scientists, beekeepers, farmers, members of environmental organizations and other key stakeholders, nearly all of whom must not have any conflict of interest or affiliation with industry. The Pollinator Protection Board would be charged with annual review of potentially bee-toxic pesticides, to ensure continued assessments the initial suspensions. Beyond Pesticides holds the position that such continuous oversight free from conflict of interest is necessary to adequately protect vital pollinators, especially in the face of worsening mass declines. The current SAPA creates a similar board structure and authorities to the Organic Foods Production Act.

“Pollinators and other insects are vital to our economy and our livelihoods. This analysis is a call to action to do all we can to protect these valuable insects,” Rep. Blumenauer said, referencing a recent study “that paints a terrifying picture for the future of insects and our planet.”

Numerous scientific studies implicate systemic insecticides as key contributors to the global decline of pollinator populations. Systemic insecticides have been found to weaken both behavioral and immune resistance to parasites, pathogens, and temperature stress in honey bees and native pollinators. Several independent studies of managed and wild bees in the field have shown significant colony and population declines as a direct result of neonicotinoid crop treatment (1, 2, 3). There is widespread consensus in the scientific community that systemic insecticides are responsible for pollinator declines and need to be restricted, as evidenced by a 2018 “Call to restrict neonicotinoids” published in Science and signed by 233 scientists.

“The health of our food system depends on the health of our pollinators. The status quo is like flying blind – we shouldn’t be using these pesticides when we don’t know their full impact,” said Rep. Blumenauer in the introduction to the previous iteration of the bill. “The EPA has a responsibility to get to the bottom of this issue and protect pollinators.”

EPA scientists have found that neonicotinoids pose far-reaching risks to birds and aquatic invertebrates, in addition to pollinators. EPA’s risk assessments find deadly impacts to birds from neonicotinoid-treated seeds, poisoned insect prey, and contaminated grasses. University researchers have found that tiny amounts of neonicotinoids are enough to cause migrating songbirds to lose their sense of direction and become emaciated. A 2018 study by U.S. Geological Survey (USGS) researchers found neonics widespread in the Great Lakes at levels that harm aquatic insects—the foundation of healthy aquatic ecosystems.

Human health is also at stake. A recent study by USGS and the University of Iowa found two metabolites of imidacloprid in drinking water that have never been evaluated for their potential risks to human and environmental health. Experts warn that these metabolites may morph further into new forms of chlorinated disinfection byproducts (DBPs) during routine water treatment processes, with potential for high toxicity to humans due to loss of insect-specificity.

Canada’s pesticide regulatory agency recently proposed a phase-out of two widely used neonicotinoids, thiamethoxam and clothianidin, based on harms to bees and aquatic ecosystems. In 2018, Europe instituted a ban on neonicotinoids for outdoor use based on based on the General Court of the European Union’s 2018 ruling affirming their harms to pollinators.

Rep. Blumenauer is offering a legislative remedy to address the U.S. pollinator crisis. But Congress won’t act unless members hear from their constituents. Read the latest draft of the bill to understand how the new act would transform pollinator protection in the U.S., and urge your representative to support the Saving America’s Pollinator Act 2019. With managed honey bee losses remaining at unsustainable levels and wild pollinators and insects of all taxa at risk of extinction, it is time for the U.S. to finally protect pollinators.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: congress.gov

(Beyond Pesticides, March 1, 2019) The costs of pesticide use extend far beyond the invoices farmers pay for purchase of the chemicals to use on their crops. The real costs related to pesticide use and exposure include those of health care, lost productivity and income, and environmental damage (loss of environmental services and biodiversity; compromised air, water, and soil quality). There has been relatively little research focused on those real and extensive costs; this Daily News Blog turns its attention to several that have made the attempt.

January 2019 saw the publication of a new book, Sicker Fatter Poorer: The Urgent Threat of Hormone-Disrupting Chemicals to Our Health and Future … and What We Can Do About It, by Leonardo Trasande, MD, MPP, which examines how some chemicals — including organophosphate and organochlorine pesticides — disrupt human endocrine (hormonal) function, and damage health, sometimes irreparably. The book further investigates the economic costs of associated diseases and other health problems to the U.S. economy — on the order of 2.3% of GDP (gross domestic product), or $340 billion, annually. As Dr. Trasande notes, “The reality is that policy predicts exposure, exposure predicts disease and disease ultimately costs our economy.”

Dr. Trasande is a leading researcher in children’s environmental health whose research focuses on organic contaminants as endocrine disruptors; he leads one of 35 centers that participate in the National Institute of Health’s Environmental Influences on Child Health Outcomes (ECHO) program. Dr. Trasande is the Jim G. Hendrick, MD Professor, Vice Chair for Research in the Department of Pediatrics, and Chief of the Division of Environmental Pediatrics at New York University (NYU) School of Medicine. He also directs the NYU Center for the Investigation of Environmental Hazards.

An endocrine-disrupting compound is an “exogenous substance that causes adverse health effects in an intact organism, or its progeny, secondary to changes in endocrine function.” The endocrine disruptive impacts of exposures to these compounds include “scrambling” of hormones’ chemical communications, which guide metabolic (and other) processes. Exposures can lead to infertility and other male and female reproductive dysfunctions, prostate and breast cancer, birth defects, cardiopulmonary disease, neurobehavioral and learning dysfunction, and immune dysregulation. Another very significant impact is on the body’s use of nutrients — exposure to endocrine disruptors (EDs) can influence the conversion of nutrients’ energy (primarily as glucose) into fat rather than muscle (or other kinds of tissue), and contribute to widespread obesity and diabetes.

The more than 1,000 chemicals that disrupt hormonal function fall into four categories: pesticides, used not only in agriculture, but also, for pest and weed management (on managed turf/landscapes, in buildings, on human and animal bodies, and in home gardens); bisphenol A (BPA), found in linings of aluminum cans, in some plastics, and on cash register receipts; brominated flame retardants, used in furniture, electronics, and mattresses; and phthalates, found in food packaging and personal care products.

The net recommendation of Dr. Trasande’s book for individuals is to reduce exposures to endocrine disruptors: avoid products with phthalates and those with flame retardants; avoid plastics and canned foods; and opt whenever possible for organically grown foods, which are protective of human health from the health impacts of pesticides.

As noted, the economic costs of pesticide use, because of disease and disability impacts, have received scant attention, but that may be changing. Dr. Trasande was the lead author (with 11 co-authors) of a 2015 investigation that attempted to estimate such costs: “Estimating Burden and Disease Costs of Exposure to Endocrine-Disrupting Chemicals in the European Union,” published in The Journal of Clinical Endocrinology & Metabolism. The study aimed to measure a range of both health and economic costs that can be reasonably attributed to endocrine-disrupting chemical exposures in the European Union (EU).

That study analyzed the incidence of health impacts from endocrine disruptor exposures and the estimated costs of these sequellae through a multivariate approach that included an assessment of the “fractional contribution” of the environment to causation of illness, a method developed in 1981 by the U.S. Institute of Medicine and in broad use until today.

The co-authors’ conclusions: “EDC [endocrine-disrupting chemicals] exposures in the EU are likely to contribute substantially to disease and dysfunction across the life course with costs in the hundreds of billions of Euros per year. These estimates represent only those EDCs with the highest probability of causation; a broader analysis would have produced greater estimates of burden of disease and costs. . . . The most substantial costs were related to loss of IQ and intellectual disability attributable to prenatal organophosphate exposure; base case estimates identified €146 billion in attributable costs, whereas sensitivity analyses suggested that costs might actually range from €46.8 to 195 billion annually. Phthalate-attributable adult obesity was the second largest driver of costs, at €15.6 billion per year. The total costs of all conditions probably attributable to EDCs were €191 billion, with sensitivity analyses suggesting costs ranging from €81.3 to 269 billion annually.”

The researchers pointedly comment on the failure of current policy and regulations to account for these impacts, and note that, because longitudinal studies of EDC exposure early in life are only just beginning to be done, the impacts could swell with those coming results. The co-authors are hopeful that this study will, in its use of this model, transform decision making by governments re: environmental health risks toward emphasis on complete assessment of the potential costs of failing to prevent chronic disease through the use of safer alternatives to EDCs.

The co-authors further comment: “These costs will accrue annually insofar as exposures that are harmful continue unabated. . . . Calculations of the health and economic benefits associated with reducing exposure to environmental chemicals have proven extremely informative to regulatory decision-making. . . . Regulatory action to limit exposure to the most widely prevalent and potentially hazardous EDCs is likely to produce substantial economic benefits. These economic benefits should inform decision-making on measures to protect public health.”

And notably, they point to the importance of this work for the U.S. and the developing world: “The findings described here suggest potentially large burdens of disease and associated costs in the developed world, insofar as exposures are similar. Future studies could extend and apply this approach to the U.S., where the National Health and Nutrition Examination Survey, among other studies, offers arguably more comprehensive and national reference points for extrapolation. In the industrializing world, the attributable disease burden and costs could well be higher in a much weaker regulatory framework.”

A number of other studies have looked at aspects of the “costs” issue, perhaps most recently, a 2018 investigation by Teresa M. Attina, MD, PhD, et al. (including, again, Dr. Trasande), published in the Journal of Clinical Epidemiology. “Racial/ethnic disparities in disease burden and costs related to exposure to endocrine-disrupting chemicals in the United States: an exploratory analysis” reminds readers that, baseline, racial and ethnic disparities exist in incidence of chronic disease, in access to appropriate healthcare, and notably, in exposures to ED chemicals as a function of the built environment, diet, and use of consumer products, all of which are influenced at least in part by socioeconomic status. (See the Beyond Pesticides Daily News Blog archive on Environmental Justice issues.) This investigation also expands the “costs” discussion by evidencing the disproportionate costs of ED exposures, and associated diseases and health impacts, across racial and ethnic groups.

The study looked at the distribution of ED exposures and levels of “disease burden” in populations identified as non-Hispanic white, non-Hispanic black, Mexican-American, Other Hispanic, and Other/Multicultural, and used the “fractional contribution” method (see above) to estimate costs of “environmentally mediated disease.” Total cost for exposure-related disease was $179.8 billion for non-Hispanic whites (52.3% of total costs); $56.8 billion for non-Hispanic black (16.5% of total); $50.1 billion for Mexican-Americans (14.6% of total); $5.7 billion for “other” Hispanics (1.6% of total); and $51.7 billion (15.0% of total) for those deemed Other/Multicultural. For context, those populations as percentages of total population are: non-Hispanic white, 66.1%; non-Hispanic black, 12.6%; Mexican-American, 13.5%; Other Hispanic, .4%; and Other/Multicultural, 7.4%.

Nearly all exposure levels and incidence of associated health issues were higher for the racial and/or ethnic minority groups (as proportions of the study’s target populations). The data show that, for example, the “loss of IQ points and intellectual disabilities” impacts due to organophosphate exposure, measured as a percentage of total cases across all racial/ethnic categories, were (in the same categorical order as above): 44.2%, 14.9%, 13.4%, 12.3%, and 14.7% — showing the proportionally outsize impacts on minority populations. Disparities are reflected, unsurprisingly, in the costs noted above, and in the disaggregated and proportional costs of the organophosphate exposures and health problems across groups.

The authors note that, “Persistent health disparities have been extensively documented in the United States, related to both medical and nonmedical factors. Access to care, insurance coverage, and ability to pay are among the more ‘conventional’ factors contributing to health disparities. . . . The higher levels of exposure in racial/ethnic minorities together with disparities in the availability of resources considered to be protective factors, such as green spaces or healthy food options, can have a cumulative effect, substantially contributing to racial/ethnic disparities in health. Our results are consistent with existing evidence that racial/ethnic minorities may be disproportionately affected by the negative health effects of toxic environmental exposure.”

They further opine, “Effective strategies [to reduce ED exposure] at the individual level need to be complemented by strategies that target the entire household, as well as state and federal policies. . . . Here we encourage a paradigm shift when evaluating health disparities, focusing on [those] driven by different exposures across race/ethnicity groups. We believe this shift may identify new opportunities for disease prevention in the demographic segments of the U.S. population who need it most, as well as offer opportunities to devise social policies that specifically address environmental inequalities.” Policy makers should attend to these realities in any case, but the cost arguments may provide additional incentive in establishing more-protective regulation of ED chemicals, and pesticides, in particular.

Beyond Pesticides has covered some aspects of the costs of pesticide use, including a look at a 2005 publication, in Environment, Development, and Sustainability, on “Environmental and Economic Costs of the Application of Pesticides Primarily in the United States,” by David Pimentel. This investigation conducted an    assessment of the (then) approximately $10 billion in environmental and societal damages as a result of pesticide use. The author analyzed pesticide impacts on: “public health; livestock and livestock product losses; increased control expenses resulting from pesticide-related destruction of natural enemies and from the development of pesticide resistance in pests; crop pollination problems and honeybee losses; crop and crop product losses; bird, fish, and other wildlife losses; and governmental expenditures to reduce the environmental and social costs of the recommended application of pesticides.”

The study identified the annual major (as of 2005) economic and environmental losses attributable to pesticide use at $1.1 billion in public health costs; $1.5 billion due to developed pesticide resistance in organisms; $1.4 billion in crop losses caused by pesticides; $2.2 billion related to bird losses; and $2.0 billion due to groundwater contamination. Dr. Pimentel noted that this analysis was not comprehensive, and that had it been — i.e., “if the full environmental, public health, and social costs could be measured as a whole — the total cost might be nearly double. . . . Such a complete and long-term cost/benefit analysis of pesticide use would reduce the perceived profitability of pesticides,” and presumably, their widespread use.

More recently, Beyond Pesticides provided coverage of a 2016 study that set out the estimated cost of ED-induced reproductive disorders (uterine fibroids associated with exposure to the organochlorine DDE, or diphenyldichloroethene) in women in the EU — the equivalent in U.S. dollars of $1.4 billion annually. In 2017, a European study that showed that the costs of the disease burden and healthcare related to chemical environmental exposures, writ large, may constitute a figure somewhere north of 10% of global gross domestic product (GDP). That figure should shock everyone, motivate policymakers to become much more proactive on the chemical regulatory front, and move the public to help raise the alarm on the risks of the use of pesticides and other dangerous chemicals.

Read more from Beyond Pesticides about ED pesticides and chemicals, and ways to protect people from exposures, including eating organically and advocating for better regulatory policies generally, and through Beyond Pesticides’ Action of the Week. In addition, upcoming is a once-a-year opportunity to learn more, and to meet scientists and advocates at the Beyond Pesticides 36^th National Pesticide Forum, April 13–14, 2019 in Irvine, California.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399291

(Beyond Pesticides, February 28, 2019) Earlier this month, a team of U.S. scientists published a meta-analysis of studies on glyphosate-based herbicides (GBH), concluding that the evidence “suggests a compelling link between exposures to GBH and increased risk of NHL [non-Hodgkin lymphoma],” corroborating findings by the International Agency for Research on Cancer. The analysis, authored by researchers from University of California, Berkeley, University of Washington, Seattle, and the Icahn School of Medicine at Mount Sinai, New York, is the latest to support the conclusions established by the International Agency for Research on Cancer that products containing glyphosate pose a cancer risk to humans. As research continues to accumulate on the risks posed by this chemical, the case for transitioning to less toxic alternatives to safeguard public health is becoming increasingly urgent.

Researchers took every available published human study on NHL and glyphosate, including the most recently updated data from the ongoing U.S. Agricultural Health Study (AHS), in conducting their review. Focus was put on individuals within these studies exposed to the highest amounts of glyphosate. The reasoning, researchers indicate, is that if there is a true association between glyphosate and a health outcome like cancer, exposures to higher amounts for a longer period of time is most likely to reveal this link. Higher exposures are also less likely to present concerns with confounders and other statistical interference. The study authors indicate this is the same approach that has been employed to estimate risks for chemicals like benzene and formaldehyde, but no similar analysis has been conducted on glyphosate.

Statistical analysis revealed there to be a 41% increased risk of NHL resulting from high exposure to glyphosate-based herbicides. To compare and add weight to their results, researchers also conducted a second statistical analysis using older (2005) AHS data, which surprisingly revealed a higher, 45% risk.

“This paper makes a stronger case than previous meta-analyses that there is evidence of an increased risk of NHL due to glyphosate exposure,” said co-author Lianne Sheppard, PhD, a professor in the Environmental and Occupational Health Sciences department at the University of Washington to the Guardian. “From a population health point of view there are some real concerns.”

Dr. Sheppard participated in the U.S. Environmental Protection Agency’s advisory council on the agency’s review of glyphosate’s carcinogenic potential, and joined other advisors in a letter to the agency stated it did not follow proper scientific methods. “It was pretty obvious they didn’t follow their own rules. Is there evidence that it is carcinogenic? The answer is yes,” Dr. Sheppard told the Guardian. “As a result of this research, I am even more convinced that it is.”

As is typical of destructive and outdated industries, agrichemical giant BayerMonsanto has worked to teach the controversy to its pro-pesticide advocates, with brazen attempts to muddle the science, or scuttle official inquiries into glyphosate’s safety.

There is strong evidence that BayerMonsanto had ghostwritten research on glyphosate (Roundup) that was later attributed to academics, according to a New York Times report on Monsanto’s internal emails. There is now an investigation by the Inspector General for EPA into whether or not an EPA official engaged in collusion with Monsanto regarding the agency’s safety assessment of glyphosate by working to kill a separate evaluation on glyphosate from the US Department of Health and Human Services. The collusion was uncovered in the discovery phase of a lawsuit filed by cancer victims that link their illness to glyphosate exposure.

Online trolls and disinformation campaigns waged by the chemical industry continue, which often influences public opinion. Independent scientific studies are critically important during this period. There is strong evidence of glyphosate’s carcinogenic properties, and more reason than ever to get active in your community to eliminate not only its use, but the whole range of toxic synthetic herbicides and pesticides in favor of less toxic alternatives. Contact Beyond Pesticides for assistance in organizing your community, including strategies and model policies that can work to replace toxic pesticide use.

For more information about glyphosate and its danger to health and the environment, see Roundup Causes Cancer, Roundup (Glyphosate) Exposed, and Beyond Pesticides general fact sheet on Glyphosate.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: Reviews in Mutation Research (peer-reviewed journal), The Guardian, UW News (press release)

(Beyond Pesticides, February 27, 2019) U.S. PIRG tested 20 common beers and wines and found glyphosate residues in all but one. Glyphosate, the active ingredient in Roundup, is the most commonly used agrichemical in the world. Though it is linked to many health and environmental issues, there is no current EPA limit for glyphosate residues in beer or wine. The U.S. Department of Agriculture (USDA) does not regularly test for glyphosate on either food or beverages.

Researchers used an enzyme linked immunosorbent assay (ELISA) to detect glyphosate levels. Sutter Home Merlot had the highest level of glyphosate residues at 51 ppb (parts per billion). Barefoot Cabernet Sauvignon and Beringer Estates Moscato had slightly lower levels: 36.3 ppb and 42.6 ppb, respectively. Organic wines results were ~5 ppb.

The beer samples had just slightly lower average levels of residues, the highest being Tsingtao beer with 49 ppb. Miller Lite, Corona, and Budweiser ranged from 25-30 ppb. Samuel Smith’s Organic Lager had a 5.7 ppb glyphosate concentration, and Peak Beer Organic IPA was the only sample with no detectable level of glyphosate.

By U.S. Geological Survey (USGS) estimates, nearly 300 million pounds of glyphosate are annually applied to U.S. crops. Vineyards spray glyphosate between rows of grapes to kill weeds. Farmers growing grains for beer often use “Roundup Ready” crops that have been genetically modified to be resistant to the herbicide, or they might use it to “kill down” crops at the end of the season so they can be harvested earlier.

While it is surprising that even the organic products had residues of this distinctly non-organic product, they could have been contaminated by the pesticide drifting up to several hundred feet from other farms or from glyphosate leftover in the soil if the farm was formerly conventional.

Glyphosate is associated with a wide range of illnesses, including genetic damage, liver and kidney damage, and endocrine disruption. A recent meta-analysis found the overall meta-relative risk of non-Hodgkin’s lymphoma was increased by 41% in individuals exposed to glyphosate-based herbicides. The herbicide is also an antibiotic and disrupts human microbiota. The U.S. PIRG report notes that even 0.1 ppb of glyphosate can harm beneficial gut bacteria, while pathogenic gut bacteria show resistance. Concerningly, bacteria exposed to widely used herbicides like roundup develop antibiotic resistance 100,000 times faster than average.  Additionally, 0.1 ppb of glyphosate has been shown to stimulate certain types of breast cancer cells.

Not only damaging to human health, glyphosate also has a striking negative impact on the environment. It harms bee gut microbiota, destroys pollinator habitat, and contaminates waterways.

The levels of residues found in the wine and beer samples are not comparatively high to other foods. EPA allows levels of glyphosate residues in food at levels ranging from 200 to 400,000 ppb. For reference, recent testing conducted by Friends of the Earth found average residues in oat cereals to be 360 ppb.

Given the multiple avenues that one is exposed to glyphosate on any given day (cereal, wine, vegetables, rain, air, etc.), it should come as no surprise that glyphosate is found nearly ubiquitously in human bodies – a recent U.S. study found traces of glyphosate in 93% of tested urine samples.

U.S. PIRG recommends several changes at the end of its report, including that the EPA ban use of glyphosate in alignment with a precautionary principle. However, a ban of a particular pesticide can result in an equally offensive, but slightly chemically different, replacement. Investigative reporter Carey Gillam calls glyphosate “the poster child for the bigger pesticide problem.” There is an urgent and ongoing need to transition from chemically-dependent, toxic practices to regenerative, organic agricultural systems. See Beyond Pesticides’ organic agriculture program page.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source:CALPIRG

(Beyond Pesticides, February 26, 2019) Breakfast cereal, apples, applesauce and pinto beans made and sold by Kroger contain residues of toxic pesticides linked to a range of series health and environmental problems, according to a residue study by Friends of the Earth.

This is alarming. Kid-friendly food like applesauce and Cheerios should not contain dangerous pesticides. Kids are the most vulnerable to these pesticides and shouldn’t be exposed to brain-damaging or cancer-causing pesticides when they eat their breakfast or snacks. The connection between pesticides and cancer, learning disabilities, and other diseases is supported by hundreds of studies in Beyond Pesticides’ Pesticide-Induced Diseases Database.

These new tests, which corroborate numerous residue studies, mean that Kroger customers may be purchasing food with the intent of providing safe and healthy food for their families, but end up unknowingly exposing them to toxic pesticides.

Join the national week of action by either delivering a letter to Kroger in person, or sending an email to Kroger Chief Executive Rodney McMullen.

The pesticides found in Kroger’s food are harmful to human health and pollinators. Friends of the Earth found residues of cancer-causing glyphosate, brain-damaging organophosphates, and bee-killing neonicotinoid pesticides.

Organophosphates can cause damage to children’s developing brains, including reduced IQ, loss of memory and attention deficit disorders, as well as acute pesticide poisoning in adults and children. They also poison farmworkers and wildlife including pollinators, birds and aquatic organisms.

Glyphosate, aka Monsanto’s Roundup®, is linked to cancer and has contributed to the widespread die-off of monarch butterflies. Monarchs have declined by over 90 percent in the past two decades and are on the brink of extinction.

Bee-killing neonicotinoids have contributed to widespread bee die-offs, which are critical to every one in three bites of food we eat and many of the foods sold at Kroger.  These pesticides are also associated with endocrine disruption and may lead to changes in behavior and attention.

Kroger should not be selling any food to consumers that is grown with these toxic pesticides.

Join the national week of action by delivering a letter to Kroger in person, or sending an email to Kroger Chief Executive Rodney McMullen

We know Kroger has the power to stop selling products grown with toxic pesticides. Costco adopted a policy to phase out neonicotinoids and chlorpyrifos (an organophosphate pesticide) on the fruits, vegetables and garden plants that it sells. The policy demonstrates that it is possible for supermarkets to eliminate toxic pesticides from store shelves. Kroger has no excuse. It can commit to stop stocking its shelves with food grown with brain damaging organophosphates, Monsanto’s Roundup® and Bayer’s neonicotinoids.

We must shift the market fast if we want to protect public health and save bees and other pollinators. These dangerous pesticides can’t be on supermarket store shelves — especially the healthiest and most affordable foods supermarkets sell.

Please help us to ramp up pressure on Kroger immediately to make sure it doesn’t turn away from the results of this report and takes immediate action.

(Beyond Pesticides, February 22, 2019) A bill introduced in the New York State Assembly and the Senate this month will break the century-long legal exclusion of agricultural workers from common labor protections. Among other protections, the Farmworker Fair Labor Practices Act will give New York farmworkers the right to collective bargaining, making employer intimidation and retaliation against organizing workers illegal. Citing farmworkers’ exposure to toxic chemicals among other occupational risks, former dairy farmworker and worker organizer Crispin Hernandez states, “The legislation would do a lot to end the pervasive climate of fear, intimidation and retaliation that exists on farms today. It would also make farmworkers’ lives safer.”

The National Farm Worker Ministry notes that, “A union contract allows workers to report problems on the job without fear of getting fired.” In the case of farmworkers, problems on the job include exposures to toxic pesticides that workers, if organized, could freely report and collectively negotiate to remove from use to ensure their safety.

The bill, introduced to the Assembly by Queens Assemblymember Cathy Nolan and to the Senate by freshman Senator Jessica Ramos (D), will amend the New York State Labor Relations Act (NYSLRA) by removing farmworkers from the list of excluded laborers. “To me there is no greater imperative than ensuring that farmworkers have their rights before we increase farming in our state,” said Senator Ramos, referring to the potential development of a new legalized marijuana industry that would expand the state’s agricultural sector.

The NYSLRA was modeled directly after the Fair Labor Standards Act (FLSA), which, together with the 1935 National Labor Relations Act, excluded farmworkers and domestic workers from labor protections. At the time that those laws were drafted, the agricultural and domestic workforce consisted largely of African Americans. Advocates maintain that the roots of these laws, and their continued application to a now largely Latinx population, are based in structural racism.

The new legislation is supported by the New York Civil Liberties Union, on the basis that, “Organization for the purposes of negotiation, furtherance of interests, and mutual protection is a civil liberty, shared by private and public employees alike.” However, as with past versions, A.1867 is receiving pushback from the New York Farm Bureau, which is urging public hearings to voice concerns over economic security for farms that employ agricultural laborers, the vast majority of which are large industrialized corporate farms. “I am willing to hear both sides, but nothing is going to convince me that these farmworkers don’t deserve their human rights,” says Senator Ramos.

In parallel to the legislative push, Mr. Hernandez, now an organizer at the Worker’s Center of Central New York, filed a lawsuit this month against the state and the Farm Bureau on the grounds that denying farmworkers the rights to organize and collectively bargain under the current NYSLRA is in violation of the state constitution. Results of the case are pending, and a decision is expected in the coming months.

Current national and state labor laws fail to provide agricultural workers the collective power to ensure working conditions safe from toxic pesticide exposures and other workplace hazards. Amendments to the FLSA in the 1960s earned farmworkers a subset of minimum protections, such as minimum wage and recordkeeping provisions, but did not give workers the power to collectively ensure safe working conditions. Similarly, the Migrant and Seasonal Agricultural Worker Protection Act of 1983 offered some additional protections, such as disclosure requirements for employers, but did not grant farmworkers the right to collective bargaining or unionizing.

With reference to the FLSA, the nonprofit Farmworker Justice states, “The law’s protections against the hazards of students working in shopping malls are stronger than the protections against children working in agriculture where toxic pesticides, heavy machinery and other hazards threaten their future.” Protections for children are arguably the most lacking and the most imperative in the agricultural sector, where neurodevelopmental toxins and endocrine disruptors put youth at especially high risk.

New York farmworkers and farmworker justice advocates have been pushing for amendments to the NYLSA for over 20 years, but the state has not passed any new agricultural labor legislation since 1999. The last New York agricultural labor reform bill came to the senate in 2010, where it lost by three votes. With a Democratic-controlled State Senate, this might be the year the bill breaks through.

In recent years, the agricultural justice movement has gained new momentum in New York, sparked in large part by Hernandez’s organizing efforts. Fueled by public support in the face of his employer’s retaliation against organizing activities, Mr. Hernandez filed a lawsuit against the state in 2016. In a symbolic victory, Governor Andrew Cuomo and former Attorney General Eric Schneiderman both agreed publicly that the farmworker exclusion in the NYLSA violated the state constitution, and neither defended the lawsuit in court. However, as in the current case, the Farm Bureau intervened, testifying that the seasonal nature of agricultural work necessitates limiting workers’ ability to organize. The case was closed in 2018, with the majority opinion denying any constitutional violations. Undeterred, Mr. Hernandez and fellow worker advocates are keeping the momentum alive, fighting on two fronts this time.

The movement for farmworker justice holds intimate ties to the fight for stronger pesticide regulations. Cesar Chavez, the esteemed lifelong advocate for farmworker rights and founder of United Farm Workers (UFW), put his full energy into the fight against pesticides, drawing attention to the poisoning of farmworkers and their children. However, in recent years progress has been stymied in large part by employer intimidation and retaliation of workers attempting to organize.

Current regulations are not viewed by Beyond Pesticides as adequately protection of agricultural workers, and farmworker poisoning continues unchecked, begging the question: if the government does not protect workers and their families, and employers do not protect workers and their families, who will? With renewed energy in the labor movement, farmworker coalitions are positioning themselves to bring negotiation and labor tactics back as tools for transforming agricultural practices. Learn more about historic efforts and active organizations fighting for farmworker justice on the Beyond Pesticides Agricultural Justice page. Stay abreast of new developments in the movement for agricultural transformation by following the Daily News Blog.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

(Beyond Pesticides, February 22, 2019) Lake Erie, the 11^th largest freshwater lake in the world, is once again plagued with pollution, although in this decade it is due primarily to agricultural runoff — as opposed to the raw sewage and industrial effluents that afflicted it in the mid-20^th century. Concerned and weary Toledo, Ohio residents are seeking remedies through the adoption of a ballot initiative, “Lake Erie Bill of Rights,” that will go before local voters this month. It asks: should Lake Erie, as an entity, have the legal right “to exist, flourish, and naturally evolve”? The New York Times reported on this unusual ballot question, which asks whether the lake ought to be granted rights more typically ascribed to people. If the measure passes, people would be able to sue polluters on behalf of the lake, using the argument that Lake Erie’s rights had been violated.

Fifty years ago, prior to the passage of the 1972 Clean Water Act, U.S. water bodies, including the Great Lakes and their tributaries, were in big trouble. One of Lake Erie’s tributaries — the Cuyahoga River — became infamous for literally catching fire due to the sewage and industrial waste that were freely dumped into it. The Michigan Environmental Council, in reviewing the book When Our Rivers Caught Fire, by John Hartig, noted the author’s chronicling of the “rise of Great Lakes industrialization in the early and mid-20^th century, when the lakes and their tributaries were considered public sewers and waste disposal lagoons.” Mr. Hartig wrote: “Industry was king, and dirty rivers were considered a sign of prosperity.” That barometer of success is happily behind us, but the agro-chemical sector continues to be a mighty contributor to pollution of the Great Lakes, through its production, marketing, and sales of synthetic, petrochemically derived fertilizers, and pesticides.

Lake Erie has endured, in recent years, summertime algal blooms spurred by terrestrial runoff containing animal manure and synthetic fertilizers, as well as the consequences of invasive fish species. The lake is also at risk of impacts from oil spills, from both vessels traversing the lake and pipelines that operate nearby. Fouling of public resources, despite real and significant progress from the 1970s through the first decade-plus of the 21^st century, continues to threaten public health and the integrity of terrestrial and marine ecosystems, as well as the environmental services they provide. Currently, pollution of waterways tends to comprise agricultural runoff (nutrient pollution, especially phosphorous and nitrogen); pesticide contamination; and the occasional industrial (petroleum, chemical, or mining) accident or malfeasance.

Given the current administration in Washington, DC, and its goal for federal agencies of “reducing regulation,” these issues again are rising to the forefront of concern. A 2017 Gallup poll found that across the nation, people are more concerned about water pollution than they have been in nearly two decades: in the poll, 63% of people “worry a great deal about pollution of drinking water,” and 57% “worry a great deal about pollution of rivers, lakes, and reservoirs.”

Toledoans for Safe Water, an advocacy group, gathered 11,000 signatures in an effort to advance the ballot initiative, which was drafted with the assistance of CELDF, the Community Environmental Legal Defense Fund (see more below). The health of Lake Erie is no small thing to Toledo-area residents, who depend on the lake for their drinking water. In 2014, the city all but closed down when the lake became so polluted with the slimy algal mats — from phosphorus runoff from upstream farms — that hospitals and stores and restaurants shuttered, and half a million people had to depend on bottled water in that year’s very hot August.

The text of the ballot question begins: “Establishing a bill of rights for Lake Erie, which prohibits activities and projects that would violate the bill of rights: We the people of the City of Toledo declare that Lake Erie and the Lake Erie watershed comprise an ecosystem upon which millions of people and countless species depend for health, drinking water and survival. We further declare that this ecosystem, which has suffered for more than a century under continuous assault and ruin due to industrialization, is in imminent danger of irreversible devastation due to continued abuse by people and corporations enabled by reckless government policies, permitting and licensing of activities that unremittingly create cumulative harm, and lack of protective intervention. Continued abuse consisting of direct dumping of industrial wastes, runoff of noxious substances from large scale agricultural practices, including factory hog and chicken farms, combined with the effects of global climate change, constitute an immediate emergency.”

This effort, like a number of similar initiatives that have taken place in various municipalities in recent years, rests on a “Rights of Nature” argument, which says that features of the natural world have an inherent right to exist with fundamental integrity intact. Because critical to our legal and judicial system is the notion of “standing” — the legal right to bring suit against an entity by virtue of enduring harm — such efforts look to establish legal status for an aspect, or aspects, of the local natural world, such as a water body, forest, fauna, flora, etc. Legal arguments in litigation brought on this basis often seek to demonstrate that current laws are inadequate to protect nature against environmental harm.

Other, similar initiatives include: Tamaqua Borough, Pennsylvania, approved in 2006 a Rights of Nature ordinance after it banned industry from dumping dredged minerals and sewage sludge into open pit mines. The law said that corporations “could not ‘interfere with the existence and flourishing of natural communities or ecosystems, or to cause damage’ to them within the township.” 2010 saw the passage of a Pittsburgh city ordinance that prohibited fracking within city limits. In 2013, Santa Monica, California passed a law requiring the city to “recognize the rights of people, natural communities and ecosystems to exist, regenerate and flourish.”

In Minnesota, the White Earth Band of Ojibwe recently passed a tribal law establishing the natural rights of a plant central to their culture — wild rice (Zizania aquatica), or manoomin, the Ojibwe term. It is the first time that a plant has been granted “personhood” in the U.S., and is understood to be establishing a foundation on which to mount opposition to an Enbridge Energy oil pipeline that would threaten waters in which local tribes have treaty rights to harvest rice, hunt, and fish. A similar law has been adopted by a Chippewa tribal group, the 1855 Treaty Authority, that represents the beneficiaries of an 1855 land pact between the Chippewa tribes and the U.S. government.

Of course, there are opponents to Rights of Nature initiatives. In the Toledo case, opposition comes primarily from large agricultural operations in the area, which shed the fertilizer runoff (which often include pesticide residues, which can cause fish kills) that feeds the toxic algae in Lake Erie, causing lethal-to-other-life algal blooms that deprive the water of oxygen. Farmers say that if the measure passes, thousands of farms could be sued for damages for polluting the lake and be driven out of business. Proponents of the initiative admit that should the question win at the ballot, it will very likely be challenged in court — either as having little legal footing (i.e., standing) or precedent, and/or as reaching beyond the scope of city law.

During the past decade-plus, other attempts to establish nature-based rights have been supported and guided by CELDF. The organization describes its work as “a paradigm shift, a move away from unsustainable practices that harm communities, and a move towards local self-government.” It helps communities with establishment of legal community rights, including environmental rights, worker rights, rights of nature, and democratic rights. Typically, establishment of such rights happens through creation of local laws that seek to set out one or more of those rights as a basis for preventing activities that a community finds unacceptable — most often, activities such as fracking, water pollution, unhealthful working conditions, pesticide use, or the environmental and/or labor ravages of particular industries, such as mining.

The Toledo effort, and a number of others around the country, perhaps owe some of their grounding to a 1972 Supreme Court ruling in Sierra Club v. Morton (Roger Morton, then U.S. Secretary of the Interior). In that case, the Sierra Club sought — and failed — to prevent development of a portion of the Sequoia National Forest; the court found, 4–3, that the Sierra Club did not have standing in the suit because it failed to show that any of its members had suffered or would suffer injury as a result of the defendant’s actions. But Justices William O. Douglas, Harry A. Blackmun, and William J. Brennan, Jr. wrote critical dissenting opinions, respectively, opining that “standing doctrine should allow environmental organizations such as the Sierra Club to sue on behalf of inanimate objects such as land”; that “when faced with new issues of potentially enormous and permanent consequences, such as environmental issues, the Court should not be quite so rigid about its legal requirements”; and that the Court should have considered the case on its merits. Justice William O. Douglas additionally wrote that “contemporary public concern for protecting nature’s ecological equilibrium should lead to the conferral of standing upon environmental objects to sue for their own preservation.”

Of the Toledo ballot initiative, CELDF Executive Director Thomas Linzey has said that the “intent of the initiative is twofold — to send a warning that the community is fed up with a lack of state and federal action to protect Lake Erie, and to force the courts to recognize that ecosystems like the lake ‘possess independent rights to survive and be healthy. In other words, that rivers have a right to flow, forests have a right to thrive, and lakes have a right to be clean.” Even if the ballot measure fails in Toledo, CELDF indicates, such efforts demonstrate the resolve of communities to fight environmental degradation, and send the message that some companies might better look elsewhere to do business. Supporters of Rights of Nature initiatives are, some environmentalists say, inviting a rethinking of nature and the place of humans in it. As Mr. Linzey said, “There’s no precedent for any of this. It is almost a new consciousness — that a community is not just Homo sapiens.”

Beyond Pesticides has written previously about the risks to water, ecosystems, and organisms of nutrient- and pesticide-riddled agricultural runoff, not only from farms, but also, from golf courses and other managed landscapes, and about the advantages of organic land management. (Some time ago, Beyond Pesticides reported about the health of water resources nationally.) Beyond Pesticides advocates for the protective — and regenerative — advantages of organic, ecologically based agriculture. Stay current with developments in efforts to protect human and environmental health through its Daily News Blog.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

https://www.nytimes.com/2019/02/17/us/lake-erie-legal-rights.html

(Beyond Pesticides, February 21, 2019) In 2018, the Environmental Protection Agency (EPA) approved 16.2 million acres of crops to be sprayed with the bee-toxic insecticide sulfoxaflor under an emergency exemption. Sulfoxaflor was used in 18 different states on cotton and sorghum — plants known to attract bees.

In response to a lawsuit headed by beekeepers, the EPA reclassified sulfoxaflor in 2016 and, recognizing its toxicity to bees, prohibited use on crops that draw in these pollinators. However, Section 18 of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) gives the EPA authority to permit temporary emergency use of unapproved pesticides. This loophole is used regularly in response to predictable stressors. “Emergency” use was approved 78 times for sulfoxaflor on sorghum and cotton between 2012-2017.

Sulfoxaflor is a systemic insecticide that acts similarly to neonicotinoid pesticides. After application, the chemical is absorbed and distributed throughout the plant, including pollen and nectar. These kinds of chemicals are selective agonists of insects’ nicotinic acetylcholine receptors—they bind to the receptor and cause it to activate. The impact on foraging bees is sublethal, but devastating on a population level. Even at low levels, sulfoxaflor impairs reproduction and reduces bumblebee colony size. Sufloxaflor is functionally identical to the pesticide imidacloprid, which negatively impacts foraging and immune responses in bees.

The EPA’s Office of Inspector General (OIG) has recognized the broad misuse of Section 18. A 2018 report from OIG notes that EPA “does not have outcome measures in place to determine how well the emergency exemption process maintains human health and environmental safeguards.” Section 18 is intended to be utilized for unanticipated, urgent, and short-lived pest situations. Instead, it is harnessed as an effective, chronic workaround FIFRA registration and appropriate limits of use.

With 41% of insects on the fast track to extinction, advocates say that EPA’s continued malfeasance is unacceptable. The consequences of ignoring the impact of toxic pesticides in favor of short-term gains in crop yields are not hypothetical or minute. A third of worldwide food production is owed to pollinators, and they are disappearing fast. There is a real emergency at hand.

Beyond Pesticides has long pushed for a precautionary approach to pesticide approval and use.

Considering the insect apocalypse (among other environmental catastrophes), it is absolutely necessary to not only limit use of specific toxic pesticides, but also promote regenerative and organic practices.

You can write to your Congressional legislators and urge them to close the Section 18 emergency loophole and adopt all the suggestions of the Office of the Inspector General. If you are looking for a hands-on way to support your local pollinators, you can utilize Beyond Pesticides’ BEE Protective Habitat Guide this spring.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: Center for Biological Diversity

(Beyond Pesticides, February 20, 2019) Women exposed to DDT during ‘early windows of susceptibility’ in their childhood are at increased risk of developing breast cancer, according to new research published in the Journal of the National Cancer Institute. Nearly 75 years after the chemical was first used in the U.S., and 50 years after its ban, DDT is continuing to adversely affect the health of Americans. The data brings needed attention to the dangers of early-life pesticide exposure, and underlines the need to take a precautionary approach to the introduction of biocides in our environment so that future generations do not suffer from the same mistakes of the past.

“What we have learned is that timing really matters. We know that if harmful exposures occur at times when breast tissue is rapidly changing, such as during puberty, they impact breast development in ways that can later result in cancer,” said lead author Barbara A. Cohn, PhD, of the Public Health Institute’s (PHI) Child Health and Development Studies. “The research published today suggests that DDT affects breast cancer as an endocrine disruptor, that the period of time between first exposure and cancer risk seems to be around 40 years–and that other endocrine disrupting chemicals could potentially simulate this kind of risk pattern.”

PHI and Dr. Cohn’s research has followed over 15,000 women for nearly six decades of life, tracking participants’ body burden (the amount of chemical contamination measured in an individual) of DDT in their blood at first exposure, during pregnancy, and if diagnosed with breast cancer. Researchers identified 153 individuals diagnosed with breast cancer from state records. Then, using data on exposure levels collected during pregnancies from 1959 to 1967, each diagnosed woman was matched up with up to three women enrolled in the study who did not develop breast cancer (in order to provide a control variable).

According to a PHI press release, the researchers found that:

• A woman’s first exposure to p,p’-DDT was associated with the timing of her breast cancer diagnosis, which occurred approximately 40 years later.
• A doubling of DDT was associated with an almost three-fold increased risk of postmenopausal breast cancer (at age 50-54) for women first exposed after infancy.
• Women at increased risk for premenopausal breast cancer (before age 50) were first exposed to DDT during in utero and infancy through puberty, but not after the age of 14; the highest risk was associated with first exposure before age 3.
• DDT exposure during childhood and puberty (ages 3-13) was a risk factor for both early (before age 50) and later breast cancer (age 50-54).
• Women who were first exposed after age 14 only had an increased risk of breast cancer after menopause (age 50-54). These women were not at increased risk for breast cancer before the age of 50.

“Even though there have been many studies of the environment and breast cancer, only a very small fraction have actually measured environmental exposures during windows of susceptibility, in this case in early infancy and prior to menarche,” said study author Mary Beth Terry, PhD, Professor of Epidemiology and Environmental Health Sciences at the Mailman School of Public Health at Columbia University and the Herbert Irving Comprehensive Cancer Center. “The studies that have measured environmental exposures during windows of susceptibility, like our study, are much more consistent in supporting a positive association with breast cancer risk,” said Dr. Terry.

As this study reveals, exposure to pesticides as children are developing can result in a higher risk of disease later into life. Unfortunately, researchers can only determine these impacts in hindsight through epidemiological studies. While DDT is the poster child for this concern, other ‘legacy’ chemicals –unnecessarily still in use – are emerging as modern contenders. Glyphosate for example, first registered as an herbicide in the early 1970s, has now accumulated significant data on its carcinogenicity. Paraquat, first registered in the 1960s, is now strongly linked to the onset of Parkinson’s disease. And linuron, also registered in the 1960s was only recently shown to be associated with the development of Multiple Sclerosis. These are only snapshots of the range of science that continues to accumulate linking pesticide exposure to the development of disease later in life.

These studies, and the predictable lag time between exposure, health impacts, and epidemiological data on those impacts should lead lawmakers and regulators to consider taking a more precautionary approach to the introduction of these chemicals into the environment.

Beyond Pesticides has long advocated for an alternatives assessment in the registration of pesticides. The alternatives assessment approach rejects uses and exposures deemed acceptable under the current model of evaluating pesticides when there are available alternatives available to manage insect and weed issues. For example, in agriculture, where data shows clear links to pesticide use and cancer, it would no longer be possible to use hazardous pesticides when there are organic systems with competitive productivity.

Support a precautionary approach and system of food production that eschews toxic pesticides as a regular course of action by buying organic whenever possible, particularly for young children with growing bodies more susceptible to chemical exposure. Read more and help spread the word about the hazards pesticides pose to children through our Children and Pesticides Don’t Mix fact sheet.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: Public Health Institute Press Release

(Beyond Pesticides, February 19, 2019) At the request of Beyond Pesticides, the Environmental Protection Agency (EPA) has extended its public comment period on antibiotics in citrus production until March 14. With this extra time, please share this action widely to stop this threat.

If you have already written your member of Congress to comment on this, please consider distributing this action broadly and submitting a comment to EPA.

We have a two-part action for you to take.

1. Use our online form to send a letter to Congress.
2. Leave a comment on the EPA docket at regulations.gov.Please personalize our messages by adding your own story, or that of a loved one. Let your representatives and the EPA know why you want to prevent bacterial resistance!

Background
Despite the building national and international crisis of deadly bacterial resistance to antibiotics, this new allowance would expand on an emergency use decision the Environmental Protection Agency made in 2017. It permits up to 480,000 acres of citrus trees in Florida to be treated with more than 650,000 pounds of streptomycin per year; 23,000 citrus acres in California will likely be treated annually.

The World Health Organization has called bacterial resistance “one of the biggest threats to global health, food security, and development today.” The two approved antibacterial chemicals to be used as pesticides in citrus production are streptomycin and oxytetracycline. Their use was permitted by the U.S. Environmental Protection Agency (EPA) under an emergency exemption in May, 2017 for a citrus greening disease caused by the bacterium Candidatus Liberibacter asiaticus (CLas) in Florida citrus crops through December of 2019.

The Environmental Protection Agency announced March 15, “EPA is issuing these tolerances without notice and opportunity for public comment as provided in FFDCA [Federal Food, Drug and Cosmetic Act] section 408(l)(6).” EPA states, “[T]ime-limited tolerances are established for residues of streptomycin in or on fruit, citrus, group 10-10, at 2 ppm, and the dried pulp of these commodities at 6 ppm.” For oxytetracycline, EPA is allowing residues “in or on all commodities of fruit, citrus, group 10-10, at 0.4 ppm.” [See below; organic standards do not allow antibiotic use.] Now, EPA is moving forward with a permanent allowance of these chemicals.

See Agricultural Uses of Antibiotics Escalate Bacterial Resistance. Beyond Pesticides, with other organizations, led a successful effort to remove antibiotics from organic apple and pear production because of their contribution to antibiotic resistance and the availability of alternative practices and inputs.

As bacteria become resistant to the most commonly prescribed antibiotics, the results are longer-lasting infections, higher medical expenses, the need for more costly or hazardous medications, and the inability to treat life-threatening infections. The development and spread of antibiotic resistance is the inevitable effect of antibiotic use. Bacteria evolve quickly, and antibiotics provide strong selection pressure for those strains with genes for resistance. Both antibiotics proposed for expanded use are important for fighting human disease. Tetracycline is used for many common infections of the respiratory tract, sinuses, middle ear, and urinary tract, as well as for anthrax, plague, cholera, and Legionnaire’s disease, though it is used less frequently because of resistance. Streptomycin is used for tuberculosis, tularemia, plague, bacterial endocarditis, brucellosis, and other diseases, but its usefulness is limited by widespread resistance (U.S. National Library of Medicine, 2006).

Exposure to antibiotics can disturb the microbiota in the gut. In addition to interfering with digestion, a disrupted gut microbiome can contribute to a whole host of “21st century diseases,” including diabetes, obesity, food allergies, heart disease, antibiotic-resistant infections, cancer, asthma, autism, irritable bowel syndrome, multiple sclerosis, rheumatoid arthritis, celiac disease, inflammatory bowel disease, and more. Furthermore, the human immune system is largely composed of microbiota.

Actions

1. Using this form, Tell your U.S. Senators and Representative to urge EPA to reject the use of antibiotics in food production, including citrus production.
2. Please put your comment in the EPA docket at REGULATIONS.GOV (a few extra clicks!)

You can cut-and-paste the language below (“Comment to EPA”) and submit it to the EPA docket at Regulations.gov. If you have a personal story with antibiotic resistance, please begin your comment with that. Reach out to others, including medical personnel, who can share their experiences with EPA.

Comment to EPA (cut-and-paste in EPA’s REGULATIONS.GOV; add personal perspective)
I write to urge EPA to reject the use of antibiotics, including streptomycin and oxytetracycline, in citrus production. This creates a public health threat that EPA must consider in real terms, as it relates to longer-lasting infections, higher medical expenses, the need for more costly or hazardous medications, and the inability to treat life-threatening infections. Antibiotic resistance is a real and urgent public health threat and represents an existential threat to modern civilization. 
Antibiotic resistance kills over 23,000 people each year, according to the Centers for Disease Control and Prevention (CDC). In addition to the CDC, the World Health Organization has cited this escalating problem as one of the biggest public health challenges of our time.

“By 2050, resistance is estimated to add 10 million annual deaths globally with a cumulative cost to the world economy of US$100 trillion,” said Jack Heinemann, PhD, University of Canterbury’s School of Biological Sciences. Exposure to antibiotics can disturb the microbiota in the gut. In addition to interfering with digestion, a disrupted gut microbiome can contribute to a whole host of “21st century diseases,” including diabetes, obesity, food allergies, heart disease, antibiotic-resistant infections, cancer, asthma, autism, irritable bowel syndrome, multiple sclerosis, rheumatoid arthritis, celiac disease, inflammatory bowel disease, and more. The human immune system is largely composed of microbiota.

Note that it may not be widely appreciated that use of antibiotics on fruit trees can contribute to resistance to the antibiotic in human pathogens. The human pathogenic organisms themselves do not need to be sprayed by the antibiotic because movement of genes in bacteria is not solely “vertical,” that is from parent to progeny—but can be “horizontal”— from one bacterial species to another. So, a pool of resistant soil bacteria or commensal gut bacteria can provide the genetic material for resistance in human pathogens.

Consider the real cost to the American people and internationally and prohibit the use of streptomycin and oxytetracycline in citrus production by setting a tolerance or allowable residue of zero.

 Thank you.

(Beyond Pesticides, February 15, 2019) A study, published in January 2019 in the journal Environmental Health, demonstrates that consumption of organic foods reduces significantly the levels of synthetic pesticide residues in the bodies of U.S. children and adults. Pesticide residues are found four times as frequently in conventionally grown food as in organically produced foodstuffs. Although the number of subjects in this study was relatively small, the results point to the importance of organics, and add to the evidence that organic food production and consumption are key to protecting human health.

Study subjects comprised members of racially diverse families — from Oakland, Minneapolis, Baltimore, and Atlanta — who did not typically consume an organic diet. Study participants, ages 4 to 52, ate their typical diet of conventionally grown foods for five days; for the following six days, they switched to a certified organic diet (provided by researchers) for consumption at home, work, school, or daycare, including all foods and beverages other than water. Urine samples were gathered prior to the “organic” days, and first thing on the morning after those six days. Fourteen different pesticides and metabolites were present in all participants’ urine in the “pre-organic” analysis; following the organic diet phase, all but one of the urinary levels of those pesticide biomarker compounds had dropped dramatically — by an average of more than 60%.

The study determines levels of residues on the basis of the presence, in excreted urine, of metabolites and parent compounds of neonicotinoids, organophosphates, pyrethroids, and 2,4-D. The most significant reductions are identified for the organophosphates malathion and chlorpyrifos, chemicals of urgent concern because of their extreme neurotoxicity, particularly for children. Some scientists have recommended a complete ban on the use of organophosphates, and Hawai’i became the first (and only) to ban chlorpyrifos in May, when the Governor signed a bill passed by the legislature the previous month.

Interestingly, given that neonicotinoids are the most widely used class of pesticides globally, of the two tested for in this investigation (clothianidin and a metabolite of imidacloprid), researchers detected the former in all samples, but the latter fell below the limit of detection in all samples. Study authors speculate that because imidacloprid is frequently found as a residue on food, it may be that this particular metabolite is not the best biomarker for evaluating dietary exposure to the compound. [Note: scientists at the U.S. Geological Survey (USGS) and the University of Iowa (UI) found drinking water contaminated with two neonicotinoid metabolites of imidacloprid that had not previously been identified in drinking water — desnitro-imidacloprid and imidacloprid-urea.]

Diet accounts for a considerable proportion of people’s exposures to pesticides in the U.S.; 2016 data from the United States Department of Agriculture (USDA) show that 47% of food produced domestically, and 49% of imported foods had detectable pesticide residues. Though there are some critical knowledge gaps (e.g., specific health outcomes associated with chronic dietary exposure to mixtures of pesticides), exposure to pesticide residues has been associated with a huge variety of health risks in people, including neurological and cognitive, developmental, reproductive, respiratory, and endocrine impacts.

Any number of studies point to organics as protective. The results of the subject study confirm, in part, those of earlier research on the matter, including: a 2014 investigation that identified reduced levels of urinary dialkyl phosphate (DAP), a metabolite of OPs, after a week-long shift to an organic diet; a 2015 study that found that adults who consumed organic produce had lower urinary levels of organophosphate residues (as detected via levels of DAPs); and another in 2015 that concluded that a switch to an organic diet reduced the body burden of pesticides in children, especially those in low-income urban, and in agricultural families.

The authors find that organic diet interventions cause significant reductions in all but one of the eighteen pesticide analytes tested. The largest reductions are in metabolites of the neurotoxic organophosphate insecticides malathion (95% ± 3%) and chlorpyrifos (60% ± 10%), and the systemic neonicotinoid clothianidin (83% ± 4). Authors highlight that neonicotinoid exposure is understudied, especially given its widespread and expanding usage and known toxic effects, and recommend that CDC take a lead role in including neonicotinoids in NHANES [National Health and Nutrition Examination Survey] testing. Organophosphates, on the other hand, have a long and well-known track record of chronic toxicity to humans.

Organophosphates (OPs) were originally developed by German scientists during World War II as the active agents in nerve gas. It is not surprising then that OPs, including malathion and chlorpyrifos, are recognized as the most toxic of all pesticides to humans and other vertebrates. Organophosphate exposure, even at low doses, has serious consequences for brain development and functioning. Long-term, low-dose exposure to OPs has been linked to neural and cognitive damage, learning disorders and neurological health problems, including Parkinson’s disease. Children are unacceptably threatened by continued OP use, as publicly recognized by EPA in 2016.

The study authors also report significant reductions in the herbicide 2,4-D and endocrine disrupting pyrehtroid metabolites 3PBA, FBPA, cDDCA and tDCCA among all participants. Interestingly, when researchers analyze data from adults and children separately, they find no significant drop in 3PBA and tDCCA among children following organic diet intervention. This suggests that children may face alternate exposure routes and/or have longer retention periods for pyrethroids, a factor that would further exacerbate chronic endocrine disruptor exposure during vulnerable periods of development.

These findings corroborate previous work showing that consumers take in significant and health-threatening levels of pesticides through conventional diets, and can dramatically reduce these intakes by switching to organic. A 2018 French research study of adults also found that higher frequency of organic food consumption — which is associated with lower pesticide exposure — was protective against several cancers. That investigation found that the most frequent consumers of organic food had 25% fewer cancers overall than those who never ate organic, and that those with the highest percentages of organic foods in their diet saw particularly large reductions in incidence of lymphomas, and significant reductions in postmenopausal breast cancers.

Research that has used an organic dietary “intervention” has seen, in some cases, startling degrees of reduction in post-protocol pesticide residues. In 2006, researchers noted that pesticide metabolites dropped to below detectable limits after an organic diet intervention and remained undetectable until a conventional diet was resumed. In a 2014 Australian study, a one-week organic diet protocol resulted in reductions of two pesticide metabolites by 89% and 96%, respectively. Taken together, all these research results suggest that there is greater dietary exposure to pesticides from conventionally produced foods than organic foods and that consumption of organic food significantly reduces this exposure.

Study co-author Kendra Klein, PhD, who is a senior staff scientist at Friends of the Earth (FOE), funder of this 2019 investigation, had this to say: “This study shows that organic works. We all have the right to food that is free of toxic pesticides. Farmers and farmworkers growing our nation’s food and rural communities have a right not to be exposed to chemicals linked to cancer, autism and infertility. And the way we grow food should protect, not harm, our environment. We urgently need our elected leaders to support our farmers in making healthy organic food available for all.” See the Friends of the Earth advocacy page here for more on the study and FOE’s “Organic for All” campaign.

If these consumer exposure findings seem alarming, what raises greater concern is farmworker and frontline community and children’s exposure to pesticides used in food production. While at least some consumers have a choice – though that too depends on neighborhood and income – farmworkers and communities living near conventionally managed farms, pesticide production plants, and waste management sites do not. See Eating with a Conscience.

Millions of Americans are faced daily with exposure levels to toxins that scientists and regulators are well aware cause lasting chronic damage to the brain and body. EPA has openly admitted that pesticide risks to agricultural workers, children and vulnerable populations exceed levels of concern.

Beyond Pesticides advocates for organic agriculture (as well as land management), for the benefits to human health, to the health of our environment (and both terrestrial and marine ecosystems), and to the Earth’s biota. Read more on the importance of organic, how to support it, and how to eat organically. Check out more resources here.

That “organic works” is surely good, if not new, news. As the Center for Food Safety has quipped, though in utter seriousness, “choosing organic foods isn’t a lifestyle, but a lifesaver.”

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: https://www.sciencedirect.com/science/article/pii/S0013935119300246#bib4

(Beyond Pesticides, February 14, 2019) Over the course of the last two weeks in Bavaria – a southern state of Germany – locals rallied in an effort to save the bees. Braving the cold in eye-catching bee outfits, a broad coalition of activists collected over a million signatures (the necessary 10% of the state’s eligible voters) to move a petition into legislature. The petition pushes forward changes in farming practices to support pollinators; while bees are the charismatic champion of the campaign, changes will support biodiversity in general.

Now that signatures are gathered, the state parliament has three months to handle citizens’ requests. Then, parliament can either accept the proposal as is or put it to a statewide referendum. In a statewide referendum, there will be a “yes” or “no” vote by a simple majority, with government bound by the result.

A central motion within the petition is to increase percentage of organic farmland from 10% to 30% by 2030. This number is based on the global movement to conserve 30% of the world by 2030 in order to avoid environmental catastrophe. Proponents of the petition suggest that the demand for organic products is higher than current Bavarian capabilities, and that the move would be economically beneficial for farmers.

The petition also puts responsibility on all farmers to create habitat within their agricultural lands that is suitable to wildlife. There is a focus on creating more flowering meadows by mowing later in the year and expanding areas of natural grassland. Edge areas such as hedges and trees will be required along with mandatory 5-meter-wide buffer margins on all streams and ditches. These “gewässerrandstreifen” both protect waterways from agricultural runoff and offer habitat for pollinators. Additionally, non-organic farmers will be required to reduce their use of pesticides.

Currently, Bavarian farmers are given a financial subsidy if they voluntarily decide to make environmentally-beneficial changes. If the petition makes it through legislation, environmental compliance would be compulsory. Environmentalists note that current agricultural conservation efforts are insufficient to change the tide of insect decline. Recent studies show alarming drops in insect populations – more than 75% of flying insects in Germany have been wiped out since 1989. As 44% of the total area of Bavaria is used for agriculture, changes in practices would likely have a major impact.

There is significant push back from the conservative ruling body of parliament and major farming groups. Farmers in the Bayerischer Bauern Verband (Bavarian Farmers’ Association) fear reduced productivity or even dispossession of their land. Critics say that the measures punish farmers and with undue responsibility and restrictions. Many farmers rely on subsidies, and about half already participate in environmental programs.

In a time of worldwide crisis for insects, local bee-enthusiasts see the petition as a way to lead necessary change. “If we wait until the whole world joins in,” Karin Staffler, a beekeeper in Ausberg, wrote, “we’ll be waiting until there’s nothing left to save.”

Beyond Pesticides supports local activists to make change within their communities and believes, like some Bavarians, that organic is a solution to environmental issues. Our tools for change serves as a resource to help individuals organize at the local, state, and national level.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Sources: National Geographic, The Local, MunichNOW Media, The Munich Eye

(Beyond Pesticides, February 13, 2019) Friends of the Earth (FOE) released a report last week again showing pesticide residues in the food supply. The report, Toxic Secret, found store and name brand foods produced and sold by the top four U.S. food retailers — Kroger (NYSE:KR), Walmart (NYSE: WMT), Costco (NYSE:COST) and Albertsons — contain residues of toxic pesticides linked to a range of serious health and environmental problems. Among the pesticides found is the herbicide glyphosate, confirming residue testing results found in numerous studies. Glyphosate, the active ingredient in Roundup, has has been detected in popular foods, including “100% pure” honey, Doritos, Oreos, Goldfish, Ritz Crackers, German beers, California wines, and UK bread. Glyphosate has been ranked as potentially cancer causing in humans and adversely affects the human gut microbiome. See Residue Testing Find More Glyphosate in Popular Cereals.

The FOE study finds that oat cereals, apples, applesauce, spinach and pinto beans at the retailers contained detectable amounts of glyphosate, organophosphates and neonicotinoids. The average level of glyphosate found in cereal samples (360 parts per billion) was more than twice the level set by scientists at Environmental Working Group for lifetime cancer risk for children. The average level of glyphosate found in pinto beans (509 ppb) was more than 4.5 times the benchmark.*

“Toxic pesticides are showing up in what should be some of the healthiest and most affordable foods supermarkets sell,” said Kendra Klein, PhD, senior staff scientist at Friends of the Earth. “Children, farmworkers and rural communities are routinely exposed to multiple pesticides linked to cancer, learning disabilities and hormone disruption. This is unacceptable. We’re calling on food retailers to get toxic pesticides out of their supply chains and off store shelves and help make organic food available to all Americans.”

Findings of the food testing are significant because of the ubiquity of toxic pesticides found in many different types of non-organic foods children eat on a daily basis. Findings include:

• Glyphosate, a probable human carcinogen according to the World Health Organization’s cancer research agency, was found on 100% of oat cereal samples and 100% of pinto bean samples tested.
• Organophosphates, which are so toxic to children’s developing brains that scientists have called for a complete ban, were found in 100% of applesauce samples, 61% of whole apples and 25% of spinach samples, at levels ranging from 0 to 3.31 nmol/g.
• Neonicotinoids, which the European Union has banned due to robust science linking the chemicals to bee die-offs and which have been linked to endocrine disruption and autism spectrum disorder, were found in 80% of spinach and 73% of applesauce samples ranging from 0 to 0.14 nmol/g.

Brands tested by an independent laboratory included Great Value (Walmart), Kroger (Kroger), Signature Kitchens and Signature Select (Albertsons/Safeway). Kroger, Walmart, Albertsons and Costco control over one third of all food and beverage sales in the U.S. Toxics Action Center and over 100 organizations are urging these companies and all food retailers to phase-out toxic pesticides in their supply chains and increase offerings of domestic organic foods, which are produced without these and many other toxic synthetic pesticides.

FOE and the groups releasing the report are calling on Congress to pass Rep. Velazquez’s bill H.R. 230 to ban the organophosphate pesticide chlorpyrifos. See Help Get Neurotoxic Pesticides, Chlorpyrifos, Out of Agriculture. The report details additional actions state and federal governments could take to eliminate the use of neonicotinoids, glyphosate and organophosphates, incentivize transition to organic production and direct public dollars to purchase certified organic food and beverages.

The groups that joined with FOE in releasing the report include Beyond Toxics, CATA-El Comite de Apoyo a Los Trabajadores Agricolas, Ecology Center, Environment Texas, Friends of the Earth, Grassroots Environmental Education, Maryland Pesticide Education Network, Northwest Center for Alternatives to Pesticides, Ohio Ecological Food and Farm Association, People and Pollinators Action Network, Pesticide Action Network North America, Toxic Free North Carolina, and Turner Environmental Law Center.

Beyond the ingestion of toxic pesticide residues, our food choices have a direct effect on the health of our environment and those who grow and harvest what we eat.  That’s why food labeled organic is the right choice. In addition to serious health questions linked to actual residues of toxic pesticides on the food we eat, our food buying decisions support or reject hazardous agricultural practices, protection of farmworkers and farm families, and stewardship of the earth. It is important to eat organic food –nurtured in a system of food production, handling and certification that rejects hazardous synthetic chemicals. USDA organic certification is the only system of food labeling that is subject to independent public review and oversight, assuring consumers that toxic, synthetic pesticides used in conventional agriculture are replaced by management practices focused on soil biology, biodiversity, and plant health. This eliminates commonly used toxic chemicals in the production and processing of food that is not labeled organic–pesticides that contaminate our water and air, hurt biodiversity, harm farmworkers, and kill bees, birds, fish and other wildlife. See Eating with a Conscience.

* Environmental Working Group determined that a one-in-a-million cancer risk would be posed by ingestion of 0.01 milligrams of glyphosate per day. To reach this maximum dose, one would have to eat a single 60-gram serving of oat cereal with a glyphosate level of 160 parts per billion (ppb) or a 90 gram serving of pinto beans with a glyphosate level of 110 ppb. The highest residue level from a cereal product sample (931 ppb, purchased from Walmart) would result in an estimated 58 µg/day glyphosate exposure, which is nearly six times greater than EWG’s health benchmark. The highest residue level from a pinto bean product sample (1,849 ppb, purchased from Albertson’s) would result in an estimated 168 µg/day glyphosate, which is nearly 17 times greater.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: Friends of the Earth

(Beyond Pesticides, February 11, 2019) A new systematic review of insect population studies worldwide reports on “the dreadful state of insect biodiversity in the world, as almost half of the species are rapidly declining and a third are being threatened with extinction.” The study concludes with the dire prediction that insects as a whole will go extinct in the next few decades if patterns of intensive agriculture, in particular pesticide use, continue.

The review, published in Biological Conservation, analyzes 73 insect population studies conducted within the past 40 years, filtered to include only those that quantitatively assess all insect species within a taxa over a span of 10 or more years. Researchers Francisco Sánchez-Bayo, PhD and Kris A.G. Wyckhuys, PhD uncover the disturbing truth behind this mass of data: one in every three insect species monitored worldwide is threatened with extinction. Even more concerning is the finding that 41% of insect species worldwide are in decline, outpacing the more well-publicized vertebrate declines by 200%. Only a few species are expanding in range or occupying vacant niches – not nearly enough to compensate for the massive losses.

In 8% of the studies in the review, citizen science data is analyzed in addition to researcher-collected survey data. The authors recognize that inclusion of citizen science can introduce bias, but note that if anything, citizen science reports would dampen the observed species loss effects due to their bias towards documenting rare species. In short, the authors’ estimates for biodiversity losses are, unfortunately, a conservative lower bound on the true scale of insect declines.

More than half of the studies that Drs. Sánchez-Bayo and Wyckhuys review point directly to intensive agriculture and increased reliance on agrochemicals as causal factors driving insect declines. Several more consider pesticides to be the most likely agent responsible for insect declines, masked under the category of “unexplained factors” in cases where tested variables, such as habitat loss, land use conversion and climate change, are insufficient in explaining losses. “[T]he intensification of agriculture over the past six decades stands as the root cause of the problem, and within it the widespread, relentless use of synthetic pesticides is a major driver of insect losses in recent times,” authors state. Authors emphasize pesticides in particular as the primary culprit: “Several multivariate and correlative statistical analyses confirm that the impact of pesticides on biodiversity is larger than that of other intensive agricultural practices…”

The bulk of evidence implicating pesticide use in the loss of insect biodiversity is both astounding and unsurprising. Insecticides kill insects, often indiscriminately and with devastating consequences for biodiversity, ecosystem stability and critical ecosystem services. Charismatic favorites, among them pollinators like butterflies and bees, are no exception to the rule. Study authors highlight a comprehensive analysis of nearly half a million records from Britain, which reveal that four separate phases of wild bee extinctions followed directly from specific policy changes that expanded the use of chemical fertilizers and pesticides. The review includes so many examples of pesticide-induced mass pollinator declines too numerous to list here, but notable highlights include:

(1)    Declines in 80% of 576 species of butterflies studied in Europe are linked to fertilizer and pesticide use.

(2)    Declines in California butterflies began sharply following the introduction of systemic neonicotinoid insecticides in 1995.

(3)    Bumblebee declines in the US have been steepest in regions with high percentage intensified pesticide use.

(4)    Honey bee colony losses began immediately following the introduction of DDT, and spiked again due to compromised immunity induced by neonicotinoids and other systemic insecticides.

The study contains further data on declines across environmental indicator species (such as ground beetles, damselflies, caddisflies and stoneflies), insects that are critical to soil fertility (such as dung beetles  and saprophytic beetles, which unlock critical nutrients trapped in wood), and insects that serve as natural enemies to common pests (such as ladybirds and dragonflies). Many of these species also serve as critical food items for vertebrates, such as shrews, moles, hedgehogs, anteaters, lizards, amphibians, bats, birds, and fish.

This comprehensive review confirms devastating declines across diverse classes of insects that are necessary for human sustenance. In the words of the authors, “As insect biodiversity is essential for the proper functioning of all ecosystems, the current trends are disrupting – to varying degree – the invaluable pollination, natural pest control, food resources, nutrient recycling and decomposition services that many insects provide.”

It is easy to feel overwhelmed by the astounding degree of evidence corroborating massive declines across diverse taxa in study regions throughout the world. More overwhelming still are the predictions authors make about the future with continued reliance on agrochemicals: complete extinction of the insects that form the base of the entire ecosystem.

The authors offer a solution to the sobering reality they present. “A rethinking of current agricultural practices, in particular a serious reduction in pesticide usage and its substitution with more sustainable, ecologically-based practices, is urgently needed to slow or reverse current trends, allow the recovery of declining insect populations and safeguard the vital ecosystem services they provide.” Beyond Pesticides holds the position that reduction is not sufficient. We must move beyond reduction and commit to complete transformation of our agricultural system if we hope to stave off the dire fate this study predicts.

Beyond Pesticides is a resource for activists pushing to end pesticide use and adopt least-toxic, organic practices. Join the movement to end destructive pesticide use by engaging at the local, state and federal levels to transform our agricultural system. See previous Daily News citing researcher David Goulson, PhD and his conclusion, “We appear to be making vast tracts of land inhospitable to most forms of life, and are currently on course for ecological Armageddon,” which he told The Guardian.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: Biological Conservation

(Beyond Pesticides, February 11, 2019) Aminocyclopyrachlor (ACP) is a tree-killing pesticide masquerading as a broadleaf herbicide. The Oregon Department of Agriculture (ODA) has the opportunity to lead the country in banning this inherently dangerous chemical. According to ODA, nearly 1,500 dead or dying trees have been reported along Oregon’s iconic Interstate 20, home to old growth ponderosa pines. Many of these 150- to 300-year old trees are now dead from ACP exposure. ODA indicated that “because [ACP] is a relatively new herbicide it is unknown how many trees stressed from past applications of [ACP] will die in the future.”

Even at tiny levels, ACP run-off and drift kills trees. Tell Oregon’s Department of Agriculture to lead the country in completely banning its use.

In 2014, DuPont chemical company settled a nearly $2 million lawsuit with the U.S. Environmental Protection Agency (EPA) after the herbicide (under the brand name Imprelis®) was found to kill trees at golf courses, homeowners associations, businesses, and private residences. Despite this history, regulators left ACP on the market. Its use was banned on lawns and turfgrass, but allowed for roadside rights-of-way. A couple years ago, Bayer purchased the rights to ACP from DuPont and continues to market and sell the chemical under the brand names Perspective®, Streamline®, and Viewpoint®. It should be no surprise to officials that this tree-killing herbicide is killing trees, but we must now deal with their errors of judgment.

ODA announced late last year that it was temporarily banning the use of ACP on roadsides while it put together a new rule. That rule is now available for public comment, and while it would make this temporary ban on roadside uses permanent, Oregon officials stopped short of a complete ban, allowing a limited one-time per year exemption from the ban when spraying an invasive weed in a limited area. While this is an important step, it is clear that there is enough evidence to completely ban the use of this chemical in Oregon.

Tell ODA to strengthen its final rule on ACP and completely ban the chemical from use in the state!

Although ODA’s new rule prohibits roadside right-of way spraying, it does not ban all uses of the chemical. In effect, this is simply setting the stage for the next round of news stories picturing ACP-poisoned trees.

Real action against tree-killing ACP is needed now. ODA will accept public comments from any U.S. resident, so regardless of where you are in the country, send the letter below to ODA today! Deadline for comments is 2/26/2019.

At the federal level, Beyond Pesticides joined with our partners at the Center for Biological Diversity and Beyond Toxics to file a Freedom of Information Act request in order to get more information about this tree-killing pesticide. We’ll keep fighting EPA’s approval of this herbicide, but please help encourage the state of Oregon to step up and lead the way!

Letter to Oregon Department of Agriculture:

Thank you for taking action against roadside uses of the tree-killing pesticide aminocyclopyrachlor (ACP). I am encouraged by the restrictions outlined in ODA’s proposed permanent rulemaking. However, given the range of damage this chemical has caused throughout the state, I strongly urge the Department to go further, and strengthen the final rule into a complete ban on the use of this chemical in Oregon.

According to ODA, nearly 1,500 dead or dying trees have been reported along iconic Interstate 20, home to old growth ponderosa pines. Many of these 150-to-300 year-old trees are now dead from ACP exposure, and ODA indicated that “because [ACP] is a relatively new herbicide it is unknown how many trees stressed from past applications of [ACP] will die in the future.”

In 2014, DuPont chemical company settled a nearly $2 million lawsuit with the U.S. Environmental Protection Agency (EPA) after the herbicide was found to kill trees at golf courses, homeowners associations, businesses, and private residences. Despite this history, regulators left ACP on the market. Its use was banned on lawns and turfgrass but allowed for roadside rights-of-way.

While the uses eliminated under the proposed rulemaking are an important step, leaving this chemical on the market is simply setting up the next tragic event in the state. Oregon has the chance to take a precautionary approach, and lead the country in banning all uses of ACP.

Thank you for the opportunity to express my support for this rule and encourage a complete ban on ACP.

Sincerely,

(Beyond Pesticides, February 8, 2019) Scientists from the U.S. Geological Survey (USGS) and the University of Iowa (UI) have published worrisome news on the neonicotinoid front. The experts discovered two metabolites of imidacloprid (a neonicotinoid insecticide) residues that had not previously been identified in drinking water — desnitro-imidacloprid and imidacloprid-urea. The researchers note both that these metabolites have never been evaluated for their potential risks to human and environmental health, and that there may be potential risks of anthropogenic compounds that can be created when water with neonicotinoid residues, and thus, these metabolites, undergo typical water treatment (often chlorination and/or pH treatment). They note that, “The mammalian toxicity of transformation products formed during water treatment processes remains unknown. It is possible that chlorination of neonicotinoids and their metabolites will . . . alter their bioactivity.”

The joint, federally funded collaboration investigated neonicotinoid pesticides (“neonics”) in tap water to determine whether neonic metabolites are relevant to pesticide exposure through drinking water, and to identify any products of the chlorination of neonics and their metabolites. The scientists simulated realistic drinking water conditions in their research to demonstrate, in laboratory circumstances, that chlorinated disinfection byproduct chemicals are produced. The study, conducted by seven researchers and titled “Chlorinated Byproducts of Neonicotinoids and Their Metabolites: An Unrecognized Human Exposure Potential?” was published in Environmental Science & Technology Letters in mid-January 2019.

Because neonicotinoids are the most widely used category of insecticide, residues are commonly found on surface waters, from which drinking water is not infrequently sourced. Previous work by this group of researchers (by Klarich, K.L., et al., published in 20179 in Environmental Science & Technology Letters) and a Canadian study — by Sultana, T., et al., and published in the journal Chemosphere in 2018 — found the presence of neonic residues in drinking water.

The metabolites of neonics are generated in the environment in microbial breakdown processes and some abiotic processes (photolysis and hydrolysis). Given the ubiquity of these compounds, it is unsurprising that they would now be identified in drinking water. There is additional concern that — because metabolites, such as desnitro-imidacloprid and descyano-thiacloprid, are more than 300 and nearly 200 times more toxic to mammals, respectively, than imidacloprid — even very low levels of exposure may carry risk of harm.

The experts from USGS and UI also warn that these metabolites may morph further into new forms of chlorinated disinfection byproducts (DBPs) during routine water treatment (chlorination) processes. These DBPs have never been tracked or tested and may represent risks to human health. (Other kinds of DBPs in drinking water are highly toxic.) The study authors note increased concern that the DBPs of such metabolites may exhibit enhanced bioactivity — e.g., carcinogenicity and/or genotoxicity. The Results and Discussion section of the published research states: “The greater potential toxicity and the frequent presence in these [subject] water samples of neonicotinoid metabolites demonstrate the need to consider their fate and persistence in drinking water treatment systems (e.g., during chlorination and other treatment processes) and their potential effects on human health. Indeed, neonicotinoids have been measured year-round in streams of impacted watersheds, and our results demonstrate that consumers of drinking water derived from vulnerable sources may be exposed to neonicotinoids and their metabolites.”

The presence of neonics in drinking water is concerning per se, because federal regulators have never addressed what might be “safe” levels of such insecticides in tap water, but the potential harms related to the presence of neonic metabolites in drinking water raises worry to another level. Neonicotinoids are the most widely used category of insecticides, posing both acute and chronic risks for aquatic life and birds; the toxicity of DBPs is unknown, though it may actually be greater than that of the neonic itself. Neonics are poorly regulated by the Environmental Protection Agency (EPA) and other regulators: their toxicity, which was assumed by EPA to be confined to target insects, is actually devastating for beneficial insects (bees and other pollinators), and for aquatic invertebrate species. Neonicotinoids have been linked with neurological effects and with autism-like impacts on children who were exposed prenatally.

In part in response to this emerging research, the Natural Resources Defense Council is asking EPA to include all neonic metabolites and DBPs in its human health risk assessment of the neonic pesticides, due later in 2019. The organization adds that “In addition to including all relevant neonic metabolites in its risk assessment, EPA should also assess the cumulative risks from all the neonic pesticides and their toxic metabolites together. It is alarming that EPA seems to have no plan for conducting a cumulative risk assessment for this toxic and persistent class of pesticides.”

Neonicotinoids are a real problem, certainly for pollinators and other insects, birds, fish, invertebrates, and amphibians, but also, for humans. Because more than 90% of neonicotinoids are used to coat seeds, and thus, represent a huge vector for spread of the insecticide and associated risks, a shift away from this practice is critical. (See Beyond Pesticides’ resource page for growers and gardeners — Companies that Grow and Distribute Organic Seeds and Plants.) There are far-less-toxic ways to deal with pest issues; see Beyond Pesticides’ Managing Pests Safely Without Neonicotinoids, and its advocacy for organic farming  practices, which reduce and/or obviate the need for such insecticides, herbicides, and fungicides.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Sources: https://www.nrdc.org/experts/jennifer-sass/neonic-pesticide-may-become-more-toxic-tap-water and https://pubs.acs.org/doi/abs/10.1021/acs.estlett.8b00706?journalCode=estlcu&

(Beyond Pesticides, February 7, 2019) A new study, released in Environmental Science and Policy, systematically reviews all state-level pollinator protection acts passed since 2000 and makes a somewhat dim diagnosis: as a rule, state policies fall far below the mark for protecting invaluable ecosystem services and ensuring long-term, sustainable food production. Authors judge the legislation against a set of pollinator protection policy benchmarks established in 2016 by a group of scientists from the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES). Citing the ten policy recommendations laid out by IPBES experts, researchers point to the failure of all enacted state policies to address three main target areas – (1) to improve genetically modified crop risk assessment, (2) to incentivize farmers to make the switch from agrochemical dependence to sustainable benefits from ecosystem services, and, critically, (3) to support diversified farming systems. Beyond Pesticides notes one additional missed target: (4) funding for research on organic, diversified, and ecologically intensified farming.

The study includes a total of 109 state laws passed from 2000 to 2017, which authors tracked down by searching usa.gov and state legislative websites and by submitting requests to state librarians. To uncover common themes and patterns among these laws, researchers used NVivo text analysis software, coded to pull out words and phrases relating to the targeted policy areas. They find that policy targets shifted across the study span and seemed to track broad public awareness campaigns. In the mid-2000s, in response to mounting public attention around Colony Collapse Disorder, several states adopted policies aimed towards promoting honey bee health. In more recent years, a deeper appreciation for the importance of native pollinators has led to more broadly framed pollinator protection plans. Among these, researchers pointed to Minnesota, Vermont, Connecticut and California as models for crafting legislation designed to achieve comprehensive, programmatically supported pollinator protection plans.

Beyond Pesticides cautions against holding up existing pollinator protection plans (P3’s) as models for lawmakers interested in building substantive measures to support sustainable agriculture. P3’s are weakly construed and toothless, relying on “voluntary agreements” rather than substantive regulations to affect change. Moreover, along with almost every state-level pollinator policy on the books, P3’s have failed to address the foremost driver of pollinator losses: over-dependence on toxic agrochemicals.

There are a few states, however, that have adopted a stronger stance. In the face of growing awareness of the devastating impacts of bee-toxic pesticides, in particular the infamous neonicotinoids, Maryland and Connecticut passed policies for stricter pesticide regulation. Most recently, a piece of Maryland legislation passed in 2017 banned neonicotinoids from use on state-managed pollinator habitat, building off of the gains made in the state’s precedent-setting 2016 neonicotinoid consumer ban.

Overall, the researchers conclude that state-level policies have a long way to go to meet the standards of supporting sustainable agriculture. Among the major missed targets study authors identified are policies to incentivize and enforce, whenever possible, the transition from agrochemical dependence to ecosystem service farming. IPBES scientists have proposed adjusting insurance packages to provide incentives for farmers who move towards ecological intensification, including efforts to promote pollinators. In the long run, however, they say stricter pesticide regulations along with the naturally-enforced economic incentives of beneficial ecosystem feedback should replace the need for such methods and lead to broader adoption of organic and ecological farming methods.

According to an independent review of source documents by Beyond Pesticides, the policies studied failed yet another target: funding research on organic, diversified and ecologically intensified farming. Existing policies have supported research on managed honey bee health and adjustments to conventional agriculture and public land management. None have promoted research on improving yields to what IPBES scientists identified as “farming systems known to support pollinators”: organic, diversified, and ecologically intensified farming. Beyond Pesticides holds the position that research on modest modifications to conventional farming is inadequate to meet the needs of our growing global population, which is threatened by unsustainable and ecologically devastating reliance on fossil fuels, water and chemical inputs. A complete transition to organic farming practices is imperative and urgent, according to Beyond Pesticides, to protect, reestablish and sustainably benefit from vital ecosystem services before they are completely wiped out.

Beyond Pesticides is a resource for activists wishing to expand their engagement into the legislative realm. For those already involved in ongoing pollinator legislation, you can draw lessons from documented successes and failures to build stronger, more targeted pollinator protection laws that enforce pesticide regulation and build economic incentives and supports for organic, ecologically sustainable practices. Stay abreast of ongoing legislation to protect pollinators and our food system at the state and national level by following the Beyond Pesticides Daily News Blog.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: Environmental Policy Science and Policy

(Beyond Pesticides, February 6, 2019) The American Association for the Advancement of Science (AAAS) has awarded two researchers the group’s Scientific Freedom and Responsibility Award for their work uncovering the link between glyphosate and chronic kidney disease (CKD), which has killed at least 25,000 Sri Lankans and 20,000 Central Americans. Award recipients Sarath Guanatilake, MD, and Channa Jayasumana, PhD, faced death threats and claims of research misconduct as they went toe to toe with agrichemical industry giant Monsanto (now Bayer’s Monsanto), the major manufacturer of glyphosate-based products like Roundup.

“To right a wrong when significant financial interests are at stake and the power imbalance between industry and individual is at play takes the unique combination of scientific rigor, professional persistence and acceptance of personal risk demonstrated by the two scientists recognized by this year’s award,” says Jessica Wyndham, director of the Scientific Responsibility, Human Rights and Law Program at AAAS.

In the mid-90s, reports began to emerge of Sri Lankan rice farmers – many otherwise healthy, young adults, succumbing to CKD. Dr. Gunatilake, a researcher at California State University, Long Beach (CSULB), was hired by the Sri Lanka Ministry of Health to investigate the cause of the disease. Around the same time, Dr. Jayasumana was working on his doctoral degree, and was able to link up with Dr. Gunatilake’s efforts, and join CSULB. Dr. Jayasumana provided Dr. Gunatilake with rice, drinking water, and urine samples that were subsequently analyzed in the lab. Results found that drinking water was contaminated with glyphosate and heavy metals, and that these compounds were making their way to workers kidneys.

Evidence shows that glyphosate bonds with heavy metals like arsenic and cadmium, forming stable compounds in water that do not break down until reaching the kidneys. CKD is a disease that develops relatively slowly, impairing the kidney’s ability to filter excess waste and fluid from the blood. Outcomes are generally poor with CKD, ultimately resulting in the need for dialysis, kidney transplant, or death. The results were published in a major scientific report in the International Journal of Environmental Research and Public Health.

The study brought international attention to the CKD, with many other developing countries in Central America, North Africa, and Southeast Asia noting similar epidemics. The Drs. were subject to intense scrutiny and pressure for their research. In typical pesticide industry malfeasance, twelve industry-funded scientists filed research misconduct complaints against Dr. Gunatilake, who was unsurprisingly exonerated. More concerning, both scientists received death threats for simply reporting their discoveries.  This link shows the type of response Bayer’s Monsanto has posted to their website concerning the Drs.’ research.

A testament to the power of perseverance, the scientists work led a temporary important ban on glyphosate and lasting restrictions on its use in Sri Lanka. And Dr. Gunatilake has now raised more than $20,000 to help the families of victims.

“What started as a bold effort to provide a voice for the impoverished, powerless rice paddy farmers in Sri Lanka has now blossomed into a worldwide environmental movement through research, advocacy, networking and collaboration,” wrote public health professional Hanan Obeidi in the award nomination letter.

As the Drs.’ research shows, glyphosate’s link to cancer is only the tip of the iceberg when it comes to the range of chronic impacts resulting from exposure to the herbicide. Read more about the range of damage caused by this chemical in Beyond Pesticides fact sheets. Work to support a system that does not lead to rampant poisoning of farmworkers here and abroad by toxic synthetic pesticides by purchasing organic whenever possible.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: EurekAlert- AAAS Press Release

(Beyond Pesticides, February 5, 2019) Linuron, an herbicide registered for use by the U.S. Environmental Protection Agency (EPA), yet recently banned in Europe due to health concerns, appears to trigger inflammatory signals that have been linked to the onset of Multiple Sclerosis (MS). This new evidence, published in the journal Cell by researchers at Brigham and Women’s Hospital in Boston, MA, indicates that exposure to chemicals and pesticides in the environment may be a risk factor in the development of neurodegenerative diseases. “We created a platform to systematically investigate the understudied effects of environmental exposures,” said study coauthor Francisco Quintana, PhD. “The goal of our work is to return results that can guide future epidemiological studies and identify actionable targets.”

Researchers began their investigation with 976 chemicals identified by EPA’s ToxCast program, an inventory of compounds that have undergone screening for a battery of laboratory tests. Within that inventory, 75 chemicals, including linuron, were found to interfere with the signaling pathways linked to MS.

To confirm the adverse impacts, scientists used the embryos of zebrafish, animals often used as models in laboratory research. The zebrafish embryos were altered to contain low levels of myelin, a protein that protects nerve cells, as is similar in patients that have MS. The embyros were also engineered to produce a green fluorescent protein when damaged.

The zebrafish model revealed five compounds that increased inflammation in the central nervous system. These chemicals were then tested on mouse astrocytes, star shaped cells that occur in the brain and spinal cord and perform many functions, including the provision of nutrients to nervous tissue and repairing the brain after traumatic injury. Both the herbicide linuron and another chemical, methyl carbamate, used in textiles, polymers, and pharmaceuticals, caused inflammation in mouse astrocytes.

Scientists then analyzed brain tissue samples from patients with MS, and found that it contained higher levels of the inflammatory signaling pathways also seen as a result of linuron exposure. Although epidemiological studies are needed to further evaluate the impact of linuron, this research brings needed attention to the concept of the ‘exposome.’

“Our findings support the need for systematic investigation of the effects of the ‘exposome’—all of the environmental exposures people experience in their lifetime—on neurologic diseases and other conditions,” said Dr. Quintana. “Studies of the exposome have the potential to identify unknown origins of inflammation and key environmental factors that may contribute to risk.”

Scientists indicate their results were limited by number of chemicals within the ToxCast program, and a wider availability of chemicals for lab testing would likely yield additional candidates that cause inflammation in the central nervous system.
“When we study inflammation and neurodegeneration, we learn that the environment may play just as important of a role as genetics,” Dr. Quintana noted.

Evidence is increasingly showing that the probable carcinogen glyphosate is merely the posterchild for a litany of other toxic herbicides that can wreak havoc on human health. The herbicide paraquat has long been associated with the onset of Parkinson’s disease. Atrazine, another broadleaf herbicide, has been linked to a range of diseases, including birth defects, cancer, impaired neurodevelopment, and reproductive disorders. While these herbicides are EPA-registered and used widely in the U.S., France has banned glyphosate use, and the entire EU has banned atrazine, paraquat, and the topic of the current study, linuron, due to human health concerns.

Read up on the range of all too common diseases linked to pesticide exposure in Beyond Pesticides’ Pesticide Induced Diseases Database. And for information on avoiding the hazardous herbicides and pesticides on conventional food found in the grocery store, see the Eating with a Conscience database.

All unattributed positions and opinions in this piece are those of Beyond Pesticides.

Source: Brigham and Women’s Hospital Press Release, Cell (peer-reviewed journal)